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Results 201 - 250 of 6787
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Cheng I-Fang - - 2013
Fluorescent labelling and chromogenic reactions that are commonly used in conventional immunoassays typically utilize diffusion dominated transport of analytes, which is limited by slow reaction rates and long detection times. By integrating alternating current (AC) electrokinetics and electrochemical impedance spectroscopy (EIS), we construct an immunochip for rapid, sensitive, and label-free ...
Coutier Laurianne - - 2013
BACKGROUND: The measurement of specific airway resistance during tidal breathing (sRawtb ) has gained popularity in children, but methodological concerns have been raised regarding the electronic compensation for the thermal artifact. The panting method (sRawp ) is efficient in minimizing the latter, but may be associated with a change in ...
Vaezeafshar Reza - - 2013
OBJECTIVES/HYPOTHESIS: To evaluate the safety and efficacy of endoscopic calcium hydroxyapatite injection in patients with patulous Eustachian tube. STUDY DESIGN: Retrospective case series. METHODS: Fourteen patients diagnosed with patulous Eustachian tube (PET) underwent endoscopic hydroxyapatite injection under general anesthesia. All patients had at least two of three major PET symptoms ...
Hoekman Peter K - - 2013
OBJECTIVES/HYPOTHESIS: To report the utilization and cost effectiveness of magnetic resonance imaging (MRI) in the evaluation of patients with idiopathic olfactory loss. STUDY DESIGN: Case series with chart review. METHODS: A retrospective review of patients presenting with olfactory disorders at a university-based taste and smell center from July 1998 through ...
Te Beek Erik T - - 2013
Recent interest in NK1 receptor antagonists has focused on a potential role in the treatment of drug addiction and substance abuse. In the present study, the potential for interactions between the NK1 receptor antagonist aprepitant and alcohol, given as an infusion at a target level of 0.65 g/L, was evaluated. Amitriptyline ...
Catsburg Chelsea E - - 2013
N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e. nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite and amines. Heme has been shown to ...
Ardeshir Amir - - 2013
Idiopathic chronic diarrhea (ICD) is a common cause of morbidity and mortality among juvenile rhesus macaques. While lesions may be absent at colonoscopy, the histopathologic evaluation of the biopsy specimens is consistent with human macroscopic colitis (MC). In this study, we developed an isotropic uniform random sampling method to evaluate ...
Kaye Erica - - 2013
BACKGROUND: Parents' perceptions of the quality of information communicated by their child's oncologist about the child's cancer are not well understood. PROCEDURE: We conducted a cross-sectional survey of 194 parents of children with cancer (response rate 70%), treated at the Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Mass, and ...
Sivrikaya Fatih - - 2013
Forest ecosystems have an important role in carbon cycle at both regional and global scales as an important carbon sink. Forest degradation and land cover changes, caused by deforestation and conversion to non-forest area, have a strong impact on carbon storage. The carbon storage of forest biomass and its changes ...
Laccourreye Ollivier - - 2013
OBJECTIVES/HYPOTHESIS: To analyze local failure following lateral pharyngotomy for selected untreated invasive squamous cell carcinoma (SCC) of the lateral oropharynx. STUDY DESIGN: Retrospective review from a university teaching hospital. METHODS: Inception cohort of 91 patients who underwent lateral pharyngotomy for an isolated and previously untreated selected invasive carcinoma of the ...
Nau Sebastian - - 2013
Highly efficient and stable blue light emission is observed in novel copolymers that are produced from specially designed building blocks. A PEDOT:PSS-induced chemical degradation of the polymer light-emitting diodes (PLEDs) is identified at the interface, and it is found to be accompanied by a shift in the emission color. A ...
Milla Luis A - - 2013
The canonical Sonic Hedgehog (Shh)/Gli pathway plays multiples roles during Central Nervous System (CNS) development. In order to elucidate the molecular repertoire of Shh mediators, we have recently described novel transcriptional targets in response to Shh pathway modulation. Among them, we were able to identify Neogenin1 (Neo1), a death dependence ...
