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Fulvio Pasquale F - - 2013
Hierarchical nanoporous nitrogen-doped carbons were prepared from task specific ionic liquids having a bis-imidazolium motif linked with various organic groups. While ethyl chains linking the imidazolium ions afforded microporous-mesoporous carbons, long or aromatic groups resulted in microporous samples.
Zhang Dingyuan - - 2013
A facile and efficient one-pot synthesis of β-hydroxy-γ-lactams from α,α-dialkyl β-oxo amides and trimethylsulfoxonium iodide in the presence of sodium hydride via a tandem Corey-Chaykovsky reaction and an intramolecular lactamization process is developed.
Singhal Anshika - - 2013
Mycobacterium tuberculosis modulates expression of various metabolism-related genes to adapt in the adverse host environment. The gene coding for M. tuberculosis S-adenosylhomocysteine hydrolase (Mtb-SahH) is essential for optimal growth and the protein product is involved in intermediary metabolism. However, the relevance of SahH in mycobacterial physiology is unknown. In this ...
Adato Ronen - - 2013
Infrared absorption spectroscopy is a powerful biochemical analysis tool as it extracts detailed molecular structural information in a label-free fashion. Its molecular specificity renders the technique sensitive to the subtle conformational changes exhibited by proteins in response to a variety of stimuli. Yet, sensitivity limitations and the extremely strong absorption ...
Mathon Bertrand - - 2013
A 5-year-old boy was operated on for a non-metastatic medulloblastoma of the fourth ventricle (figure 1). Chemotherapy and bifractionated craniospinal radiotherapy were administered. Four years later, T1-weighted MRI with contrast revealed abnormal vessels in the right sylvian fissure that gradually increased during follow-up; angiography confirmed an arteriovenous malformation (AVM) (figure ...
Cahill Leah E LE Harvard School of Public Health, 655 Huntington Ave, Bldg II, Room 349, Boston, MA 02115, USA. - - 2013
Among adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations. However, it remains unknown whether specific eating habits regardless of dietary composition influence coronary heart disease (CHD) risk. The objective of this study was to prospectively examine eating habits and risk of ...
Benke Bahiru P - - 2013
Ion transporters have been developed from acyclic octapeptides comprising l/d alanine and m-aminobenzoic acid. These octapeptides transport cations up to 3 times faster than their cyclic analog through lipid vesicles. Preliminary CD, XRD and computational studies allude to a 6-9 Å wide tetrameric ion channel as the active ion transporter.
Jijy E - - 2013
An efficient one pot strategy for the synthesis of cyclopentene fused chromanone derivatives through the direct oxidative coupling of salicylaldehydes with bicyclic olefins in the presence of a rhodium-copper catalyst system is described. This is the first report on the ring opening-ring closing of bicyclic hydrazines via metal catalyzed oxidative ...
Memmel Elisabeth - - 2013
The Gram-positive bacterium Staphylococcus aureus is a human pathogen increasingly causing severe infections, especially in hospital environments. Moreover, strains which are resistant against various types of antibiotics are developing and spreading widely as in the case of the community-acquired MRSA (methicillin resistant S. aureus). In this study metabolic glycoengineering with ...
Zhang Yan - - 2013
Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.
Yuan Yali - - 2013
We for the first time fabricate a pseudo triple-enzyme cascade electrocatalytic electrochemical aptasensor by using the alcohol dehydrogenase (ADH) as well as the autonomously assembled hemin-G-quadruplex that simultaneously acted as an NADH oxidase and HRP-mimicking DNAzyme.
KriukienÄ— Edita - - 2013
Dynamic patterns of cytosine-5 methylation and successive hydroxylation are part of epigenetic regulation in eukaryotes, including humans, which contributes to normal phenotypic variation and disease risk. Here we present an approach for the mapping of unmodified regions of the genome, which we call the unmethylome. Our technique is based on ...
