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Results 201 - 250 of 1287
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DeBergh J Robb JR Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.
Liu Wen-Bo WB Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, - - 2013
Highly congested vicinal stereocenters comprised of tertiary and all-carbon quaternary centers were generated via Ir-catalyzed asymmetric allylic alkylation of β-ketoesters. These catalytic reactions proceed in excellent yields with a broad scope on either reaction partner and with outstanding regio-, diastereo-, and enantiocontrol. Implementation of a subsequent Pd-catalyzed alkylation affords dialkylated ...
Yang Yang Y Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
An orthogonal set of catalyst systems has been developed for the Suzuki-Miyaura coupling of 3,3-disubstituted and 3-monosubstituted allylboronates with (hetero)aryl halides. These methods allow for the highly selective preparation of either the α- or the γ-isomeric coupling product.
Langley Joanne M JM Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, - - 2013
Mismatch between circulating influenza B viruses (Yamagata and Victoria lineages) and vaccine strains occurs frequently. In a randomized controlled trial, immunogenicity and safety of an inactivated quadrivalent influenza vaccine candidate (QIV) versus trivalent inactivated influenza vaccine (TIV)-Victoria(Vic) and TIV-Yamagata(Yam) in children 3-17 years of age was evaluated. In an open-label ...
Kato Masaru - - 2013
Photosystem II (PSII) offers a biological and sustainable route of photochemical water oxidation to O2 and can provide protons and electrons for the generation of solar fuels, such as H2. We present a rational strategy to electrostatically improve the orientation of PSII from a thermophilic cyanobacterium, Thermosynechococcus elongatus , on ...
Becerra Alexandra - - 2013
Condensation of homochiral primary amines with 1-methyl-1H-imidazole-2-carbaldehyde affords the corresponding imidazolyl-imine compounds (L1-L3) which have been employed as ligands for the preparation of half-sandwich rhodium and iridium complexes of the formula [(η(5)-C5Me5)MClLn][SbF6]. Treatment of these chloride compounds with AgSbF6 renders dicationic aqua-complexes [(η(5)-C5Me5)MLn(H2O)] [SbF6]2 which act as catalysts for the ...
Park Hyeon - - 2013
Monomers containing either cycloalkenes with low ring strain or 1-alkynes are poor monomers for olefin metathesis polymerization. Ironically, keeping two inactive functional groups in proximity within one molecule can make it an excellent monomer for metathesis polymerization. Recently, we demonstrated that monomer 1 having cyclohexene and propargyl moieties underwent rapid ...
Catalani S - - 2013
Abstract Introduction. Vanadium (V) is a minor constituent of the Titanium-Aluminum-Vanadium (TiAlV) alloy currently used in cementless hip prostheses. Present study aimed at verifying the correlation of vanadium levels among different matrices and assessing reference levels of the ion in a population of patients wearing a well-functioning hip prosthesis. Methods. ...
Lin Dan-Yu DY Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA. - - 2013
It is not economically feasible to sequence all study subjects in a large cohort. A cost-effective strategy is to sequence only the subjects with the extreme values of a quantitative trait. In the National Heart, Lung, and Blood Institute Exome Sequencing Project, subjects with the highest or lowest values of ...
Mahapatra Subham S Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, - - 2013
The total synthesis of amphidinolide C and a second-generation synthesis of amphidinolide F have been accomplished through the use of a common intermediate to access both the C1-C8 and the C18-C25 sections. The development of a Ag-catalyzed cyclization of a propargyl benzoate diol is described to access both trans-tetrahydrofuran rings. ...
Hou Linrui - - 2013
From the perspective of practical application, the development of fluorescent nanocrystals with low toxicity and desirable optical properties is highly needed. Here we report a new liquid-liquid interfacial synthesis of single-crystalline ZnTe nanorods with high fluorescence. With the use of long-alkyl-chain fatty acid as the capping ligand, the reaction of ...
