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Results 451 - 500 of 1282
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Kurashige Yuki - - 2013
It is a long-standing goal to understand the reaction mechanisms of catalytic metalloenzymes at an entangled many-electron level, but this is hampered by the exponential complexity of quantum mechanics. Here, by exploiting the special structure of physical quantum states and using the density matrix renormalization group, we compute near-exact many-electron ...
Giannerini Massimo - - 2013
Catalytic carbon-carbon bond formation based on cross-coupling reactions plays a central role in the production of natural products, pharmaceuticals, agrochemicals and organic materials. Coupling reactions of a variety of organometallic reagents and organic halides have changed the face of modern synthetic chemistry. However, the high reactivity and poor selectivity of ...
Wang Jing J Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, - - 2013
Mast cells (MCs) contribute to atherogenesis by releasing pro-inflammatory mediators to activate vascular cells and other inflammatory cells. This study examined whether MC activation or stabilization affects diet-induced atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice. When Ldlr(-/-) mice consumed an atherogenic diet for 3 or 6 months, MC activation with ...
Andreozzi F - - 2013
Carotid Intima-Media Thickness (C-IMT) is a reliable predictor of cardiovascular events. We examined if increased C-IMT was associated with defects in glucose metabolism in non-diabetic subjects independently of age. In 366 Caucasian non-diabetic subjects of the CARAMERIS study, we measured glucose response during a 75 g-Oral Glucose Tolerance Test (OGTT), insulin ...
Kark Jeremy D - - 2013
Shorter leukocyte telomere length (LTL) is associated with higher incidence of coronary heart disease (CHD) and increased mortality. We examined the association of LTL with coronary artery calcification (CAC), which reflects the cumulative burden of coronary atherosclerosis, in an urban Arab sample of Palestinians, a population at high risk of ...
Idei Naomi - - 2013
It is clinically important to estimate the degree of endothelial dysfunction. Several methods have been used to assess endothelial function in humans. Recently, we developed a new noninvasive method for measurement of vascular response to reactive hyperemia in the brachial artery, named enclosed zone flow-mediated vasodilation (ezFMD). The purpose of ...
Persoon Ilona F - - 2013
Previous research showed an antimicrobial effect of vanadium chloroperoxidase (VCPO) on in vitro Enterococcus faecalis biofilms. The current study aimed to optimize the use of this enzyme at the root canal pH using a modified VCPO (mVCPO) that was adapted to function at a higher pH and to explore the biocompatibility ...
Siqueira José F JF - - 2013
This ex vivo study evaluated the disinfecting and shaping ability of 3 protocols used in the preparation of mesial root canals of mandibular molars by means of correlative bacteriologic and micro-computed tomographic (μμCT) analysis. The mesial canals of extracted mandibular molars were contaminated with Enterococcus faecalis for 30 days and assigned ...
Farnier Michel - - 2013
Apolipoprotein (apo) B is highly predictive of coronary risk, especially in patients with high triglycerides (TG). This post hoc analysis evaluated the effects of lipid-lowering therapy on correlations between apoB and low-density lipoprotein cholesterol (apoB:LDL-C) and non-high-density lipoprotein cholesterol (apoB:non-HDL-C) in patients with TG< and ≥200 mg/dL. This analysis used data ...
Ohno Shuji - - 2013
11β-hydroxysteroid dehydrogenase (HSD11B) catalyzes the interconversion between active and inactive glucocorticoid, and is known to exist as two distinct isozymes: HSD11B1 and HSD11B2. A third HSD11B isozyme, HSD11B1L (SCDR10b), has recently been identified. Human HSD11B1L, which was characterized as a unidirectional NADP(+)-dependent cortisol dehydrogenase, appears to be specifically expressed in ...
Braicu Cornelia - - 2013
p53 protein is probably the best known tumor suppressor. Earlier reports proved that human breast cancer cells expressing mutant p53 displayed resistance to apoptosis. This study is intended to investigate, the potential applications of RNA interference (RNAi) to block p53 expression, as well as its subsequent effect on cell growth, ...
Turgeon Julie - - 2013
Fish oil consumption has been associated with a reduced incidence of cardiovascular diseases. However, the precise mechanisms involved are not completely understood. Here we tested the hypothesis that a fish oil-enriched diet improves neovascularization in response to ischemia. C57Bl/6 mice were fed a diet containing either 20% fish oil, rich ...
Wu Jiakai - - 2013
Maternal smoking increases the risk of respiratory symptoms in children. Glutathione S-transferases (GSTs) detoxify xenobiotics from tobacco smoke, and functional polymorphism in GST gene(s) could predispose children to the detrimental effects of maternal smoking. Our objective was to investigate interactions between GST variants and maternal smoking in relation to the ...
Trial Chloé - - 2013
The treatment of chronic wounds is slow and difficult and the presence of an infection can further delay the healing. Diagnosis of this infection is clinical. It must be accompanied by targeted sampling carried out in accordance with a specific technique in order to adapt the treatment as best as ...
Jonniaux Sandrine - - 2013
Faced with a changed body, several nursing care interventions are possible in order to restore self-esteem. Relational and personal care techniques or other forms of body mediation are all tools which can be used in order to reposition the patients at the centre of the care.
