Search Results
Results 101 - 150 of 1255
1 2 3 4 5 6 7 8 9 10 >
Kreft Holger - - 2013
Holt et al. (Report, 4 January 2013, p. 74) propose substantial modifications of Wallace's long-standing zoogeographic regions based on clustering of a pairwise similarity matrix of vertebrate assemblages. We worry about their compromised use of phylogenies and show that a fundamental point of their analysis--i.e., the delineation of new realms--is ...
Holt Ben G - - 2013
Kreft and Jetz's critique of our recent update of Wallace's zoogeographical regions disregards the extensive sensitivity analyses we undertook, which demonstrate the robustness of our results to the choice of phylogenetic data and clustering algorithm. Their suggested distinction between "transition zones" and biogeographic regions is worthy of further investigation but ...
Banerjee Abhijit - - 2013
To study the impact of the choice of injection points in the diffusion of a new product in a society, we developed a model of word-of-mouth diffusion and then applied it to data on social networks and participation in a newly available microfinance loan program in 43 Indian villages. Our ...
Filippatos Theodosios D - - 2013
Several epidemiological studies have clearly shown that low plasma levels of high density lipoprotein cholesterol (HDL-C) represent a cardiovascular disease (CVD) risk factor. However, it is unclear if there is a causal association between HDL-C concentration and CVD. A recent study published in the Lancet, which performed two Mendelian randomization ...
Sanchez-Jimenez Erick Francisco - - 2013
To review the initial presentation and demonstrate the importance of Takotsubo cardiomyopathy. A PubMed search using the terms "Takotsubo cardiomyopathy (TC)" and "apical ballooning syndrome" yielded 211 publications. Only those that were relevant were fully reviewed. The gender, age, precipitating stressor, main complaint at presentation, electrocardiogram (ECG) at admission and ...
Prajapati Jayesh S - - 2013
To evaluate the short and intermediate term outcome of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. We conducted a prospective analysis of all patients who underwent PTRA ...
Pant Sadip - - 2013
Patent foramen ovale (PFO) closure for systemic hypoxemia is controversial. The first systematic, albeit retrospective, study was recently presented which showed good procedural and clinical success for PFO closure for this indication. We present a case of acute right to left intra-cardiac shunt across PFO where the shunting is not ...
Zis Panagiotis - - 2013
Cardiovascular adverse events in patients with myasthenia gravis (MG) are rare, but the early recognition of such events is crucial. We describe a case of a non-coronary myocardial infarction (MI) during the initial treatment period with pyridostigmine bromide in a female patient with MG. Clinicians should be cautious about the ...
Khan Muhammad A - - 2013
Heart failure (HF) and atrial fibrillation (AF) frequently coexist and have emerged as major cardiovascular epidemics. There is growing evidence that AF is an independent prognostic marker in HF and affects patients with both reduced as well as preserved LV systolic function. There has been a general move in clinical ...
Korantzopoulos Panagiotis - - 2013
To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1 + 1 mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as ...
Hamid Tahir - - 2013
Patients with chronic aortic dissections are at high risk of catheter-induced complications. We report a 41-year-old patient with a type B aortic dissection (Stanford) who underwent successful three-vessel percutaneous coronary intervention via the right radial artery approach following a non-ST elevation myocardial infarction. The patient remained asymptomatic at 6 mo ...
Cannillo Margherita - - 2013
Patients with chronic aortic dissections are at high risk of catheter-induced complications. We report a Berberine is used in traditional Chinese medicine for the treatment of congestive heart failure, hypertension, diabetes, and dyslipidaemia and has a good safety profile. We report a case of a 53-year-old sportsman referred to our ...
Nault Jean Charles - - 2013
Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cirrhotic preneoplastic macronodules (25%) and hepatocellular adenomas with malignant transformation in hepatocellular carcinomas (44%). In hepatocellular tumours, telomerase reverse-transcripase- and CTNNB1-activating mutations are significantly associated. Moreover, ...
Jones Michael W M - - 2013
X-ray tomography can provide structural information of whole cells in close to their native state. Radiation-induced damage, however, imposes a practical limit to image resolution, and as such, a choice between damage, image contrast, and image resolution must be made. New coherent diffractive imaging techniques, such Fresnel Coherent Diffractive Imaging ...
Dvorak Marc - - 2013
Owing to its remarkable electronic and transport properties, graphene has great potential of replacing silicon for next-generation electronics and optoelectronics; but its zero bandgap associated with Dirac fermions prevents such applications. Among numerous attempts to create semiconducting graphene, periodic patterning using defects, passivation, doping, nanoscale perforation, etc., is particularly promising ...
Song Ning-Ning - - 2013
Both microwave absorption and magnetocaloric effect (MCE) are two essential performances of magnetic materials. We observe that LaFe11.6Si1.4C0.2H1.7 intermetallic compound exhibits the advantages of both giant microwave absorption exceeding -42 dB and magnetic entropy change of -20 Jkg(-1)K(-1). The excellent electromagnetic wave absorption results from the large magnetic loss and dielectric loss ...