Wason James M S - - 2013
In phase II cancer trials, tumour response is either the primary or an important secondary endpoint. Tumour response is a binary composite endpoint determined, according to the Response Evaluation Criteria in Solid Tumors, by (1) whether the percentage change in tumour size is greater than a prescribed threshold and (2) ...
Shek Yuen Lai - - 2013
Guanine-rich DNA sequences that may form G-quadruplexes are located in strategic DNA loci with the ability to regulate biological events. G-quadruplexes have been under intensive scrutiny owing to their potential to serve as novel drug targets in emerging anticancer strategies. Thermodynamic characterization G-quadruplexes is an important and necessary step in ...
Li Chang-Zhi - - 2013
Simple and solution-processible tetrabutyl-ammonium salts (TBAX) can dope fullerene and its derivatives to achieve conductive thin films (σ as high as 0.56 S/m). The electron transfer between the anions of TBAXs and n-type semiconductors induces doping without encountering any harsh activation. These provide valid support for the surfactant interfacial doping ...
Massimo Tanja - - 2013
PURPOSE: Allergic bronchial asthma is one of the most common chronic diseases worldwide. For many years, the climate at moderate altitude has been used as an alternative therapy for patients suffering from bronchial asthma. The aim of such therapy is to reduce the medication dose and to improve the quality ...
Yoshizawa Shuichiro - - 2013
BACKGROUND: To investigate the association between each clinical diagnosis criterion for sleep bruxism (SB) and the frequency of jaw motor events during sleep. METHODS: Video-polysomnography was performed on 17 healthy adult subjects (mean age, 26.7 ± 2.8 years), with at least one of the following clinical signs and symptoms of SB: (1) a ...
Daniel Carolin - - 2013
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions in immune- but also non-immune cells. However, dysregulation of NFAT thereby favours malignant growth ...
Mori Noriko - - 2013
High choline kinase-α (Chk-α) expression is frequently observed in cancer cells, making it a novel target for pharmacological and molecular inhibition. As inhibiting agents are delivered systemically, it is important to determine Chk-α expression levels in endothelial cells that line both normal and tumor vasculature, and the effect of Chk-α ...
Chapuy Claudia I - - 2013
OBJECTIVE: To assess clinical success and safety of endoscopic pharyngoesophageal dilation after chemoradiation or radiation for head and neck cancer and to identify variables associated with dilation failure. STUDY DESIGN: Case series with chart review. METHODS: Between 2000 and 2008, a total of 111 patients treated with chemoradiation or radiation ...
Okamoto Ryoko - - 2013
We have synthesized thirty-nine 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ] analogs having 2 side-chains attached to carbon-20 (Gemini) with various modifications and compared their anticancer activities. Five structure-function rules emerged to identify analogs with enhanced anti-cancer activity. One of these active analogs, BXL-01-0126 was more potent than 1,25(OH)2 D3 in mediating ...
Tu Tsang-Wei - - 2013
The dysmyelinated axons of shiverer mice exhibit impaired conduction characteristics, similar to early postnatal axons before myelination, whereas the patterns of neuronal activity and connectivity are relatively comparable with those of wild-type myelinated axons. This unique dysmyelination pattern is exploited in the present study to determine the role of compact ...
Heim Bradley T - - 2013
This paper estimates whether state-level implementation of community rating and guaranteed issue regulations in the non-group health insurance market during the 1990s affected the decision of taxpayers to be self-employed. Using a panel of tax returns that span 1987-2000, we find no statistically significant effect of the reforms on the ...
Mocellin Simone - - 2013
BACKGROUND: Interferon alpha is the only agent approved for the postoperative adjuvant treatment of high-risk cutaneous melanoma. However, the survival advantage associated with this treatment is unclear, especially in terms of overall survival. Thus, adjuvant interferon is not universally considered a gold standard treatment by all oncologists. OBJECTIVES: To assess ...
Pereira Carina - - 2013
Up-regulation of cyclooxygenase-2 (COX-2) is an early and key event in human colorectal carcinogenesis (CRC). Nevertheless, the molecular mechanisms leading to this over-expression are largely unknown. We previously reported an association between the -1195G allele and higher predisposition for CRC in a Caucasian population. The biological explanation for the involvement ...
