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Verma Sanny - - 2013
Highly dispersed Pd-nanoparticles grafted onto amino-functionalized nanocrystalline starch were found to be excellent heterogeneous catalysts for the aerobic oxidation of a variety of alcohols to their corresponding carbonyl compounds in excellent yields. The prepared catalyst was found to be selective for the oxidation of primary alcohols to aldehydes without giving ...
Kato Chisato - - 2013
Herein we report the synthesis of α-Dawson type POM, Li6[α-P2W18O62]·28H2O, directly from the use of Li2WO4 as the tungstate source. The salt obtained was soluble not only in water but also in a range of polar and non-polar organic solvents, such as benzene.
Lee Young Hoon - - 2013
Terpyridine ligands with ter- and quater-phenyl substituents at the 4' position provide bis(ligand)Co(ii) complexes showing very different magnetic properties to those of their analogues with long-chain aliphatic substituents, with no evidence of "re-entrant" behavior involving multiple high- and low-spin species. Structure determinations of [Co(tptpy)2](BF4)2·CH3OH and [Co(qptpy)2](BPh4)2·3.5dmf·2H2O (dmf = N,N-dimethylformamide) show ...
Verdon James P - - 2013
Geological storage of CO2 that has been captured at large, point source emitters represents a key potential method for reduction of anthropogenic greenhouse gas emissions. However, this technology will only be viable if it can be guaranteed that injected CO2 will remain trapped in the subsurface for thousands of years ...
Chen Guanhua - - 2013
In cancer research, as in all of medicine, it is important to classify patients into etiologically and therapeutically relevant subtypes to improve diagnosis and treatment. One way to do this is to use clustering methods to find subgroups of homogeneous individuals based on genetic profiles together with heuristic clinical analysis. ...
Hanson Kirsten K - - 2013
Residence within a customized vacuole is a highly successful strategy used by diverse intracellular microorganisms. The parasitophorous vacuole membrane (PVM) is the critical interface between Plasmodium parasites and their possibly hostile, yet ultimately sustaining, host cell environment. We show that torins, developed as ATP-competitive mammalian target of rapamycin (mTOR) kinase ...
Neesse Albrecht - - 2013
Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and poor tissue perfusion. These features are proposed to limit the access of therapies to neoplastic cells and blunt treatment efficacy. Indeed, several agents that target the PDA tumor microenvironment promote concomitant chemotherapy delivery and increased antineoplastic response in murine models ...
Underwood William - - 2013
The Arabidopsis PENETRATION RESISTANCE 3 (PEN3) ATP binding cassette transporter participates in nonhost resistance to fungal and oomycete pathogens and is required for full penetration resistance to the barley powdery mildew Blumeria graminis f. sp. hordei. PEN3 resides in the plasma membrane and is recruited to sites of attempted penetration ...
Block Jonathan - - 2013
When the Obama administration announced it was delaying enforcement of the employer mandate in the ACA for one year, employer groups celebrated. But others had some troubling questions. "One has to hope, however, that the administration has thought through the ramifications of this delay for the other provisions," says Tim ...
Neto Brenno A D - - 2013
We describe the synthesis of novel mononuclear and dinuclear copper complexes and an investigation of their behaviour in solution using mass spectrometry (ESI-MS and ESI-MS/MS) and in the solid state using X-ray crystallography. The complexes were synthesized from two widely used diacetylpryridine (dap) ligands, i.e. 2,6-diacetylpyridinebis(benzoic acid hydrazone) and 2,6-diacetylpyridinebis(2-aminobenzoic ...
Bhattacharyya Sudipta - - 2013
Three Cu(II) complexes of bis-pyrazole based ligands have been synthesized and structurally characterized by X-ray crystallography. One of the ligand (L2) contains a methionine ester conjugated to a bis-pyrazole carboxylate through an amide linkage. The binding constant for complexes 1-3 with CT DNA are of the order of 10(4) M(-1). ...
Schroeder Dustin M - - 2013
Thwaites Glacier is one of the largest, most rapidly changing glaciers on Earth, and its landward-sloping bed reaches the interior of the marine West Antarctic Ice Sheet, which impounds enough ice to yield meters of sea-level rise. Marine ice sheets with landward-sloping beds have a potentially unstable configuration in which ...
Eikeset Anne Maria - - 2013
Fish stocks experiencing high fishing mortality show a tendency to mature earlier and at a smaller size, which may have a genetic component and therefore long-lasting economic and biological effects. To date, the economic effects of such ecoevolutionary dynamics have not been empirically investigated. Using 70 y of data, we ...
