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Hernychova Lenka L Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech - - 2013
MDM2 is a multidomain protein that functions as an E3 ubiquitin ligase, transcription repressor, mRNA-binding protein, translation factor, and molecular chaperone. The small molecule Nutlin-3 has been engineered to bind to the N-terminal hydrophobic pocket domain of MDM2. This binding of Nutlin-3 has two consequences: (i) antagonistic effects through competitive ...
Tischer Alexander A Division of Hematology, Departments of Internal Medicine and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, - - 2013
Platelet attachment to von Willebrand factor (vWF) requires the interaction between the platelet GP1bα and exposed vWF-A1 domains. Structural insights into the mechanism of the A1-GP1bα interaction have been limited to an N-terminally truncated A1 domain that lacks residues Q1238  - E1260 that make up the linker between the D3 and ...
Skudlarski Pawel P Olin Neuropsychiatry Research Center, Hartford Hospital/Institute of Living, Hartford, Conn., USA. - - 2013
OBJECTIVE Both schizophrenia and bipolar disorder are hypothesized to involve disordered brain connectivity. Prior studies show low white matter integrity, measured with diffusion tensor imaging, for both disorders. The authors studied disease specificity and endophenotypic status of these abnormalities by examining patients and their unaffected relatives. METHOD The 513 participants ...
de Kuijper Gerda G Vanboeijen, Intellectual Disability Center, Assen, The Netherlands. - - 2013
Antipsychotics are frequently prescribed agents in individuals with intellectual disability, often for behavioral symptoms. Efficacy of antipsychotics for this is ambiguous, so discontinuation should be considered. Weight gain and metabolic dysregulation are well-known adverse effects of antipsychotics which increase the risk of the metabolic syndrome. We performed a discontinuation study ...
Raebel Marsha A MA Kaiser Permanente Colorado Institute for Health Research, Denver, CO 80231, USA. - - 2013
To propose a unifying set of definitions for prescription adherence research utilizing electronic health record prescribing databases, prescription dispensing databases, and pharmacy claims databases and to provide a conceptual framework to operationalize these definitions consistently across studies. We reviewed recent literature to identify definitions in electronic database studies of prescription-filling ...
Huang Wenzhe W Department of Pharmacology, SUNY Upstate Cancer Research Institute, State University of New York Upstate Medical University, Syracuse, NY 13210, - - 2013
A unique core-inversible micelle (CIM) was formed via PEG(5k)CA8 for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line.
Jo Jung Ki JK Department of Urology, Hanyang University College of Medicine, Seoul, - - 2013
To analyze the quality of studies reporting randomized clinical trials (RCTs) in the field of endourology. RCTs published in the Journal of Endourology from 1993 until 2011 were identified. The Jadad scale, van Tulder scale, and Cochrane Collaboration Risk of Bias Tool (CCRBT) were used to assess the quality of ...
Chen Zhi Chang ZC Institute of Plant Science and Resources, Okayama University, Chuo 2-20-1, Kurashiki, - - 2013
Yorkshire fog (Holcus lanatus), which belongs to the Poaceae family and is a close relative of the agronomic crop oat (Avena sativa), is a widely adaptable grass species that is able to grow on highly acidic soils with high levels of Al, but the mechanism underlying the high Al tolerance ...
Tsui Judith I JI Department of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education (CARE) Unit, Boston University School of Medicine/Boston Medical Center, Boston, MA, - - 2013
To evaluate whether pain was associated with increased risk of using heroin, stimulants or cannabis among HIV-infected drinkers in Russia. Secondary analysis of longitudinal data from the HERMITAGE study (HIV's Evolution in Russia-Mitigating Infection Transmission and Alcoholism in a Growing Epidemic), a behavioral randomized controlled trial, with data collected at ...
Day Nancy F NF Department of Neuroscience, the University of Minnesota, Twin Cities, Minnesota, 55455; Graduate Program in Neuroscience, the University of Minnesota, Twin Cities, Minnesota, 55455; Center for Neurobehavioral Development, the University of Minnesota, Twin Cities, Minnesota, - - 2013
The function and modulation of neural circuits underlying motor skill may involve rhythmic oscillations (Feller, 1999; Marder and Goaillard, 2006; Churchland et al., 2012). In the proposed pattern generator for birdsong, the cortical nucleus HVC, the frequency and power of oscillatory bursting during singing increases with development (Crandall et al., ...
Ebert Daniel H DH Department of Neurobiology, Harvard Medical School, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, - - 2013
Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at high levels similar to that of histones, and binds to ...
