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Results 451 - 500 of 6787
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Kaufman Kenneth R - - 2013
Stigma towards epilepsy results in barriers to social integration, education, employment, and marriage, with increased divorce rates. There is a societal need to realise that many persons with epilepsy (PWE) lead normal lives and can be highly educated with effective employment. Integration of PWE into sports is therapeutic both for ...
Sumida Kosuke - - 2013
There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they ...
Kutty A - - 2013
Eccrine porocarcinoma (EPC) was first described in 1963 by Pinkus and Mehregan, where it was referred to as 'epidermotropic eccrine carcinoma' (1) . EPC is a rare malignant tumour that develops from the intraepidermal portion of the eccrine gland. It can either arise secondary to the malignant transformation of a ...
Zhou Tingting - - 2013
Accumulated evidence indicates that phase separation occurs in potassium intercalated iron selenides, a superconducting phase coexisting with the antiferromagnetic phase K2Fe4Se5, the so-called '245 phase'. Here, we report a comparative study of substitution effects by Co and Mn for Fe sites in K0.8Fe2-ySe2 within the phase separation scenario. Our results ...
Pogliani Laura - - 2013
Abstract Background: Following the "back to sleep" recommendations, a striking rise in deformational plagiocephaly (DP) occurred. However additional maternal, pregnancy and infant conditions may play a role. Objectives: We aimed to evaluate the prevalence of and risk factors for DP at birth. Additionally, given the association between assisted reproductive technologies ...
Santos Rosana G C - - 2013
Glutamine may be a precursor for NO synthesis, which may play a crucial role in bacterial translocation (BT). The goal of the present study was to investigate the potential effects of glutamine on BT and the immunological response in an experimental model of NO synthase inhibition by NG-nitro-L-arginine methyl ester ...
Ikemura Kenji - - 2013
  The renal tubular secretion of cationic drugs is dominated by basolateral organic cation transporter 2 (rOCT2/SLC22A2) and luminal multidrug and toxin extrusion 1 (rMATE1/SLC47A1). Little is known about the variation in the expression of these renal transporters after liver ischemia-reperfusion (I/R) injury. Here, we examined the pharmacokinetics of cationic drug, ...
Kottner J - - 2013
Aging is associated with structural and functional changes of the skin that result in increased vulnerability. The aim of this systematic review is to synthesize empirical evidence about efficacy and effectiveness of basic skin care interventions to maintain skin integrity in the aged. The databases MEDLINE, EMBASE, CINAHL (1990 to ...
D'Angelo Fabrizia - - 2013
Macrophages play a critical role in intestinal wound repair. However, the mechanisms of macrophage-assisted wound repair remain poorly understood. We aimed to better characterize the repair activities of murine and human macrophages. Murine macrophages were differentiated from bone marrow cells and human macrophages from monocytes isolated from peripheral blood mononuclear ...
Fani L - - 2013
Obesity is one of the greatest public health challenges of the 21st century. Obesity is currently responsible for ∼0.7-2.8% of a country's health costs worldwide. Treatment is often not effective because weight regulation is complex. Appetite and energy control are regulated in the brain. Melanocortin-4 receptor (MC4R) has a central ...
Naldi L - - 2013
MADAM, we read with interest the paper from the European Multicentre Photopatch Test Study (EMCPPTS) Taskforce in the May issue of the Journal [1]. The study analyzed the results of Photopatch testing (PPT) on patients referred for suspected Photocontact dermatitis (PACD) to selected reference centres in Europe. The PPT series ...
de la Ossa Dolores Hernán Pérez - - 2013
Abstract Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer, AIDS and multiple sclerosis), analgesics, and in the treatment of multiple sclerosis and cancer, among other conditions. However, despite their high clinical potential, only few dosage forms are available to date. In this paper, the ...
Deiner Kristy - - 2013
The first step in many community ecology studies is to produce a species list from a sample of individuals. Community ecologists now have two viable ways of producing a species list: morphological and barcode identification. In this study, we compared the taxonomic resolution gained by a combined use of both ...
