Search Results
Results 401 - 450 of 2614
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Walther Thomas - - 2013
In Saccharomyces cerevisiae, synthesis of trehalose-6-phosphate (T6P) is essential for growth on most fermentable carbon sources. The metabolic response to glucose was analysed in mutants with different capacity to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, TPS1, which had no measurable T6P exhibited impaired ...
Fabbrocini Gabriella - - 2013
Abstract Background: Treatment of Seborrheic Dermatitis (SD) includes various options with different success and safety limitations. Objective: To evaluate the efficacy of topical nicotinamide (NCT) in the treatment of SD. Methods: A total of 48 patients with mild to moderate SD of the face were enrolled in the study (36 ...
Bang Soohyun - - 2013
BACKGROUND: Gromwell is known to have diverse pharmacological, cosmetic, and nutritional benefits for humans. Nevertheless, the biological influence of Gromwell extract (GE) on the general physiology of eukaryotic cells remains unknown. In this study, we performed a global transcriptome analysis to identify genes affected by the addition of GE with ...
Chen Qiang - - 2013
A new type of physically linked double-network hydrogel is synthesized by a simple, time-saving, facile, easily controlled, one-pot method. The resulting agar/polyacrylamide double-network hydrogels exhibit good mechanical properties, excellent recoverability, and a unique free-shapeable property, which makes them very promising hydrogels for load-bearing soft tissues.
Gallo Michele - - 2013
Tissue engineering of heart valves investigates the possibility to create a fully compatible and biomimetic graft able to provide host cell repopulation like the native living valve. Decellularized aortic and pulmonary valves and synthetic polymers have been used to promote the creation of a native-like scaffold suitable to be colonized ...
Ribeiro Juliane - - 2013
The aim of this study was to evaluate the frequency of Aichivirus C infection in the three major industrial pig-producing regions of Brazil. This retrospective study evaluated 63 faecal samples that were collected between 2004 and 2011 from suckling piglets (1 to 3 weeks old) belonging to 46 pig herds located ...
Schüler Herwig - - 2013
ADP-ribosylation of proteins is emerging as a very versatile post-translational modification in various signaling pathways. Poly(ADP-ribosyl)ation, with the massive charge accumulation that it confers, can break up chromatin structure by interfering with protein-DNA interactions, and alter the surface properties of substrate proteins. Mono-ADP-ribosylation can alter the chemistry of specific protein ...
Rief Peter - - 2013
We report a case of a foreign body embolism caused by a tip of an explanted port-a-cath system. The embolus could be removed with a gooseneck snare catheter, the patient fully recovered.
Neyt Mattias - - 2013
Objectives: Mechanical circulatory support through left ventricular assist devices (LVADs) improves survival and quality of life for patients with end-stage heart failure who are ineligible for cardiac transplantation. Our aim was to calculate the cost-effectiveness of continuous-flow LVADs. Methods: A cost-utility analysis from a societal perspective was performed. A lifetime ...
Peng Z - - 2013
It is recognized now that intrinsically disordered proteins (IDPs), which do not have unique 3D structures as a whole or in noticeable parts, constitute a significant fraction of any given proteome. IDPs are characterized by an astonishing structural and functional diversity that defines their ability to be universal regulators of ...
Elfarra Hamdi - - 2013
A case of pacemaker electrode infection with Staphylococcus aureus is presented. In order to avoid sternotomy, the right ventricular pacemaker lead, which had been implanted for 15 years, was successfully extracted using a laser sheath despite large endocarditic vegetations on the pacemaker lead. After completion of a 6-week course of antibiotics, ...
Takayama Yohei - - 2013
A total synthesis of ammosamide B (), a member of the pyrroloquinoline alkaloid family isolated from marine Streptomyces, is described. The characteristic core tricyclic structure of was constructed using a novel, tandem Friedel-Crafts reaction sequence to transform the symmetric tetra-amino substituted benzene derivative into the tricyclic pyrroloquinoline product , which ...
