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Results 451 - 500 of 4474
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Lu Tong - - 2013
Abstract Objective: To develop an image visualization system based on graphic processing unit (GPU) hardware acceleration for clinical use in hepatocellular carcinoma (HCC) interventional planning. Methods: We developed a liver tumor planning tool to assist the physician in providing patient-specific analysis and visualization. We employed a spatial distance computation algorithm ...
Rosa Flávia Troncon - - 2013
Some researchers found decreased levels of plasma taurine in obese subjects and animals, and reduced expression of an important enzyme of taurine synthesis. These evidences, coupled with the metabolic imbalance of obesity and the possible anti-inflammatory and antioxidant effects of taurine, highlighted the use of taurine as a supplement in ...
Zhang Yi-Hua - - 2013
New 1D lanthanide-organic frameworks, [Ln(dpdc)1.5(IP)(H2O)]n (Ln = Sm 1, Eu 2, Gd 3; dpdc = 2,2'-diphenyldicarboxylate and IP = 1H-imidazo[4,5-f][1,10]-phenanthroline), were synthesized. White light emission was realized by two approaches: a single component Sm(iii) framework and a two-component Eu(iii)-doped Gd(iii) framework.
Alipour Hossein - - 2013
The concentrations of four heavy metals (Pb, Cd, Ni and Cr) were measured in tissues of pelagic (Rutilus caspicus) and benthic (Neogobius gorlap) fishes from the Miankaleh international wetland. The maximum concentrations of Pb, Cd, Ni, and Cr (2.06, 1.20, 1.14 and 0.70 μg g(-1), respectively) were measured in the liver of ...
Laalami Soumaya - - 2013
The instability of messenger RNA is fundamental to the control of gene expression. In bacteria, mRNA degradation generally follows an "all-or-none" pattern. This implies that if control is to be efficient, it must occur at the initiating (and presumably rate-limiting) step of the degradation process. Studies of E. coli and ...
Matsumoto Akira - - 2013
Field-effect-transistor (FET) based electrical signal transduction is an increasingly prevalent strategy for bio-sensing. This technique, often termed "Bio-FETs", provides an essentially label-free and real-time based bio-sensing platform effective for a variety of targets. This review highlights recent progress and challenges in the field. A special focus is on the comprehension ...
Ba Hengxing - - 2013
Abstract To further refine the classification and phylogeny of sika deer subspecies, the well-annotated sequences of the complete mitochondrial DNA (mtDNA) control region of 13 sika deer subspecies from GenBank were downloaded, aligned and analyzed in this study. By reconstructing the phylogenetic tree with an extended sample set, the results ...
Oh Kyung-Hwan - - 2013
In order to investigate the interaction of well-known regulation systems, quorum sensing and stringent response for the expression of virulence genes in enterohemorrhagic Escherichia coli (EHEC), E. coli strains with mutations in the two regulation systems, ΔluxS (ECM101) and ΔluxSΔrelAΔspoT (ECM201), and ΔluxS complemented strain to ECM201 (ECM202) were created ...
Hillock Kristina A - - 2013
Styela clava is a subtidal invasive marine species in Northern Europe, Atlantic Canada, Australia and New Zealand. It grows attached to solid substrata, including boat hulls, ropes, moorings, piers and aquaculture equipment, all of which can aid its spread to new locations. It interferes with feeding of mussels and oysters, ...
Banerjee Arnab - - 2013
A pyrene-thiophene conjugate has been used for the efficient detection of intracellular irons through the generation of bright green luminescence. Amongst three different probes being reported, it is observed that the efficiency for the naked eye green luminescent detection of iron increases on moving from naphthalene to anthracene to pyrene. ...
Samanta Subhas - - 2013
Introduction of S-ethyl groups in all four ortho positions of azobenzene prevents reduction of the azo group by intracellular glutathione, while enhancing the absorptivity to ∼10 000 M(-1) cm(-1) in the blue and green regions of the visible spectrum. cis-to-trans isomerization occurs thermally on the minutes timescale. Further, this substitution pattern ...
Kimber Ian - - 2013
Abstract There is considerable interest in the immunobiological processes through which the development of allergic sensitization to chemicals is initiated and orchestrated. One of the most intriguing issues is the basis for the elicitation by chemical sensitizers of different forms of allergic reaction; that is, allergic contact dermatitis or sensitization ...
