Search Results
Results 151 - 200 of 6785
1 2 3 4 5 6 7 8 9 10 >
Marik Paul E PE Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA. - - 2013
Despite a previous meta-analysis that concluded that central venous pressure should not be used to make clinical decisions regarding fluid management, central venous pressure continues to be recommended for this purpose. To perform an updated meta-analysis incorporating recent studies that investigated indices predictive of fluid responsiveness. A priori subgroup analysis ...
Teperman Lewis L Mary Lea Johnson Richards Organ Transplant Center, New York University School of Medicine, New York, NY 10016, USA. - - 2013
Mycophenolate mofetil (MMF) and sirolimus (SRL) have been used for calcineurin inhibitor (CNI) minimization to reduce nephrotoxicity following liver transplantation. In this prospective, open-label, multicenter study, patients undergoing transplantation from July 2005 to June 2007 who were maintained on MMF/CNI were randomized 4 to 12 weeks after transplantation to receive ...
Warshak Carri R CR Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267-0526, - - 2013
We hypothesise that the rate of stillbirth is increased in mothers younger than 18 years of age compared to adult mothers, and that obesity further increases the risk of stillbirth in this population. We conducted a population-based cohort study comparing rates of stillbirth between adolescent, defined as young women under ...
Kejner Alexandra E AE Department of Otolaryngology, University of Alabama-Birmingham, Birmingham, Alabama, - - 2013
To evaluate bone invasion, survival, and expression of bone morphogenetic protein-6 (BMP-6) in oral cavity cancer in the context of known biomarkers indicative of poor prognosis. Molecular expression study combined with retrospective chart review of corresponding patients at a tertiary care center. Between 2000 and 2009, a total of 197 ...
Larsen Pernille Stemann PS Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen. - - 2013
During the past 25 years, many pregnancy and birth cohorts have been established. Each cohort provides unique opportunities for examining associations of early-life exposures with child development and health. However, to fully exploit the large amount of available resources and to facilitate cross-cohort collaboration, it is necessary to have accessible ...
Hunter Gary R GR Department of Human Studies, University of Alabama at Birmingham, AL 35294-1250, USA. - - 2013
To examine the effects of three different frequencies of combined resistance and aerobic training on total energy expenditure (TEE) and activity-related energy expenditure (AEE) in a group of older adults. Seventy-two women, 60-74 yr old, were randomly assigned to one of three groups: 1 d · wk(-1) of aerobic training ...
Xu Huanbin H Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, - - 2013
Recent advances in the immunology, pathogenesis, and prevention of human immunodeficiency virus (HIV) infection continue to reveal clues to the mechanisms involved in the progressive immunodeficiency attributed to infection, but more importantly have shed light on the correlates of immunity to infection and disease progression. HIV selectively infects, eliminates, and/or ...
Okoye Afam A AA Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. - - 2013
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive depletion of CD4(+) T-cell populations in close association with progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections (OI). Disease progression in untreated human immunodeficiency virus (HIV) infection can take many years, and it was originally hypothesized ...
Paiardini Mirko M Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30329, USA. - - 2013
Systemic chronic immune activation is considered today as the driving force of CD4(+) T-cell depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune activation persists even in HIV-infected patients in which viral replication is successfully inhibited by anti-retroviral therapy, with the extent of this residual immune activation being associated ...
Burdo Tricia H TH Department of Biology, Boston College, Chestnut Hill, MA 02467, - - 2013
Neurological sequelae of human immunodeficiency virus (HIV) infection have been and remain a significant problem. Monocytes and macrophages in humans and monkeys are susceptible to infection by HIV and simian immunodeficiency virus (SIV), and are considered to be a main mechanism by which the central nervous system (CNS) is infected. ...
Chang Christina C CC Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, - - 2013
Despite significant reductions in morbidity and mortality secondary to availability of effective combination anti-retroviral therapy (cART), human immunodeficiency virus (HIV) infection still accounts for 1.5 million deaths annually. The majority of deaths occur in sub-Saharan Africa where rates of opportunistic co-infections are disproportionately high. In this review, we discuss the ...
Demers Korey R KR Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
A detailed understanding of the immune response to human immunodeficiency virus (HIV) infection is needed to inform prevention and therapeutic strategies that aim to contain the acquired immunodeficiency syndrome (AIDS) pandemic. The cellular immune response plays a critical role in controlling viral replication during HIV infection and will likely need ...