Greuber Emileigh K EK Department of Pharmacology & Cancer Biology, Duke University School of Medicine, BOX 3813, Durham, North Carolina 27710, - - 2013
The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion. ABL1 was first identified as an oncogene required for the development of leukaemias initiated by retroviruses or chromosome translocations. The demonstration that small-molecule ABL kinase ...
Izquierdo Javier - - 2013
A dual activation strategy integrating N-heterocyclic carbene (NHC) catalysis and a second Lewis base has been developed. NHC-bound homoenolate equivalents derived from α,β-unsaturated aldehydes combine with transient reactive o-quinone methides in an enantioselective formal [4 + 3] fashion to access 2-benzoxopinones. The overall approach provides a general blueprint for the ...
Cook Nathan P - - 2013
Photoluminescent molecules are widely used for real-time monitoring of peptide aggregation. In this Article, we detail both experimental and computational modeling to elucidate the interaction between [Ru(bpy)2dppz](2+) and amyloid-β (Aβ1-40) aggregates. The transition from monomeric to fibrillar Aβ is of interest in the study of Alzheimer's disease. Concentration-dependent experiments allowed ...
Sadasivam Subhashini S Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, - - 2013
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the ...
Brosh Robert M RM - - 2013
Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects. Although considerable effort has been made to understand the functions of DNA helicases that are important for genomic stability and cellular homeostasis, ...
Chen Sheng - - 2013
A hierarchically structured three-dimensional network nanofibrous composite membrane was prepared through in situ growing uniform polyaniline nanofibers on the surfaces of poly(ethylene-co-glycidyl methacrylate) (PE-co-GMA) nanofibers. And the nanocomposite membrane was fabricated into a super sensitive sensor of ammonia gas in ambient temperature. Morphological analysis of the nanocomposite membranes revealed uniform ...
Dutta Ranjan - - 2013
The environmentally important and toxic arsenate anion (HAsO4(2-)) is trapped in the cavity of a dimeric capsular assembly formed by a tripodal urea receptor. The selective binding of HAsO4(2-) over other anions is observed in a semi-aqueous solvent using a (1)H NMR titration study.
Chang Ti-Cheng TC Department of Animal Science, Center for Reproductive Biology and Health, College of Agricultural Sciences and Integrative Biosciences Graduate Program Option in Bioinformatics and Genomics, The Pennsylvania State University, University Park, PA 16802, - - 2013
The male-specific region of the mammalian Y chromosome (MSY) contains clusters of genes essential for male reproduction. The highly repetitive and degenerative nature of the Y chromosome impedes genomic and transcriptomic characterization. Although the Y chromosome sequence is available for the human, chimpanzee, and macaque, little is known about the ...
Li Gang - - 2013
Two novel heteroacenes 2,3,9,10-tetra(furan-2-yl)-1,4,8,11-tetraaza-6,13-dioxapentacene (FAOP, 1) and 2,3,9,10-tetra(thiophen-2-yl)-1,4,8,11-tetraaza-6,13-dioxapentacene (TAOP, 2) was successfully synthesized through a one-step condensation reaction, which have been fully characterized by (1)H NMR (nuclear magnetic resonance), (13)C NMR, FT-IR (Fourier transform infrared spectroscopy), and HRMS (high-resolution mass spectrum). The sandwich-structure memory devices have been fabricated using FAOP ...
Shieh Joseph T C - - 2013
Noncompaction/hypertrabeculation is increasingly being recognized in children and adults, yet we understand little about the causes of disease. Genes associated with noncompaction/hypertrabeculation have been identified, but how can these assist in clinical management? Genomic technologies have also expanded tremendously, making testing more comprehensive, but they also present new questions given ...
Zhang Wenjun - - 2013
Ventricular trabeculation and compaction are two of the many essential steps for generating a functionally competent ventricular wall. A significant reduction in trabeculation is usually associated with ventricular compact zone deficiencies (hypoplastic wall), which commonly leads to embryonic heart failure and early embryonic lethality. In contrast, hypertrabeculation and lack of ...