Bao Wenna - - 2013
cis-Epoxysuccinate hydrolase (CESH) from Bordetella sp. BK-52, an epoxide hydrolase (EH), catalyzes the stereospecific hydrolysis of cis-epoxysuccinate to D(-)-tartrate. The enzyme, which shows no homology to other reported EHs, belongs to the DUF849 superfamily of prokaryotic proteins, which have unknown function. Metal composition analysis revealed that the CESH is a ...
Lian Xiao-Feng - - 2013
OBJECTIVE: We prospectively compared surgical reduction or fusion in situ with posterior lumbar interbody fusion (PLIF) for adult isthmic spondylolisthesis in terms of surgical invasiveness, clinical and radiographical outcomes, and complications. METHODS: From January 2006 to June 2008, 88 adult patients with isthmic spondylolisthesis who underwent surgical treatment in our ...
Daguano Juliana K M F - - 2013
The mechanical strength of bioactive glasses can be improved by controlled crystallization, turning its use as bulk bone implants viable. However, crystallization may affect the bioactivity of the material. The aim of this study was to develop glass-ceramics of the nominal composition (wt%) 52.75(3CaO·P2O5)-30SiO2-17.25MgO, with different crystallized fractions and to ...
Sun Chia-Liang - - 2013
The atomistic nucleation sites of Pt nanoparticles (Pt NPs) on N-doped carbon nanotubes (N-CNTs) were investigated using C and N K-edge and Pt L3-edge X-ray absorption near-edge structure (XANES)/extended X-ray absorption fine structure (EXAFS) spectroscopy. Transmission electron microscopy and XANES/EXAFS results revealed that the self-organized Pt NPs on N-CNTs are ...
Appleton Darryn L - - 2013
Transradial percutaneous coronary intervention is associated with significant reductions in access site complications and major bleeding as compared with the transfemoral approach. Bivalirudin is now the most commonly used anticoagulant for transradial percutaneous coronary intervention in the U.S., while weight adjusted unfractionated heparin remains the most common choice outside the ...
Sakamaki I - - 2013
Immunomodulatory drugs (IMiDs) are effective therapeutic agents with direct inhibitory effects on malignant B- and plasma cells and immunomodulatory effects on the T cell activation. This dual function of IMiDs makes them appealing candidates for combination with a cancer vaccine. We investigated the immune stimulatory effects of lenalidomide, administrated to ...
Muruganandan Shanmugam - - 2013
Bone is a dynamic tissue that is continuously remodelled through the action of formative osteoblasts and resorptive osteoclasts. Chemerin is a secreted protein that activates chemokine-like receptor 1 (CMKLR1), a G protein-coupled receptor expressed by various cell types including adipocytes, osteoblasts, mesenchymal stem cells, and macrophages. Previously, we identified chemerin ...
Li Xin-Hao - - 2013
Porous carbons and porous carbon nitrides are well known support materials. Some of these materials are, however, not only a geometric construct for immobilization, enabling mass transport at the same time, but contribute due to their extended electronic structure to a potential catalytic event as such. When appropriate band schemes ...
Salvatoni Alessandro - - 2013
BACKGROUND: At the clinical onset of type 1 diabetes mellitus (T1D), enterovirus (EV) infections are suspected to play a role. EVs in blood are seen as a possible biomarker of T1D. EV infections may occur in temporal and geographic clusters and may spread within families. OBJECTIVE: We checked whether EVs ...
Tang Ya-Juan - - 2013
Despite being widely accepted as an important cause of spontaneous intracranial hemorrhage (ICH), cerebral amyloid angiopathy (CAA) has seldom been studied in the Chinese population. The current study aims to investigate the incidence and features of CAA in surgically treated ICH patients in China. From May 2006 to April 2011, ...
Gerber Nicolas - - 2013
PURPOSE : For the facilitation of minimally invasive robotically performed direct cochlea access (DCA) procedure, a surgical planning tool which enables the surgeon to define landmarks for patient-to-image registration, identify the necessary anatomical structures and define a safe DCA trajectory using patient image data (typically computed tomography (CT) or cone ...
Tafreshi Narges K - - 2013
The melanocortin 1 receptor (MC1R) is overexpressed in most melanoma metastases, making it a promising target for imaging of melanomas. In this study, the expression of MC1R in a large fraction of patients with melanoma was confirmed using mRNA and tissue microarray. Here, we have characterized the in vivo tumor ...
