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Siyad M A - - 2013
The present paper describes the synthesis, characterization and assessment of a novel class of insoluble polymeric polystyrene supports which combines polar poly(ethylene glycol)dimethacrylate as a cross-linker and poly(ethylene glycol) grafted poly(N,N-bisethylamine) as a dendritic template. Poly(N,N-bisethylamine) dendrimers were generated by a series of reactions such as Schiff base integration, acidolysis, ...
Huo Xing-Xing - - 2013
As one of food-borne parasitic diseases, toxoplasmosis entails the risk of developing reactivation in immunocompromised patients. The synthetic dipeptide pidotimod is a potent immunostimulating agent that improves the immunodefenses in immunodepression. To investigate the efficacy of pidotimod as a preventive treatment, we used a murine model of reactivated toxoplasmosis with ...
Betti R - - 2013
BACKGROUND: Poromas are benign adnexal tumours generally believed to be of eccrine origin, which usually develop on palmoplantar sites. However, it is thought that a percentage of poromas develop on non-palmoplantar or 'unusual' sites. AIM: To review cases of poromas with reference to their clinicoepidemiological characteristics, paying particular attention to ...
Li Min - - 2013
An improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry (2D LC-QToF MS) system was developed for the lipid profiling of human plasma, in which different lipid classes were separated by the first dimensional normal-phase (NP) LC and different lipid molecular species were separated by the second dimensional reversed-phase (RP) LC. ...
Beloglazova N V - - 2013
A quantitative fluorescence-labeled immunosorbent assay and qualitative on-site column tests were developed for the determination of aflatoxin M1 in milk products. The use of liposomes loaded with quantum dots as a label significantly increased the assay sensitivity by encapsulating multiple quantum dots in a single liposome and, therefore, amplifying the ...
Cuers Julia - - 2013
Three hydroxypropyl methylcellulose samples (HPMC1-3, DSMe = 1.45, 1.29, and 1.36; MSHP = 0.28, 0.46, and 0.84) were analyzed with respect to their methyl and hydroxypropyl substitution pattern in the polymer chains. Ionization yield of HPMC oligomers in electrospray ionization ion trap mass spectrometry (ESI-IT-MS) is strongly influenced by the hydroxypropyl pattern. Therefore, a ...
Mayhew Caitlin E - - 2013
Early recognition of pulmonary vein stenosis (PVS) is crucial for optimizing clinical outcomes. Our goal was to characterize radiographic patterns specific to pediatric patients with PVS to facilitate early detection. PATIENTS AND METHODS: Pediatric patients with multivessel (≥2) intraluminal PVS were identified from a single-center registry. Initial chest radiographs were ...
Zhan Jie - - 2013
In this work, molecularly imprinted polymer (MIP) particles were synthesized using a semicovalent method based on a specific thermally reversible bond, and these particles were used for the rapid detection of the azo dye acid orange II. The imprinted polymers-which were prepared via the covalent reaction of 3-(triethoxysilyl)propyl isocyanate with ...
Suh Jung Hee - - 2013
The glomerular basement membrane (GBM) is the central, non-cellular layer of the glomerular filtration barrier that is situated between the two cellular components-fenestrated endothelial cells and interdigitated podocyte foot processes. The GBM is composed primarily of four types of extracellular matrix macromolecule-laminin-521, type IV collagen α3α4α5, the heparan sulphate proteoglycan ...
Hwang Yongyun - - 2013
Organelles such as endosomes and the Golgi apparatus play a critical role in regulating signal transmission to the nucleus. Recent experiments have shown that appropriate positioning of these organelles within the intracellular space is critical for effective signal regulation. To understand the mechanism behind this observation, we consider a reaction-diffusion ...
Shen Xiao-Min - - 2013
A series of novel silicon(iv) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC50 value as low as 6 nM, which can ...
Gao Mingming - - 2013
High-fat diet (HFD) induced obesity is associated with low-grade inflammation, insulin resistance (IR), and glucose intolerance. The objective of this study is to assess the effect of interleukin 10 (IL10), an anti-inflammatory cytokine, on blocking HFD-induced obesity and obesity-associated metabolic disorders by hydrodynamic delivery of IL10-containing plasmid. Animals fed a ...