Albertazzi Lorenzo - - 2013
Multivalency has an important but poorly understood role in molecular self-organization. We present the noncovalent synthesis of a multicomponent supramolecular polymer in which chemically distinct monomers spontaneously coassemble into a dynamic, functional structure. We show that a multivalent recruiter is able to bind selectively to one subset of monomers (receptors) ...
Ballesteros-Plaza David - - 2013
During evolution, viruses have optimized the interaction with host factors to increase the efficiency of fundamental processes such as DNA replication. Bacteriophage 29 protein p1 is a membrane-associated protein that forms large protofilament sheets that resemble eukaryotic tubulin and bacterial filamenting temperature-sensitive mutant Z protein (FtsZ) polymers. In the absence ...
Jung Dae Soo DS Graduate School of Energy Environment Water Sustainability, World Class University and KAIST Institute NanoCentury and Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon 305-701, - - 2013
The rice husk is the outer covering of a rice kernel and protects the inner ingredients from external attack by insects and bacteria. To perform this function while ventilating air and moisture, rice plants have developed unique nanoporous silica layers in their husks through years of natural evolution. Despite the ...
Lynch Michael M Department of Biology, Indiana University, Bloomington, IN 47405, USA. - - 2013
One of the most striking features of proteins is their common assembly into multimeric structures, usually homomers with even numbers of subunits all derived from the same genetic locus. However, although substantial structural variation for orthologous proteins exists within and among major phylogenetic lineages, in striking contrast to patterns of ...
Ballabeni Andrea A Department of Systems Biology, Harvard Medical School, Boston, MA 02115, - - 2013
Cdc10-dependent transcript 1 (Cdt1) is an essential DNA replication protein whose accumulation at the end of the cell cycle promotes the formation of pre-replicative complexes and replication in the next cell cycle. Geminin is thought to be involved in licensing replication by promoting the accumulation of Cdt1 in mitosis, because ...
van den Berg Ewout E Department of Mathematics, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, - - 2013
Advances in solid-state technology have enabled the development of silicon photomultiplier sensor arrays capable of sensing individual photons. Combined with high-frequency time-to-digital converters (TDCs), this technology opens up the prospect of sensors capable of recording with high accuracy both the time and location of each detected photon. Such a capability ...
Emanuel Kerry A KA Program in Atmospheres, Oceans, and Climate, Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. - - 2013
A recently developed technique for simulating large [O(10(4))] numbers of tropical cyclones in climate states described by global gridded data is applied to simulations of historical and future climate states simulated by six Coupled Model Intercomparison Project 5 (CMIP5) global climate models. Tropical cyclones downscaled from the climate of the ...
Müller Jennifer J Department of Biology, University of Erlangen, 91058 Erlangen, - - 2013
A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis, on the surface of the same B cell or in trans, on ...
Kim Jae-Young JY Department ofThoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, - - 2013
TANK-binding kinase 1 (TBK1) has emerged as a novel therapeutic target for unspecified subset of lung cancers. TBK1 reportedly mediates prosurvival signaling by activating NF-κB and AKT. However, we observed that TBK1 knockdown also decreased viability of cells expressing constitutively active NF-κB and interferon regulatory factor 3. Basal phospho-AKT level ...
Hwang-Verslues Wendy W WW Genomics Research Center, Academia Sinica, Taipei 115, - - 2013
The circadian clock gene Period2 (PER2) has been suggested to be a tumor suppressor. However, detailed mechanistic evidence has not been provided to support this hypothesis. We found that loss of PER2 enhanced invasion and activated expression of epithelial-mesenchymal transition (EMT) genes including TWIST1, SLUG, and SNAIL. This finding was ...
Cao Muqing M Ministry of Education Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing 100084, - - 2013
Specification of organelle size is crucial for cell function, yet we know little about the molecular mechanisms that report and regulate organelle growth and steady-state dimensions. The biflagellated green alga Chlamydomonas requires continuous-length feedback to integrate the multiple events that support flagellar assembly and disassembly and at the same time ...
Minot Samuel S Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, - - 2013
Humans are colonized by immense populations of viruses, which metagenomic analysis shows are mostly unique to each individual. To investigate the origin and evolution of the human gut virome, we analyzed the viral community of one adult individual over 2.5 y by extremely deep metagenomic sequencing (56 billion bases of ...
Li Yaping Y Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, - - 2013
The putative liquid-liquid phase transition in supercooled water has been used to explain many anomalous behaviors of water. However, no direct experimental verification of such a phase transition has been accomplished, and theoretical studies from different simulations contradict each other. We investigated the putative liquid-liquid phase transition using the Water ...
