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Bardou-Jacquet Edouard E CHU Rennes, Liver Disease Unit, Rennes, France; INSERM UMR991, University of Rennes 1, Rennes, France; CHU Rennes, National Reference Center for Rare Iron Overload Diseases of Genetic Origin, Rennes, - - 2014
Defects in human hemochromatosis protein (HFE) cause iron overload due to reduced hepatic hepcidin secretion. Liver transplantation (LT) is a key treatment for potential complications from HFE-related hereditary hemochromatosis (HH). This study evaluated hepcidin secretion and iron burden after LT to elucidate HH pathophysiology. Patients (n=18) homozygous for the p.Cys282Tyr ...
Zaghiyan Karen K Divisions of *Colorectal Surgery and †Gastroenterology; and ‡Department of Biostatistics and Bioinformatics, Cedars Sinai Medical Center, Los Angeles, - - 2014
To evaluate the safety of perioperative low-dose steroids (LDS) versus high-dose steroids (HDS) in steroid-treated patients with inflammatory bowel disease (IBD) undergoing major colorectal surgery. Corticosteroid-treated patients undergoing major colorectal surgery are commonly prescribed HDS to prevent perioperative adrenal insufficiency and cardiovascular collapse. There is little evidence to support this ...
Haid Sibylle - - 2014
Hepatitis C Virus (HCV) entry involves at least four cellular factors, including CD81, the scavenger receptor class B type I (SCARB-1), occludin (OCLN), and claudin-1 (CLDN1). In addition, CLDN6 and CLDN9 have been shown to substitute for CLDN1 as HCV entry factors in human nonliver cells. We examined the role ...
Rowe Ian A IA Hepatitis C Virus Research Group, Institute for Biomedical Research, University of Birmingham, Birmingham, UK; Centre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute for Biomedical Research, University of Birmingham, Birmingham, - - 2014
Hepatitis C virus (HCV) is a major cause of global morbidity, causing chronic liver injury that can progress to cirrhosis and hepatocellular carcinoma. The liver is a large and complex organ containing multiple cell types, including hepatocytes, sinusoidal endothelial cells (LSEC), Kupffer cells, and biliary epithelial cells. Hepatocytes are the ...
Taraban Roman - - 2013
To be competitive, contemporary engineers must be capable of both processing and communicating information effectively. Available research suggests that Indian students would be disadvantaged in information literacy in their language of instruction (English) compared to U.S. students because English is not Indian students' native language. Compared to U.S. students, Indian ...
Ellegaard Ole - - 2013
Valid and reliable information on the use and effects of chemicals is a key factor in the industry and not least within many regulatory agencies. Identification data from lists of substances sometimes leads to incomplete bibliographic analysis in the major chemical databases. The present study takes as its starting point ...
Moritou Yuki - - 2013
The impact of single-nucleotide polymorphisms (SNP) of patatin-like phospholipase domain-containing protein 3 (PNPLA3) on development of hepatocellular carcinoma (HCC) is not clarified for Japanese patients with chronic hepatitis C. The present study investigated the associations of rs738409 PNPLA3 with HCC development after the antiviral therapy with peg-interferon and ribavirin for ...
Adugna Asfaw - - 2013
Seed dispersal is one of the vehicles of gene flow in plants. If a seed carrying transgene(s) is dispersed into the environment, the fate can be determined by its persistence in the soil bank, which can also vary in different ecotypes of a species and the physical environment of the ...
Masiulionis Virginia E - - 2013
It is generally accepted that material collected by leaf-cutting ants of the genus Acromyrmex consists solely of plant matter, which is used in the nest as substrate for a symbiotic fungus providing nutrition to the ants. There is only one previous report of any leaf-cutting ant foraging directly on fungal ...
Ateshian Gerard A - - 2013
Computational tools are often needed to model the complex behavior of biological tissues and cells when they are represented as mixtures of multiple neutral or charged constituents. This study presents the formulation of a finite element modeling framework for describing multiphasic materials in the open-source finite element software febio.1 Multiphasic ...