Klatt Nichole R NR Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, - - 2013
Despite complete or near-complete suppression of human immunodeficiency virus (HIV) replication with combination antiretroviral therapy, both HIV and chronic inflammation/immune dysfunction persist indefinitely. Untangling the association between the virus and the host immune environment during therapy might lead to novel interventions aimed at either curing the infection or preventing the ...
Nelson Peter T PT Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, - - 2013
The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased parenchymal amyloid plaques. We tested how the APOE genotype correlated with cerebral amyloid angiopathy (CAA) by analyzing 371 brains for parenchymal and meningeal CAA in 4 brain regions (frontal, parietal, temporal, and occipital neocortex). The overall severity ...
Liu Yang Y The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, - - 2013
Motoneuron death after spinal cord injury or disease results in muscle denervation, atrophy, and paralysis. We have previously transplanted embryonic ventral spinal cord cells into the peripheral nerve to reinnervate denervated muscles and to reduce muscle atrophy, but reinnervation was incomplete. Here, our aim was to determine whether brief electrical ...
Tobin Nicole H NH Children's Hospital Los Angeles, Los Angeles, CA, - - 2013
Most infants born to human immunodeficiency virus (HIV)-infected women escape HIV infection. Infants evade infection despite an immature immune system and, in the case of breastfeeding, prolonged repetitive exposure. If infants become infected, the course of their infection and response to treatment differs dramatically depending upon the timing (in utero, ...
Mascola John R JR Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. - - 2013
The development of an effective vaccine has been hindered by the enormous diversity of human immunodeficiency virus-1 (HIV-1) and its ability to escape a myriad of host immune responses. In addition, conserved vulnerable regions on the HIV-1 envelope glycoprotein are often poorly immunogenic and elicit broadly neutralizing antibody responses (BNAbs) ...
Wilson Eleanor M P EM HIV Pathogenesis Unit, Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, - - 2013
Antiretroviral therapy (ART) is a life-saving intervention in human immunodeficiency virus (HIV) infection. Immune restoration after ART dramatically reduces the incidence and severity of opportunistic diseases and death. On some occasions, immune restoration may be erratic, leading to acute inflammatory responses (known as immune reconstitution inflammatory syndrome) shortly after ART ...
Coates Daniel R DR Vision Science Graduate Program, and School of Optometry, University of California-Berkeley, CA 94720, USA. - - 2013
Acuity measurement is a fundamental method to assess visual performance in the clinic. Little is known about how acuity measured in the presence of neighboring letters, as in the case of letter charts, changes with contrast and with nonfoveal viewing. This information is crucial for acuity measurement using low-contrast charts ...
Martin Maureen P MP Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, - - 2013
Host genetic factors are a major contributing factor to the inter-individual variation observed in response to human immunodeficiency virus (HIV) infection and are linked to resistance to HIV infection among exposed individuals, as well as rate of disease progression and the likelihood of viral transmission. Of the genetic variants that ...
Wood Lianna F LF Seattle Biomedical Research Institute, Seattle, WA, - - 2013
The global spread of human immunodeficiency virus (HIV) is dependent on the ability of this virus to efficiently cross from one host to the next by traversing a mucosal membrane. Unraveling how mucosal exposure of HIV results in systemic infection is critical for the development of effective therapeutic strategies. This ...
Wu Junfang J Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research, National Study Center for Trauma and EMS, University of Maryland, School of Medicine, Bressler Research Building, 655 W. Baltimore Street, Room #6-009, Baltimore, MD 21201, USA. - - 2013
Spinal cord injury (SCI) causes not only sensorimotor and cognitive deficits, but frequently also severe chronic pain that is difficult to treat (SCI pain). We previously showed that hyperesthesia, as well as spontaneous pain induced by electrolytic lesions in the rat spinothalamic tract, is associated with increased spontaneous and sensory-evoked ...
Tang Siuwah S Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, - - 2013
MicroRNAs (miRNAs) are 18- to 22-nucleotide-long, single-stranded, noncoding RNAs that regulate important biological processes including differentiation, proliferation, and response to cellular stressors such as hypoxia, nutrient depletion, and traversion of the cell cycle by controlling protein expression within the cell. Many investigators have profiled cancer tissue and serum miRNAs to ...
Kilburn Duncan D T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, - - 2013
Biological macromolecules have evolved to fold and operate in the crowded environment of the cell. We have shown previously that molecular crowding stabilizes folded RNA structures. Here we report SAXS measurements on a 64 kDa bacterial group I ribozyme in the presence of mono- and divalent ions and PEG crowders ...