Takii Yuki - - 2013
The synthesis and structural analysis of the hetero-bimetallic M-Al complexes MMe[(O-2,4-(t)Bu2C6H2-6-CH2)2(μ2-O-2,4-(t)Bu2C6H2-6-CH2)N][Me2Al(μ2-O(i)Pr)] [M = Zr, Hf], prepared from M(O(i)Pr)[{(O-2,4-(t)Bu2C6H2)-6-CH2}3N] by treating with 1.0 equiv. of AlMe3, have been explored: these complexes exhibited catalytic activities for ethylene polymerisation in n-octane in the presence of methylaluminoxane (MAO). The Zr-Al analogue showed high catalytic ...
Li Lüying - - 2013
Three mononuclear copper complexes [Cu(PDTP)Cl2] (PDTP = 4-phenyl-2,6-di(thiazole-2-yl)pyridine, CuPDTP), [Cu(ADTP)Cl2] (ADTP = 4-(anthracen-9-yl)-2,6-di(thiazole-2-yl)pyridine, CuADTP) and [Cu(BFDTP)Cl2] (BFDTP = 4-(benzofuran-2-yl)-2,6-di(thiazole-2-yl)pyridine, CuBFDTP) were synthesized and characterized. The X-ray single crystallography results indicated that the Cu(ii) ions showed slightly distorted square pyramid coordination environments, and the ligands deviated from ideal planarity in all ...
Gao Junkuo - - 2013
Here, we report on a surfactant-thermal method to prepare four new 3-D crystalline heterometal-organic frameworks (HMOFs). The results indicate that our new strategy for growing crystalline materials in surfactant media has great potential for the synthesis of novel MOFs with various structures.
Shieh Joseph T C - - 2013
Cardiomyopathies are remarkably variable in form. Although hearts may be dilated or hypertrophic, the spectrum of cardiomyopathies includes left ventricular noncompaction/hypertrabeculation and right ventricular wall disorders. These conditions have been increasingly recognized in patients given advances in clinical diagnostics. Here we present information on cardiac pathophysiology, from ventricular wall formation ...
Jefferies John L - - 2013
Barth syndrome (BTHS) is an X-linked recessive disorder that is typically characterized by cardiomyopathy (CMP), skeletal myopathy, growth retardation, neutropenia, and increased urinary levels of 3-methylglutaconic acid (3-MGCA). There may be a wide variability of phenotypes amongst BTHS patients with some exhibiting some or all of these findings. BTHS was ...
Baron Ellen Jo EJ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. - - 2013
The critical role of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the health care team. This document, developed by both laboratory and clinical experts, provides information on which tests are valuable and ...
Kirchner James W JW Department of Environmental System Sciences, ETH Zürich, CH-8092 Zürich, Switzerland. - - 2013
The chemical dynamics of lakes and streams affect their suitability as aquatic habitats and as water supplies for human needs. Because water quality is typically monitored only weekly or monthly, however, the higher-frequency dynamics of stream chemistry have remained largely invisible. To illuminate a wider spectrum of water quality dynamics, ...
Di Credico Barbara - - 2013
This article describes the synthesis, characterization, and application of new UV-absorbing microcapsules encapsulating a UV-responsive photochromic dye for application in the damage-sensing field. Microcapsules filled with a photochromic spiropyran, dissolved in sunflower oil as core material, were synthesized by reacting a TDI-based polyisocyanate prepolymer with a benzophenone-based amine to obtain ...
Buck Alexander T - - 2013
We report an organo-paramagnetic switch consisting of a linked bis(viologen) dication diradical that can be cycled reversibly between diamagnetic and paramagnetic states via noncovalent guest-host chemistry with cucurbit[7]uril (CB[7]) in room-temperature water. Computations suggest that the nature of the interaction between the viologen cation radical units is that of a ...