Chang Yoonjee - - 2013
Staphylococcus aureus is a well-known pathogen that causes several serious diseases in humans and animals. As part of the efforts to control this pathogen, a newly isolated bacteriophage, SA12, which specifically targets S. aureus, was characterized, and its genome was completely sequenced. Host range and bacteriophage challenge tests demonstrated its ...
Brouxhon Sabine M - - 2013
Recent literature suggests that sEcad exerts pro-oncogenic effects, possibly acting as a ligand for the human epidermal growth factor family. Here we show that sEcad is a novel candidate protein for drug targeting since it is increased in human and mouse HER2-positive (HER2+) breast tumors, MMTV-PyMT bodily fluids and human ...
Khalifa Fahmi - - 2013
The objective was to develop a novel and automated comprehensive framework for the non-invasive identification and classification of kidney non-rejection and acute rejection transplants using 2D dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The proposed approach consists of four steps. First, kidney objects are segmented from the surrounding structures with a ...
Raphael Jean L - - 2013
BACKGROUND: Blood transfusions represent a major therapeutic option in acute management of sickle cell disease (SCD). Few data exist documenting trends in transfusion among children with SCD, particularly during hospitalization. PROCEDURE: This was an analysis of cross-sectional data of hospital discharges within the Kid's Inpatient Database (years 1997, 2000, 2003, ...
Yang Baiyu - - 2013
Three polymorphic sites at chromosome 8q24 (rs7837328, rs10808555, rs6983267) have been associated with risk for colorectal adenomas. It was also previously reported that the single nucleotide polymorphism (SNP) rs6983267 may enhance Wnt signaling, which regulates cell proliferation. To investigate associations between the 8q24 variants and colorectal epithelial cell proliferation in ...
Jung Sungmin - - 2013
Spotlight on etching: (11-22) semipolar GaN plane light-emitting diodes (LEDs) are demonstrated using a wet-etching process. A trigonal prism cell structure with a (0001) c plane and nnn{10-10} m planes is formed after KOH wet etching, and leads to a better ohmic contact and enhanced light extraction. LEDs fabricated by ...
Igamberdiev Abir U - - 2013
The expression of genes encoding various enzymes participating in photosynthetic and respiratory metabolism is regulated by light via the phytochrome system. While many photosynthetic, photorespiratory and some respiratory enzymes, such as the rotenone-insensitive NADH and NADPH dehydrogenases and the alternative oxidase, are stimulated by light, succinate dehydrogenase, subunits of the ...
Horstmann M - - 2013
OBJECTIVES: To compare functional pelvic cine-MRI in patients with post-prostatectomy incontinence before and after implantation of a bulbourethral composite suspension. PATIENTS AND METHODS: Functional pelvic 1.5 T cine-MRI was performed at rest, under standardized Valsalva pressure and during micturition in six patients with post-prostatectomy incontinence before and 3 months after a ...
Carr Dj - - 2013
Uterus didelphys is a rare congenital abnormality of the reproductive tract. Although it occurs in various species, there are no published reports describing pregnancy outcome in association with this abnormality. Herein we describe a case of successful unilateral singleton pregnancy in a ewe incidentally found to have uterus didelphys during ...
Luo Mai - - 2013
A rapid, simple, reliable, and environment-friendly method for the residue analysis of the enantiomers of four chiral fungicides including hexaconazole, triadimefon, tebuconazole, and penconazole in water samples was developed by dispersive liquid-liquid microextraction (DLLME) pretreatment followed by chiral high-performance liquid chromatography (HPLC)-DAD detection. The enantiomers were separated on a Chiralpak ...
Song Na-Young - - 2013
Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This ...
Chen C-C Jj - - 2013
BACKGROUND: This study was aimed at investigating the impact of assisted cycling therapy (ACT) on fine manual dexterity in adults with Down's syndrome (DS). METHODS: Nine persons with DS completed four different interventions: voluntary exercise (VE), voluntary with music (VEM), assisted exercise (AE) and no exercise (NE). Fine manual dexterity ...
