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Results 401 - 450 of 1208
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Caprioli Manuela M Department of Biosciences, University of Milan, Milano, - - 2013
Telomere length and dynamics are increasingly scrutinized as ultimate determinants of performance, including age-dependent mortality and fecundity. Few studies have investigated longevity in relation to telomere length (TL) in the wild and none has analysed longevity in relation to TL soon after hatching, despite the fact that telomere shortening may ...
Sehara Yoshihide Y Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, - - 2013
Transient global ischemia causes selective, delayed death of hippocampal CA1 pyramidal neurons in humans and animals. It is well established that estrogens ameliorate neuronal death in animal models of focal and global ischemia. However, the role of signal transducer and activator of transcription-3 (STAT3) and its target genes in estradiol ...
Shi Wenwen - - 2013
The precise regulation of synaptic growth is critical for the proper formation and plasticity of functional neural circuits. Identification and characterization of factors that regulate synaptic growth and function have been under intensive investigation. Here we report that brain tumor (brat), which was identified as a translational repressor in multiple ...
Hedge J J Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK. - - 2013
Early characterization of the epidemiology and evolution of a pandemic is essential for determining the most appropriate interventions. During the 2009 H1N1 influenza A pandemic, public databases facilitated widespread sharing of genetic sequence data from the outset. We use Bayesian phylogenetics to simulate real-time estimates of the evolutionary rate, date ...
Jadidi A S - - 2013
Since the last decade important advances in diagnostics, understanding and the ablation techniques of ventricular tachycardia (VT) have been made. Both, patients with idiopathic VT and patients with structural heart disease and scar-related VT undergo VT ablation, that targets the underlying substrate responsible for VT development. Use of 3-dimensional electro-anatomic ...
Eagleman David M - - 2013
Communicating science to the public takes time away from busy research careers. So why would you do it? I here offer six reasons. First, we owe that understanding to the people who fund our experiments, the taxpaying public. Second, we can leverage our skills as scientists to inspire critical thinking ...
Wu Junfang J Department of Anesthesiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201-1579, - - 2013
Spinal cord injury (SCI) frequently causes severe, persistent central neuropathic pain that responds poorly to conventional pain treatments. Brain-derived neurotrophic factor (BDNF) signaling appears to contribute to central sensitization and nocifensive behaviors in certain animal models of chronic pain through effects mediated in part by the alternatively spliced truncated isoform ...
Matsunaga Ryo - - 2013
Protein fibrils are expected to have applications as functional nanomaterials because of their sophisticated structures; however, nanoscale ordering of the functional units of protein fibrils remains challenging. Here we design a series of self-polymerizing protein monomers, referred to as protein shackles, derived from modified recombinant subunits of pili from Streptococcus ...
Leatherbarrow Brian - - 2013
This article provides a comprehensive discussion on the complications of blepharoplasty. We discuss the importance of preoperative counselling and surgical planning to provide the patient with a satisfactory outcome. Strategies are presented to manage common complications.
Tanis Jessica E JE Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2013
Disruption of neuronal Ca(2+) homeostasis contributes to neurodegenerative diseases through mechanisms that are not fully understood. A polymorphism in CALHM1, a recently described ion channel that regulates intracellular Ca(2+) levels, is a possible risk factor for late-onset Alzheimer's disease. Since there are six potentially redundant CALHM family members in humans, ...
Bruot Nicolas N Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, - - 2013
As a model of ciliary beat, we use two-state oscillators that have a defined direction of oscillation and have strong synchronization properties. By allowing the direction of oscillation to vary according to the interaction with the fluid, with a timescale longer than the timescale of synchronization, we show in simulations ...
Gordon Patrick J PJ Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, - - 2013
The LIM-Homeodomain transcription factor Lhx2 is an essential organizer of early eye development and is subsequently expressed in retinal progenitor cells (RPCs). To determine its requirement in RPCs, we performed a temporal series of conditional inactivations in mice with the early RPC driver Pax6 α-Cre and the tamoxifen-inducible Hes1(CreERT2) driver. ...
Zhang Xiao-lei XL Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, - - 2013
Dendritic spines are a major substrate of brain plasticity. Although many studies have focused on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated regulation of spine dynamics and synaptic function in adult brain, much less is know about protein kinase A (PKA)-dependent regulation of spine shape dynamics during postnatal brain development. Synaptopodin is ...