Zhou Li - - 2013
Solvothermal reactions of 2,5-thiophenedicarboxylate (H2tdc) and N-auxiliary ligands in the presence of cobalt(ii), zinc(ii) and cadmium(ii) salts have given rise to seven new metal-organic frameworks, namely, [Co2(tdc)2(bpp)2(H2O)·(H2O)]n (bpp = 1,3-bis(4-pyridyl)propane) (), [Cd(tdc)(bpp)(H2O)·(H2O)2]n (), [Zn2(tdc)2(bbi)2·(H2O)2]n (bbi = 1,1'-(1,4-butanediyl)bis(imidazole)) (), [Co4(tdc)3(bimb)4(H2O)5·(tdc)·(DMF)·(H2O)2]n (bimb = 4,4'-bis(1-imidazolyl)biphenyl) (), [Zn4(O)(tdc)3(bimb)4·(H2O)5.25·(CH3OH)]n (), [Cd4(tdc)4(bimb)6·(H2O)2·(CH3OH)2·(DMF)4] () and [Co2(tdc)2(tib)2·(H2tdc)·(DMF)2] (tib ...
Zhang F - - 2013
In the present study we investigated the molecular mechanisms regulating the expression of RAR-related orphan receptor gamma t (RORγt), the central factor controlling interleukin (IL)-17 transcription and Th17 differentiation. In key studies, we found that cells from mice with major deletions of E-protein transcription factors, E2A and HEB, display greatly ...
Kwak Sang Won - - 2013
The natural product parthenolide induces apoptosis in cancer cells. However, the mechanism of apoptosis in ovarian cancer cells exposed to parthenolide is not clear. In addition, it is unclear whether parthenolide-induced apoptosis is mediated by the formation of reactive oxygen species and the depletion of GSH contents, and the effect ...
Paven Maxime - - 2013
In a gas membrane, gas is transferred between a liquid and a gas through a microporous membrane. The main challenge is to achieve a high gas transfer while preventing wetting and clogging. With respect to the oxygenation of blood, haemocompatibility is also required. Here we coat macroporous meshes with a ...
Kondapalli Kalyan C - - 2013
NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structure of bacterial NhaA ...
Shabanpoor Fazel - - 2013
We describe a general methodology for fluorescent labelling of peptide conjugates of phosphorodiamidate morpholino oligonucleotides (PMOs) by alkyne functionalization of peptides, subsequent conjugation to PMOs and labelling with a fluorescent compound (Cy5-azide). Two peptide-PMO (PPMO) examples are shown. No detrimental effect of such labelled PMOs was seen in a biological ...
Deedwania Prakash - - 2013
Heart rate is an important contributor in the pathophysiology of both coronary artery disease (CAD) and heart failure (HF). Ivabradine is an anti-anginal and anti-ischaemic agent, which selectively and specifically inhibits the I f current in the sino-atrial node and provides pure heart rate reduction without altering other cardiac parameters, ...
Frydecka Dorota - - 2013
Immense body of evidence indicates that dysfunction of immune system is implicated in the etiology of schizophrenia. The immune theory of schizophrenia is supported by alterations in cytokine profile in the brain and peripheral blood. Given the strong genetic background of schizophrenia, it might be assumed that aberrant production of ...
Cao Yan-Yan - - 2013
A recent genome-wide association study elucidated that 4q25 was implicated in ischemic stroke, but subsequent studies showed inconsistent results. In order to get coincident conclusion, we investigated two SNPs (rs2200733, rs10033464) on chromosome 4q25 in 1,388 stroke patients and 1,629 controls from Chinese Han population and then performed a meta-analysis. ...
Jiang Yusong - - 2013
Two-dimensional electrophoresis, coupled with MALDI-TOF-MS, was used to identify differentially expressed proteins between young and mature leaves of sweet potato [Ipomoea batatas (L.) Lam]. The results showed that there were 25 differential proteins between young and mature leaves. The Rubisco activase (RCA) that catalyzes the activation of Rubisco in vivo ...
Csont Tamás - - 2013
Although complex multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in hyperlipidemia which is a major risk factor for cardiovascular diseases. Therefore, here we investigated if a preparation developed for human ...
Lopes Marcos S - - 2013
Traditional breeding programs consider an average pairwise kinship between sibs. Based on pedigree information, the relationship matrix is used for genetic evaluations disregarding variation due to Mendelian sampling. Therefore, inbreeding and kinship coefficients are either over or underestimated resulting in reduction of accuracy of genetic evaluations and genetic progress. Single ...