Toh Her Shuang - - 2013
Cystic fibrosis is a common disease which has an associated characteristic symptom of high sweat chloride content. Thus, chloride ion quantification in sweat is important towards the screening of cystic fibrosis. Electrochemical methods, being cost effective and convenient, can be exploited for this. The electrochemical oxidation of silver nanoparticles in ...
Fagundes Caio T - - 2013
A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the structure of the enzyme involved in the synthesis of this second messenger and ...
Dwivedi M - - 2013
BACKGROUND: NALP1 has been suggested to be involved in a wide-range of susceptibility to autoimmune diseases including generalized vitiligo (GV). Genetic polymorphisms in NALP1 have been previously shown to be associated with GV and speculated to be involved in the regulation of its expression. OBJECTIVES: The present study explores NALP1 ...
Shai Daniel - - 2013
Abstract Objective: To evaluate pregnancy outcome and rates of anemia in patients following bariatric operation in comparison with obese pregnant women. Methods: A retrospective population-based study comparing pregnancy outcome of patients following bariatric with the obese population, was conducted. Multivariate logistic regression models were constructed to control for confounders. In ...
Wang Ming - - 2013
Abstract The decoration of nanoparticle surfaces with receptor-specific ligands can improve the delivery of their therapeutic load to cancer cells. Using as the ligand, U11, a peptide specific for the cancer-associated urokinase plasminogen activator receptor, we examined the effect of manipulation of nanoparticle properties on the targeting specificity of U11-nanoparticles. ...
Funayama Tadashi - - 2013
AIM: In-situation safety behaviors play an important role in the maintenance of anxiety because they prevent patients from experiencing unambiguous disconfirmation of their unrealistic beliefs about feared catastrophes. Strategies for identifying particular safety behaviors, however, have not been sufficiently investigated. The aims of the present study were to (i) develop ...
Saneei Parvane - - 2013
The effects of the Dietary Approaches to Stop Hypertension (DASH) eating plan on childhood metabolic syndrome (MetS) and insulin resistance remain to be determined. The present study aimed to assess the effects of recommendations to follow the DASH diet v. usual dietary advice (UDA) on the MetS and its features ...
Mariño Rodrigo J - - 2013
AIM: This paper presents an economic evaluation, from a societal viewpoint, comparing a community-based oral health promotion program aimed at improving the gingival health of immigrant older adults, with one-on-one chairside oral hygiene instructions at a public dental clinic in Melbourne, Australia. METHODS: The costs associated with implementing and operating ...
Obrero Angeles - - 2013
The control of gene expression is a crucial regulatory mechanism in carotenoid accumulation of fruits and flowers. We investigated the role of transcriptional regulation of nine genes involved in the carotenoid biosynthesis pathway in three varieties of Cucurbita pepo with evident differences in fruit color. The transcriptional levels of the ...
Berneburg M - - 2013
Plaque psoriasis is an inflammatory disease affecting approximately two percent of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (PUVA) is one of the most effective therapies of psoriasis. The photosensitizer 8 methoxypsoralen (8-MOP) can be applied either orally (system PUVA) or ...
Thompson Genevieve N - - 2013
Objectives: A challenge in understanding the needs of dementia family caregivers (DFC) within the purview of dementia as a terminal illness rests on the fact that literature in this area is dispersed across disciplines and not specifically grounded within the realm of palliative care. The objective of this paper is ...
Bassiouny Yasmin Ahmed - - 2013
Abstract Objective: To compare the incidence of congenital anomalies by ultrasound in intracytoplasmic sperm injection (ICSI) pregnancies and in spontaneous pregnancies with correlation to the neonatal outcome. Methods: This is a prospective comparative study carried out in Kasr Al Aini hospital Cairo University from January 2010 to December 2012 comparing ...
