Search Results
Results 451 - 500 of 1282
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Raschenberger Julia - - 2013
Short telomere length has been described to be associated with biological aging including atherosclerosis phenotypes. However, information in patients with symptomatic peripheral arterial disease (PAD) is sparse. We therefore aimed to investigate whether inter-individual differences in relative telomere length (RTL) are associated with symptomatic PAD. We measured RTL by a ...
Peel Michael - - 2013
Cyclophilins (Cyps) are ubiquitous proteins that effect the cis-trans isomerization of Pro amide bonds, and are thus crucial to protein folding. CypA is the most prevalent of the ∼19 human Cyps, and plays a crucial role in viral infectivity, most notably for HIV-1 and HCV. Cyclophilins have been shown to ...
Kurashige Yuki - - 2013
It is a long-standing goal to understand the reaction mechanisms of catalytic metalloenzymes at an entangled many-electron level, but this is hampered by the exponential complexity of quantum mechanics. Here, by exploiting the special structure of physical quantum states and using the density matrix renormalization group, we compute near-exact many-electron ...
Giannerini Massimo - - 2013
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the production of natural products, pharmaceuticals, agrochemicals and organic materials. Coupling reactions of a variety of organometallic reagents and organic halides have changed the face of modern synthetic chemistry. However, the high reactivity and poor selectivity of ...
Wang Jing - - 2013
Mast cells (MCs) contribute to atherogenesis by releasing pro-inflammatory mediators to activate vascular cells and other inflammatory cells. This study examined whether MC activation or stabilization affects diet-induced atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice. When Ldlr(-/-) mice consumed an atherogenic diet for 3 or 6 months, MC activation with ...
Andreozzi F - - 2013
Carotid Intima-Media Thickness (C-IMT) is a reliable predictor of cardiovascular events. We examined if increased C-IMT was associated with defects in glucose metabolism in non-diabetic subjects independently of age. In 366 Caucasian non-diabetic subjects of the CARAMERIS study, we measured glucose response during a 75 g-Oral Glucose Tolerance Test (OGTT), insulin ...
Kark Jeremy D - - 2013
Shorter leukocyte telomere length (LTL) is associated with higher incidence of coronary heart disease (CHD) and increased mortality. We examined the association of LTL with coronary artery calcification (CAC), which reflects the cumulative burden of coronary atherosclerosis, in an urban Arab sample of Palestinians, a population at high risk of ...
Idei Naomi - - 2013
It is clinically important to estimate the degree of endothelial dysfunction. Several methods have been used to assess endothelial function in humans. Recently, we developed a new noninvasive method for measurement of vascular response to reactive hyperemia in the brachial artery, named enclosed zone flow-mediated vasodilation (ezFMD). The purpose of ...
Persoon Ilona F - - 2013
Previous research showed an antimicrobial effect of vanadium chloroperoxidase (VCPO) on in vitro Enterococcus faecalis biofilms. The current study aimed to optimize the use of this enzyme at the root canal pH using a modified VCPO (mVCPO) that was adapted to function at a higher pH and to explore the biocompatibility ...
Siqueira José F JF - - 2013
This ex vivo study evaluated the disinfecting and shaping ability of 3 protocols used in the preparation of mesial root canals of mandibular molars by means of correlative bacteriologic and micro-computed tomographic (μμCT) analysis. The mesial canals of extracted mandibular molars were contaminated with Enterococcus faecalis for 30 days and assigned ...
Farnier Michel - - 2013
Apolipoprotein (apo) B is highly predictive of coronary risk, especially in patients with high triglycerides (TG). This post hoc analysis evaluated the effects of lipid-lowering therapy on correlations between apoB and low-density lipoprotein cholesterol (apoB:LDL-C) and non-high-density lipoprotein cholesterol (apoB:non-HDL-C) in patients with TG< and ≥200 mg/dL. This analysis used data ...
Ohno Shuji - - 2013
11β-hydroxysteroid dehydrogenase (HSD11B) catalyzes the interconversion between active and inactive glucocorticoid, and is known to exist as two distinct isozymes: HSD11B1 and HSD11B2. A third HSD11B isozyme, HSD11B1L (SCDR10b), has recently been identified. Human HSD11B1L, which was characterized as a unidirectional NADP(+)-dependent cortisol dehydrogenase, appears to be specifically expressed in ...
Braicu Cornelia - - 2013
p53 protein is probably the best known tumor suppressor. Earlier reports proved that human breast cancer cells expressing mutant p53 displayed resistance to apoptosis. This study is intended to investigate, the potential applications of RNA interference (RNAi) to block p53 expression, as well as its subsequent effect on cell growth, ...
Turgeon Julie - - 2013
Fish oil consumption has been associated with a reduced incidence of cardiovascular diseases. However, the precise mechanisms involved are not completely understood. Here we tested the hypothesis that a fish oil-enriched diet improves neovascularization in response to ischemia. C57Bl/6 mice were fed a diet containing either 20% fish oil, rich ...