Bertaccini Edward J EJ * Professor, Department of Anesthesia, Stanford University School of Medicine, Stanford, California, and Anesthesiologist and Intensivist, Palo Alto VA Health Care System, Palo Alto, California. † Doctoral Candidate, ‡ Professor of Computational Structural Biology, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden; Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. § Professor of Chemistry in Anesthesia, Department of Anesthesia, Stanford University School of - - 2013
Anesthetics mediate portions of their activity via modulation of the γ-aminobutyric acid receptor (GABAaR). Although its molecular structure remains unknown, significant progress has been made toward understanding its interactions with anesthetics via molecular modeling. The structure of the torpedo acetylcholine receptor (nAChRα), the structures of the α4 and β2 subunits ...
Hill S Kristian - - 2013
Familial neuropsychological deficits are well established in schizophrenia but remain less well characterized in other psychotic disorders. This study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares cognitive impairment in schizophrenia and bipolar disorder with psychosis, 2) tests a continuum model of cognitive dysfunction in psychotic disorders, ...
Koh Christopher C Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, - - 2013
The American Association for the Study of Liver Diseases (AASLD) practice guidelines provide recommendations in diagnosing and managing patients with liver disease from available scientific evidence in combination with expert consensus opinions. The aim was to systematically review the evolution of recommendations from AASLD guidelines and identify gaps limiting the ...
Liang Wen-Yih WY *Department of Pathology and Laboratory Medicine, Veterans General Hospital-Taipei, Taipei †Department of Pathology, National Yang-Ming University School of Medicine, Taiwan, Republic of China ‡Department of Pathology, Gastrointestinal Pathology Service §Department of Surgery, Division of Gastrointestinal Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, - - 2013
Peritoneal involvement is an important adverse prognostic factor in colorectal cancer (CRC) and determines a shift in the pathologic tumor node metastasis stage. Because peritoneal involvement is difficult to identify, use of special stains highlighting the peritoneal elastic lamina and mesothelial surface has been proposed. This study aims to determine ...
D'Angelo F F Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, Lausanne, - - 2013
Macrophages play a critical role in intestinal wound repair. However, the mechanisms of macrophage-assisted wound repair remain poorly understood. We aimed to characterize more clearly the repair activities of murine and human macrophages. Murine macrophages were differentiated from bone marrow cells and human macrophages from monocytes isolated from peripheral blood ...
Sumida K K Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, - - 2013
There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they ...
Hansen Erik E Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA, 19107, - - 2013
Acute postoperative infection after total hip arthroplasty (THA) is typically treated with irrigation and débridement and exchange of the modular femoral head and acetabular liner. Given a rate of failure exceeding 50% in some series, a one-stage exchange has been suggested as a potential alternative because it allows more thorough ...
Omenda Maxwel M MM *Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA; †Program in Pathobiology, University of Washington, Seattle WA; ‡Department of Medicine, University of Washington, Seattle WA; §Department of Pediatrics, University of Nairobi, Nairobi, Kenya; ‖Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA; Departments of ¶Biostatistics; #Global Health, University of Washington, Seattle, WA; and **Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, - - 2013
: Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in ...
Ching ShiNung S * Research Fellow, Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts; Research Fellow, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts; Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts. † Research Assistant, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital. ‡ Instructor, Department of Neurology, Harvard Medical School; Assistant in Neurology, Department of Neurology, Massachusetts General Hospital. § Assistant Professor, Department of Anaesthesia, Harvard Medical School; Assistant Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital; Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. ‖ Instructor, Department of Anaesthesia, Harvard Medical School; Instructor, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital; Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. # Warren M. Zapol Professor of Anaesthesia, Department of Anaesthesia, Harvard Medical School; Anesthetist, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital; Professor of Computational Neuroscience, Edward Hood Taplin Professor of Medical Engineering, Institute for Medical Engineering and Sciences, Department of Brain and Cognitive Sciences, Harvard-MIT Health Sciences and Technology Program, Massachusetts Institute of - - 2013
A medically induced coma is an anesthetic state of profound brain inactivation created to treat status epilepticus and to provide cerebral protection after traumatic brain injuries. The authors hypothesized that a closed-loop anesthetic delivery system could automatically and precisely control the electroencephalogram state of burst suppression and efficiently maintain a ...