Sakuda Atsushi - - 2013
All-solid-state secondary batteries that employ inorganic solid electrolytes are desirable because they are potentially safer than conventional batteries. The ionic conductivities of solid electrolytes are currently attracting great attention. In addition to the conductivity, the mechanical properties of solid electrolytes are important for improving the energy density and cycle performance. ...
Jeon In-Yup - - 2013
Nitrogen fixation is essential for the synthesis of many important chemicals (e.g., fertilizers, explosives) and basic building blocks for all forms of life (e.g., nucleotides for DNA and RNA, amino acids for proteins). However, direct nitrogen fixation is challenging as nitrogen (N2) does not easily react with other chemicals. By ...
Jevtovikj Ivana - - 2013
The reaction of [Na2(thf)4(P4Mes4)] () with tributyltin chloride gives 1,2,3,4-tetramesityl-1,4-bis(tri-n-butyltin)tetraphosphane () which is stable towards disproportionation in solution at room temperature.
Baule Adrian - - 2013
Finding the optimal random packing of non-spherical particles is an open problem with great significance in a broad range of scientific and engineering fields. So far, this search has been performed only empirically on a case-by-case basis, in particular, for shapes like dimers, spherocylinders and ellipsoids of revolution. Here we ...
Quinn Colin - - 2013
A 39-year-old woman presented with progressive weakness over the past 2&frac12; years. She initially noticed weakness in her legs after falling while getting out of a boat. Her leg weakness slowly progressed over the next 2 years to the point where she was having great difficulty with stairs and getting ...
Waki Minoru - - 2013
Rate enhancement of the selective oxidation of hexoses was achieved on an ethynylpyridine (EPy)-functionalized Pt/Al2O3 catalyst. Host-guest interaction between the EPy ligand and a hexose sugar reactant produced a complex with induced chirality on the catalyst surface.
Ding Li - - 2013
Two thioxanthone-based fluorescent probes exhibited prominent solvatofluorochromism, and they were further found to be useful as fluorescence indicators for the qualitative and quantitative detection of low-level water content in various solvent media.
Chen Chia-Yun - - 2013
Multiple etching pathways for the formation of porous Si nanostructures are visualized with the addition of ethylene glycol in metal-assisted chemical etching. The monotonic transition from solid to porous morphologies of Si nanostructures along with remarkable photoluminescence (PL) emission efficiency and distinct wetting phenomena can be observed.
Zhao Zhi-Gang - - 2013
Oxygen conversion process between O2 and H2O by means of electrochemistry or photochemistry has lately received a great deal of attention. Cobalt-phosphate (Co-Pi) catalyst is a new type of cost-effective artificial oxygen-evolving complex (OEC) with amorphous features during photosynthesis. However, can such Co-Pi OEC also act as oxygen reduction reaction ...
Thyoka Mandela - - 2013
Surgical repair of oesophageal atresia may result in anastomotic strictures. These strictures are often treated by balloon dilatation (BD) and currently balloon dilatation (fluoroscopic or endoscopic) is the preferred primary treatment method. Here we review the current evidence of the outcomes of balloon dilatation of anastomotic strictures secondary to surgical ...
He Yimiao - - 2013
A metal-free synthesis of diversified pyrido[1,2-a]benzimidazoles and 1H-benzo[d]imidazoles from N-aryl-2-aminopyridines and N-arylamidines has been developed. The C-H cycloamination reaction was catalyzed by hypervalent iodine(iii) species generated in situ from iodobenzene (catalytic) and peracetic acid (stoichiometric). The reaction proceeded smoothly at ambient temperature to provide the corresponding N-heterocycles in good to ...
Mukherjee Sanjoy - - 2013
Four "V" shaped 1,8-naphthalimides () have been synthesized and their fluorescence quantum-yields correlated to their molecular flexibility. The correlation was used for detection of Hg(ii) via a chemodosimetric approach. was found to be an AIE active molecule with the formation of fluorescent nanoaggregates.
Egami Hiromichi - - 2013
Iron-catalyzed trifluoromethylation with concomitant 1,2-migration of an aryl group starting from diaryl allyl alcohol was achieved under mild conditions. This reaction system affords α-substituted-β-trifluoromethyl carbonyl compounds in high efficiency. In the case of substrates bearing different aryl groups, selective migration was observed.
