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Results 201 - 250 of 1237
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Barr Francis A FA Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England, UK. - - 2013
Rab GTPases are highly conserved components of vesicle trafficking pathways that help to ensure the fusion of a vesicle with a specific target organelle membrane. Specific regulatory pathways promote kinetic proofreading of membrane surfaces by Rab GTPases, and permit accumulation of active Rabs only at the required sites. Emerging evidence ...
Mansi Ishak I Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas, USA. - - 2013
Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. A retrospective cohort study with propensity score matching. San Antonio Military Multi-Market. Tricare Prime/Plus beneficiaries ...
Atkins Benjamin D BD Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, - - 2013
The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase but drops during mitotic exit and cytokinesis. Cdc5/Polo kinase is an important upstream cell cycle regulator ...
Rothschild Bruce - - 2013
Bursitis is quite responsive to therapeutic intervention, once the afflicted area is accurately identified. This is especially notable for some hip complaints. Patients' use of the term "hip" can relate to anything from the low back to groin to lateral thigh pain. Trochanteric area surface localization of "hip" pain may ...
Rothschild Bruce - - 2013
Lateral epicondylitis is a relatively common clinical problem, easily recognized on palpation of the lateral protuberance on the elbow. Despite the "itis" suffix, it is not an inflammatory process. Therapeutic approaches with topical non-steroidal anti-inflammatory drugs, corticosteroids and anesthetics have limited benefit, as would be expected if inflammation is not ...
Rosenthal Philip - - 2013
Adjacent segment pathology affects 25% of patients within ten years of anterior cervical diskectomy and fusion (ACDF). Laboratory studies demonstrate fused segments increase adjacent level stress including elevated intradiscal pressure and increased range of motion. Radiographic adjacent segment pathology (RASP) has been associated to ACDF in multiple statistically significant studies. ...
Molloy Alan P - - 2013
The incidence of cancer is increasing worldwide, with the advent of a myriad of new treatment options, so is the overall survival of these patients. However, from an orthopaedic perspective, there comes the challenge of treating more patients with a variety of metastatic bone lesions. The consequences of such lesions ...
Jacobs Cale A - - 2013
To quantify and reduce the errors in visual estimation of knee flexion contractures during total knee arthroplasty (TKA). This study was divided into two parts: Quantification of error and reduction of error. To quantify error, 3 orthopedic surgeons visually estimated preoperative knee flexion contractures from lateral digital images of 23 ...
Korres Nektarios - - 2013
To investigate the in vivo effects of type I diabetes on the mechanical strength of tibial bone in a rodent model. The biomechanical effect of diabetes on the structural integrity of the tibia in streptozotocin induced diabetic Wistar rats was analysed. Induction of diabetes was achieved by an intra-peritoneal injection and confirmed ...
Küçükdurmaz Fatih - - 2013
To increase the stability of sternotomy and so decrease the complications because of instability. Tests were performed on 20 fresh sheep sterna which were isolated from the sterno-costal joints of the ribs. Median straight and interlocking sternotomies were performed on 10 sterna each, set as groups 1 and 2, respectively. ...
Etemadifar Mohammad Reza - - 2013
To assess possible relationships of knowledge and related factors with educational level and osteoporosis-related life habits. This was a cross sectional study conducted on 268 women (≥ 35 years old) from June 2011 to August 2011. The sample collection was done in outpatient clinics in three university hospitals in Isfahan, ...
Lykissas Marios G - - 2013
To compare the functional outcomes of patients who underwent open surgery vs Ponseti method for the management of idiopathic clubfoot and to determine whether correlations exist between functional outcome and radiographic measurements. A meta-analysis of the literature was conducted for studies concerning primary treatment of patients with idiopathic clubfoot. We ...
Küçükdurmaz Fatih - - 2013
To define the optimum safe angle of use for an eccentrically aligned proximal interlocking screw (PIS) for intramedullary nailing (IMN). Thirty-six dry cadaver ulnas were split into two equal pieces sagitally. The following points were identified for each ulna: the deepest point of the incisura olecrani (A), the point where ...
