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Fujisawa N - - 2013
A 1,000-fold difference has been reported in dioxin sensitivity between avian species. This difference is because the 2 amino acids in the type 1 aryl hydrocarbon receptor (AhR1), at positions 325 and 381, correspond to Leu324 and Ser380 in chickens. The chicken had been reported to be the only avian ...
Fabrizio Cecilia S - - 2013
There is a dearth of high-level evidence for brief programs designed to promote positive parent-child relationships in nonwestern cultures. We present a pilot randomized controlled trial of a four-session intervention to enhance the parenting skills that promote a positive relationship with pre-adolescent children in Hong Kong. Our intervention, Harmony@Home, utilized ...
Cotte Laurent - - 2013
OBJECTIVE:: To investigate the safety, tolerability, pharmacokinetics, and antiviral activity of BMS-986001 (a nucleoside reverse transcriptase inhibitor) in treatment-experienced, HIV-1-infected subjects not exposed to antiretroviral treatment in the previous 3 months. METHODS:: Thirty-two HIV-1-infected subjects were randomized (3:1) to receive BMS-986001 or placebo once daily for 10 days in this ...
van Geenen Erwin-Jan M - - 2013
OBJECTIVES: Several randomized controlled trials studied the role of endoscopic retrograde cholangiopancreaticography (ERCP) and endoscopic sphincterotomy (ES) in acute biliary pancreatitis (ABP). No study assessed whether these trials resulted in international consensus in published meta-analyses and treatment guidelines. METHODS: A systematic review, according to the Preferred Reporting Items for Systematic ...
Engels Paul T - - 2013
OBJECTIVES:: To 1) review the existing evidence for early mobilization of the critically ill patients in the ICU with polytrauma; 2) provide intensivists with an introduction to the biomechanics, physiology, and nomenclature of injuries; 3) summarize the evidence for early mobilization in each anatomic area; and 4) provide recommendations for ...
Redford Melissa A - - 2013
The goals of the current study were (1) to assess differences in child and adult pausing, and (2) to determine whether characteristics of child and adult pausing can be explained by the same language variables. Spontaneous speech samples were obtained from ten 5-year-olds and their accompanying parent using a storytelling/retelling ...
Avila K A - - 2013
PURPOSE: Mucoceles are cystic lesions, resulting from an obstruction in the paranasal sinuses and an accumulation of mucus, causing enlargement of the affected paranasal sinus. The signs and symptoms depend on the affected sinus. Treatment consists of surgical resection. The purpose of this study was to describe the clinical presentation ...
Niho Seiji - - 2013
INTRODUCTION:: We conducted a phase II study of combination chemotherapy with irinotecan (CPT) and cisplatin (CDDP) in patients with advanced large-cell neuroendocrine carcinoma (LCNEC) of the lung. METHODS:: Patients received irinotecan (60 mg/m, days 1, 8, and 15) and cisplatin (60 mg/m, day 1) every 4 weeks for up to ...
Kulpa Deanna A - - 2013
A major challenge in the development of a cure for human immunodeficiency virus (HIV) has been the incomplete understanding of the basic mechanisms underlying HIV persistence during antiretroviral therapy. It is now realized that the establishment of a latently infected reservoir refractory to immune system recognition has thus far hindered ...
Charlesworth Amanda - - 2013
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This ...
Huang Hsu-Ching HC Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, - - 2013
Lung cancer with breast metastasis is rare. However, differentiating between primary breast cancer and metastatic lung adenocarcinoma is of clinical importance. The metastasis cascade of how cancer cells migrate from the primary lung tumor to the breast is not clear yet. Pathology and cytology databases were searched for patients diagnosed ...
Fan Wei W Center of Reproductive Medicine, The West China Second University Hospital, Sichuan University, Sichuan, People's Republic of China. - - 2013
Human sex hormone-binding globulin (SHBG) is a specific plasma transport glycoprotein for sex steroid hormones, and serum SHBG levels were decreased in polycystic ovary syndrome (PCOS) patients. To clarify the conflicting data in the literature concerning the association between PCOS and the (TAAAA)n SHBG polymorphism, and influence of the (TAAAA)n ...
Stephenson Kathryn E KE Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, - - 2013
A global human immunodeficiency virus-1 (HIV-1) vaccine will have to elicit immune responses capable of providing protection against a tremendous diversity of HIV-1 variants. In this review, we first describe the current state of the HIV-1 vaccine field, outlining the immune responses that are desired in a global HIV-1 vaccine. ...
