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Zaghiyan Karen K Divisions of *Colorectal Surgery and †Gastroenterology; and ‡Department of Biostatistics and Bioinformatics, Cedars Sinai Medical Center, Los Angeles, - - 2014
To evaluate the safety of perioperative low-dose steroids (LDS) versus high-dose steroids (HDS) in steroid-treated patients with inflammatory bowel disease (IBD) undergoing major colorectal surgery. Corticosteroid-treated patients undergoing major colorectal surgery are commonly prescribed HDS to prevent perioperative adrenal insufficiency and cardiovascular collapse. There is little evidence to support this ...
Taraban Roman - - 2013
To be competitive, contemporary engineers must be capable of both processing and communicating information effectively. Available research suggests that Indian students would be disadvantaged in information literacy in their language of instruction (English) compared to U.S. students because English is not Indian students' native language. Compared to U.S. students, Indian ...
Ellegaard Ole - - 2013
Valid and reliable information on the use and effects of chemicals is a key factor in the industry and not least within many regulatory agencies. Identification data from lists of substances sometimes leads to incomplete bibliographic analysis in the major chemical databases. The present study takes as its starting point ...
Moritou Yuki - - 2013
The impact of single-nucleotide polymorphisms (SNP) of patatin-like phospholipase domain-containing protein 3 (PNPLA3) on development of hepatocellular carcinoma (HCC) is not clarified for Japanese patients with chronic hepatitis C. The present study investigated the associations of rs738409 PNPLA3 with HCC development after the antiviral therapy with peg-interferon and ribavirin for ...
Adugna Asfaw - - 2013
Seed dispersal is one of the vehicles of gene flow in plants. If a seed carrying transgene(s) is dispersed into the environment, the fate can be determined by its persistence in the soil bank, which can also vary in different ecotypes of a species and the physical environment of the ...
Masiulionis Virginia E - - 2013
It is generally accepted that material collected by leaf-cutting ants of the genus Acromyrmex consists solely of plant matter, which is used in the nest as substrate for a symbiotic fungus providing nutrition to the ants. There is only one previous report of any leaf-cutting ant foraging directly on fungal ...
Bertaccini Edward J EJ * Professor, Department of Anesthesia, Stanford University School of Medicine, Stanford, California, and Anesthesiologist and Intensivist, Palo Alto VA Health Care System, Palo Alto, California. † Doctoral Candidate, ‡ Professor of Computational Structural Biology, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden; Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. § Professor of Chemistry in Anesthesia, Department of Anesthesia, Stanford University School of - - 2013
Anesthetics mediate portions of their activity via modulation of the γ-aminobutyric acid receptor (GABAaR). Although its molecular structure remains unknown, significant progress has been made toward understanding its interactions with anesthetics via molecular modeling. The structure of the torpedo acetylcholine receptor (nAChRα), the structures of the α4 and β2 subunits ...
Koh Christopher C Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, - - 2013
The American Association for the Study of Liver Diseases (AASLD) practice guidelines provide recommendations in diagnosing and managing patients with liver disease from available scientific evidence in combination with expert consensus opinions. The aim was to systematically review the evolution of recommendations from AASLD guidelines and identify gaps limiting the ...
Liang Wen-Yih WY *Department of Pathology and Laboratory Medicine, Veterans General Hospital-Taipei, Taipei †Department of Pathology, National Yang-Ming University School of Medicine, Taiwan, Republic of China ‡Department of Pathology, Gastrointestinal Pathology Service §Department of Surgery, Division of Gastrointestinal Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, - - 2013
Peritoneal involvement is an important adverse prognostic factor in colorectal cancer (CRC) and determines a shift in the pathologic tumor node metastasis stage. Because peritoneal involvement is difficult to identify, use of special stains highlighting the peritoneal elastic lamina and mesothelial surface has been proposed. This study aims to determine ...
Omenda Maxwel M MM *Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA; †Program in Pathobiology, University of Washington, Seattle WA; ‡Department of Medicine, University of Washington, Seattle WA; §Department of Pediatrics, University of Nairobi, Nairobi, Kenya; ‖Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA; Departments of ¶Biostatistics; #Global Health, University of Washington, Seattle, WA; and **Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, - - 2013
: Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in ...
van Eldijk Mark B MB Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The - - 2013
CS2 hydrolase, a zinc-dependent enzyme that converts carbon disulfide to carbon dioxide and hydrogen sulfide, exists as a mixture of octameric ring and hexadecameric catenane forms in solution. A combination of size exclusion chromatography, multi-angle laser light scattering, and mass spectrometric analyses revealed that the unusual catenane structure is not ...