Hang Li-Hua - - 2013
In this study, we aimed to investigate the role of spinal CC chemokine ligand 5 (CCL5) in the development of bone cancer pain (BCP). A BCP model was established by inoculation of Walker 256 cells into the intramedullary space of rat tibia. The levels of spinal CCL5 mRNA and protein ...
Hudson David M - - 2013
Abstract Prolyl 3-hydroxylation is a rare but conserved post-translational modification in many collagen types and, when defective, may be linked to a number of human diseases with musculoskeletal and potentially ocular and renal pathologies. Prolyl 3-hydroxylase-1 (P3H1), the enzyme responsible for converting proline to 3-hydroxyproline (3Hyp) in type I collagen, ...
Zupanič Franc - - 2013
This work studied the phases in the Al corner of the Al-Mn-Be phase diagram in the as-cast state and heat-treated conditions. Metallographic investigations, X-ray diffraction, scanning electron microscopy, and energy-dispersive spectroscopy were used for identifying the phases. The Be contents in the identified phases were precisely determined using Auger electron ...
Yoong Corinne - - 2013
Metastatic Crohn's disease (MCD) is a rare, non-contiguous cutaneous manifestation of Crohn's disease. To date, there have been only four reports in the literature of an effective treatment of this condition with infliximab and there are no long-term follow-up studies on adult MCD patients treated with infliximab. We present a ...
Greiner Chieko - - 2013
In Japan, where older people already make up more than 23% of the population and the proportion is still growing, the burden on those caring for people with dementia is an increasing problem. This burden is magnified by wandering behavior, a peripheral symptom. Thus, there is a need for an ...
Kanba Shigenobu - - 2013
The Japanese Society of Mood Disorders established a committee for treatment guidelines of mood disorders, which created the first edition of a treatment guideline for bipolar disorders on 10 March 2011. The committee has now created a second edition, which we report here. In creating this treatment guideline, the first ...
Darji Ketur - - 2013
The fruit of Maclura pomifera tree is a sustainable source for the pharmacologically interesting isoflavones, osajin and pomiferin. A reversed-phase HPLC method was developed to identify osage orange samples with high isoflavone content and to determine the optimum conditions for sample preparation. Analytical run time was 8 min at a ...
Fajín José L C - - 2013
The adsorption of cysteine onto the intrinsically chiral gold surface, Au(321)R,S, was investigated by means of a periodic supercell density functional theory approach. The results are compared with those obtained at the same level of theory with a non-chiral surface having the same terrace orientation, the Au(111) surface. Neutral and ...
Chen Tai-Heng - - 2013
OBJECTIVES: The present study aims to evaluate the efficacy and complications of combined noninvasive ventilation (NIV) and assisted coughing by mechanical in-exsufflator (MIE) for acute respiratory failure (ARF) in children with neuromuscular disease (NMD). METHODS: A prospective study was conducted in the pediatric intensive care unit. Children with NMD and ...
Brown Authors Justin E - - 2013
Recent developments have seen the expansion of the system of radiological protection for humans to one including protection of the environment against detrimental effects of radiation exposure although a fully developed framework for integration of human and ecological risk assessment for radionuclides is only at an early stage. In the ...
Eising Jacobien B - - 2013
RATIONALE: Wheezing is a very common symptom in preschool children. Nocturnal wheezing is present in many asthmatic patients, due to enhanced airflow limitation overnight. We assessed the prevalence of nocturnal wheezing in young children and correlated this with respiratory system resistance and history of wheezing symptoms. METHODS: Using a continuous ...
McNally Richard J Q - - 2013
Previously we identified space-time clustering in certain childhood cancers. The present study aimed to determine whether there was cross-space-time clustering between different diagnostic groups. A total of 32,295 cases were diagnosed during 1969-1993. Cross-space-time clustering was analysed by a second-order procedure based on Diggle's method. Locations were birth and diagnosis ...
Gaboli Mirella - - 2013
OBJECTIVE: To achieve a consensus of opinion among an expert group of pediatric pulmonologists regarding the appropriateness of the off-label use of palivizumab for some pediatric patients with severe respiratory diseases. METHODS: A two-round modified Delphi technique was used. A 43-item self-administered questionnaire grouped into seven clinical scenarios was developed. ...