Okamoto Ryoko R Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, - - 2014
We have synthesized 39 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] analogs having two side chains attached to carbon-20 (Gemini) with various modifications and compared their anticancer activities. Five structure-function rules emerged to identify analogs with enhanced anticancer activity. One of these active analogs, BXL-01-0126, was more potent than 1,25(OH)2D3 in mediating 50% clonal ...
Walker Gary V GV Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we identified 73,077 patients aged ≥66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - ...
Chen Junqiang - - 2013
To retrospectively compare the efficacy of radiation therapy (RT) and chemotherapy plus RT (CRT) for the postoperative treatment of node-positive thoracic esophageal squamous cell carcinoma (TESCC) and to determine the incidence and severity of toxic reactions. We retrospectively reviewed data from 304 patients who had undergone esophagectomy with 3-field lymph ...
Herman Joseph M JM Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA. - - 2013
Long-term survival rates for patients with resected pancreatic ductal adenocarcinoma (PDAC) have stagnated at 20% for more than a decade, demonstrating the need to develop novel adjuvant therapies. Gemcitabine-erlotinib therapy has demonstrated a survival benefit for patients with metastatic PDAC. Here we report the first phase 2 study of erlotinib ...
Pinkham Mark B - - 2013
To describe the anatomic distribution of regionally recurrent disease in patients with stage III melanoma in the axilla after curative-intent surgery with and without adjuvant radiation therapy. A single-institution, retrospective analysis of a prospective database of 277 patients undergoing curative-intent treatment for stage III melanoma in the axilla between 1992 ...
Ong Chin Loon - - 2013
We investigated the dosimetric impact of the interplay effect during RapidArc stereotactic body radiation therapy for lung tumors using flattening filter-free (FFF) beams with different dose rates. Seven tumors with motion ≤20 mm, treated with 10-MV FFF RapidArc, were analyzed. A programmable phantom with sinusoidal longitudinal motion (30-mm diameter "tumor" ...
Catsburg Chelsea E CE Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, - - 2014
N-Nitroso compounds (NOCs) have been proposed as possible bladder carcinogens. The main sources of exogenous exposure to NOCs are cigarette smoke and diet, particularly processed (i.e., nitrite-treated) meats. Perhaps more importantly, NOCs can be formed endogenously from dietary precursors such as nitrate, nitrite and amines. Heme has been shown to ...
Yao Xiaosai X David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, - - 2013
Many targets have been identified in solid tumors for antibody therapy but it is less clear what surface antigens may be most commonly expressed on disseminated tumor cells. Using malignant pleural effusions as a source of disseminated tumor cells, we compared a panel of 35 antigens for their cancer specificity, ...
Odd David Edward DE Neonatal Unit, Southmead Hospital, Bristol, UK; Clinical Science at North Bristol, University of Bristol, Bristol, UK. - - 2013
To investigate whether children born between 32 and 36 weeks of gestation have an increased risk of motor coordination difficulties or cerebral palsy (CP) at age 7 years. A cohort study based on the Avon Longitudinal Study of Parents and Children (ALSPAC). The primary outcomes were poor motor coordination, defined ...
Perkins Kenneth A KA Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, - - 2013
It is important to find economical methods in early Phase 2 studies to screen drugs potentially useful to aid smoking cessation. A method has been developed that detects efficacy of varenicline and nicotine patch. This study aimed to evaluate whether the method would detect the efficacy of bupropion and identify ...
Tache Veronique V 1 Department of Obstetrics and Gynecology, University of California , Davis, Sacramento, - - 2013
Tissue oxygen tension regulates differentiation of multiple types of stem cells. In the placenta, hypoxia has been associated with abnormal trophoblast differentiation and placental insufficiency syndromes of preeclampsia (PE) and intrauterine growth restriction (IUGR). Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor involved in many cellular processes, including differentiation. ...
Bradford Carol R CR Department of Otolaryngology-Head and Neck Surgery, Medical School, Ohio State University, Columbus, - - 2014
To determine if tumor biomarkers were predictive of outcome in a prospective cohort of patients with advanced larynx cancer treated in a phase II clinical trial. Prospectively collected biopsy specimens from 58 patients entered into a Phase II trial of organ preservation in advanced laryngeal cancer were evaluated for expression ...
Lu Jianqin J Center for Pharmacogenetics, University of Pittsburgh , Pittsburgh, Pennsylvania 15261, United - - 2013
Various PEG-Vitamin E conjugates including d-α-tocopheryl poly(ethylene glycol) succinate 1000 (TPGS) have been extensively studied as a nonionic surfactant in various drug delivery systems. However, limited information is available about the structure-activity relationship of PEG-Vitamin E conjugates as a micellar formulation for paclitaxel (PTX). In this study, four PEG-Vitamin E ...