Neumann William L - - 2013
Autoimmune gastritis is a chronic progressive inflammatory condition that results in the replacement of the parietal cell mass by atrophic and metaplastic mucosa. A complex interaction of autoantibodies against the parietal cell proton pump and sensitized T cells progressively destroy the parietal cells, inducing hypochlorhydria and then achlorhydria, while autoantibodies ...
Zhang Xiao-Ping - - 2013
The first luminescent Bi-Cd-organic framework, Bi2Cd(2,6-pdc)4(H2O)2·H2O (2,6-H2pdc = pyridine-2,6-dicarboxylate), has been synthesized by using bismuth (Bi) oxides and cadmium (Cd) salts as metal sources under hydrothermal conditions. Tunable and white light luminescence was obtained through the doping of different Ln(3+) ions into the Bi-Cd-organic framework.
Schmid Gernot - - 2013
Based on numerical computations using commercially available finite difference time domain code and a state-of-the art anatomical model of a 5-year old child, the influence of skin conductivity on the induced electric field strength inside the tissue for homogeneous front-to-back magnetic field exposure and homogeneous vertical electric field exposure was ...
Di Martino A - - 2013
Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we ...
Lee S G - - 2013
A worldwide depletion of the ozone layer has been observed over the past decade(1,2) . This concern was heightened when evidence emerged that ozone losses (albeit smaller than over Antarctica) were also taking place in the Arctic and over heavily populated mid-latitudes in both the northern and southern hemispheres. Ultraviolet ...
Coulibaly G - - 2013
Introduction. Meeting treatment targets for dialysis is a seemingly impossible challenge for most countries of sub-Saharan Africa. To assess this problem, we conducted this study of mineral and bone disorders in subjects undergoing hemodialysis at the Ouagadougou hemodialysis unit, the only such unit in Burkina Faso. Patients and methods. This ...
Makrutzki G - - 2013
Several methods for the detection of Trichinella in meat are legally prescribed in regulation (EC) No 2075/2005, which prescribes the magnetic stirrer method for pooled sample digestion (MSM) as the reference method. However, the MSM's multistage protocol requires several preparatory steps that seem to be accountable for the loss of ...
Agnusdei V - - 2013
T acute lymphoblastic leukemia (T-ALL) is characterized by several genetic alterations and poor prognosis in about 20-25% of patients. Notably, about 60% of T-ALL shows increased Notch1 activity, due to activating NOTCH1 mutations, or alterations in the FBW7 gene, which confer to the cell a strong growth advantage. Therapeutic targeting ...
van de Hoef Tim P - - 2013
Aims: Large intracoronary thrombus in patients with acute coronary syndromes remains a challenge in percutaneous coronary intervention, despite technical advances of manual aspiration catheters and mechanical thrombectomy devices. The Trevo® Pro 4 is a novel self-expanding mechanical thrombus retrieval device, designed for removal of occlusive thrombi in the setting of ...
Raju Jincy - - 2013
Abstract Dental X-ray has played an important role in identification of missing or unidentified persons. Particularly in cases where other identification clues like fingerprint, iris, etc. are not available and, moreover, dental features remain more or less invariant over time. The purpose of dental image processing is to match the ...
Sun Yifeng - - 2013
Purpose: Five-year survival rates were widely dispersed in pN2 non-small cell lung cancer (NSCLC). The present study aims to investigate the prognosis of patients with lymph node metastasis beyond lobe-specific mediastinal regions. Methods: A total of 654 pathologically proved N2-NSCLC patients were enrolled. All patients underwent a major pulmonary resection ...
Fujita Kishu - - 2013
A 74-year-old woman presented with progressive dyspnea on exertion. Transthoracic echocardiography (TTE) demonstrated significant left ventricular outflow tract (LVOT) obstruction with a pressure gradient of 100 mmHg caused by a sigmoid septum (SS). Mitral regurgitation (MR) of a mild to moderate degree occurred due to systolic anterior motion (SAM) of ...