Feketeová Linda - - 2013
Oxidative damage to DNA yields guanine radical cations. Their gas-phase IR spectroscopic signature and acidity have been modelled by the radical cation of 9-methylguanine. Comparisons with quantum chemistry calculations suggest that radical cation formation produces the ground-state keto tautomer, which has an N-H acidity enhanced by ∼470 kJ mol(-1).
Han Dong-Soo - - 2013
Lattice vibration modes are collective excitations in periodic arrays of atoms or molecules. These modes determine novel transport properties in solid crystals. Analogously, in periodical arrangements of magnetic vortex-state disks, collective vortex motions have been predicted. Here, we experimentally observe wave modes of collective vortex gyration in one-dimensional (1D) periodic ...
Xu Mingdi - - 2013
A novel difunctional DNA-nanogold (AuNP) dendrimer with a hemin-G-quadruplex was for the first time utilized as the nanotag for the in situ amplified electronic signal for nucleic acid detection by coupling high-efficiency DNAzyme with the intercalated methylene blue (MB).
Wu Wei - - 2013
Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study, and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, ...
Zhang Peng - - 2013
Real-time dynamics of native super-paramagnetic nanoparticles (SPMNPs) with different sizes were observed in a microchip at the single-particle level. Based on the optimized magnetic field conditions obtained in the single-nanoparticle study, the SPMNPs were successfully separated and detected within ∼15 s from the model polydisperse mixture.
Xu Chengjun - - 2013
We present a one-step synthesis process for ultrathin non-crystalline MnO2 nanosheets. Their thickness is about 2 nm and the width varies from 5 to 20 nm. They induce a higher capacitance than zero-dimensional spheres or one-dimensional rods. When heat treated at elevated temperature MnO2 nanosheets partly grow into crystalline Mn2O3 ...
Xu Wang - - 2013
Caffeine has attracted abundant attention due to its extensive existence in beverages and medicines. However, to detect it sensitively and conveniently remains a challenge, especially in resource-limited regions. Here we report a novel aqueous phase fluorescent caffeine sensor named Caffeine Orange which exhibits 250-fold fluorescence enhancement upon caffeine activation and ...
Wang Guiyuan - - 2013
A thin film of polyaniline (PANI) nanofibers on the stainless steels with fluoro-thiol modification was prepared through an optimal polymerization time of aniline using HClO4 as a dopant, showing robust superhydrophobic, transparent and anti-fingerprint properties.
Kalra Vivek B - - 2013
A 69-year-old man developed acute-onset confusion and hypertension with systolic pressures in the 160s 1 day after carotid endarterectomy for right facial droop from left hemispheric lacunar infarcts. CT perfusion (figure, A-D) demonstrated findings consistent with cerebral hyperperfusion syndrome (CHS) following revascularization. CHS is caused by loss of autoregulation, hypertension, ...
Jha Neetu - - 2013
Chemically modified single-walled carbon nanotubes (SWNTs) with varying degrees of functionalization were utilized for the fabrication of SWNT thin film catalyst support layers (CSLs) in polymer electrolyte membrane fuel cells (PEMFCs), which were suitable for benchmarking against the US DOE 2017 targets. Use of the optimum level of SWNT -COOH ...
Kilic Leyla - - 2013
Adjuvant chemoradiotherapy (CRT) is the standard of care for gastric cancer patients in the USA. However, in countries where D2 lymph node dissection is performed, the effect of radiotherapy on locoregional recurrence is controversial. The aim of this study is to compare the outcomes in pN3 gastric cancer patients following ...
Gu Yonge - - 2013
Self-propelled biocatalytic motors based on plant tissues are described. The tissue motors rely on their rich catalase activity towards biocatalytic decomposition of the H2O2 fuel and generation of the bubble thrust. These biomotors obviate the need for pure enzymes, and offer a remarkably low cost, good lifetime and thermostability.