Liang Fei - - 2013
Delayed neuropsychological sequelae (DNS) are the most severe and clinically intractable complications following acute carbon monoxide (CO) poisoning. Symptoms of DNS often resemble those of Parkinson's disease (PD), suggesting shared neurological deficits. Furthermore, Parkinson protein 2 (PARK2) mutations are associated with PD and other neurodegenerative diseases. The association signal was ...
Chatsuriyawong Siriporn - - 2013
The presence of endothelial dysfunction (ED) constitutes an early risk factor for cardiovascular disease (CVD) in children. Nitric oxide (NO) and endothelin (EDN) are generated in endothelial cells and are critical regulators of vascular function, with ED resulting from an imbalance between these two molecules. We hypothesized that genetic variants ...
Van Diest Mike - - 2013
Fall injuries are responsible for physical dysfunction, significant disability, and loss of independence among elderly. Poor postural control is one of the major risk factors for falling but can be trained in fall prevention programs. These however suffer from low therapy adherence, particularly if prevention is the goal. To provide ...
Ohama Takashi - - 2013
Epithelial tissues depend on intercellular homodimerization of E-cadherin and loss of E-cadherin is central to the epithelial to mesenchymal transition seen in multiple human diseases. Signaling pathways regulate E-cadherin function and cellular distribution via phosphorylation of the cytoplasmic region by kinases such as casein kinases but the protein phosphatases involved ...
Ostergaard Leif - - 2013
The mortality after aneurysmal subarachnoid hemorrhage (SAH) is 50%, and most survivors suffer severe functional and cognitive deficits. Half of SAH patients deteriorate 5 to 14 days after the initial bleeding, so-called delayed cerebral ischemia (DCI). Although often attributed to vasospasms, DCI may develop in the absence of angiographic vasospasms, ...
Gao Kai - - 2013
Parkinson's disease (PD), the second most common neurodegenerative disease, is characterized by loss of dopaminergic neurons in the substantia nigra. The clinical manifestations of PD encompass a variety of motor and non-motor symptoms. Mutations in the F-box protein 7 gene (FBXO7) have been identified to cause Parkinsonian-pyramidal syndrome, an autosomal ...
Li He - - 2013
Increasing evidence suggests that cancer is a metabolic disease. Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), the enzyme that catalyses the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate in glucose metabolism, in gastric cancer (GC) development. Our data indicated that FBP2 was downregulated in GC tissues (86.2%, ...
Dvorakova Eva - - 2013
The accumulation of the misfolded forms of cellular prion protein, i.e. prions (PrPSc), in the brain is one of the crucial characteristics of fatal neurodegenerative disorders, called transmissible spongiform encephalopathies (TSEs). Cellular prion protein is normally linked to the cell surface by the glycosylphosphatidylinositol (GPI) anchor. There is accumulating evidence ...
Vult von Steyern Kristina K Center for Medical Imaging and Physiology, Skåne University Hospital, Lund, Lund University, 221 85, Lund, Sweden, - - 2013
The first radiographic scoring system for pulmonary cystic fibrosis was presented in 1958. Since then a multitude of scoring systems for radiography and computed tomography (CT) have been presented, recently also for tomosynthesis and magnetic resonance imaging (MRI). The aim of the current review was to analyse and compare the ...
Frias Vilaça Ana A Department of Imagiology, Hospital-Escola da Universidade Fernando Pessoa, Gondomar, Porto, Portugal, - - 2013
Air/gas outside the aero-digestive tract is abnormal; depending on its location, it is usually called emphysema, referring to trapped air/gas in tissues, or ectopic air/gas. It can be associated to a wide range of disorders, and although it usually is an innocuous condition, it should prompt a search for the ...
Wang Xiao-Zeng - - 2013
The importance of matrix metalloproteinase 8 (MMP8) expression during the progression of thoracic aortic dissection (TAD) has been recently emphasized. Genetic variations that affect proteinase expression or activity might contribute to the pathogenesis of TAD. In this study, we investigated whether the MMP8 C-799T genotype is associated with TAD. The ...
Fraser Abigail - - 2013
The aim of this study was to investigate the association between maternal diabetes in pregnancy and offspring cognitive ability and also to assess whether the association was due to intrauterine mechanisms or shared familial characteristics. We linked national registers and conducted a prospective cohort study of singleton Swedish-born men to ...