Castellano Brian M BM Department of Chemistry, San José State University, San José, CA 95192-0101, - - 2013
This study introduces a new thermodynamic framework for aqueous reaction equilibria that treats water as a coreactant in the development of a general binding equation. The approach features an explicit consideration for the change in hydration that occurs when two solvated surfaces come into contact. As an outcome of this ...
Wray Naomi R NR Queensland Brain Institute, The University of Queensland, QBI Building, St Lucia, Queensland 4071, - - 2013
The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how ...
Kedem Alon A IVF Unit and Reproduction Lab, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat-Gan, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. - - 2013
To prospectively study the AMH expression and secretion pattern in mural granulosa cells (GCs) and follicular fluid (FF) from small follicles and medium follicles that were collected from normo-ovulatory (NO) and polycystic ovary syndrome (PCOS) patients undergoing in vitro maturation (IVM) treatments. FF AMH levels and mRNA expression of mural ...
Zhao Kai K Monell Chemical Senses Center, Philadelphia, Pennsylvania, U.S.A; Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, - - 2014
Nasal obstruction is the principal symptom that drives patients with rhinosinus disease to seek medical treatment. However, patient perception of obstruction often bears little relationship to actual measured physical obstruction of airflow. This lack of an objective clinical tool hinders effective diagnosis and treatment. Previous work has suggested that the ...
Weber Irene T IT Departments of Chemistry and Biology, Georgia State University , Atlanta, Georgia, United - - 2013
HIV-1 protease is an important target for the development of antiviral inhibitors to treat AIDS. A room-temperature joint X-ray/neutron structure of the protease in complex with clinical drug amprenavir has been determined at 2.0 Å resolution. The structure provides direct determination of hydrogen atom positions in the enzyme active site. ...
Hao Guiyang G Department of Radiology, The University of Texas Southwestern Medical Center , Dallas, Texas 75390, United - - 2013
2[(3-Amino-3-carboxypropyl)(hydroxy)(phosphinyl)methyl]pentane-1,5-dioic acid) (GPI) is a highly potent inhibitor of prostate specific membrane antigen (PSMA) with a rapid in vivo clearance profile from nontarget organs including kidneys, but its use for imaging of PSMA is impeded by an endogenous anion (serum phosphate) competition, which compromises its specific binding to the antigen. ...
Akabayov Sabine R SR Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, - - 2013
Enzymatic reactions occur in a crowded and confined environment in vivo, containing proteins, RNA and DNA. Previous reports have shown that interactions between macromolecules, and reactions rates differ significantly between crowded environments and dilute buffers. However, the direct effect of crowding on the level of high-resolution structures of macromolecules has ...
Kim Jong-Seo JS Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United - - 2013
A resin-assisted enrichment method has been developed for specific isolation of protein N-terminal peptides to facilitate LC-MS/MS characterization of proteolytic processing, a major form of posttranslational modifications. In this method, protein thiols are blocked by reduction and alkylation, and protein lysine residues are converted to homoarginines. Protein N-termini are selectively ...
Kiss Orsolya O Semmelweis Egyetem, Általános Orvostudományi Kar, II. Patológiai Intézet, Budapest. - - 2013
Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. The aim of the authors was to compare the ...
Tóth Veronika V Semmelweis Egyetem, Általános Orvostudományi Kar, Bőr-, Nemikórtani és Bőronkológiai Klinika, Budapest. - - 2013
Survival of patients with malignant melanoma primarily depends on tumor stage. Hungarian National Cancer Registry does not specify tumors according to TNM stages. The authors aimed to survey the stage distribution of melanomas at the Department of Dermatology, Dermatooncology and Venerology, Semmelweis University. 1160 patients (558 males and 602 females, ...
Bakkné Nagy Mónika M Debreceni Egyetem, Népegészségügyi Kar, Komplex Rehabilitáció Msc, Debrecen. - - 2013
Smoking habits are influenced by environmental (family, friends) and psychologic factors. To investigate environmental factors which influence the smoking habits of monozygotic and dizygotic twins. 45 monozygotic and 23 dizygotic twin pairs (age 35±16 years) completed a questionnaire. Maternal non-smoking decreases the risk of smoking of the twin children by ...
Molics Bálint B Pécsi Tudományegyetem, Egészségtudományi Kar, Fizioterápiás és Táplálkozástudományi Intézet, Pécs, Rét u. 4. 7623 Pécsi. - - 2013
Limited information is available on physiotherapy treatment of lower extremity injuries. The purpose of this study included analysis of the utilization of outpatient physiotherapy services in case of injuries of the lower extremity. Data derived from the database of the National Health Insurance Fund Administration, Hungary. The number of cases ...