Mateen Farrah J FJ Department of International Health, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. - - 2013
A growing number of international stakeholders are engaged with neurologic diseases. This article provides a brief overview of important international stakeholders in the practice of neurology, including global disease-specific programs, United Nations agencies, governmental agencies with international influence, nongovernmental organizations, international professional organizations, large private donors, private-public partnerships, commercial interests, ...
Goldstein Larry B - - 2013
In his Global Perspectives article, Dr. Chin(1) reported on the resource constraints related to the provision of stroke care in Africa. This was based on his experience visiting Mulago Hospital, Uganda's primary tertiary care referral center. He appropriately points out the very limited data related to stroke prevention and treatment ...
Ji Wei - - 2013
Based on bovine serum albumin (BSA)-modified Au NPs, a simple and cost-effective approach was proposed to fabricate an anti-aggregated Au NP sensing platform for the detection of metal ions. It exhibits excellent stability even under highly ionic conditions due to its electrostatic stabilization, as well as the steric stabilization.
Tai Yi-Cheng - - 2013
A 61-year-old man had acute stupor and left-sided weakness. Head CT showed right thalamic hemorrhage (figure 1, A and B). Regaining consciousness the next day, he had bilateral convergence excess and upward gaze limitation (figure 2), with preserved light and oculocephalic reflexes. The phenomenon disappeared in sleep.
Mansi Ishak I Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas, USA. - - 2013
Statin use may be associated with increased musculoskeletal adverse events, especially in physically active individuals. To determine whether statin use is associated with musculoskeletal conditions, including arthropathy and injury, in a military health care system. A retrospective cohort study with propensity score matching. San Antonio Military Multi-Market. Tricare Prime/Plus beneficiaries ...
- - 2013
Erik Shannon, RLAT, Animal Care Technician III - Supervisor, Division of Comparative Medicine, Washington University School of Medicine, St. Louis, MO.
Albert Benjamin B Laboratoire de Biologie Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Université de Toulouse, F-31000 Toulouse, - - 2013
Chromosomes architecture is viewed as a key component of gene regulation, but principles of chromosomal folding remain elusive. Here we used high-throughput live cell microscopy to characterize the conformation and dynamics of the longest chromosome of Saccharomyces cerevisiae (XII). Chromosome XII carries the ribosomal DNA (rDNA) that defines the nucleolus, ...
Onishi Masayuki M Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, - - 2013
In yeast and animal cytokinesis, the small guanosine triphosphatase (GTPase) Rho1/RhoA has an established role in formation of the contractile actomyosin ring, but its role, if any, during cleavage-furrow ingression and abscission is poorly understood. Through genetic screens in yeast, we found that either activation of Rho1 or inactivation of ...
Schoborg Todd T Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, - - 2013
Chromatin insulators assist in the formation of higher-order chromatin structures by mediating long-range contacts between distant genomic sites. It has been suggested that insulators accomplish this task by forming dense nuclear foci termed insulator bodies that result from the coalescence of multiple protein-bound insulators. However, these structures remain poorly understood, ...
Negus S Stevens - - 2013
Pain is often associated with clinically relevant depression of behavior and mood, and relief of pain-related depression is a common goal of treatment in both human and veterinary medicine. In the development of pharmacological compounds to treat pain and related depression, preclinical studies may be used to evaluate the analgesic ...
Balasubramanian Mohan K MK Temasek Life Sciences Laboratory, 2 Department of Biological Sciences, and 3 Mechanobiology Institute, National University of Singapore, Singapore - - 2013
In many eukaryotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction and new membrane organization. Two studies in this issue (Onishi et al. 2013. J. Cell Biol. and Atkins et al. 2013. J. Cell Biol. establish that precise activation and/or inactivation of Rho1 and ...
Atkins Benjamin D BD Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, - - 2013
The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase but drops during mitotic exit and cytokinesis. Cdc5/Polo kinase is an important upstream cell cycle regulator ...
Park Inai I Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, - - 2013
BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortened mitotic timing. The generation of the SAC signal was intact, as Mad2 localization to the ...
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