Wu Jiakai - - 2013
Maternal smoking increases the risk of respiratory symptoms in children. Glutathione S-transferases (GSTs) detoxify xenobiotics from tobacco smoke, and functional polymorphism in GST gene(s) could predispose children to the detrimental effects of maternal smoking. Our objective was to investigate interactions between GST variants and maternal smoking in relation to the ...
Trial Chloé - - 2013
The treatment of chronic wounds is slow and difficult and the presence of an infection can further delay the healing. Diagnosis of this infection is clinical. It must be accompanied by targeted sampling carried out in accordance with a specific technique in order to adapt the treatment as best as ...
Jonniaux Sandrine - - 2013
Faced with a changed body, several nursing care interventions are possible in order to restore self-esteem. Relational and personal care techniques or other forms of body mediation are all tools which can be used in order to reposition the patients at the centre of the care.
Espié Marc - - 2013
A major public health issue, breast cancer affects 53000 women each year in France. The leading cause of cancer deaths in women, its risk factors are numerous and include age, early puberty and/or late menopause, later age at first pregnancy as well as a family history of the disease.
Gommier-Lefort Valérie - - 2013
In the Centre region of France, breast cancer is one of the three most common and most fatal forms of the disease. Chartres hospitals offer complete care provision on a single site and assess the time taken for the appropriate care to be put in place. The nurse coordinator plays ...
Wintz Lydie - - 2013
Around 20 to 30% of women treated for breast cancer undergo a mastectomy in France. Of these patients, 70% do not have reconstructive surgery. It would seem that information surrounding reconstructive procedures is insufficient. Tools created in partnership with caregivers and patients are necessary to help women understand the choices ...
Biffaud Jean-Christophe - - 2013
The incidence of lymphoedema after breast cancer surgery with axillary dissection varies according to different studies, from 15 to 47%. The risk is 60% higher in cases of axillary radiotherapy. A rehabilitation service was undertaken as part of a research project aiming to show the benefit of the early treatment ...
Dejter Sandra - - 2013
The treatment of breast cancer generates changes to the body and a person's self-image. The caregivers' support focuses on the woman's grief for her old body and the acceptance of a changed intimacy. Listening to each woman is essential for acknowledging her fears in the face of this mutated body, ...
Dariel Odessa - - 2013
Q-Methodology offers an alternative to traditional methodological approaches. It is similar to qualitative methods while at the same time guaranteeing a statistical data analysis. It can be particularly interesting for the development of nursing sciences.
Tofield Andros - - 2013
The MEP Heart Group is a discussion forum aimed at promoting measures to reduce the burden of cardiovascular disease in the European Union and raise cardiovascular disease as a priority on the EU political agenda.
Tofield Andros - - 2013
Exposure to air pollution is associated with increased mortality after myocardial infarction
Clancy Paula - - 2013
Angiotensin II (AII) receptor 1 (ATR1) and angiotensin converting enzyme 1 (ACE1) blockers have been shown to reduce acute cardiovascular events in patients, improve plaque stability and modify matrix metalloproteinase (MMP) expression. However, the role of the ACE1/AII/ATR1 axis in interstitial collagenase regulation has not been fully explored. In this ...
Nery Mariana F - - 2013
Cetaceans, early in their evolutionary history, had developed many physiological adaptations to secondarily return to the sea. Among these adaptations, changes in molecules that transport oxygen and that ultimately support large periods of acute tissue hypoxia probably represent one big step toward the conquest of aquatic environments. Myoglobin contributes to ...
Sawers Andrew B - - 2013
Microprocessor-controlled prosthetic knees (MPKs) have been developed as an alternative to non-microprocessor-controlled knees (NMPKs) to address challenges facing individuals with lower-limb loss. A body of scientific literature comparing MPKs and NMPKs exists but has yet to be critically appraised. Therefore, we conducted a systematic review to examine outcomes associated with ...
Wilkenfeld Ari Jacob Levi - - 2013
Spastic drop foot is a functional impairment causing significant morbidity and mortality. Multiple treatments are available for this condition, but it is often not clear which treatment or combination of treatments is optimal for a given patient. One relatively recent therapy is the use of functional electrical stimulation to stimulate ...
Daggett Virginia S - - 2013
Traumatic brain injury (TBI) has emerged as a major cause of morbidity among U.S. servicemembers who have served in Iraq and Afghanistan. Even mild TBI (mTBI) can result in cognitive impairments that can affect the community reintegration of Veterans postdeployment. The purpose of this study was to explore the needs ...
Hubert Geoffroy - - 2013
Service dogs help people with mobility impairments. They are trained to perform a variety of tasks, such as opening doors, retrieving the telephone, picking up objects, and pulling manual wheelchairs (MWCs). More specifically, using the traction provided by the service dog has physical benefits because MWC users can operate their ...
Guidali Marco - - 2013
Robot-assisted therapy has become increasingly common in neurorehabilitation. Sophisticated controllers have been developed for robots to assist and cooperate with the patient. It is difficult for the patient to judge to what extent the robot contributes to the execution of a movement. Therefore, methods to comprehensively quantify the patient's contribution ...