Ichimura Hideo - - 2013
Left upper lobectomy may be followed by complications such as thrombus formation in a stump of the left superior pulmonary vein (LSPV), which may cause systemic embolization. We have encountered four such cases, which account for 3.4% of all left upper lobectomies performed at our institution. Right renal infarction was ...
Inoue Takahiro - - 2013
Persistent fifth aortic arch (PFAA) associated with interruption of the fourth aortic arch is a rare malformation, usually requiring surgical intervention in childhood. A 51-year-old woman developed a distal aortic arch aneurysm associated with PFAA after patch aortoplasty for coarctation of the aorta at the age of 18. To our ...
Yasuda Shota - - 2013
We describe our experience with stent-graft placement in a patient with a clinically diagnosed syphilitic aortic aneurysm.The patient was a 43-year-old man with syphilitic and human immunodeficiency virus (HIV) co-infection. Computed tomography (CT) revealed an aortic aneurysm with 89 mm in maximum size which was located at distal aortic arch ...
Silva Joana D - - 2013
Aims: Percutaneous coronary intervention (PCI) of bifurcation lesions is complex and is technically very demanding. Coronary angiography is considered the gold standard method to guide PCI but has several limitations. The purpose of this study is to determine the utility of stent enhancement with StentBoost® (StB), a novel fluoroscopic imaging ...
Meyer K M - - 2013
A 41-year-old man presented at our clinic with several bluish to purple nodular plaques (measuring 2 to 3 cm in diameter) on the upper chest (Fig. 1a; arrows) and the back. The lesions had existed for approximately 8 years without causing any symptoms. Three years ago, disseminated brown-reddish macules had ...
Plat Jogchum - - 2013
Oxysterols (oxidised cholesterol) may play a role in the pathogenesis of CVD. Similar to cholesterol, plant sterols are susceptible to oxidation. However, less is known about the potential atherogenicity of oxidised plant sterols (oxyphytosterols). In the present study, the atherogenicity of a mixture of oxyphytosterols was examined by feeding female ...
Böhm Michael - - 2013
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Renal sympathetic denervation is a novel therapeutic technique for the treatment of patients with resistant hypertension. Clinical trials of renal sympathetic denervation have shown significant reductions in blood pressure ...
Gokhale Sg - - 2013
Abstract Objective: To determine transfusion compatibility of maternal RBCs for her neonate upto 4 weeks of age, irrespective of maternal- neonatal ABO mismatch Methods: This was a prospective observational study involving eligible mothers with their neonates delivered in participating site from July 1, 2012 till December31, 2012. Mother's blood was ...
Perreault Melissa L - - 2013
The pharmacological modification of dopamine transmission has long been employed as a therapeutic tool in the treatment of many mental health disorders. However, as many of the pharmacotherapies today are not without significant side effects, or they alleviate only a particular subset of symptoms, the identification of novel therapeutic targets ...
Jelovac Ana - - 2013
High rates of early relapse following electroconvulsive therapy (ECT) are typically reported in the literature. Current treatment guidelines offer little information to clinicians on the optimal nature of maintenance therapy following ECT. The aim of this study was to provide a systematic overview of the existing evidence regarding post ECT ...
Kaufman Kenneth R - - 2013
Stigma towards epilepsy results in barriers to social integration, education, employment, and marriage, with increased divorce rates. There is a societal need to realise that many persons with epilepsy (PWE) lead normal lives and can be highly educated with effective employment. Integration of PWE into sports is therapeutic both for ...
Sumida Kosuke - - 2013
There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they ...
Kutty A - - 2013
Eccrine porocarcinoma (EPC) was first described in 1963 by Pinkus and Mehregan, where it was referred to as 'epidermotropic eccrine carcinoma' (1) . EPC is a rare malignant tumour that develops from the intraepidermal portion of the eccrine gland. It can either arise secondary to the malignant transformation of a ...
Zhou Tingting - - 2013
Accumulated evidence indicates that phase separation occurs in potassium intercalated iron selenides, a superconducting phase coexisting with the antiferromagnetic phase K2Fe4Se5, the so-called '245 phase'. Here, we report a comparative study of substitution effects by Co and Mn for Fe sites in K0.8Fe2-ySe2 within the phase separation scenario. Our results ...