Hanson Erik A - - 2013
OBJECTIVE: Multispectral, multichannel, or time series image segmentation is important for image analysis in a wide range of applications. Regularization of the segmentation is commonly performed using local image information causing the segmented image to be locally smooth or piecewise constant. A new spatial regularization method, incorporating non-local information, was ...
Shin Byeongkil - - 2013
The TiO2-system powders were investigated with respect to the crystallinity and the microstructure. The biocidal activity increased from TiO2 to binary MnOx-TiO2 to ternary MnOx-WO3-TiO2 against Vibrio fischeri as a model of Gram-negative bacteria. Anatase and rutile TiO2 were not toxic even at 200 mg/L, but anatase has been observed in ...
Pickard Amelia - - 2013
Myotonic dystrophy type 1 (MD1) is the commonest muscular dystrophy found in adults; however, it may present in the neonatal period with hypotonia, talipes, poor feeding, and respiratory failure. Inheritance is autosomal dominant with a defect in the DMPK gene found on the long arm of chromosome 19 with variable ...
Abdel-Gawad H - - 2013
Maize seeds obtained from (14)C-ethion treated plants contained about 0.01 % of the originally applied radioactivity 1 month following the last pesticide application. Hexane and methanol extracts of the seeds accounted for 35 % and 22.5 % of the radioactive residues, respectively, with 40 % remaining in the seed cake. Commercial processing procedures resulted in ...
Bradbury Sarah - - 2013
The current study aimed to elucidate the role of pharmacokinetic (PK) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4-methylenedioxymethamphetamine (MDMA) self-administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of 1.0 mg/kg MDMA (iv) prior to, and following, the acquisition of ...
Okuyama Kazuaki - - 2013
Coronary artery occlusion during transcatheter aortic valve replacement is a rare complication. However, it is a very severe and life threatening event. Although there are some possible causes of this phenomenon, definite etiologies and predictors are unknown because of the small number. We describe one case of left main coronary ...
Kumar Naresh - - 2013
AIM: The aim of the present study was to evaluate the bi-axial flexural strength of experimental unfilled resins and resin-based composites at varying deformation rates following 1-week dry, 1-week wet, and 13-week wet storage regimes. METHODS: A total of 270 disc-shaped specimens (12 mm diameter, 1 mm thickness) of either unfilled resins ...
de Graaff J C - - 2013
Intravenous cannulation can be difficult in children. Recently, new devices using near-infrared light to make blood vessels visible have become available. We aimed to evaluate the effectiveness of three such devices in facilitating peripheral intravenous cannulation in children. In this cluster randomised clinical trial, daily operating rooms at a tertiary ...
He Jing Yu - - 2013
Codonopsis Radix has been prescribed as the roots of Codonopsis pilosula, C. pilosula var. modesta and C. tangshen in Chinese Pharmacopoeia. In order to find out genetic markers for identifying the 3 taxa and to authenticate Codonopsis Radix, the molecular analysis of the internal transcribed spacer sequence of nuclear ribosomal ...
Treglia G - - 2013
Aim: To perform a meta-analysis of published data on the prevalence and risk of malignancy of focal thyroid incidental uptake (FTIs) detected by Fluorine-18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/CT. Methods: A comprehensive literature search of studies published up to and including December 2012 was performed. Pooled prevalence and ...
Wang Chao - - 2013
Left ventricular noncompaction (LVNC) is an uncommon genetic disorder of endocardial morphogenesis, which carries a high mortality from heart failure or sudden cardiac death. This condition is often first diagnosed in adults, but it has also been described in children with other cardiac anomalies. We discuss the management of a ...
Becker Petra M - - 2013
This paper gives an insight into key factors, which impair enzymatic protein digestion. By nature, some proteins in raw products are already poorly digestible because of structural peculiarities, or due to their occurrence in plant cytoplasmic organelles or in cell membranes. In plant-based protein, molecular and structural changes can be ...