Sun Ke - - 2013
3D interdigitated microbattery architectures (3D-IMA) are fabricated by printing concentrated lithium oxide-based inks. The microbatteries are composed of interdigitated, high-aspect ratio cathode and anode structures. Our 3D-IMA, which exhibit high areal energy and power densities, may find potential application in autonomously powered microdevices.
Sherafat-Kazemzadeh R - - 2013
BACKGROUND: The importance of hyperphagia as a cause for energy imbalance in humans with Bardet-Biedl syndrome (BBS) has not been established. We therefore compared hyperphagic symptoms in patients with BBS vs. controls. METHODS: : We studied 13 patients with BBS and 23 non-syndromic controls with similar age, sex and body mass ...
Gifford A H - - 2013
INTRODUCTION: Cystic fibrosis (CF) is characterized by low circulating levels of insulin-like growth factor-1 (IGF-1), a hormone produced by the liver that governs anabolism and influences immune cell function. Because treatment of CF pulmonary exacerbation (CFPE) often improves body weight and lung function, we questioned whether serum IGF-1 trends were ...
Avdievich Nikolai I - - 2013
Transceiver surface coil arrays improve transmit performance (B1 /√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging, the number of array elements must be increased with a corresponding decrease in their size. With a large number of small interacting antennas, decoupling ...
McCarthy H D - - 2013
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Skeletal muscle is considered a major site of insulin-mediated glucose disposal and is thus a key tissue in whole-body glucose homeostasis. Low muscle mass and fitness is associated with metabolic risk and muscular strength is positively related to higher insulin sensitivity in children ...
Xie R F - - 2013
OBJECTIVES: The aim of this study is to establish an available animal model which can evaluate in vivo viability of stored human platelets (HuPLTs). BACKGROUND: The viability in vivo of HuPLTs was usually evaluated by transfusing HuPLTs into animals before clinical trials. It is necessary to develop a method which ...
Orsey Andrea D - - 2013
BACKGROUND: Although sleep and physical activity often are impaired among adult cancer patients, there is limited data among pediatric oncology populations. We conducted a prospective study to investigate the relationship between physical activity (PA) and sleep among children with cancer. PROCEDURE: Between 11/12/09 and 02/06/12, PA while awake and sleep ...
Varun B R - - 2013
AIM: Oral squamous cell carcinoma (OSCC) may be preceded by potentially malignant disorders such as leukoplakia and oral submucous fibrosis (OSF). p63 in concert with p53 regulates cell proliferation and differentiation and may have a role in potentially malignant and malignant lesions of the oral cavity. The aim of the ...
Pérez-Mayoral Julyann - - 2013
Studies have shown that DNA repair capacity (DRC) is significantly decreased in breast cancer patients, but the molecular causes of inter-individual variation in DRC are unknown. We hypothesized that genetic variation in the nucleotide excision repair pathway genes can modulate DRC and breast cancer risk in Puerto Rican women. A ...
Ren Jian Jun - - 2013
The filamentous fungus Botrytis cinerea is an important agricultural pathogen affecting a wide range of cultivated plants. Since World War II, chemical fungicides have been the go-to method for agricultural pathogen control. However, the potential adverse environmental and health effects of these chemicals have led to an increasing demand for ...
Vuk T - - 2013
OBJECTIVES: Quality control results on leukoreduced buffy-coat platelet pools during the 7-year period (2005-2011) are presented with the aim to assess their overall quality and trends recorded during the study period. METHODS: Data of the Quality Assurance Department, Croatian Institute of Transfusion Medicine were used in the study. Measurement results ...
Seco-Rovira V - - 2013
Lectins have been widely used to study the pattern of cellular glycoconjugates in numerous species. In the process of cellular apoptosis, it has been observed that changes occur in the membrane sugar sequences of these apoptotic cells. The aim of our work was to identify which lectins, out of an ...
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