Lane-Degraaf Kelly E - - 2013
Landscape complexity can mitigate or facilitate host dispersal, influencing patterns of pathogen transmission. Spatial transmission of pathogens through landscapes, therefore, presents an important but not fully elucidated aspect of transmission dynamics. Using an agent-based model (LiNK) that incorporates GIS data, we examined the effects of landscape information on the spatial ...
Fletcher Richard S - - 2013
The identification of the loci and specific alleles underlying variation in quantitative traits is an important goal for evolutionary biologists and breeders. Despite major advancements in genomics technology, moving from QTL to causal alleles remains a major challenge in genetics research. Near-isogenic lines are the ideal raw material for QTL ...
Fong Jessica H - - 2013
Advances in high-throughput sequencing technology have yielded a large number of publicly available vertebrate genomes, many of which are selected for inclusion in NCBI's RefSeq project and subsequently processed by NCBI's eukaryotic annotation pipeline. Genome annotation results are affected by differences in available support evidence and may be impacted by ...
Le Guellec Sandrine - - 2013
Intranasal deposition of aerosols is often studied using in vitro nasal cavity models. However, the relevance of these models to predict in vivo human deposition has not been validated. This study compared in vivo nasal aerosol deposition and in vitro deposition in a human plastinated head model (NC1) and its ...
Zou Y - - 2013
BACKGROUND/OBJECTIVES:This paper aims to compare children's thyroid volume (Tvol) by age and gender in Zhejiang province in order to explore the factors influencing Tvol in this area.SUBJECTS/METHODS:This survey was a cross-sectional survey of a provincial representative sample of Zhejiang province children aged 6-12 years. The children were asked to provide ...
Gong Qiyong - - 2013
Neuroimaging techniques hold the promise that they may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups. This study employed a multivariate approach to examine the potential of resting-state functional Magnetic Resonance ...
Kerschbaumer M - - 2013
Allopatric speciation often yields ecologically equivalent sister species, so that their secondary admixis enforces competition. The shores of Lake Tanganyika harbor about 120 distinct populations of the cichlid genus Tropheus, but only some are sympatric. When alone, Tropheus occupies a relatively broad depth zone, but in sympatry, fish segregate by ...
Toporowska-Kowalska E - - 2013
Background/Objectives:To analyse the approach to diagnose gastroesophageal reflux (GER) and the qualification criteria for anti-reflux (AR) procedures in Polish children fed via gastrostomy between 2000 and 2010.Subjects/Methods:An electronic questionnaire containing questions on the demographic and clinical data of patients with gastrostomies was distributed to six Polish centres of nutritional therapy. ...
Fox Michael G - - 2013
We examined differences in pumpkinseed (Lepomis gibbosus) life-history traits between native North American and introduced European populations, and tested three life-history predictions related to the effect of temperature, growth, waterbody size, and the presence/absence of predators on native and non-native populations. Pumpkinseed populations exhibit more 'opportunistic' traits (earlier maturity, smaller ...
Scurr M - - 2013
Although elevated CD4(+)Foxp3(+) regulatory T cell (Treg) frequencies within tumors are well documented, the functional and phenotypic characteristics of CD4(+)Foxp3(+) and CD4(+)Foxp3(-) T cell subsets from matched blood, healthy colon, and colorectal cancer require in-depth investigation. Flow cytometry revealed that the majority of intratumoral CD4(+)Foxp3(+) T cells (Tregs) were Helios(+) ...
Nakanoko Tomonori - - 2013
Neoadjuvant chemoradiotherapy (NACRT) for esophageal squamous cell carcinoma (ESCC) is beneficial in the setting of a complete pathological response. Rad51 expression affects both chemo- and radiosensitivity in many cancers; however, its role in ESCC is unclear. Rad51 expression was investigated by immunohistochemical staining with resected specimens in 89 ESCC patients ...
Chaar Ines - - 2013
One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate whether their alterations could be considered as a predictor factor of prognosis ...
W─ůsik Agnieszka - - 2013
Oxidative stress is a major contributing factor in a range of brain pathologies and in the etiology of depression. 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous substance which is present in the mammalian brain and exhibits neuroprotective, and monoamine oxidase (MAO)-inhibiting properties. In the present study, in order to investigate the potential ...
Dent Rebecca A - - 2013
This Phase I study evaluated the safety, tolerability and efficacy of olaparib, a potent oral PARP inhibitor, in combination with paclitaxel in patients with metastatic triple-negative breast cancer (mTNBC). Eligible patients who had received <=1 prior cytotoxic regimen for mTNBC were treated with olaparib 200 mg bid continuously plus weekly ...
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