Szabo Csaba C Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA. - - 2013
The physiological functions of hydrogen sulfide (H2S) include vasorelaxation, stimulation of cellular bioenergetics, and promotion of angiogenesis. Analysis of human colon cancer biopsies and patient-matched normal margin mucosa revealed the selective up-regulation of the H2S-producing enzyme cystathionine-β-synthase (CBS) in colon cancer, resulting in an increased rate of H2S production. Similarly, ...
Barisic Neven N School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, - - 2013
Upon introducing charge carriers into the copper-oxygen sheets of the enigmatic lamellar cuprates, the ground state evolves from an insulator to a superconductor and eventually to a seemingly conventional metal (a Fermi liquid). Much has remained elusive about the nature of this evolution and about the peculiar metallic state at ...
Rezgui Vanessa Anissa Nathalie VA Department of Biology, Institute of Biochemistry, Eidgenössiche Technische Hochschule Zürich, 8093 Zürich, - - 2013
tRNA modifications are crucial to ensure translation efficiency and fidelity. In eukaryotes, the URM1 and ELP pathways increase cellular resistance to various stress conditions, such as nutrient starvation and oxidative agents, by promoting thiolation and methoxycarbonylmethylation, respectively, of the wobble uridine of cytoplasmic (tK(UUU)), (tQ(UUG)), and (tE(UUC)). Although in vitro ...
Lee Hanna H Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, - - 2013
When host cells are infected by an RNA virus, pattern-recognition receptors (PRRs) recognize the viral RNA and induce the antiviral innate immunity. Toll-like receptor 7 (TLR7) detects the genomic RNA of incoming murine leukemia virus (MLV) in endosomes and mediates the antiviral response. However, the RNA-sensing PRR that recognizes the ...
Cléry Antoine A Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology, 8093 Zurich, - - 2013
Serine/arginine (SR) proteins, one of the major families of alternative-splicing regulators in Eukarya, have two types of RNA-recognition motifs (RRMs): a canonical RRM and a pseudo-RRM. Although pseudo-RRMs are crucial for activity of SR proteins, their mode of action was unknown. By solving the structure of the human SRSF1 pseudo-RRM ...
Currie Janet J Center for Health and Wellbeing, Princeton University, Princeton, NJ 08540, - - 2013
A large literature describes relationships between month of birth, birth weight, and gestation. These relationships are hypothesized to reflect the causal impact of seasonal environmental factors. However, recent work casts doubt on this interpretation by showing that mothers with lower socioeconomic status are more likely to give birth in months ...
Garaj Slaven S Department of Physics and Molecular and Cellular Biology, and School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, - - 2013
It has recently been recognized that solid-state nanopores in single-atomic-layer graphene membranes can be used to electronically detect and characterize single long charged polymer molecules. We have now fabricated nanopores in single-layer graphene that are closely matched to the diameter of a double-stranded DNA molecule. Ionic current signals during electrophoretically ...
Di Rienzo Carmine C Center for Nanotechnology Innovation at National Enterprise for nanoScience and nanoTechnology, Istituto Italiano di Tecnologia, 56127 Pisa, - - 2013
Spatial distribution and dynamics of plasma-membrane proteins are thought to be modulated by lipid composition and by the underlying cytoskeleton, which forms transient barriers to diffusion. So far this idea was probed by single-particle tracking of membrane components in which gold particles or antibodies were used to individually monitor the ...
Nakagawa So S Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, - - 2013
The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain (DBD), has diverged into dozens of subfamilies in animals, fungi, and related protists. We have used a combination of maximum-likelihood ...
Majumder Anurima A Department of Molecular Physiology and Biophysics and Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52242, - - 2013
In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein transducin translocates from rod outer segments to inner segments/spherules in bright light, but the functional consequences of translocation remain unclear. We generated transgenic mice where light-induced transducin translocation is impaired. These mice exhibited slow ...
Mazzon Michela M Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United - - 2013
Viruses have evolved sophisticated strategies to exploit host cell function for their benefit. Here we show that under physiologically normal oxygen levels (normoxia) vaccinia virus (VACV) infection leads to a rapid stabilization of hypoxia-inducible factor (HIF)-1α, its translocation into the nucleus and the activation of HIF-responsive genes, such as vascular ...
Shin June Ho JH Department of Otolaryngology-Head, and Neck Surgery, Stanford Cancer Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, - - 2013
The aryl hydrocarbon receptor (AhR) has become increasingly recognized for its role in the differentiation and activity of immune cell subsets; however, its role in regulating the activity of natural killer (NK) cells has not been described. Here, we show that AhR expression is induced in murine NK cells upon ...