Chislock Elizabeth M EM Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, - - 2013
Endothelial dysfunction is associated with diverse cardiovascular pathologies. Here, we show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelial function and the regulation of angiogenic factor pathways important for vascular homeostasis. Endothelial Abl deletion in Arg-null mice led to late-stage embryonic and perinatal ...
Lukens Wayne W - - 2013
f Orbital bonding in actinide and lanthanide complexes is critical to their behavior in a variety of areas from separations to magnetic properties. Octahedral f(1) hexahalide complexes have been extensively used to study f orbital bonding due to their simple electronic structure and extensive spectroscopic characterization. The recent expansion of ...
Wang Jing - - 2013
The non-specific interaction between the surface of gold nanorods (GNRs) and biomolecules is a significant problem in hyperthermia applications. In this work, a novel surface modification strategy was performed using zwitterionic oxidized glutathione (GSSG) to modify the GNRs through robust Au-S bond formation. The GSSG-GNRs were stable in aqueous solution ...
Ewers David - - 2013
Excitatory amino acid transporters (EAATs) are a class of glutamate transporters that terminate glutamatergic synaptic transmission in the mammalian CNS. GltPh, an archeal EAAT homolog from Pyrococcus horikoshii, is currently the only member with a known 3D structure. Here, we studied the kinetics of substrate binding of a single tryptophan ...
Vaysburd Marina M Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United - - 2013
Host species have evolved mechanisms that can inhibit pathogen replication even after a cell has been successfully invaded. Here we show that tripartite-motif protein 21 (TRIM21), a ubiquitously expressed E3 ubiquitin ligase that targets viruses inside the cytosol, protects mice against fatal viral infection. Upon infection with mouse adenovirus-1, naive ...
Genna Douglas T - - 2013
This paper describes the heterogenization of single-site transition-metal catalysts in metal-organic frameworks (MOFs) via cation exchange. A variety of cationic complexes of Pd, Fe, Ir, Rh, and Ru have been incorporated into ZJU-28, and the new materials have been characterized by optical microscopy, inductively coupled plasma optical emission spectroscopy, and ...
Li Weizuo - - 2013
A new β-diketone, 5,6-dimethoxy-2(2,2,2-trifluoroethyl)-1-indone (5,6-DTFI), has been designed and synthesized. Two series of four 5,6-DTFI Sm(3+) and Eu(3+) complexes, namely, Eu(5,6-DTFI)3(H2O)2 (1), Eu(5,6-DTFI)3(Phen) (2), Sm(5,6-DTFI)3(H2O)2 (3) and Sm(5,6-DTFI)3(Phen) (4) (Phen = 1,10-phenanthroline), have been isolated. X-ray diffraction analysis reveals that all complexes 1-4 are of mononuclear structures. Luminescent and phosphorescent ...
Wang An-Liang - - 2013
Low cost, high activity, and long-term durability are the main requirements for commercializing fuel cell electrocatalysts. Despite tremendous efforts, developing non-Pt anode electrocatalysts with high activity and long-term durability at low cost remains a significant technical challenge. Here we report a new type of hybrid Pd/PANI/Pd sandwich-structured nanotube array (SNTA) ...
Johnson Alexander W AW Department of Psychology, Michigan State University, East Lansing, MI 48824, - - 2013
Guided by features of molecular, cellular, and circuit dysfunction affecting the prefrontal cortex in clinical investigations, we targeted prefrontal cortex in studies of a model for neuropsychiatric illness using transgenic mice expressing a putative dominant-negative disrupted in schizophrenia 1 (DN-DISC1). We detected marked augmentation of GAPDH-seven in absentia homolog Siah ...
Fried Stephen D SD Department of Chemistry, Stanford University, Stanford, CA 94305-5012, - - 2013
Pauling's suggestion that enzymes are complementary in structure to the activated complexes of the reactions they catalyze has provided the conceptual basis to explain how enzymes obtain their fantastic catalytic prowess, and has served as a guiding principle in drug design for over 50 y. However, this model by itself ...