Hatters Friedman Susan S Departments of Psychiatry and Pediatrics, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH, USA. - - 2013
To describe characteristics of mothers who would likely benefit from on-site short-term psychiatric services while their infant is in the neonatal intensive care unit (NICU). For 150 consecutive mothers who were referred for psychiatric evaluation and psychotherapeutic intervention in an innovative NICU mental health programme, baseline information was collected. Data ...
Li Deyu D Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alkyl adducts, such as 1-methyladenine, 3-methylcytosine, 3-ethylcytosine, 1-methylguanine, 3-methylthymine, and N(6)-methyladenine, ...
Ju Yawen Y Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New - - 2013
The troponin complex, which consists of three regulatory proteins (troponin C, troponin I, and troponin T), is known to regulate muscle contraction in skeletal and cardiac muscle, but its role in smooth muscle remains controversial. Troponin T3 (TnnT3) is a fast skeletal muscle troponin believed to be expressed only in ...
Piñar Guadalupe G Department of Biotechnology, VIBT-Vienna Institute of BioTechnology, University of Natural Resources and Life Sciences, Vienna, - - 2013
The Capuchin Catacombs of Palermo contain over 1800 preserved bodies dating from the 16th to 20th centuries AD and showing evidence of biodeterioration. An extensive microbiological and molecular investigation was recently performed. Samples were taken from skin, muscle, hair, bone, stuffing materials, clothes, and surrounding walls as well as from ...
Mitchell Joshua R JR Department of Otolaryngology-Head and Neck Surgery (, Vanderbilt University, Nashville, Tennessee, - - 2014
To investigate phonation-related extracellular matrix (ECM) changes in the vocal fold lamina propria after microflap surgery using an in vivo rabbit phonation model. Prospective animal study. Twenty-four New Zealand White rabbits were used in this study. Quantitative polymerase chain reaction and immunohistochemistry were used to investigate alterations in vocal fold ...
Corkey Britton K - - 2013
We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.
Harslund Jakob J Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, - - 2013
Staphylococcus aureus is a common cause of skin and soft tissue infections in animal and humans. In the current study, we hypothesized that early host responses to S. aureus infection leading to the recruitment of neutrophils and control of the bacterium at the site of infection depend on the expression of ...
Tremp Annie Z AZ Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, - - 2013
A shared feature of the motile stages (zoites) of malaria parasites is a cortical cytoskeletal structure termed subpellicular network (SPN), thought to define and maintain cell shape. Plasmodium alveolins comprise structural components of the SPN, and alveolin gene knockout causes morphological abnormalities that coincide with markedly reduced tensile strength of ...
Lee Hyosung H Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and ⊥Department of Chemistry, University of North Carolina , Chapel Hill, North Carolina 27599, United - - 2013
We have reported that compounds containing a biaryl linked unit (Ar-X-Ar') modulated Na(+) currents by promoting slow inactivation and fast inactivation processes and by inducing frequency (use)-dependent inhibition of Na(+) currents. These electrophysiological properties have been associated with the mode of action of several antiepileptic drugs. In this study, we ...
Šebek Jiří J Institute of Chemistry and The Fritz Haber Research Center, The Hebrew University, Jerusalem 91904, - - 2013
The vibrational spectroscopy of C-H stretches in organic molecules is of considerable importance for the characterization of these systems and for exploration of their properties. These stretches are strongly anharmonic, and thus methods including anharmonicity have to be used. The vibrational self-consistent field (VSCF) is applied to the following organic ...
Backmark A E AE Discovery Sciences, Reagents and Assay Development, AstraZeneca Pharmaceuticals, Mölndal, - - 2013
Screening of protein variants requires specific detection methods to assay protein levels and stability in crude mixtures. Many strategies apply fluorescence-detection size-exclusion chromatography (FSEC) using green fluorescent protein (GFP) fusion proteins to qualitatively monitor expression, stability, and monodispersity. However, GFP fusion proteins have several important disadvantages; including false-positives, protein aggregation ...
Kundrotas Petras J PJ Center for Bioinformatics and Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas 66047, - - 2013
Proteins often bind other proteins in more than one way. Thus alternative binding modes is an essential feature of protein interactions. Such binding modes may be detected by X-ray crystallography and thus reflected in Protein Data Bank. The alternative binding is often observed not for the protein itself but for ...
Wang Lincong L The College of Computer Science and Technology, Jilin University, Changchun, Jilin, China. - - 2013
A plethora of both experimental and computational methods have been proposed in the past 20 years for the identification of hot spots at a protein-protein interface. The experimental determination of a protein-protein complex followed by alanine scanning mutagenesis, though able to determine hot spots with much precision, is expensive and ...