Miettinen Markku M *Laboratory of Pathology, National Cancer Institute, Bethesda ‡Joint Pathology Center, Silver Spring, MD †HUSLab, Helsinki, - - 2013
ERG transcription factor is constitutively expressed in endothelial cells. Because benign and malignant vascular endothelia retain the ERG expression, ERG is considered a useful marker for angiosarcomas and related tumors. ERG is also expressed in a subset of prostate carcinomas and Ewing sarcomas due to ERG-involved translocations; therefore, this marker ...
Lai Chao-Lun CL Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, - - 2013
Since a report of lenticular opacities in dogs treated with high dosages of statins, the debate on the relationship between statin therapy and cataracts has not reached a conclusion. The aim of this study was to evaluate the association between statin therapy and the risk of cataract surgery in an ...
van Eldijk Mark B MB Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The - - 2013
CS2 hydrolase, a zinc-dependent enzyme that converts carbon disulfide to carbon dioxide and hydrogen sulfide, exists as a mixture of octameric ring and hexadecameric catenane forms in solution. A combination of size exclusion chromatography, multi-angle laser light scattering, and mass spectrometric analyses revealed that the unusual catenane structure is not ...
Halasi Marianna M Department of Medicine, University of Illinois at Chicago, 60612, - - 2013
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified inhibition of proteasome inhibitors as a novel activity of NAC. Both NAC and catalase, another known scavenger of ROS, similarly inhibited ROS levels and apoptosis associated ...
Pavlova E V EV Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. - - 2013
Multiple myeloma and B cell lymphoma are leading causes of death in Gaucher's disease but the nature of the stimulus driving the often noted clonal expansion of immunoglobulin-secreting B cells and cognate lymphoid malignancy is unknown. We investigated the long-term development of B cell malignancies in an authentic model of ...
Cai Kai K Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, 92093-0704, - - 2013
DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). We have found that chenodeoxycholic acid and the synthetic FXR (farnesoid X receptor) ligand GW4064 induce the mRNA and protein expression of DGKθ in the HepG2 cell line and ...
Putkonen Anu - - 2013
This randomized controlled trial studied whether seclusion and restraint could be prevented in the psychiatric care of persons with schizophrenia without an increase of violence. Over the course of a year, 13 wards of a secured national psychiatric hospital in Finland received information about seclusion and restraint prevention. Four high-security ...
Benzonana Laura L LL Section of Anesthetics, Pain Medicine, and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United - - 2013
Growing evidence indicates that perioperative factors, including choice of anesthetic, affect cancer recurrence after surgery although little is known about the effect of anesthetics on cancer cells themselves. Certain anesthetics are known to affect hypoxia cell signaling mechanisms in healthy cells by up-regulating hypoxia-inducible factors (HIFs). HIFs are also heavily ...
Nataraj Raviraj R Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, - - 2013
This study presents a methodology to determine thumb and index finger kinematics while utilizing a minimal set of markers. The motion capture of skin-surface markers presents inherent challenges for the accurate and comprehensive measurement of digit kinematics. As such, it is desirable to utilize robust methods for assessing digit kinematics ...
Liang Qiuli Q Center for Free Radical Biology, University of Alabama at Birmingham, 35294, - - 2013
Sirt3 (sirtuin 3) is an NAD-dependent deacetylase localized to mitochondria. Sirt3 expression is increased in mouse muscle and liver by starvation, which could protect against the starvation-dependent increase in oxidative stress and protein damage. Damaged proteins and organelles depend on autophagy for removal and this is critical for cell survival, ...