Rusakiewicz Sylvie S INSERM U1015, Institut Gustave Roussy (IGR), 94805 Villejuif, - - 2013
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by a lymphocytic exocrinopathy. However, patients often have evidence of systemic autoimmunity, and they are at markedly increased risk for the development of non- Hodgkin's lymphoma. Similar to other autoimmune disorders, a strong interferon (IFN) signature is present among subsets ...
Cheng Ning N Developmental Neural Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, - - 2013
Neural circuits maintain a precise organization that is vital for normal brain functions and behaviors, but become disrupted during neurological disease. Understanding the connection between wiring accuracy and function to measure disease progression or recovery has been difficult because of the complexity of behavioral circuits. The olfactory system maintains well-defined ...
Ming Xiaotian X Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, - - 2013
We have previously demonstrated that Sox17 regulates cell cycle exit and differentiation in oligodendrocyte progenitor cells. Here we investigated its function in white matter (WM) development and adult injury with a newly generated transgenic mouse overexpressing Sox17 in the oligodendrocyte lineage under the CNPase promoter. Sox17 overexpression in CNP-Sox17 mice ...
Girard Michaël J A MJ Department of Bioengineering, National University of Singapore, Singapore, Republic of Singapore. - - 2013
Measurement of optic nerve head (ONH) deformations could be useful in the clinical management of glaucoma. Here, we propose a novel three-dimensional tissue-tracking algorithm designed to be used in vivo. We carry out preliminary verification of the algorithm by testing its accuracy and its robustness. An algorithm based on digital ...
- - 2013
HHS is issuing this final rule to clarify how section 340B(e) of the Public Health Service Act (PHSA) will be implemented. The final rule applies section 340B(e) of the PHSA only to drugs transferred, prescribed, sold, or otherwise used for the rare condition or disease for which the orphan drug ...
Sarma Rahul - - 2013
The ability of the osmolyte, trimethylamine-N-oxide (TMAO), to protect proteins from deleterious effect of urea, another commonly available osmolyte, is well-established. However, the molecular mechanism of this counteraction is not understood yet. To provide a molecular level understanding of how TMAO protects proteins in highly concentrated urea solution, we report ...
Shandilya Bhavesh K - - 2013
The selective control of O-H/O-D bond dissociation in reduced dimensionality model of HOD molecule has been explored through IR+UV femtosecond pulses. The IR pulse has been optimized using simulated annealing stochastic approach to maximize population of a desired low quanta vibrational state. Since those vibrational wavefunctions of the ground electronic ...
Wang Wen-Fei WF School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics LE12 5RD, United - - 2013
To investigate Krüppel-like factor 8 (KLF8) expression in gastric cancer and its relationship with angiogenesis and prognosis of gastric cancer. One hundred and fifty-four patients with gastric cancer who underwent successful curative resection were retrospectively enrolled in the study. Fifty tumor-adjacent healthy gastric tissues (≥ 5 cm from the tumor ...
Walther Christian F J - - 2013
Quantized Liquid Density-Functional Theory (QLDFT) [S. Patchkovskii and T. Heine, Phys. Rev. E 80, 031603 (2009)], a method developed to assess the adsorption of gas molecules in porous nanomaterials, is reformulated within the grand canonical ensemble. With the grand potential it is possible to compare directly external and internal thermodynamic ...
Liu Chun-Sheng - - 2013
Unlike on hexagonal graphene where Li atoms tend to cluster, using density functional theory, we demonstrate that Li atoms remain isolated on tetrasymmetrical T graphene due to a nonuniform charge distribution in T graphene. Furthermore, we examine the adsorption of several common gas molecules and find that Li-decorated T graphene ...
Willey T M - - 2013
Phthalocyanines, a class of macrocyclic, square planar molecules, are extensively studied as semiconductor materials for chemical sensors, dye-sensitized solar cells, and other applications. In this study, we use angular dependent near-edge x-ray absorption fine structure (NEXAFS) spectroscopy as a quantitative probe of the orientation and electronic structure of H2-, Fe-, ...
Xu Xiang-Huai XH Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, - - 2013
To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy. Sixteen patients with refractory GERC were given an 8-wk course of baclofen 20 mg three times a day as an add-on therapy to omeprazole. Changes in the cough ...