Marik Paul E PE Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA. - - 2013
Despite a previous meta-analysis that concluded that central venous pressure should not be used to make clinical decisions regarding fluid management, central venous pressure continues to be recommended for this purpose. To perform an updated meta-analysis incorporating recent studies that investigated indices predictive of fluid responsiveness. A priori subgroup analysis ...
Teperman Lewis L Mary Lea Johnson Richards Organ Transplant Center, New York University School of Medicine, New York, NY 10016, USA. - - 2013
Mycophenolate mofetil (MMF) and sirolimus (SRL) have been used for calcineurin inhibitor (CNI) minimization to reduce nephrotoxicity following liver transplantation. In this prospective, open-label, multicenter study, patients undergoing transplantation from July 2005 to June 2007 who were maintained on MMF/CNI were randomized 4 to 12 weeks after transplantation to receive ...
Warshak Carri R CR Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267-0526, - - 2013
We hypothesise that the rate of stillbirth is increased in mothers younger than 18 years of age compared to adult mothers, and that obesity further increases the risk of stillbirth in this population. We conducted a population-based cohort study comparing rates of stillbirth between adolescent, defined as young women under ...
Larsen Pernille Stemann PS Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen. - - 2013
During the past 25 years, many pregnancy and birth cohorts have been established. Each cohort provides unique opportunities for examining associations of early-life exposures with child development and health. However, to fully exploit the large amount of available resources and to facilitate cross-cohort collaboration, it is necessary to have accessible ...
Hunter Gary R GR Department of Human Studies, University of Alabama at Birmingham, AL 35294-1250, USA. - - 2013
To examine the effects of three different frequencies of combined resistance and aerobic training on total energy expenditure (TEE) and activity-related energy expenditure (AEE) in a group of older adults. Seventy-two women, 60-74 yr old, were randomly assigned to one of three groups: 1 d · wk(-1) of aerobic training ...
Xu Huanbin H Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, - - 2013
Recent advances in the immunology, pathogenesis, and prevention of human immunodeficiency virus (HIV) infection continue to reveal clues to the mechanisms involved in the progressive immunodeficiency attributed to infection, but more importantly have shed light on the correlates of immunity to infection and disease progression. HIV selectively infects, eliminates, and/or ...
Okoye Afam A AA Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. - - 2013
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive depletion of CD4(+) T-cell populations in close association with progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections (OI). Disease progression in untreated human immunodeficiency virus (HIV) infection can take many years, and it was originally hypothesized ...
Paiardini Mirko M Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30329, USA. - - 2013
Systemic chronic immune activation is considered today as the driving force of CD4(+) T-cell depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune activation persists even in HIV-infected patients in which viral replication is successfully inhibited by anti-retroviral therapy, with the extent of this residual immune activation being associated ...
Burdo Tricia H TH Department of Biology, Boston College, Chestnut Hill, MA 02467, - - 2013
Neurological sequelae of human immunodeficiency virus (HIV) infection have been and remain a significant problem. Monocytes and macrophages in humans and monkeys are susceptible to infection by HIV and simian immunodeficiency virus (SIV), and are considered to be a main mechanism by which the central nervous system (CNS) is infected. ...
Chang Christina C CC Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, - - 2013
Despite significant reductions in morbidity and mortality secondary to availability of effective combination anti-retroviral therapy (cART), human immunodeficiency virus (HIV) infection still accounts for 1.5 million deaths annually. The majority of deaths occur in sub-Saharan Africa where rates of opportunistic co-infections are disproportionately high. In this review, we discuss the ...
Demers Korey R KR Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
A detailed understanding of the immune response to human immunodeficiency virus (HIV) infection is needed to inform prevention and therapeutic strategies that aim to contain the acquired immunodeficiency syndrome (AIDS) pandemic. The cellular immune response plays a critical role in controlling viral replication during HIV infection and will likely need ...
Klatt Nichole R NR Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, - - 2013
Despite complete or near-complete suppression of human immunodeficiency virus (HIV) replication with combination antiretroviral therapy, both HIV and chronic inflammation/immune dysfunction persist indefinitely. Untangling the association between the virus and the host immune environment during therapy might lead to novel interventions aimed at either curing the infection or preventing the ...
Nelson Peter T PT Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, - - 2013
The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased parenchymal amyloid plaques. We tested how the APOE genotype correlated with cerebral amyloid angiopathy (CAA) by analyzing 371 brains for parenchymal and meningeal CAA in 4 brain regions (frontal, parietal, temporal, and occipital neocortex). The overall severity ...