Lam-Rachlin Jennifer J Perinatology Research Branch, Wayne State University/Hutzel Women ’ s Hospital, MI 48201, USA. - - 2013
The objective of this study was to determine whether maternal plasma concentrations of soluble α-klotho are different between women with microbial invasion of the intra-amniotic cavity (MIAC) and those without MIAC among preterm labor and intact membranes (PTL) or preterm prelabor rupture of membranes (pPROM). A cross-sectional study was conducted ...
Waters Ryan J RJ 1 Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust , Southampton, United Kingdom - - 2013
Clinical outcome after traumatic brain injury (TBI) is variable and cannot easily be predicted. There is increasing evidence to suggest that there may be genetic influences on outcome. Cytokines play an important role in mediating the inflammatory response provoked within the central nervous system after TBI. This study was designed ...
Vajda Sandor S Department of Biomedical Engineering, Boston University, Boston, Massachusetts, - - 2013
Most structure prediction algorithms consist of initial sampling of the conformational space, followed by rescoring and possibly refinement of a number of selected structures. Here we focus on protein docking, and show that while decoupling sampling and scoring facilitates method development, integration of the two steps can lead to substantial ...
Colombo Emanuela E Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, Milan, - - 2013
The neurotrophin system has a role in skeletal muscle biology. Conditional depletion of BDNF in mouse muscle precursor cells alters myogenesis and regeneration in vivo. However, the expression, localization and function of BDNF in human skeletal muscle tissue is not known, so the relevance of the rodent findings for human ...
Cotman Susan L - - 2013
Neuronal ceroid lipofuscinosis (NCL), first clinically described in 1826 and pathologically defined in the 1960s, refers to a group of disorders mostly diagnosed in the childhood years that involve the accumulation of lysosomal storage material with characteristic ultrastructure and prominent neurodegenerative features including vision loss, seizures, motor and cognitive function ...
Shoemaker Sarah M - - 2013
The Lewis S. Feuer papers at Brandeis University include correspondence, manuscripts, Feuer's collection of radical literature, and other personal and professional materials. The process by which these materials came to Brandeis and were organized into an archival collection reveals connections and lacunae inherent in the material record and illuminates the ...
Hernychova Lenka L Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech - - 2013
MDM2 is a multidomain protein that functions as an E3 ubiquitin ligase, transcription repressor, mRNA-binding protein, translation factor, and molecular chaperone. The small molecule Nutlin-3 has been engineered to bind to the N-terminal hydrophobic pocket domain of MDM2. This binding of Nutlin-3 has two consequences: (i) antagonistic effects through competitive ...
Ogunyemi Omolola I OI Center for Biomedical Informatics, Charles Drew University of Medicine and Science, Los Angeles, CA 90262, USA. - - 2013
The need for a common format for electronic exchange of clinical data prompted federal endorsement of applicable standards. However, despite obvious similarities, a consensus standard has not yet been selected in the comparative effectiveness research (CER) community. Using qualitative metrics for data retrieval and information loss across a variety of ...
Hines-Beard Jessica J Department of Ophthalmology and Visual Sciences, Vanderbilt University, 11435 MRBIV, 2213 Garland Ave, Nashville, TN 37232-8808, USA. - - 2013
Erythropoietin (EPO) can protect the retina from acute damage, but long-term systemic treatment induces polycythemia. Intraocular gene delivery of EPO is not protective despite producing high levels of EPO likely due to its bellshaped dose curve. The goal of this study was to identify a therapeutic dose of continuously produced ...
de Kuijper Gerda G Vanboeijen, Intellectual Disability Center, Assen, The Netherlands. - - 2013
Antipsychotics are frequently prescribed agents in individuals with intellectual disability, often for behavioral symptoms. Efficacy of antipsychotics for this is ambiguous, so discontinuation should be considered. Weight gain and metabolic dysregulation are well-known adverse effects of antipsychotics which increase the risk of the metabolic syndrome. We performed a discontinuation study ...