Kosumi Daisuke - - 2013
Ultrafast excited-state dynamics of the photosynthetic pigment (Mg-)bacteriochlorophyll a and its Zn-substituted form were investigated by steady-state absorption∕fluorescence and femtosecond pump-probe spectroscopic measurements. The obtained steady-state absorption and fluorescence spectra of bacteriochlorophyll a in solution showed that the central metal compound significantly affects the energy of the Qx state, but ...
Bouwens Mariëlle W E MW Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center, 6202 AZ Maastricht, The - - 2013
To examine performances regarding prediction of polyp histology using high-definition (HD) i-scan in a group of endoscopists with varying levels of experience. We used a digital library of HD i-scan still images, comprising twin pictures (surface enhancement and tone enhancement), collected at our university hospital. We defined endoscopic features of ...
Gaur Abhijeet - - 2013
X-ray absorption fine structure spectra of five copper(I) thiourea complexes [Cu4(thu)6 (NO3)4 (H2O)4] (1), [Cu4(thu)9 (NO3)4 (H2O)4] (2), [Cu2(thu)6 (SO4) H2O] (3), [Cu2(thu)5 (SO4) (H2O)3] (4), and [Cu(thu)Cl 0.5H2O] (5) have been investigated. Complexes 1 and 3 are supposed to have one type of copper centers in trigonal planar and ...
Harmandaris Vagelis - - 2013
The effect of self-concentration and intermolecular packing on the dynamics of polyisoprene (PI)/polystyrene (PS) blends is examined by extensive atomistic simulations. Direct information on local structure of the blend system allows a quantitative calculation of self- and effective composition terms at various length scales that are introduced to proposed models ...
Chatterley Adam S - - 2013
Photodissociation dynamics after excitation of the à state ν'2 = 4 (umbrella) level of ammonia are investigated using ultrafast time-resolved velocity map ion imaging (TR-VMI). These studies extend upon previous TR-VMI measurements [K. L. Wells, G. Perriam, and V. G. Stavros, J. Chem. Phys. 130, 074308 (2009)], which reported the ...
Cotta-Pereira Ricardo Lemos RL Department of Surgery, Federal University of Rio De Janeiro State-UNIRIO, Rio de Janeiro, RJ 20270-004, Brazil. - - 2013
Unlike hepatic haemorrhage following blunt abdominal trauma, spontaneous abdomen bleeding is rare, even in the presence of a hepatocellular adenoma (HA) or carcinoma. However, the diagnosis of a tumour underlying a haematoma after liver trauma is unusual, especially when it occurs more after two years after the accident. Here, we ...
Mackenzie Rebecca B - - 2013
Microwave spectra are reported for the C3v symmetric complexes Kr-SO3 and Kr-SO3-CO. The S-C distance in the trimer, 2.871(9) Å, is the same as that previously determined for SO3-CO to within the estimated uncertainties. The Kr-S distances are 3.438(3) Å and 3.488(6) Å in Kr-SO3 and Kr-SO3-CO, respectively, indicating that ...
Lim Darryl D Department of General Surgery, Singapore General Hospital, Singapore 169608, - - 2013
Positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) is an imaging modality which reflects cellular glucose metabolism. Most malignant cells accumulate and trap ¹⁸F-FDG, allowing the visualisation of increased uptake. It is hence widely used to differentiate malignant from benign lesions. "False positive" findings of hepatic lesions have been described in ...
Ibraguimova L B - - 2013
The oxygen absorbance was studied at wavelengths 200-270 nm in Schumann-Runge system behind the front of a strong shock wave. Using these data, the vibrational temperature Tv behind the front of shock waves was measured at temperatures 4000-10 800 K in undiluted oxygen. Determination of Tv was based on the measurements ...
Kaemmerer Elke E Department of Pediatrics and Institute of Pathology, RWTH Aachen University, D-52074 Aachen, - - 2013
Crohn's disease (CD), a variant of chronic inflammatory bowel disease, frequently affects the terminal ileum and coecal region. The clinical symptoms are often subtle and depend on the inflammatory activity of disease. In women of child-bearing age, florid intestinal endometriosis can simulate CD. Moreover, current pathophysiological concepts include intestinal endometriosis ...
Builth-Williams J D - - 2013
Triple differential cross section measurements for the electron-impact ionization of the highest occupied molecular orbitals of tetrahydropyran and 1,4-dioxane are presented. For each molecule, experimental measurements were performed using the (e,2e) technique in asymmetric coplanar kinematics with an incident electron energy of 250 eV and an ejected electron energy of ...