Liu Yang Y The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, - - 2013
Motoneuron death after spinal cord injury or disease results in muscle denervation, atrophy, and paralysis. We have previously transplanted embryonic ventral spinal cord cells into the peripheral nerve to reinnervate denervated muscles and to reduce muscle atrophy, but reinnervation was incomplete. Here, our aim was to determine whether brief electrical ...
Mascola John R JR Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. - - 2013
The development of an effective vaccine has been hindered by the enormous diversity of human immunodeficiency virus-1 (HIV-1) and its ability to escape a myriad of host immune responses. In addition, conserved vulnerable regions on the HIV-1 envelope glycoprotein are often poorly immunogenic and elicit broadly neutralizing antibody responses (BNAbs) ...
Wilson Eleanor M P EM HIV Pathogenesis Unit, Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, - - 2013
Antiretroviral therapy (ART) is a life-saving intervention in human immunodeficiency virus (HIV) infection. Immune restoration after ART dramatically reduces the incidence and severity of opportunistic diseases and death. On some occasions, immune restoration may be erratic, leading to acute inflammatory responses (known as immune reconstitution inflammatory syndrome) shortly after ART ...
Coates Daniel R DR Vision Science Graduate Program, and School of Optometry, University of California-Berkeley, CA 94720, USA. - - 2013
Acuity measurement is a fundamental method to assess visual performance in the clinic. Little is known about how acuity measured in the presence of neighboring letters, as in the case of letter charts, changes with contrast and with nonfoveal viewing. This information is crucial for acuity measurement using low-contrast charts ...
Martin Maureen P MP Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, - - 2013
Host genetic factors are a major contributing factor to the inter-individual variation observed in response to human immunodeficiency virus (HIV) infection and are linked to resistance to HIV infection among exposed individuals, as well as rate of disease progression and the likelihood of viral transmission. Of the genetic variants that ...
Wood Lianna F LF Seattle Biomedical Research Institute, Seattle, WA, - - 2013
The global spread of human immunodeficiency virus (HIV) is dependent on the ability of this virus to efficiently cross from one host to the next by traversing a mucosal membrane. Unraveling how mucosal exposure of HIV results in systemic infection is critical for the development of effective therapeutic strategies. This ...
Wu Junfang J Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research, National Study Center for Trauma and EMS, University of Maryland, School of Medicine, Bressler Research Building, 655 W. Baltimore Street, Room #6-009, Baltimore, MD 21201, USA. - - 2013
Spinal cord injury (SCI) causes not only sensorimotor and cognitive deficits, but frequently also severe chronic pain that is difficult to treat (SCI pain). We previously showed that hyperesthesia, as well as spontaneous pain induced by electrolytic lesions in the rat spinothalamic tract, is associated with increased spontaneous and sensory-evoked ...
Tang Siuwah S Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, - - 2013
MicroRNAs (miRNAs) are 18- to 22-nucleotide-long, single-stranded, noncoding RNAs that regulate important biological processes including differentiation, proliferation, and response to cellular stressors such as hypoxia, nutrient depletion, and traversion of the cell cycle by controlling protein expression within the cell. Many investigators have profiled cancer tissue and serum miRNAs to ...
Kilburn Duncan D T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, - - 2013
Biological macromolecules have evolved to fold and operate in the crowded environment of the cell. We have shown previously that molecular crowding stabilizes folded RNA structures. Here we report SAXS measurements on a 64 kDa bacterial group I ribozyme in the presence of mono- and divalent ions and PEG crowders ...
Castellano Brian M BM Department of Chemistry, San José State University, San José, CA 95192-0101, - - 2013
This study introduces a new thermodynamic framework for aqueous reaction equilibria that treats water as a coreactant in the development of a general binding equation. The approach features an explicit consideration for the change in hydration that occurs when two solvated surfaces come into contact. As an outcome of this ...
Wray Naomi R NR Queensland Brain Institute, The University of Queensland, QBI Building, St Lucia, Queensland 4071, - - 2013
The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how ...
Kedem Alon A IVF Unit and Reproduction Lab, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat-Gan, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. - - 2013
To prospectively study the AMH expression and secretion pattern in mural granulosa cells (GCs) and follicular fluid (FF) from small follicles and medium follicles that were collected from normo-ovulatory (NO) and polycystic ovary syndrome (PCOS) patients undergoing in vitro maturation (IVM) treatments. FF AMH levels and mRNA expression of mural ...
Kejner Alexandra E AE Department of Otolaryngology, University of Alabama-Birmingham, Birmingham, Alabama, - - 2013
To evaluate bone invasion, survival, and expression of bone morphogenetic protein-6 (BMP-6) in oral cavity cancer in the context of known biomarkers indicative of poor prognosis. Molecular expression study combined with retrospective chart review of corresponding patients at a tertiary care center. Between 2000 and 2009, a total of 197 ...