Mehrotra Ateev A RAND Corporation, Pittsburgh, PA 15213-2665, USA. - - 2013
The Centers for Medicare and Medicaid Services and many private health plans are encouraging patients to seek orthopedic care at hospitals designated as centers of excellence. No evaluations have been conducted to compare patient outcomes and costs at centers of excellence versus other hospitals. The objective of our study was ...
Kulminski Alexander M AM Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA. - - 2013
Discovering the genetic origin of aging-related traits could greatly advance strategies aiming to extend health span. The results of genome-wide association studies (GWAS) addressing this problem are controversial, and new genetic concepts have been fostered to advance the progress in the field. A limitation of GWAS and new genetic concepts ...
Tischer Alexander A Division of Hematology, Departments of Internal Medicine and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, - - 2013
Platelet attachment to von Willebrand factor (vWF) requires the interaction between the platelet GP1bα and exposed vWF-A1 domains. Structural insights into the mechanism of the A1-GP1bα interaction have been limited to an N-terminally truncated A1 domain that lacks residues Q1238  - E1260 that make up the linker between the D3 and ...
Stornaiuolo Anna A MolMed S.p.A., Milano 20132, - - 2013
Over the last two decades, several attempts to generate packaging cells for lentiviral vectors (LV) have been made. Despite different technologies, no packaging clone is currently employed in clinical trials. We developed a new strategy for LV stable production based on the HEK-293T progenitor cells; the sequential insertion of the ...
Aguiar Sebastian S Department of Neuroscience, Pitzer College, Claremont, California 91711, USA. - - 2013
This review synthesizes behavioral research with neuromolecular mechanisms putatively involved with the low-toxicity cognitive enhancing action of Bacopa monnieri (BM), a medicinal Ayurvedic herb. BM is traditionally used for various ailments, but is best known as a neural tonic and memory enhancer. Numerous animal and in vitro studies have been ...
Jiang Xiaoqian X Division of Biomedical Informatics, University of California, San Diego, La Jolla, CA 92093, USA. - - 2013
Effective data sharing is critical for comparative effectiveness research (CER), but there are significant concerns about inappropriate disclosure of patient data. These concerns have spurred the development of new technologies for privacy-preserving data sharing and data mining. Our goal is to review existing and emerging techniques that may be appropriate ...
Snyder Claire F CF Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205-1901, USA. - - 2013
Patient-centered outcomes research (PCOR) aims to improve care quality and patient outcomes by providing information that patients, clinicians, and family members need regarding treatment alternatives, and emphasizing patient input to inform the research process. PCOR capitalizes on available data sources and generates new evidence to provide timely and relevant information ...
Raebel Marsha A MA Kaiser Permanente Colorado Institute for Health Research, Denver, CO 80231, USA. - - 2013
To propose a unifying set of definitions for prescription adherence research utilizing electronic health record prescribing databases, prescription dispensing databases, and pharmacy claims databases and to provide a conceptual framework to operationalize these definitions consistently across studies. We reviewed recent literature to identify definitions in electronic database studies of prescription-filling ...
Hersh William R WR Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA. - - 2013
The growing amount of data in operational electronic health record systems provides unprecedented opportunity for its reuse for many tasks, including comparative effectiveness research. However, there are many caveats to the use of such data. Electronic health record data from clinical settings may be inaccurate, incomplete, transformed in ways that ...
Van Voorhees Elizabeth E EE Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC), Durham, NC 277059, USA. - - 2013
Posttraumatic stress disorder (PTSD) is associated with increased smoking initiation, maintenance, and relapse. Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are neurosteroids that have been associated with mood measures as well as smoking status, and nicotine is associated with increased DHEA and DHEAS levels. Given the difficulties with mood experienced by ...
Muia J J Departments of Medicine, Washington University School of Medicine, St Louis, MO 63110, - - 2013
Most ADAMTS13 assays use non-physiological conditions (low ionic strength, low pH, barium chloride), are subject to interference from plasma proteins, hemoglobin and bilirubin, and have limited sensitivity, especially for inhibitors. We addressed these constraints by designing a substrate that can be used in undiluted plasma. A polypeptide was expressed in ...
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