Zhang Ying Y Program in Neurodevelopment and Regeneration, Yale University School of Medicine, New Haven, CT 06520, - - 2013
Human embryonic stem cells (hESCs) can be induced and differentiated to form a relatively homogeneous population of neuronal precursors in vitro. We have used this system to screen for genes necessary for neural lineage development by using a pooled human short hairpin RNA (shRNA) library screen and massively parallel sequencing. ...
Gordon Scott M SM Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio, - - 2013
Recent studies suggest HDL exists as numerous subpopulations with distinct protein/lipid compositions that are not reflected in the HDL cholesterol (HDL-C) number. In this study, we sought to evaluate HDL subpopulations in adolescents with type 2 diabetes (T2D) to determine if changes in HDL composition are associated with early vascular ...
Villalta S Armando SA Diabetes Center and the Department of Medicine, University of California, San Francisco, San Francisco, California, - - 2013
The dysregulation of receptor tyrosine kinases (RTKs) in multiple cell types during chronic inflammation is indicative of their pathogenic role in autoimmune diseases. Among the many RTKs, vascular endothelial growth factor receptor (VEGFR) stands out for its multiple effects on immunity, vascularization, and cell migration. Herein, we examined whether VEGFR ...
Fawdar Shameem S Signalling Networks in Cancer Group, Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United - - 2013
Approximately 70% of patients with non-small-cell lung cancer present with late-stage disease and have limited treatment options, so there is a pressing need to develop efficacious targeted therapies for these patients. This remains a major challenge as the underlying genetic causes of ~50% of non-small-cell lung cancers remain unknown. Here ...
Chernichenko Konstantin - - 2013
Frustrated Lewis pairs are compounds containing both Lewis acidic and Lewis basic moieties, where the formation of an adduct is prevented by steric hindrance. They are therefore highly reactive, and have been shown to be capable of heterolysis of molecular hydrogen, a property that has led to their use in ...
Jain Rajan - - 2013
Various imaging techniques have been employed to evaluate blood-brain-barrier leakiness in brain tumors, as higher tumor vascular leakiness is known to be associated with higher grade and malignant potential of the tumor, and hence can help provide additional diagnostic and prognostic information. These imaging techniques range from routine post-contrast T1 ...
Horke Daniel A - - 2013
Quinones feature prominently as electron acceptors in nature. Their electron-transfer reactions are often highly exergonic, for which Marcus theory predicts reduced electron-transfer rates because of a free-energy barrier that occurs in the inverted region. However, the electron-transfer kinetics that involve quinones can appear barrierless. Here, we consider the intrinsic properties ...
Francioso Luca - - 2013
The present work highlights the progress in the field of polymeric package reliability engineering for a flexible thermoelectric generator realized by thin-film technology on a Kapton substrate. The effects of different plasma treatments on the mechanical performance at the interface of a poly(dimethylsiloxane) (PDMS)/Kapton assembly were investigated. To increase the ...
Liao Yulong - - 2013
TiO2 films consisting of single-crystal anatase nanoparticles with exposed {001} facets were fabricated from anodized TiO2 nanotube arrays. The films' photocatalytic activities were further activated and then enhanced (∼2.5 times) by removing F(-) from the {001} facets. This study indicates that fluorine-free crystal surfaces are of great importance for the ...
Danoun Grégory - - 2013
Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl-copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me3 Si-CF3 . This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.
Barwiolek M - - 2013
New unsymmetrical Schiff bases obtained by condensation of (1R,2R)(-)cyclohexanediamine with 2-hydroxy-3,5-di-tert-butylbenzaldehyde (3,5-(t)bba) and 2-hydroxy-3-methoxybenzaldehyde (3-metoxba) or 2-hydroxy-5-nitrobenzaldehyde (5-nba) and 2-hydroxyacetophenone (hacphen) were used for the synthesis of Cu(ii) and Ni(ii) complexes. The ligands and complexes were characterized by circular dichroism (CD), UV-vis, IR, (1)H (NOE diff) (ligand) and (13)C NMR ...
Moore J K - - 2013
Abstract Context. An elevated troponin I (TnI) is associated with a poorer prognosis during critical illness. Objective. Our aims were to determine whether significant paracetamol-induced hepatotoxicity was associated with an elevated TnI; if this elevation was persistent and was associated with worse clinical outcomes. Materials and methods. In this retrospective ...
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