Lykissas Marios G - - 2013
Intercostal nerve transfer is a valuable procedure in devastating plexopathies. Intercostal nerves are a very good choice for elbow flexion or extension and shoulder abduction when the intraplexus donor nerves are not available. The best results are obtained in obstetric brachial plexus palsy patients, when direct nerve transfer is performed ...
Valli Federico - - 2013
Femoral artery pseudoaneurysms (FAPs) have been described following internal fixation of intertrocantheric, subtrocantheric and intracapsular femoral neck fractures as well as core decompression of the femoral head. The diagnosis of FAP is usually delayed because of non-specific clinical features like pain, haematoma, swelling, occasional fever and unexplained anaemia. Because of ...
Jang Sang-Hoon - - 2013
A 55-year-old female was diagnosed with L5-S1 degenerative disc disease (DDD). Initial scores by the visual analogue scale (VAS) were 5 (back) and 9 (leg) and the Oswestry disability index (ODI) was 32. Arthroplasty was performed. Clinical and radiographic monitoring took place thereafter at one month, three months, six months ...
Foo Jong Yong Abdiel - - 2013
Abstract Studies have suggested that the saturated oxygen level within one's arterial blood can provide crucial information about the status of one's cardiopulmonary system. Currently, a popular and convenient approach is to obtain this vital physiological sign through non-invasive measurement on suitable peripheral sites such as a finger, toe or ...
Carrad D J - - 2013
We have studied the efficacy of (NH4)2Sx surface passivation on the (311)A GaAs surface. We report XPS studies of simultaneously-grown (311)A and (100) heterostructures showing that the (NH4)2Sx solution removes surface oxide and sulfidizes both surfaces. Passivation is often characterized using photoluminescence measurements; we show that while (NH4)2Sx treatment gives ...
Wax J-F JF Université de Lorraine, LCP-A2MC, EA4632, 1, Boulevard Arago F-57078 Metz Cedex 3, France. - - 2013
A scheme of analysis for the dynamic structure functions in pure liquids is presented which can be implemented with both experimental and simulation data. Expressions for contributions of relaxing and propagating modes proposed earlier in the framework of the generalized collective modes approach are optimized in order to strictly fulfil ...
Blanpain Cédric C Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Brussels, Belgium. - - 2013
During embryonic and postnatal development, the different cells types that form adult tissues must be generated and specified in a precise temporal manner. During adult life, most tissues undergo constant renewal to maintain homeostasis. Lineage-tracing and genetic labelling technologies are beginning to shed light on the mechanisms and dynamics of ...
Calderwood David A DA Departments of Pharmacology and of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. david.calderwood@ - - 2013
Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix (or cellular counter-receptors) and intracellular cytoskeletal and signalling networks, enabling cells to sense and respond to their chemical and physical environment. Talins and kindlins, two families of FERM-domain proteins, bind the cytoplasmic tail of integrins, recruit cytoskeletal and signalling ...
Mansfield Karen L - - 2013
Behavioral and brain potential measures were employed to compare interference in Eriksen and Simon tasks. Assuming a dual-process model of interference elicited in speeded response tasks, we hypothesized that only lateralized stimuli in the Simon task induce fast S-R priming via direct unconditional processes, while Eriksen interference effects are induced ...
Lin Yi-Nan YN Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, - - 2013
Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein 4.1-associated protein) was previously reported to participate in centriole elongation. Here, we show that CEP120 is a cell cycle-regulated protein that directly interacts with CPAP and is required for centriole duplication. CEP120 ...
Davydenko Olga O Department of Biology, University of Pennsylvania, Philadelphia, PA - - 2013
Chromosome segregation during cell division depends on stable attachment of kinetochores to spindle microtubules. Mitotic spindle formation and kinetochore-microtubule (K-MT) capture typically occur within minutes of nuclear envelope breakdown. In contrast, during meiosis I in mouse oocytes, formation of the acentrosomal bipolar spindle takes 3-4 h, and stabilization of K-MT ...
Wakana Yuichi Y Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), 08003 Barcelona, - - 2013
Here we report that the kinesin-5 motor Klp61F, which is known for its role in bipolar spindle formation in mitosis, is required for protein transport from the Golgi complex to the cell surface in Drosophila S2 cells. Disrupting the function of its mammalian orthologue, Eg5, in HeLa cells inhibited secretion ...