Singh Onkar O GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United - - 2013
ASK1, a member of the MAPK Kinase Kinase family of proteins has been shown to play a key role in cancer, neurodegeneration and cardiovascular diseases and is emerging as a possible drug target. Here we describe a 'replacement-soaking' method that has enabled the high-throughput X-ray structure determination of ASK1/ligand complexes. ...
Ranganathan Anupama A Department of Entomology and UCD Comprehensive Cancer Center, University of California Davis, Davis, California 95616, United - - 2013
Hesperetin dihydrochalcone 4'-glucoside, 1, and phloretin 4'-glucoside, 2, belong to a family of dihydrochalcone glycosides that exhibit flavorant properties. In this study was developed a competitive, indirect homologous ELISA for the detection of targets 1 and 2 in fermentation media. Immunogen and coating antigen were prepared by conjugating hapten, 4-(3-oxo-3-(2,6-dihydroxy-4-glucoside ...
Darji Ketur K Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, Chicago, Illinois, United - - 2013
The fruit of the Maclura pomifera tree is a sustainable source for the pharmacologically interesting isoflavones, osajin and pomiferin. A reversed-phase HPLC method was developed to identify osage orange samples with high isoflavone content and to determine the optimum conditions for sample preparation. Analytical run time was 8 min at ...
Szulc-Dąbrowska Lidia L Division of Immunology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Warsaw, Poland. - - 2013
During mousepox in resistant (C57BL/6) or susceptible (BALB/c) strains of mice, stimulation of Th1 or Th2 cytokine immune response, respectively, is observed. Because mechanisms of different polarization of T cells remain elusive, in this study, we quantitatively assessed the phenotype of antigen-presenting cells (APCs) involved in ectromelia virus (ECTV) antigen ...
Zhu Wenhan W Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN, 47907, - - 2013
The intracellular pathogen Legionella pneumophila is able to strike a balance between the death and survival of the host cell during infection. Despite the presence of high level of active caspase 3, the executioner caspase of apoptotic cell death, infected permissive macrophages are markedly resistant to exogenous apoptotic stimuli. Several ...
Shi Shuyun S Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United - - 2013
A challenge in coupling ion-pair chromatography (IPC) online with electrospray ionization-mass spectrometry (ESI-MS) is that the nonvolatile ion-pair reagent (e.g., alkyl sulfate for amines or tetrabutylammonium for carboxylic acids) in the mobile phase suppresses the ESI-MS signals in the gas phase and their accumulation can clog the MS sampling interface. ...
Wang Jing - - 2013
We investigated whether pancreatitis-associated ascitic fluid (PAAF) could induce the expression of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in THP-1 cells and the mechanism(s) involved. THP-1 cells were divided into control and PAAF groups. The PAAF group was incubated with different final concentrations of PAAF, whereas the ...
Silversides F G - - 2013
Avian genetic resources have declined dramatically over the past half century, partly because the poultry community has been slow to adopt cryoconservation of avian germplasm. Techniques for gonadal cryopreservation and functional recovery have recently been developed but only some have been optimized. Chicks were castrated at 2 or 6 d ...
Emerson Mark M - - 2013
COVER PHOTOGRAPH: Drosophila embryonic axons visualized for expression of Fasciclin II (red) and a transgene that marks sema-phorin2b-positive cells (green). semaphorin2b-positive axons deviate from their normal Fasciclin II tracts in both the lateral and ventral direction in semaphorin2b mutants (upper right) compared to wildtype (upper left). From Drosophila semaphorin2b is ...
Sáez-Cirión Asier - - 2013
Less than 0.5% of human immunodeficiency virus-1 (HIV-1)-infected patients maintain viral load below the threshold of detection by conventional assays for many years without antiretroviral therapy. These patients are known as HIV controllers (HICs) and offer a unique opportunity to explore and unravel efficient mechanisms of defense against HIV. An ...
Liu Xiaofeng - - 2013
Using the double immunostaining method, the glia limitans on the surfaces of mouse and monkey brain and spinal cord were studied systematically. The results showed that the superficial glia limitans of mouse brain and spinal cord comprise a layer of surface astrocytes, while the glia limitans of monkey comprise a ...
Erci Behice - - 2013
This study determines perceived self-efficacy, personal characteristics and quality of life among Turkish adult primary care patients. The research used descriptive cross-sectional design. The sample group had moderate perceived self-efficacy and was mostly satisfied with quality of life. These findings help health professionals to improve quality of life in healthy ...
Robles Ana - - 2013
Abstract Oocyte donation can satisfy the desire to have children in women with premature ovarian failure (POF) but little progress has been made to improve reproduction using the patients' own gametes. The aim of this study was to assess the effectiveness of alternative treatments to oocyte donation in patients with ...
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