Halasi Marianna M Department of Medicine, University of Illinois at Chicago, 60612, - - 2013
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified inhibition of proteasome inhibitors as a novel activity of NAC. Both NAC and catalase, another known scavenger of ROS, similarly inhibited ROS levels and apoptosis associated ...
Liang Qiuli Q Center for Free Radical Biology, University of Alabama at Birmingham, 35294, - - 2013
Sirt3 (sirtuin 3) is an NAD-dependent deacetylase localized to mitochondria. Sirt3 expression is increased in mouse muscle and liver by starvation, which could protect against the starvation-dependent increase in oxidative stress and protein damage. Damaged proteins and organelles depend on autophagy for removal and this is critical for cell survival, ...
Pavlova E V EV Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. - - 2013
Multiple myeloma and B cell lymphoma are leading causes of death in Gaucher's disease but the nature of the stimulus driving the often noted clonal expansion of immunoglobulin-secreting B cells and cognate lymphoid malignancy is unknown. We investigated the long-term development of B cell malignancies in an authentic model of ...
Cai Kai K Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, 92093-0704, - - 2013
DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). We have found that chenodeoxycholic acid and the synthetic FXR (farnesoid X receptor) ligand GW4064 induce the mRNA and protein expression of DGKθ in the HepG2 cell line and ...
Putkonen Anu - - 2013
This randomized controlled trial studied whether seclusion and restraint could be prevented in the psychiatric care of persons with schizophrenia without an increase of violence. Over the course of a year, 13 wards of a secured national psychiatric hospital in Finland received information about seclusion and restraint prevention. Four high-security ...
Benzonana Laura L LL Section of Anesthetics, Pain Medicine, and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United - - 2013
Growing evidence indicates that perioperative factors, including choice of anesthetic, affect cancer recurrence after surgery although little is known about the effect of anesthetics on cancer cells themselves. Certain anesthetics are known to affect hypoxia cell signaling mechanisms in healthy cells by up-regulating hypoxia-inducible factors (HIFs). HIFs are also heavily ...
Cotman Susan L - - 2013
Neuronal ceroid lipofuscinosis (NCL), first clinically described in 1826 and pathologically defined in the 1960s, refers to a group of disorders mostly diagnosed in the childhood years that involve the accumulation of lysosomal storage material with characteristic ultrastructure and prominent neurodegenerative features including vision loss, seizures, motor and cognitive function ...
Shoemaker Sarah M - - 2013
The Lewis S. Feuer papers at Brandeis University include correspondence, manuscripts, Feuer's collection of radical literature, and other personal and professional materials. The process by which these materials came to Brandeis and were organized into an archival collection reveals connections and lacunae inherent in the material record and illuminates the ...
Snyder Claire F - - 2013
Patient-centered outcomes research (PCOR) aims to improve care quality and patient outcomes by providing information that patients, clinicians, and family members need regarding treatment alternatives, and emphasizing patient input to inform the research process. PCOR capitalizes on available data sources and generates new evidence to provide timely and relevant information ...
Jiang Xiaoqian X Division of Biomedical Informatics, University of California, San Diego, La Jolla, CA 92093, USA. - - 2013
Effective data sharing is critical for comparative effectiveness research (CER), but there are significant concerns about inappropriate disclosure of patient data. These concerns have spurred the development of new technologies for privacy-preserving data sharing and data mining. Our goal is to review existing and emerging techniques that may be appropriate ...
Skudlarski Pawel P Olin Neuropsychiatry Research Center, Hartford Hospital/Institute of Living, Hartford, Conn., USA. - - 2013
OBJECTIVE Both schizophrenia and bipolar disorder are hypothesized to involve disordered brain connectivity. Prior studies show low white matter integrity, measured with diffusion tensor imaging, for both disorders. The authors studied disease specificity and endophenotypic status of these abnormalities by examining patients and their unaffected relatives. METHOD The 513 participants ...
Hersh William R WR Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA. - - 2013
The growing amount of data in operational electronic health record systems provides unprecedented opportunity for its reuse for many tasks, including comparative effectiveness research. However, there are many caveats to the use of such data. Electronic health record data from clinical settings may be inaccurate, incomplete, transformed in ways that ...
Tischer Alexander A Division of Hematology, Departments of Internal Medicine and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, - - 2013
Platelet attachment to von Willebrand factor (vWF) requires the interaction between the platelet GP1bα and exposed vWF-A1 domains. Structural insights into the mechanism of the A1-GP1bα interaction have been limited to an N-terminally truncated A1 domain that lacks residues Q1238  - E1260 that make up the linker between the D3 and ...