Ji Jeong-Seon JS Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon 403-720, South - - 2013
Endoscopic band ligation (EBL) is the preferred endoscopic technique for the endoscopic treatment of acute esophageal variceal bleeding. EBL has also been used to treat nonvariceal bleeding. Recently, Han et al demonstrated that EBL can be a feasible and safe alternate technique for the management of iatrogenic gastric perforation especially ...
Tecmer Paweł - - 2013
We present an EOMCCSD (equation of motion coupled cluster with singles and doubles) study of excited states of the small [UO2](2+) and [UO2](+) model systems as well as the larger U(VI)O2(saldien) complex. In addition, the triples contribution within the EOMCCSDT and CR-EOMCCSD(T) (completely renormalized EOMCCSD with non-iterative triples) approaches for ...
Kampmann Tobias A - - 2013
We study the adsorption of semiflexible polymers such as polyelectrolytes or DNA on planar and curved substrates, e.g., spheres or washboard substrates via short-range potentials using extensive Monte Carlo simulations, scaling arguments, and analytical transfer matrix techniques. We show that the adsorption threshold of stiff or semiflexible polymers on a ...
Sergi Alessandro - - 2013
A formalism for studying the dynamics of quantum systems embedded in classical spin baths is introduced. The theory is based on generalized antisymmetric brackets and predicts the presence of open-path off-diagonal geometric phases in the evolution of the density matrix. The weak coupling limit of the equation can be integrated ...
Qin Zhengbo - - 2013
Photoelectron velocity-map imaging spectroscopy has been used to study the reaction of the anionic gold atom with the HR (R = SCH3, OCH3, OH) molecules. The solvated [Au⋯HR](-) and inserted [HAuR](-) products have been experimentally observed for R = SCH3, whereas only solvated [Au⋯HR](-) products were found for R = ...
Mao Yu-Shan YS Department of Endocrinology and Metabolism, Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020, Zhejiang Province, - - 2013
To investigate the prevalence and risk factors of polypoid lesions of the gallbladder (PLGs) in petrochemical employees in Ningbo, Zhejiang Province, China. All active and retired employees aged 20-90 years (n = 11098) of a refinery and chemical plant in eastern China were requested to participate in a health survey. ...
Kawamoto Shuhei - - 2013
A new method is proposed to estimate the bending rigidity of lipid membranes from molecular dynamics simulations. An external cylindrical guiding potential is used to impose a sinusoidal deformation to a planar membrane. The bending rigidity is obtained from the mean force acting on the cylinder by calibrating against a ...
Zhao Shuangliang - - 2013
The direct correlation function (DCF) plays a pivotal role in addressing the thermodynamic properties with non-mean-field statistical theories of liquid state. This work provides an accurate yet efficient calculation procedure for evaluating the angular-dependent DCF of bulk SPC∕E water. The DCF here represented in a discrete angles basis is computed ...
Han Jiao - - 2013
Delocalized excitons in elementary linear J aggregates of two-level molecules absorb a photon into the low-energy edge of an exciton band. Absorption of a second photon is blue-shifted as the lowest energy state is occupied. This setup of states leads to a double-peak feature in a set of two dimensional ...
Wierzbicki Piotr M PM Department of Histology, Faculty of Medicine, Medical University of Gdansk, 80210 Gdansk, Poland. - - 2013
To investigate large tumor suppressor 1 (LATS1) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC). RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized ...
Ai Bao-Quan - - 2013
Transport of the finite size spherical Brownian particles is investigated in confined narrow channels with varying cross-section width. Applying the Fick-Jacobs approximation, we obtain the expressions of the particle current, the effective diffusion coefficient, and the coherence level of Brownian transport (the Péclet number). For the case of the biased ...
D'Adamo Giuseppe - - 2013
We extend our previously developed coarse-graining strategy for linear polymers with a tunable number n of effective atoms (blobs) per chain [G. D'Adamo et al., J. Chem. Phys. 137, 024901 (2012)] to polymer systems in thermal crossover between the good-solvent and the θ regimes. We consider the thermal crossover in ...
Wang Zhisong - - 2013
Directional motion of nanoscale motors and driven particles in an isothermal environment costs a finite amount of energy despite zero work as decreed by the 2nd law, but quantifying this general limit remains difficult. Here we derive a universal equality linking directional fidelity of an arbitrary nanoscale object to the ...
Ishihara Ryu R Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan. - - 2013
To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of ...
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