Espié Marc - - 2013
A major public health issue, breast cancer affects 53000 women each year in France. The leading cause of cancer deaths in women, its risk factors are numerous and include age, early puberty and/or late menopause, later age at first pregnancy as well as a family history of the disease.
Gommier-Lefort Valérie - - 2013
In the Centre region of France, breast cancer is one of the three most common and most fatal forms of the disease. Chartres hospitals offer complete care provision on a single site and assess the time taken for the appropriate care to be put in place. The nurse coordinator plays ...
Wintz Lydie - - 2013
Around 20 to 30% of women treated for breast cancer undergo a mastectomy in France. Of these patients, 70% do not have reconstructive surgery. It would seem that information surrounding reconstructive procedures is insufficient. Tools created in partnership with caregivers and patients are necessary to help women understand the choices ...
Biffaud Jean-Christophe - - 2013
The incidence of lymphoedema after breast cancer surgery with axillary dissection varies according to different studies, from 15 to 47%. The risk is 60% higher in cases of axillary radiotherapy. A rehabilitation service was undertaken as part of a research project aiming to show the benefit of the early treatment ...
Dejter Sandra - - 2013
The treatment of breast cancer generates changes to the body and a person's self-image. The caregivers' support focuses on the woman's grief for her old body and the acceptance of a changed intimacy. Listening to each woman is essential for acknowledging her fears in the face of this mutated body, ...
Dariel Odessa - - 2013
Q-Methodology offers an alternative to traditional methodological approaches. It is similar to qualitative methods while at the same time guaranteeing a statistical data analysis. It can be particularly interesting for the development of nursing sciences.
Tofield Andros - - 2013
The MEP Heart Group is a discussion forum aimed at promoting measures to reduce the burden of cardiovascular disease in the European Union and raise cardiovascular disease as a priority on the EU political agenda.
Tofield Andros - - 2013
Exposure to air pollution is associated with increased mortality after myocardial infarction
Clancy Paula - - 2013
Angiotensin II (AII) receptor 1 (ATR1) and angiotensin converting enzyme 1 (ACE1) blockers have been shown to reduce acute cardiovascular events in patients, improve plaque stability and modify matrix metalloproteinase (MMP) expression. However, the role of the ACE1/AII/ATR1 axis in interstitial collagenase regulation has not been fully explored. In this ...
Nery Mariana F - - 2013
Cetaceans, early in their evolutionary history, had developed many physiological adaptations to secondarily return to the sea. Among these adaptations, changes in molecules that transport oxygen and that ultimately support large periods of acute tissue hypoxia probably represent one big step toward the conquest of aquatic environments. Myoglobin contributes to ...
Liu Fen - - 2013
To observe the effect of transfected microRNA-146a (miR-146a) on expression of tumor necrosis factor- ex ( TNF- ex ) in alveolar macrophages, and to analyze its regulatory mechanism in the inflammatory response of alveolar macrophages. Cy.11113 labeled with 25, 50, 100 nmol!L of Pre-miR"', respectively, were transfected into rat alveolar ...
De Pauw Antoine - - 2013
Screening for breast cancer should concern all women at some point in their life. In cases of a family history of breast cancer, an oncogenetic consultation may be offered. The identification of a genetic predisposition enables specific management strategies for the woman to be drawn up.
Geay Jean-François - - 2013
The organised screening of breast cancer, the identification of the type of lesion and the staging determine the treatment plan for this disease. The most common cancer to affect women in France and in Europe, it represents 1/3 of cancers in women and 1/4 of all cancers.
Pfeil-Thiriet Francine - - 2013
In France, one woman in eight is treated for breast cancer before the age of 75. The 2009-2013 cancer plan recommends providing support for women after cancer. A therapeutic education programme helps them reintegrate into their daily life.
Barbier Elisabeth - - 2013
Hypnosis is a non-medication based approach used increasingly in hospitals. In oncology, practised by a trained nurse hypnotherapist, it represents a complementary medicine.
- - 2013
ESC is to create an inventory of cardiovascular disease registries and a task force on data standardization
Taylor Jennifer - - 2013
There is no increase in life expectancy for vegetarians and the jury is out on the protective effects of fish
Gast Karin B - - 2013
The relative importance of insulin resistance and hyperglycemia to the development of atherosclerosis remains unclear. Furthermore, adiposity may be responsible for observed associations. Our aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis. In this cross-sectional analysis of the Netherlands Epidemiology of Obesity ...
Wang Jin-Feng - - 2013
Irradiation from diverse sources is ubiquitous and closely associated with human activities. Radiation therapy (RT), an important component of multiple radiation origins, is a common therapeutic modality for cancer. More importantly, RT provides significant contribution to oncotherapy by killing tumor cells. However, during the course of therapy, irradiation of normal ...
Bai Bing - - 2013
This study aims to investigate the clinicopathologic significance of lymphatic vessel invasion (LVI) labeled by D2-40 monoclonal antibody in esophageal squamous cell carcinoma (ESCC). Immunohistochemical assay was used to detect the expression of D2-40 and LVI in 107 ESCC patients. Then, the correlation between the clinicopathologic feature and the overall ...