Mitchell Michael - - 2013
A computer-controlled mechanism that fits a standard ankle-foot prosthesis was designed to capture the absorbed energy in the ankle and delay its release until specific times in the gait cycle. This mechanism used a direct current motor to take up and hold the compression of a carbon-fiber ankle joint. Based ...
Barnett Cleveland T - - 2013
This study examined the longitudinal changes in generic health-related quality of life (QOL), prosthesis-related QOL, falls efficacy, and walking speed in men with lower-limb amputations up to 6 months following discharge from rehabilitation. Seven male unilateral transtibial amputees completed the Medical Outcomes Study 36-Item Short Form Health Survey, the Prosthesis ...
Liu Fen - - 2013
To observe the effect of transfected microRNA-146a (miR-146a) on expression of tumor necrosis factor- ex ( TNF- ex ) in alveolar macrophages, and to analyze its regulatory mechanism in the inflammatory response of alveolar macrophages. Cy.11113 labeled with 25, 50, 100 nmol!L of Pre-miR"', respectively, were transfected into rat alveolar ...
De Pauw Antoine - - 2013
Screening for breast cancer should concern all women at some point in their life. In cases of a family history of breast cancer, an oncogenetic consultation may be offered. The identification of a genetic predisposition enables specific management strategies for the woman to be drawn up.
Geay Jean-François - - 2013
The organised screening of breast cancer, the identification of the type of lesion and the staging determine the treatment plan for this disease. The most common cancer to affect women in France and in Europe, it represents 1/3 of cancers in women and 1/4 of all cancers.
Pfeil-Thiriet Francine - - 2013
In France, one woman in eight is treated for breast cancer before the age of 75. The 2009-2013 cancer plan recommends providing support for women after cancer. A therapeutic education programme helps them reintegrate into their daily life.
Barbier Elisabeth - - 2013
Hypnosis is a non-medication based approach used increasingly in hospitals. In oncology, practised by a trained nurse hypnotherapist, it represents a complementary medicine.
Cleary Patricia A - - 2013
The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications(EDIC) studies have established multiyear mean hemoglobin A1c (HbA1c) as predictive of microvascular complications in persons with type 1 diabetes. However, multiyear mean HbA1c is not always available in the clinical setting. Skin advanced glycation end products (AGEs) are ...
- - 2013
ESC is to create an inventory of cardiovascular disease registries and a task force on data standardization
Taylor Jennifer - - 2013
There is no increase in life expectancy for vegetarians and the jury is out on the protective effects of fish
Gast Karin B - - 2013
The relative importance of insulin resistance and hyperglycemia to the development of atherosclerosis remains unclear. Furthermore, adiposity may be responsible for observed associations. Our aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis. In this cross-sectional analysis of the Netherlands Epidemiology of Obesity ...
Dorit Robert L - - 2013
The rise of antibiotic-resistant pathogens focuses our attention on the source of antibiotic resistance genes, on the existence of these genes in environments exposed to little or no antibiotics, and on the relationship between resistance genes found in the clinic and those encountered in non-clinical settings. Here, we address the ...
Wessels Karla K - - 2013
Upwards of 70% of manual wheelchair users (MWUs) experience shoulder pain. Pain is more prevalent among females than males. The causes of this sex discrepancy are not understood. Decreased range of motion (ROM) has been suggested as a major contributor, but the interaction of sex, ROM, and shoulder pain has ...
Lin Yang-Hua - - 2013
Power wheelchairs are essential for many individuals with mobility impairment. The objective of this study was to investigate the effectiveness of bimanual gliding (BG) and conventional joystick (CJ) control in an indoor environment, with application to (1) wheelchair driving performance (i.e., practice time, completion time, and driving deviation) and (2) ...
Craven Colm T D - - 2013
Damage to the spinal cord compromises motor function and sensation below the level of injury, resulting in paralysis and progressive secondary health complications. Inactivity and reduced energy requirements result in reduced cardiopulmonary fitness and an increased risk of coronary heart disease and cardiovascular complications. These risks may be minimized through ...
Blana Dimitra - - 2013
Neuroprosthetic systems based on functional electrical stimulation aim to restore motor function to individuals with paralysis following spinal cord injury. Identifying the optimal electrode set for the neuroprosthesis is complicated because it depends on the characteristics of the individual (such as injury level), the force capacities of the muscles, the ...
Borrelli James - - 2013
Supporting weight on the upper support of crutches is not recommended because it can lead to axillary nerve damage. Despite this warning, improper axillary loadings may still occur because of a lack of arm strength or fatigue. It is generally accepted that improper use of conventional axillary crutches contributes to ...
Sarabia Cachadiña Elena - - 2013
Phantom-limb pain (PLP) is a phenomenon that may appear among people with amputation. Some studies reveal that 70% of people with amputation experience PLP years postamputation. There is a lack of scientific evidence about the cause of PLP. It has been hypothesized that the autonomic nervous system (ANS) could be ...
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