Chen Lisa Y - - 2013
Continuous monitoring of in vivo biological processes and their evolution at the cellular level would enable major advances in our understanding of biology and disease. As a stepping stone towards chronic cellular monitoring, we demonstrate massively parallel fabrication and delivery of 3D multilayer micro-Tags (μTags) into living cells. Both 10 μm ...
Krockenberger Yoshiharu - - 2013
In many of today's most interesting materials, strong interactions prevail upon the magnetic moments, the electrons, and the crystal lattice, forming strong links between these different aspects of the system. Particularly, in two-dimensional cuprates, where copper is either five- or six-fold coordinated, superconductivity is commonly induced by chemical doping which ...
Shen Caiwei - - 2013
Prototyping of nanoporous carbon membranes with three-dimensional microscale patterns is significant for integration of such multifunctional materials into various miniaturized systems. Incorporating nano material synthesis into microelectronics technology, we present a novel approach to direct prototyping of carbon membranes with highly nanoporous structures inside. Membranes with significant thicknesses (1 ~ ...
Hosoda Masahiro - - 2013
Radionuclide concentrations in environmental samples such as surface soils, plants and water were evaluated by high purity germanium detector measurements. The contribution rate of short half-life radionuclides such as (132)I to the exposure dose to residents was discussed from the measured values. The highest values of the (131)I/(137)Cs activity ratio ...
Lönnstedt Oona M - - 2013
The animal world is full of brilliant colours and striking patterns that serve to hide individuals or attract the attention of others. False eyespots are pervasive across a variety of animal taxa and are among nature's most conspicuous markings. Understanding the adaptive significance of eyespots has long fascinated evolutionary ecologists. ...
Renaut C - - 2013
Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities have demonstrated optical trapping. However, ...
Karki Khadga J - - 2013
Multiple exciton generation (MEG) is a process in which more than one exciton is generated upon the absorption of a high energy photon, typically higher than two times the band gap, in semiconductor nanocrystals. It can be observed experimentally using time resolved spectroscopy such as the transient absorption measurements. Quantification ...
Agrawal Neema - - 2013
Expression of chitinase is developmentally regulated in insects in consonance with their molting process. During the larval-larval metamorphosis in Helicoverpa armigera, chitinase gene expression varies from high to negligible. In the five-day metamorphic course of fifth-instar larvae, chitinase transcript is least abundant on third day and maximal on fifth day. ...
Bassi C - - 2013
Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN antagonizes the phosphatidylinositol 3-kinase (PI3K) signaling pathway. PTEN also accumulates in the nucleus, where its function remains poorly understood. We demonstrate that SUMOylation ...
Ramirez Steve - - 2013
Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. ...
Voskoboynik Ayelet A Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. - - 2013
Histocompatibility is the basis by which multicellular organisms of the same species distinguish self from nonself. Relatively little is known about the mechanisms underlying histocompatibility reactions in lower organisms. Botryllus schlosseri is a colonial urochordate, a sister group of vertebrates, that exhibits a genetically determined natural transplantation reaction, whereby self-recognition ...
Li Ying Y Life Sciences Institute, Zhejiang University, Hangzhou, 310058 Zhejiang, P.R. - - 2013
The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a structure at the division site termed the "Z ring". During cytokinesis, the Z ring exerts a constrictive force on the membrane by using the chemical energy of guanosine triphosphate hydrolysis. However, the structural basis of this constriction ...
Kang Seong A SA Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, - - 2013
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth and is the target of rapamycin, a clinically useful drug that also prolongs life span in model organisms. A persistent mystery is why the phosphorylation of many bona fide mTORC1 substrates is resistant to rapamycin. We find ...
Wang Zhen Z Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, - - 2013
A systematic, efficient means of producing diverse libraries of asymmetrically branched N-glycans is needed to investigate the specificities and biology of glycan-binding proteins. To that end, we describe a core pentasaccharide that at potential branching positions is modified by orthogonal protecting groups to allow selective attachment of specific saccharide moieties ...
Saeidi Nima N Center for Basic and Translational Obesity Research, Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
The resolution of type 2 diabetes after Roux-en-Y gastric bypass (RYGB) attests to the important role of the gastrointestinal tract in glucose homeostasis. Previous studies in RYGB-treated rats have shown that the Roux limb displays hyperplasia and hypertrophy. Here, we report that the Roux limb of RYGB-treated rats exhibits reprogramming ...
Hari Yoshiyuki - - 2013
In order to expand the target sequence used in triplex DNA formation, seven novel nucleotide analogues were synthesized and incorporated into triplex-forming oligonucleotides by post-elongation modification approaches. Among them, , equipped with a suitable restricted conformation of sugar and nucleobase moieties, was found to have the highest sequence-selectivity and affinity ...