Stevanovic Mara - - 2013
TonB dependent transporters (TBDT) are an essential protein family in bacteria involved in the uptake of a broad variety of molecules such as siderophore-chelated iron, which was the first described substrate. Meanwhile it is known that TBDTs are involved in the uptake of many metals, sugars and polypeptides. The action ...
Clemens Stephan - - 2013
Nicotianamine (NA) is among the most studied plant metal chelators. A large body of evidence supports its crucial role for Fe distribution in plants and as a precursor of phytosiderophore synthesis in grasses. NA forms stable complexes in vitro not only with Fe(II) and Fe(III) but also with various other ...
Selim Khaled A - - 2013
The main objective of this research work focused on investigating the biological and chemical aspects of endophytic fungus Chaetomium globosum, for pharmaceutical purposes to improve the drug discovery process. The endophytic C. globosum was isolated from healthy leaves of Egyptian medicinal plant Adiantum capillus-veneris collected from Saint Katherine Protectorate, Sinai, ...
Al-Khateeb Alyaa R - - 2013
Familial ligand-defective apolipoprotein B-100 is characterized by elevated plasma low-density lipoprotein levels and premature heart disease. This study aims to determine apolipoprotein B gene mutations among Malaysians with clinical diagnoses of familial hypercholesterolemia and to compare the phenotype of patients with apolipoprotein B gene mutations to those with a low-density ...
Conti Maria Aparecida - - 2013
PURPOSE: To evaluate psychometric assessment of Stunkard Figure Rating Scale (FRS) for Brazilian male population. METHODS: The sample was composed of a control group (94 students) and a clinical group (20 eating disordered patients). Two questionnaires were applied: the FRS and the Eating Attitudes Questionnaire-26. Weight, height, and body mass ...
Connolly Michael - - 2013
INTRODUCTION: Dronedarone, a non-iodinated derivative of amiodarone, has been approved for use as a second-line agent for atrial fibrillation (AF). Following reports of possible liver injury during routine post-license monitoring, the European Medicines Agency (EMA) recommended regular liver function test (LFT) monitoring. Despite this recommendation, an audit of patients in ...
Dandempally A - - 2013
OBJECTIVE: The aim of this study was to formulate a regression equation for calculating working lengths in primary molars using EAL (Root ZX and Ipex) for teeth with and without resorption and to evaluate, in vivo, the accuracy of the electronic apex locators in determining working lengths in primary teeth ...
Kristóf Endre - - 2013
Apoptotic cells express eat-me signals which are recognized by several receptors mainly on professional phagocytes of the mononuclear phagocyte system. This "engulfment synapse" can define a safe and effective clearance of apoptotic cells in order to maintain tissue homeostasis in the entire body. We show that the expression of four ...
Baki Elif Do─čan - - 2013
Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of ...
Hansen Erik - - 2013
BACKGROUND: Acute postoperative infection after total hip arthroplasty (THA) is typically treated with irrigation and débridement and exchange of the modular femoral head and acetabular liner. Given a rate of failure exceeding 50% in some series, a one-stage exchange has been suggested as a potential alternative because it allows more ...
Liu Hongliang - - 2013
Self-cleaning on various surfaces is obtained using the facile approach of modifying the surface with a thin organogel film. The film not only absorbs oil but also holds it in a crosslinked network, which endows the material with an excellent self-cleaning ability. This facile method can be applied to various ...
Holzer Stefan - - 2013
Dementia is a complex progressive syndrome characterised by impairment of cognition (including memory, language, visuospatial skills and executive function), changes in personality and diminished activities of daily living. The impact of dementia is enormous and poses a huge challenge to patients, their carers, society at large and health systems around ...
Dimtsas Georgios S - - 2013
ABSTRACT Angiogenesis leads to new blood vessel formation and is implicated in both physiological and pathological situations. VEGF family is the major mediator of this process. The aim of our study was to evaluate the expression of VEGF-A, VEGFR-1 and VEGFR-2 and their correlation with clinicopathological parameters and prognosis in ...
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