Hernychova Lenka L Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech - - 2013
MDM2 is a multidomain protein that functions as an E3 ubiquitin ligase, transcription repressor, mRNA-binding protein, translation factor, and molecular chaperone. The small molecule Nutlin-3 has been engineered to bind to the N-terminal hydrophobic pocket domain of MDM2. This binding of Nutlin-3 has two consequences: (i) antagonistic effects through competitive ...
Ogunyemi Omolola I OI Center for Biomedical Informatics, Charles Drew University of Medicine and Science, Los Angeles, CA 90262, USA. - - 2013
The need for a common format for electronic exchange of clinical data prompted federal endorsement of applicable standards. However, despite obvious similarities, a consensus standard has not yet been selected in the comparative effectiveness research (CER) community. Using qualitative metrics for data retrieval and information loss across a variety of ...
Franko Debra L DL Harris Center for Education and Advocacy in Eating Disorders and Department of Psychiatry, Massachusetts General Hospital, Boston, USA. - - 2013
OBJECTIVE Although anorexia nervosa has a high mortality rate, our understanding of the timing and predictors of mortality in eating disorders is limited. The authors investigated mortality in a long-term study of patients with eating disorders. METHOD Beginning in 1987, 246 treatment-seeking female patients with anorexia nervosa or bulimia nervosa ...
Hines-Beard Jessica J Department of Ophthalmology and Visual Sciences, Vanderbilt University, 11435 MRBIV, 2213 Garland Ave, Nashville, TN 37232-8808, USA. - - 2013
Erythropoietin (EPO) can protect the retina from acute damage, but long-term systemic treatment induces polycythemia. Intraocular gene delivery of EPO is not protective despite producing high levels of EPO likely due to its bellshaped dose curve. The goal of this study was to identify a therapeutic dose of continuously produced ...
Mehrotra Ateev A RAND Corporation, Pittsburgh, PA 15213-2665, USA. - - 2013
The Centers for Medicare and Medicaid Services and many private health plans are encouraging patients to seek orthopedic care at hospitals designated as centers of excellence. No evaluations have been conducted to compare patient outcomes and costs at centers of excellence versus other hospitals. The objective of our study was ...
de Kuijper Gerda G Vanboeijen, Intellectual Disability Center, Assen, The Netherlands. - - 2013
Antipsychotics are frequently prescribed agents in individuals with intellectual disability, often for behavioral symptoms. Efficacy of antipsychotics for this is ambiguous, so discontinuation should be considered. Weight gain and metabolic dysregulation are well-known adverse effects of antipsychotics which increase the risk of the metabolic syndrome. We performed a discontinuation study ...
Huang Wenzhe W Department of Pharmacology, SUNY Upstate Cancer Research Institute, State University of New York Upstate Medical University, Syracuse, NY 13210, - - 2013
A unique core-inversible micelle (CIM) was formed via PEG(5k)CA8 for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line.
Tsui Judith I JI Department of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education (CARE) Unit, Boston University School of Medicine/Boston Medical Center, Boston, MA, - - 2013
To evaluate whether pain was associated with increased risk of using heroin, stimulants or cannabis among HIV-infected drinkers in Russia. Secondary analysis of longitudinal data from the HERMITAGE study (HIV's Evolution in Russia-Mitigating Infection Transmission and Alcoholism in a Growing Epidemic), a behavioral randomized controlled trial, with data collected at ...
Day Nancy F NF Department of Neuroscience, the University of Minnesota, Twin Cities, Minnesota, 55455; Graduate Program in Neuroscience, the University of Minnesota, Twin Cities, Minnesota, 55455; Center for Neurobehavioral Development, the University of Minnesota, Twin Cities, Minnesota, - - 2013
The function and modulation of neural circuits underlying motor skill may involve rhythmic oscillations (Feller, 1999; Marder and Goaillard, 2006; Churchland et al., 2012). In the proposed pattern generator for birdsong, the cortical nucleus HVC, the frequency and power of oscillatory bursting during singing increases with development (Crandall et al., ...
Ebert Daniel H DH Department of Neurobiology, Harvard Medical School, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, - - 2013
Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at high levels similar to that of histones, and binds to ...
Chen Junqiang - - 2013
To retrospectively compare the efficacy of radiation therapy (RT) and chemotherapy plus RT (CRT) for the postoperative treatment of node-positive thoracic esophageal squamous cell carcinoma (TESCC) and to determine the incidence and severity of toxic reactions. We retrospectively reviewed data from 304 patients who had undergone esophagectomy with 3-field lymph ...
Pinkham Mark B - - 2013
To describe the anatomic distribution of regionally recurrent disease in patients with stage III melanoma in the axilla after curative-intent surgery with and without adjuvant radiation therapy. A single-institution, retrospective analysis of a prospective database of 277 patients undergoing curative-intent treatment for stage III melanoma in the axilla between 1992 ...