Wang Peng - - 2013
The unprecedented reaction of trisubstituted alkenes with iron porphyrin carbenes has been successfully developed. Both multiply substituted 1,3-butadiene and cyclopentadiene products are readily accessible with high efficiency and selectivity in good yields.
Wang Chang-An - - 2013
Co3O4 hollow spheres with two-level hierarchical pores and high surface area are synthesized, and the shell thickness and the mesoporous structure are well-tuned through pre-treatment of the carbon spheres with alkali/acid. Evaluation of the Co3O4 hollow spheres for the combustion of CH4 reveals that they exhibit excellent catalytic activity and ...
Deng Fan - - 2013
The phosphorescent metalloporphyrin sensitizer PtTPTNP (TPTNP = tetraphenyltetranaphtho[2,3]porphyrin) has been successfully coupled with perylenediimide (PDI) or rubrene utilized as triplet acceptors/annihilators to upconvert 690 nm incident photons into yellow fluorescence through sensitized triplet-triplet annihilation at overall efficiencies in the 6-7% range while exhibiting exceptional photostability.
Toita Riki - - 2013
Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.
Fremaux Juliette - - 2013
The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units ...
Nishijima Masaki - - 2013
Mutant human serum albumins accelerated the photocyclodimerization of 2-anthracenecarboxylate to afford chiral cyclodimers in 75-85% enantiomeric excesses, revealing that the mutations to impair non-productive sites 1 and/or 2 enhanced the substrate binding to site 3 without seriously damaging its inherently high photochirogenic ability.
Zhang Lei - - 2013
We present herein a novel method to prepare free-standing Dried Foam Films (DFFs) whereby individual polynuclear manganese complexes cover quantitatively the holes of micro-grids; the fabricated, homogeneous films have a cross-sectional thickness of only ca. 5 nm and are characterised by high mechanical stability.
Liu Jia - - 2013
The preparation of highly hydrophobic and stable MIL-53(Al) nanomaterials was achieved by an ionothermal synthesis strategy. The hydrophobicity of MIL-53(Al)it was studied by water adsorption; and the enhancement in this property was discussed with respect to its reference to MIL-53(Al)ht.
Liu Yufei - - 2013
A highly sensitive and selective DNA biosensor based on hybridization chain reaction is described, which combines CdTe quantum dots (QDs) and a ruthenium complex. Based on the variation of fluorescence signals of the CdTe QDs, the target DNA is determined.
Blechinger Jenny - - 2013
We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
Schmidtke Christian - - 2013
Nanoparticles (NPs) play an increasingly important role in biological labeling and imaging applications. However, preserving their useful properties in an aqueous biological environment remains challenging, even more as NPs therein have to be long-time stable, biocompatible and nontoxic. For in vivo applications, size control is crucial in order to route ...
Busseron Eric - - 2013
In this review, we survey the diversity of structures and functions which are encountered in advanced self-assembled nanomaterials. We highlight their flourishing implementations in three active domains of applications: biomedical sciences, information technologies, and environmental sciences. Our main objective is to provide the reader with a concise and straightforward entry ...
Sharma Ramesh - - 2013
Dual-modality imaging, using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) simultaneously, is a powerful tool to gain valuable information correlating structure with function in biomedicine. The advantage of this dual approach is that the strengths of one modality can balance the weaknesses of the other. However, success of ...
Chantry Ruth L - - 2013
In this work we address the challenge of furthering our understanding of the driving forces responsible for the metal-metal interactions in industrially relevant bimetallic nanocatalysts, by taking a comparative approach to the atomic scale characterization of two core-shell nanorod systems (AuPd and AuRh). Using aberration-corrected scanning transmission electron microscopy, we ...
Singh Johnson Haobijam - - 2013
We report on a wafer scale fabrication method of a three-dimensional plasmonic metamaterial with strong chiroptical response in the visible region of the electromagnetic spectrum. The system was comprised of metallic nanoparticles arranged in a helical fashion, with high degree of flexibility over the choice of the underlying material, as ...
Boonrungsiman Suwimon - - 2013
Silicon supplementation has been shown to play an important role in skeleton development, however, the potential role that silicon plays in mediating bone formation, and an understanding of where it might localise in the resulting bone tissue remain elusive. An improved understanding of these processes could have important implications for ...
Wang Teng - - 2013
Herein, we demonstrate that uniform Ag nanoparticles could be directionally grafted on the tip of ZnO nanowire arrays by a simple photo-reduction method. Furthermore, the structure, position, and amount of Ag nanoparticles supported on ZnO nanowire arrays could be further rationally tailored by changing the reaction parameters such as the ...
Lee Pei-Ying - - 2013
We report the synthesis of concave magnetic MnxFe1-xO nanoparticles with high-index facet structures by a thermal decomposition approach. The particle morphology varies from cubic shape under pure Ar, to star-like shapes with exposure to air during the reaction. The oxidative etching in the presence of air (O2) strongly affects the ...
1 2 3 4 5 6 7 8 9 10 >