Sharpe Benjamin - - 2013
The cancer stem cell hypothesis postulates that a single stem-like cancer cell is able to produce all cancer cell types found in a tumor. These cells are also thought to be the causative agents of relapse following therapy. In order to confirm the importance of cancer stem cells in tumor ...
Turksen Kursad - - 2013
There is worldwide demand for therapies to promote the robust repair and regeneration with maximum regain of function of particular tissues and organs damaged by disease or injury. The potential role of adult stem cells has been highlighted by an increasing number of in vitro and in vivo studies. Nowhere ...
Miyayama Shiro - - 2013
PURPOSE: This study was designed to compare technical success and local recurrence rates of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) with/without monitoring of embolized areas using cone-beam computed tomography (CBCT). METHODS: A total of 207 HCCs ≤6 cm were treated with superselective TACE using digital subtraction angiography (DSA) alone ...
Nuijsink Marianne - - 2013
Traditionally, symptoms are important patient-oriented outcomes in asthma treatment, and assessment of symptoms is an essential component of assessing asthma control. However, variable airways obstruction, airways hyperresponsiveness and chronic inflammation are key components of the asthma syndrome, and correlations among these hallmarks and symptoms are weak or even absent. Therefore, ...
Zhi De Juan - - 2013
Although realgar bioleaching solution (RBS) has been proved to be a potential candidate for cancer therapy, the mechanisms of RBS anticancer are still far from being completely understood. Dosed with RBS in C. elegans, the multivulva phenotype resulting from oncogenic ras gain-of-function was inhibited in a dose dependent manner. It ...
Caire François - - 2013
BACKGROUND: The dorso-lateral part of the subthalamic nucleus (STN) is considered as the usual target of deep brain stimulation for Parkinson's disease. Nevertheless, the exact anatomical location of the electrode contacts used for chronic stimulation is still a matter of debate. The aim of this study was to perform a ...
Sakas D E - - 2013
The present Training Charter in Epilepsy Surgery Added Competence constitutes the third stage of a program initiated by the European Society for Stereotactic and Functional Neurosurgery (ESSFN) and substantiated in close collaboration with the Union Européennedes Médecins Spécialists (UEMS) and the European Association of Neurosurgical Societies (EANS). This program aims ...
Zugno Alexandra I - - 2013
Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neurotransmitters such as dopamine, ...
Christl Bettina - - 2013
This study aims to investigate the (1) pattern of psychosocial risk factors among mothers of unsettled infants, (2) the relationship between these risk factors and current mental health status and (3) acceptability of psychosocial risk assessment in the parentcraft setting. Women with unsettled infants aged up to 12 months were assessed ...
Alnawaiseh M - - 2013
A 75-year-old man (not a contact lens wearer) presented with Fusarium-associated hypopyon keratitis. After several weeks of empirical and subsequently targeted antimycotic treatment, no considerable improvement was observed. However, after sclerokeratoplasty (11.2 × 11.2 mm) combined with prolonged antimycotic therapy a good local result with relapse-free long-term follow-up was achieved.
Dharampal Anoeshka S - - 2013
OBJECTIVE: To investigate the value of the calcium score (CaSc) plus clinical evaluation to restrict referral for CT coronary angiography (CTCA) by reducing the number of patients with an intermediate probability of coronary artery disease (CAD). METHODS: We retrospectively included 1,975 symptomatic stable patients who underwent clinical evaluation and CaSc ...
Boyd-Ball Alison J - - 2013
This study investigated the combined influence of parental monitoring, community monitoring, and exposure to substance-using peers on early-onset alcohol use in a sample of American Indian adolescents in three Pacific Northwest tribal communities. We used structural equation modeling, including tests of indirect effects, in the investigation of 281 American Indian ...
Wu Keng - - 2013
We reported a case of a 78-year-old patient with esophagopericardial fistula who was referred for angiographic and interventional management. Emergent implantation of the esophageal stent could not lengthen or even save the patient's life. One week later, the patient died of multiple organ failure, which was probably from formation of ...
Araújo Aurigena Antunes - - 2013
The objective of this study is to investigate the participation of inflammatory and oxidative stress mediators and the effects on the expression of matrix metalloproteinase (MMP)-2, MMP-9, and receptor activator of NF-κB ligand (RANKL)/receptor activator of NF-κB (RANK)/osteoprotegerin (OPG) pathway in the response to treatment with olmesartan, an angiotensin II ...
1 2 3 4 5 6 7 8 9 10 >