Ong Chin Loon - - 2013
We investigated the dosimetric impact of the interplay effect during RapidArc stereotactic body radiation therapy for lung tumors using flattening filter-free (FFF) beams with different dose rates. Seven tumors with motion ≤20 mm, treated with 10-MV FFF RapidArc, were analyzed. A programmable phantom with sinusoidal longitudinal motion (30-mm diameter "tumor" ...
Herman Joseph M JM Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA. - - 2013
Long-term survival rates for patients with resected pancreatic ductal adenocarcinoma (PDAC) have stagnated at 20% for more than a decade, demonstrating the need to develop novel adjuvant therapies. Gemcitabine-erlotinib therapy has demonstrated a survival benefit for patients with metastatic PDAC. Here we report the first phase 2 study of erlotinib ...
Walker Gary V GV Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we identified 73,077 patients aged ≥66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - ...
Yao Xiaosai X David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, - - 2013
Many targets have been identified in solid tumors for antibody therapy but it is less clear what surface antigens may be most commonly expressed on disseminated tumor cells. Using malignant pleural effusions as a source of disseminated tumor cells, we compared a panel of 35 antigens for their cancer specificity, ...
Odd David Edward DE Neonatal Unit, Southmead Hospital, Bristol, UK; Clinical Science at North Bristol, University of Bristol, Bristol, UK. - - 2013
To investigate whether children born between 32 and 36 weeks of gestation have an increased risk of motor coordination difficulties or cerebral palsy (CP) at age 7 years. A cohort study based on the Avon Longitudinal Study of Parents and Children (ALSPAC). The primary outcomes were poor motor coordination, defined ...
Bradford Carol R CR Department of Otolaryngology-Head and Neck Surgery, Medical School, Ohio State University, Columbus, - - 2014
To determine if tumor biomarkers were predictive of outcome in a prospective cohort of patients with advanced larynx cancer treated in a phase II clinical trial. Prospectively collected biopsy specimens from 58 patients entered into a Phase II trial of organ preservation in advanced laryngeal cancer were evaluated for expression ...
Lu Jianqin J Center for Pharmacogenetics, University of Pittsburgh , Pittsburgh, Pennsylvania 15261, United - - 2013
Various PEG-Vitamin E conjugates including d-α-tocopheryl poly(ethylene glycol) succinate 1000 (TPGS) have been extensively studied as a nonionic surfactant in various drug delivery systems. However, limited information is available about the structure-activity relationship of PEG-Vitamin E conjugates as a micellar formulation for paclitaxel (PTX). In this study, four PEG-Vitamin E ...
Li Deyu D Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alkyl adducts, such as 1-methyladenine, 3-methylcytosine, 3-ethylcytosine, 1-methylguanine, 3-methylthymine, and N(6)-methyladenine, ...
Hatters Friedman Susan S Departments of Psychiatry and Pediatrics, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH, USA. - - 2013
To describe characteristics of mothers who would likely benefit from on-site short-term psychiatric services while their infant is in the neonatal intensive care unit (NICU). For 150 consecutive mothers who were referred for psychiatric evaluation and psychotherapeutic intervention in an innovative NICU mental health programme, baseline information was collected. Data ...
Piñar Guadalupe G Department of Biotechnology, VIBT-Vienna Institute of BioTechnology, University of Natural Resources and Life Sciences, Vienna, - - 2013
The Capuchin Catacombs of Palermo contain over 1800 preserved bodies dating from the 16th to 20th centuries AD and showing evidence of biodeterioration. An extensive microbiological and molecular investigation was recently performed. Samples were taken from skin, muscle, hair, bone, stuffing materials, clothes, and surrounding walls as well as from ...
Ju Yawen Y Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New - - 2013
The troponin complex, which consists of three regulatory proteins (troponin C, troponin I, and troponin T), is known to regulate muscle contraction in skeletal and cardiac muscle, but its role in smooth muscle remains controversial. Troponin T3 (TnnT3) is a fast skeletal muscle troponin believed to be expressed only in ...
Corkey Britton K - - 2013
We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.
Harslund Jakob J Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, - - 2013
Staphylococcus aureus is a common cause of skin and soft tissue infections in animal and humans. In the current study, we hypothesized that early host responses to S. aureus infection leading to the recruitment of neutrophils and control of the bacterium at the site of infection depend on the expression of ...
Tremp Annie Z AZ Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, - - 2013
A shared feature of the motile stages (zoites) of malaria parasites is a cortical cytoskeletal structure termed subpellicular network (SPN), thought to define and maintain cell shape. Plasmodium alveolins comprise structural components of the SPN, and alveolin gene knockout causes morphological abnormalities that coincide with markedly reduced tensile strength of ...
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