Pogliani Laura - - 2013
Abstract Background: Following the "back to sleep" recommendations, a striking rise in deformational plagiocephaly (DP) occurred. However additional maternal, pregnancy and infant conditions may play a role. Objectives: We aimed to evaluate the prevalence of and risk factors for DP at birth. Additionally, given the association between assisted reproductive technologies ...
Santos Rosana G C - - 2013
Glutamine may be a precursor for NO synthesis, which may play a crucial role in bacterial translocation (BT). The goal of the present study was to investigate the potential effects of glutamine on BT and the immunological response in an experimental model of NO synthase inhibition by NG-nitro-L-arginine methyl ester ...
Ikemura Kenji - - 2013
  The renal tubular secretion of cationic drugs is dominated by basolateral organic cation transporter 2 (rOCT2/SLC22A2) and luminal multidrug and toxin extrusion 1 (rMATE1/SLC47A1). Little is known about the variation in the expression of these renal transporters after liver ischemia-reperfusion (I/R) injury. Here, we examined the pharmacokinetics of cationic drug, ...
Kottner J - - 2013
Aging is associated with structural and functional changes of the skin that result in increased vulnerability. The aim of this systematic review is to synthesize empirical evidence about efficacy and effectiveness of basic skin care interventions to maintain skin integrity in the aged. The databases MEDLINE, EMBASE, CINAHL (1990 to ...
D'Angelo Fabrizia - - 2013
Macrophages play a critical role in intestinal wound repair. However, the mechanisms of macrophage-assisted wound repair remain poorly understood. We aimed to better characterize the repair activities of murine and human macrophages. Murine macrophages were differentiated from bone marrow cells and human macrophages from monocytes isolated from peripheral blood mononuclear ...
Fani L - - 2013
Obesity is one of the greatest public health challenges of the 21st century. Obesity is currently responsible for ∼0.7-2.8% of a country's health costs worldwide. Treatment is often not effective because weight regulation is complex. Appetite and energy control are regulated in the brain. Melanocortin-4 receptor (MC4R) has a central ...
Naldi L - - 2013
MADAM, we read with interest the paper from the European Multicentre Photopatch Test Study (EMCPPTS) Taskforce in the May issue of the Journal [1]. The study analyzed the results of Photopatch testing (PPT) on patients referred for suspected Photocontact dermatitis (PACD) to selected reference centres in Europe. The PPT series ...
de la Ossa Dolores Hernán Pérez - - 2013
Abstract Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer, AIDS and multiple sclerosis), analgesics, and in the treatment of multiple sclerosis and cancer, among other conditions. However, despite their high clinical potential, only few dosage forms are available to date. In this paper, the ...
Deiner Kristy - - 2013
The first step in many community ecology studies is to produce a species list from a sample of individuals. Community ecologists now have two viable ways of producing a species list: morphological and barcode identification. In this study, we compared the taxonomic resolution gained by a combined use of both ...
Toh Her Shuang - - 2013
Cystic fibrosis is a common disease which has an associated characteristic symptom of high sweat chloride content. Thus, chloride ion quantification in sweat is important towards the screening of cystic fibrosis. Electrochemical methods, being cost effective and convenient, can be exploited for this. The electrochemical oxidation of silver nanoparticles in ...
Dwivedi M - - 2013
BACKGROUND: NALP1 has been suggested to be involved in a wide-range of susceptibility to autoimmune diseases including generalized vitiligo (GV). Genetic polymorphisms in NALP1 have been previously shown to be associated with GV and speculated to be involved in the regulation of its expression. OBJECTIVES: The present study explores NALP1 ...
Shai Daniel - - 2013
Abstract Objective: To evaluate pregnancy outcome and rates of anemia in patients following bariatric operation in comparison with obese pregnant women. Methods: A retrospective population-based study comparing pregnancy outcome of patients following bariatric with the obese population, was conducted. Multivariate logistic regression models were constructed to control for confounders. In ...
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