Feng Qiang - - 2013
This study aims to explore the clinicopathologic characteristics and prognostic factors of gastric cancer patients with metachronous ovarian metastasis. Clinicopathologic data were collected from 63 post-operative gastric cancer patients with metachronous ovarian metastasis. The patients were admitted to the Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking ...
Liu Wei - - 2013
Chemotherapy is the standard treatment for small-cell lung cancer (SCLC), and leukopenia is a common side effect. This study assesses whether chemotherapy-induced leukopenia is a predictor of efficacy and whether it is associated with the survival of SCLC patients. A retrospective analysis was conducted on data from 445 patients with ...
Ouyang Dian - - 2013
Laryngeal reconstruction is needed to preserve laryngeal function in patients who have undergone extensive vertical or frontal partial laryngectomy. However, the procedure remains a difficult challenge. Several reconstruction techniques have been described, but these techniques pose risks of complications such as laryngeal stenosis. This study aimed to evaluate the postoperative ...
Duan Xiao-Feng - - 2013
Splenic metastasis is generally not a common clinical event. However, metastasis to the spleen from adrenal pheochromocytoma is extremely rare and has not been reported in literature. This report presents a case of a 58 year-old male patient who developed spleen-only metastases in July 2007. The patient had a previous ...
Wang Yi-Hao - - 2013
A 60-year-old woman with squamous cell carcinoma in the right lung was successfully treated with four cycles of combination chemotherapy after surgery, and complete remission was achieved. However, the patient developed myelodysplastic syndrome (MDS) RAEB-2 with myelofibrosis after remission, possibly because of chemotherapy or DNA methylation. The patient responded well ...
Borycki Elizabeth - - 2013
Health information technology (HIT) research findings suggested that new healthcare technologies could reduce some types of medical errors while at the same time introducing classes of medical errors (i.e., technology-induced errors). Technology-induced errors have their origins in HIT, and/or HIT contribute to their occurrence. The objective of this paper is ...
Peikari Hamid Reza - - 2013
Some hospitals have implemented computerized physician order entry (CPOE) systems to reduce the medical error rates. However, research in this area has been very limited, especially regarding the impact of CPOE use on the reduction of prescribing errors. Moreover, the past studies have dealt with the overall impact of CPOE ...
Myoung Sungmin - - 2013
This study demonstrates the feasibility of using a modified mixture of experts (ME) model with repeated measured tumoural K(trans) value to perform an automatic diagnosis of responder based on perfusion magnetic resonance imaging (MRI) of rectal cancer. The data used in this study was obtained from 39 patients with primary ...
Del Rosso James Q - - 2013
This article reviews background on proteases and their functions, their physiological significance in skin, and the potential implications of incorporating specific proteases and protease blends into dermatological products, including skin care formulations. The history of protease blend formulations used in wound model studies and for other disorders is reviewed. In ...
Choudhary Sonal - - 2013
Drug rash with eosinophilia and systemic symptoms syndrome is a severe idiosyncratic drug reaction with a long latency period. It has been described using many terms; however, drug rash with eosinophilia and systemic symptoms syndrome appears to be the most appropriate. This syndrome causes a diverse array of clinical symptoms, ...
Kim Yoo Ri - - 2013
Familial hypercholesterolemia (FH) is associated with premature atherosclerotic cardiovascular diseases, and is inherited as an autosomal dominant trait. The prevalence of heterozygous FH is one in five hundred people. Owing to dysfunctional low density lipoprotein (LDL) receptors due to genetic mutations, serum low density lipoprotein-cholesterol (LDL-C) levels are considerably increased ...
Kim Ki Hong - - 2013
It is unclear which plaque component is related with long-term clinical outcomes in patients with coronary artery occlusive disease (CAOD). We assessed the relationship between plaque compositions and long-term clinical outcomes in those patients. The study subjects consisted of 339 consecutive patients (mean 61.7±12.2 years old, 239 males) who underwent ...
Tas Muhammed Hakan - - 2013
Dobutamine stress echocardiography (DSE) is an important non-invasive imaging method for evaluating ischemia. However, wall motion interpretation can be impaired by the experience level of the interpreter and the subjectivity of the visual assessment. In our study we aimed to combine DSE and tissue syncronisation imaging to increase sensitivity for ...
Lim Young-Hyo - - 2013
The proximal portion of the abdominal aorta (AA) is characterized by minimal arteriosclerosis compared with other aortic segments. To assess the clinical usefulness of this characteristic, the correlation between ultrasonographically measured proximal AA stiffness and brachial-ankle pulse wave velocity (baPWV) was examined. 285 subjects were analyzed, half with hypertension and ...
Hong Man Yong - - 2013
Coronary artery anomalies are rare presentations in primary percutaneous coronary interventions of acute myocardial infarction. Herein, we report the case of a 59-year-old man with acute anterior myocardial infarction who had anomalous separate origin of left anterior descending artery (LAD) and left circumflex artery (LCX) from the left coronary aortic ...
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