Tobin Nicole H NH Children's Hospital Los Angeles, Los Angeles, CA, - - 2013
Most infants born to human immunodeficiency virus (HIV)-infected women escape HIV infection. Infants evade infection despite an immature immune system and, in the case of breastfeeding, prolonged repetitive exposure. If infants become infected, the course of their infection and response to treatment differs dramatically depending upon the timing (in utero, ...
Zhao Kai K Monell Chemical Senses Center, Philadelphia, Pennsylvania, U.S.A; Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, - - 2014
Nasal obstruction is the principal symptom that drives patients with rhinosinus disease to seek medical treatment. However, patient perception of obstruction often bears little relationship to actual measured physical obstruction of airflow. This lack of an objective clinical tool hinders effective diagnosis and treatment. Previous work has suggested that the ...
Weber Irene T IT Departments of Chemistry and Biology, Georgia State University , Atlanta, Georgia, United - - 2013
HIV-1 protease is an important target for the development of antiviral inhibitors to treat AIDS. A room-temperature joint X-ray/neutron structure of the protease in complex with clinical drug amprenavir has been determined at 2.0 Å resolution. The structure provides direct determination of hydrogen atom positions in the enzyme active site. ...
Hao Guiyang G Department of Radiology, The University of Texas Southwestern Medical Center , Dallas, Texas 75390, United - - 2013
2[(3-Amino-3-carboxypropyl)(hydroxy)(phosphinyl)methyl]pentane-1,5-dioic acid) (GPI) is a highly potent inhibitor of prostate specific membrane antigen (PSMA) with a rapid in vivo clearance profile from nontarget organs including kidneys, but its use for imaging of PSMA is impeded by an endogenous anion (serum phosphate) competition, which compromises its specific binding to the antigen. ...
Akabayov Sabine R SR Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, - - 2013
Enzymatic reactions occur in a crowded and confined environment in vivo, containing proteins, RNA and DNA. Previous reports have shown that interactions between macromolecules, and reactions rates differ significantly between crowded environments and dilute buffers. However, the direct effect of crowding on the level of high-resolution structures of macromolecules has ...
Kim Jong-Seo JS Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United - - 2013
A resin-assisted enrichment method has been developed for specific isolation of protein N-terminal peptides to facilitate LC-MS/MS characterization of proteolytic processing, a major form of posttranslational modifications. In this method, protein thiols are blocked by reduction and alkylation, and protein lysine residues are converted to homoarginines. Protein N-termini are selectively ...
Kiss Orsolya O Semmelweis Egyetem, Általános Orvostudományi Kar, II. Patológiai Intézet, Budapest. - - 2013
Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. The aim of the authors was to compare the ...
Tóth Veronika V Semmelweis Egyetem, Általános Orvostudományi Kar, Bőr-, Nemikórtani és Bőronkológiai Klinika, Budapest. - - 2013
Survival of patients with malignant melanoma primarily depends on tumor stage. Hungarian National Cancer Registry does not specify tumors according to TNM stages. The authors aimed to survey the stage distribution of melanomas at the Department of Dermatology, Dermatooncology and Venerology, Semmelweis University. 1160 patients (558 males and 602 females, ...
Bakkné Nagy Mónika M Debreceni Egyetem, Népegészségügyi Kar, Komplex Rehabilitáció Msc, Debrecen. - - 2013
Smoking habits are influenced by environmental (family, friends) and psychologic factors. To investigate environmental factors which influence the smoking habits of monozygotic and dizygotic twins. 45 monozygotic and 23 dizygotic twin pairs (age 35±16 years) completed a questionnaire. Maternal non-smoking decreases the risk of smoking of the twin children by ...
Molics Bálint B Pécsi Tudományegyetem, Egészségtudományi Kar, Fizioterápiás és Táplálkozástudományi Intézet, Pécs, Rét u. 4. 7623 Pécsi. - - 2013
Limited information is available on physiotherapy treatment of lower extremity injuries. The purpose of this study included analysis of the utilization of outpatient physiotherapy services in case of injuries of the lower extremity. Data derived from the database of the National Health Insurance Fund Administration, Hungary. The number of cases ...
Sharpe Benjamin - - 2013
The cancer stem cell hypothesis postulates that a single stem-like cancer cell is able to produce all cancer cell types found in a tumor. These cells are also thought to be the causative agents of relapse following therapy. In order to confirm the importance of cancer stem cells in tumor ...
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