Wang Peng P Institut de recherche en immunologie et en cancérologie, Université de Montréal, Montréal, Québec H3C 3J7, - - 2013
Cell division requires the coordination of critical protein kinases and phosphatases. Greatwall (Gwl) kinase activity inactivates PP2A-B55 at mitotic entry to promote the phosphorylation of cyclin B-Cdk1 substrates, but how Gwl is regulated is poorly understood. We found that the subcellular localization of Gwl changed dramatically during the cell cycle ...
Chen Yanmin Y Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, - - 2013
Axonal mitochondria are recruited to synaptic terminals in response to neuronal activity, but the mechanisms underlying activity-dependent regulation of mitochondrial transport are largely unknown. In this paper, using genetic mouse model combined with live imaging, we demonstrate that syntaphilin (SNPH) mediates the activity-dependent immobilization of axonal mitochondria through binding to ...
Solinet Sara S Cellular Mechanisms of Morphogenesis during Mitosis and Cell Motility, Université de Montréal, Montréal, Québec H3C 3J7, - - 2013
Ezrin, Radixin, and Moesin (ERM) proteins play important roles in many cellular processes including cell division. Recent studies have highlighted the implications of their metastatic potential in cancers. ERM's role in these processes is largely attributed to their ability to link actin filaments to the plasma membrane. In this paper, ...
Chen Zu-Lin ZL Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, - - 2013
Astrocytes express laminin and assemble basement membranes (BMs) at their endfeet, which ensheath the cerebrovasculature. The function of astrocytic laminin in cerebrovascular integrity is unknown. We show that ablation of astrocytic laminin by tissue-specific Cre-mediated recombination disrupted endfeet BMs and led to hemorrhage in deep brain regions of adult mice, ...
Isberg Jan - - 2013
Standard electronic devices encode bits of information by controlling the amount of electric charge in the circuits. Alternatively, it is possible to make devices that rely on other properties of electrons than their charge. For example, spintronic devices make use of the electron spin angular momentum as a carrier of ...
Wysin G M - - 2013
The Faraday rotation in metallic nanoparticles is considered based on a quantum model for the dielectric function ϵ(ω) in the presence of a DC magnetic field B. We focus on effects in ϵ(ω) due to interband transitions (IBTs), which are important in the blue and ultraviolet for noble metals used ...
Barzilai S - - 2013
The mechanical properties and conductance of contaminated and pure silver nanowires were studied using density functional theory (DFT) calculations. Several nanowires containing O2 on their surfaces were elongated along two different directions. All of the NWs thinned down to single atom chains. In most simulations, the breaking force was not ...
Pandey K K - - 2013
The high pressure behavior of multiferroic BiMn2O5 has been investigated using powder x-ray diffraction and Raman scattering techniques as well as density functional theory based first principles calculations. Our investigations show a reversible iso-structural phase transition in BiMn2O5 above 10 GPa. The compressibility along the c axis, i.e. along the edge-shared distorted ...
Kanduč Matej - - 2013
Using the novel thermodynamic extrapolation technique in molecular dynamics simulations, we investigate the interaction between phospholipid bilayers subject to various boundary conditions that correspond to established experimental methods for the determination of pressure-distance curves: the osmotic stress method, the hydrostatic method, and the surface force apparatus method. We discuss the ...
Alarcón A - - 2013
Following Oriols (2007 Phys. Rev. Lett. 98 066803), an algorithm to deal with the exchange interaction in non-separable quantum systems is presented. The algorithm can be applied to fermions or bosons and, by construction, it exactly ensures that any observable is totally independent of the interchange of particles. It is ...
Kemei Moureen C - - 2013
Magnetic ordering in the geometrically frustrated magnetic oxide spinels MgCr2O4 and ZnCr2O4 is accompanied by a structural change that helps to relieve the frustration. Analysis of high-resolution synchrotron x-ray scattering reveals that the low-temperature structures are well described by a two-phase model of tetragonal I41/amd and orthorhombic Fddd symmetries. The ...
Zhu Mingshan - - 2013
We report herein that Ag/AgCl-based plasmonic photocatalysts with controlled size and shape could be easily formulated by a one-pot approach via a precipitation reaction between AgNO3 or Ag(NH3)2NO3 and NaCl. It is found that near-spherical and cube-like Ag/AgCl nanoarchitectures of 500 nm could be fabricated at lower and higher temperature, ...