Pluciennik Anna A Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, - - 2013
MutLα endonuclease can be activated on covalently continuous DNA that contains a MutSα- or MutSβ-recognizable lesion and a helix perturbation that supports proliferating cell nuclear antigen (PCNA) loading by replication factor C, providing a potential mechanism for triggering mismatch repair on nonreplicating DNA. Because mouse models for somatic expansion of ...
Rao Sowmya - - 2013
The new metalloligand ferrocenylbis(phosphonite), [Fe(C5H4PR2)2 (R = OC6H3(OMe-o)(C3H5-p))], (2), is synthesized by the reaction of bis(dichlorophosphino)ferrocene Fe(C5H4PCl2)2 (1) with 4-allyl-2-methoxyphenol. The reactions of 2 with H2O2 and elemental sulfur or selenium afforded bischalcogenides, [Fe{C5H4P(E)(OC6H3(OMe-o)(C3H5-p))2}2] (3, E = O; 4, E = S; 5, E = Se), in good yield. The ...
Topal Sevinc Zehra - - 2013
Herein, the design and synthesis of pH sensing fluorophores, zinc(ii) tetraimidazophthalocyanine (Pc-1) and metal free tetraimidazophthalocyanine (Pc-2), which present "off-on-off" type molecular switches were described. Their pH sensing properties have been investigated in detail in dimethylsulfoxide in the pH range of 2.0-15.0. The respective three forms of the molecules: deprotonated, ...
Wang Wenshou - - 2013
Porous TiO2/C nanocomposite shells with high capacity, excellent cycle stability, and rate performance have been prepared. The synthesis involves coating colloidal TiO2 nanoshells with a resorcinol-formaldehyde (RF) layer with controllable thickness through a sol-gel-like process, and calcining the composites at 700 °C in an inert atmosphere to induce crystallization from ...
Zerk Timothy J - - 2013
Atom transfer radical addition (ATRA) and polymerisation (ATRP) reactions are commonly catalyzed by copper(i) complexes which react, reversibly, with a dormant alkyl halide initiator (RX) releasing a reactive organic radical R˙. The copper catalyst bears a multidentate N-donor ligand (L) and the active catalyst is simply Cu(I)L. The role of ...
Gertz Melanie M Department of Biochemistry and Research Center for Bio-Macromolecules, University of Bayreuth, 95440 Bayreuth, - - 2013
Sirtuins are protein deacetylases regulating metabolism and stress responses. The seven human Sirtuins (Sirt1-7) are attractive drug targets, but Sirtuin inhibition mechanisms are mostly unidentified. We report the molecular mechanism of Sirtuin inhibition by 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (Ex-527). Inhibitor binding to potently inhibited Sirt1 and Thermotoga maritima Sir2 and to moderately inhibited ...
Liu Jiang - - 2013
A novel two-dimensional (2D) azido-based Cu(II) network, [Cu11(pic)6(N3)16] (1), was prepared using picolinic acid (Hpic) as coligand. Interestingly, 1 is composed of symmetric double azido EO-bridged [Cu(N3)2]n chains linked by [Cu(pic)2] units making a regular ladder with a missing rung. These rung-defected ladders are assembled in a layered structure by ...
Stöger Berthold - - 2013
Barium monofluorophosphate, BaPO3F, was prepared in a polycrystalline form by fast precipitation, whereas single crystals were obtained using a long-lasting gel growth method. The samples were characterized by powder- and single-crystal X-ray diffraction, which revealed orthorhombic symmetry for the polycrystalline material and monoclinic symmetry for the single crystals. Both phases ...
Pfeifer Matthias M Department of Hematology, Oncology and Tumor Immunology, Charité Universitätsmedizin, 13353 Berlin, - - 2013
Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be defined by gene expression profiling. However, even within these defined subtypes, heterogeneity prevails. To further elucidate the pathogenesis of these entities, we determined the expression of the tumor suppressor phosphatase and tensin homolog ...
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