Hirayama Shinya - - 2013
The contact angle of a drop of gelling solution on a flat, solid surface was monitored as the hot solution was allowed to cool. When a solvent with a high cohesive energy and a wettable solid surface was used, a wetting solution turned into a dewetting solid at the gelation ...
Trolle Mads Lund - - 2013
Carbon nanotubes (CNTs) of armchair and zigzag type contain an inversion centre, and are thus intrinsically unable to generate dipole even-order nonlinearities, such as second harmonic generation (SHG). Breaking the inversion symmetry by application of an external voltage transversal to the CNT axis will, however, induce a second harmonic response. ...
Jungbauer Alois - - 2013
Continuous manufacturing has been applied in many different industries but has been pursued reluctantly in biotechnology where the batchwise process is still the standard. A shift to continuous operation can improve productivity of a process and substantially reduce the footprint. Continuous operation also allows robust purification of labile biomolecules. A ...
Ferradás R - - 2013
We calculate the electronic and transport properties of a series of metalloporphyrin molecules sandwiched between gold electrodes using a combination of density functional theory and scattering theory. The impact of strong correlations at the central metallic atom is gauged by comparing our results obtained using conventional DFT and DFT + U approaches. ...
Lin Shi-Zeng - - 2013
Recently, transport measurements have been carried out in resistively shunted long superconducting nanowires (Brenner et al 2012 Phys. Rev. B 85 224507). The measured voltage-current (V-I) characteristics were explained by the appearance of the phase slip centers in the shunted wire, and the whole wire was modeled as a single Josephson ...
Yin Jun - - 2013
The control of the nanoscale composition and structure of alloy catalysts plays an important role in heterogeneous catalysis. This paper describes novel findings of an investigation for Pd-based nanoalloy catalysts (PdCo and PdCu) for ethanol oxidation reaction (EOR) in gas phase and alkaline electrolyte. Although the PdCo catalyst exhibits a ...
Musicco Massimo - - 2013
To evaluate the incidence of cancer in persons with Alzheimer disease (AD) and the incidence of AD dementia in persons with cancer. This was a cohort study in Northern Italy on more than 1 million residents. Cancer incidence was derived from the local health authority (ASL-Mi1) tumor registry and AD ...
Xin Mei M Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, - - 2013
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and development can be exploited to repair the injured adult heart through 'reawakening' ...
Watt Fiona M FM King's College London Centre for Stem Cells and Regenerative Medicine, London, UK. - - 2013
The field of stem cells and regenerative medicine offers considerable promise as a means of delivering new treatments for a wide range of diseases. In order to maximize the effectiveness of cell-based therapies - whether stimulating expansion of endogenous cells or transplanting cells into patients - it is essential to ...
Chakraborty Chinmay C Department of Electronics and Communication Engineering, Birla Institute of Technology, Mesra, India. - - 2013
In this article, we describe the important aspects like major characteristics, research issues, and challenges with body area sensor networks in telemedicine systems for patient monitoring in different scenarios. Present and emerging developments in communications integrated with the developments in microelectronics and embedded system technologies will have a dramatic impact ...
Godsey Judi - - 2013
More than one-third of U.S. adults over the age of 20 years are classified as obese and nearly two-thirds are overweight or obese. The prevalence of obesity among U.S. children and adolescents has almost tripled since 1980, with 17% of all youth and children now considered obese. Nine million children ...
Barry Nicolas P E - - 2013
Encapsulation of the platinum(IV) prodrug mitaplatin in block copolymer nanoparticles increases drug circulation time in the blood and reduces accumulation in the kidneys, as reported by Lippard and colleagues in this issue of ACS Nano. Importantly, controlled drug release from the nanoparticles produces long-term anticancer efficacy, with the prospect of ...
Rubenstein Donald S - - 2013
The Riata 1590 lead model contains both electrically active cables (AC) and filler cables (FC) that run in pairs within lumens along the lead body. FC are yet to be described as lead components that may be externalized from either external abrasion or inside-out abrasion seen in the recalled St. ...
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