Vizzardi Enrico - - 2013
Tako-Tsubo cardiomyopathy is a transient left ventricular apical ballooning syndrome also known as stress-induced cardiomyopathy. This reversible cardiomyopathy without epicardial coronary artery disease mimics acute myocardial infarction. Right ventricular involvement, which has been infrequently reported, is present in about a quarter of cases of Tako-Tsubo cardiomyopathy and is associated with ...
D'Souza Ursula M - - 2013
Lamotrigine, a mood stabilizer used clinically in the treatment of bipolar disorder, is thought to exert actions on the serotonin system. However lamotrigine's exact mechanism of action remains unclear. The current study investigated whether lamotrigine might exert its effects through altering the expression of the serotonin transporter (5-HTT) gene and ...
Arihara Fumitaka - - 2013
Myeloid-derived suppressor cells (MDSCs) are known as key immune regulators in various human malignancies, and it is reported that CD14(+)HLA-DR(-/low) MDSCs are increased in hepatocellular carcinoma (HCC) patients. However, the host factors that regulate the frequency and the effect on the prognosis of HCC patients are still unclear. We investigated ...
Murphy T W - - 2013
Lunar laser ranging has provided many of the best tests of gravitation since the first Apollo astronauts landed on the Moon. The march to higher precision continues to this day, now entering the millimeter regime, and promising continued improvement in scientific results. This review introduces key aspects of the technique, ...
Dressler Dirk - - 2013
Botulinum toxin is considered the treatment of choice for axillary hyperhidrosis. Its dosing, however, varies widely. We wanted to study differences in efficacy and adverse effects when Botox(®) 100 MU (B100) or Botox(®) 50 MU (B50) per axilla is applied. In a prospective double blind intraindividual side to side comparison design, we ...
King Alexander J - - 2013
Colorectal metastases to the liver are increasingly being detected and accurately characterized at an earlier stage and even at the subcentimeter level. The oncological case for surgical resection of this disease is widely accepted. The advent of smaller volume disease has encouraged the development of in situ ablative technologies over ...
Chandra-Mouli Venkatraman - - 2013
BACKGROUND: Adolescents in Tanzania require health services that respond to their sexual and reproductive health -- and other -- needs and are delivered in a friendly and nonjudgemental manner. Systematizing and expanding the reach of quality adolescent friendly health service provision is part of the Tanzanian Ministry of Health and ...
Ruths Troy - - 2013
BACKGROUND: Forward-time population genetic simulations play a central role in deriving and testing evolutionary hypotheses. Such simulations may be data-intensive, depending on the settings to the various parameters controlling them. In particular, for certain settings, the data footprint may quickly exceed the memory of a single compute node. RESULTS: We ...
Flowers Chris I - - 2013
The aim of this study is to evaluate Breast Imaging Reporting and Data Systems (BI-RADS) 4A/B subcategory risk estimates for ductal carcinoma in situ (DCIS) and invasive cancer (IC), determining whether changing the proposed cutoffs to a higher biopsy threshold could safely increase cancer-to-biopsy yields while minimizing false-positive biopsies. A ...
Petersen John W - - 2013
BACKGROUND: Standard measures of left ventricular systolic and diastolic function often fail to identify left ventricular dysfunction in patients with heart failure and do not correlate with measures of functional capacity.Aim: To determine if speckle tracking echocardiography (STE)--determined measures of global and regional myocardial contractility have a linear association with ...
Ren Yu - - 2013
Porous solids have an important role in addressing some of the major energy-related problems facing society. Here we describe a porous solid, α-MnO2, with a hierarchical tetramodal pore size distribution spanning the micro-, meso- and macro pore range, centred at 0.48, 4.0, 18 and 70 nm. The hierarchical tetramodal structure is ...
Alberici Luciane C - - 2013
BACKGROUND: We have previously demonstrated that increased rates of superoxide generation by extra-mitochondrial enzymes induce the activation of the mitochondrial ATP-sensitive potassium channel (mitoKATP) in the livers of hypertriglyceridemic (HTG) mice. The resulting mild uncoupling mediated by mitoKATP protects mitochondria against oxidative damage. In this study, we investigate whether immune ...
Rive Benoît - - 2013
The N-methyl-D-aspartate receptor antagonist, memantine, is licensed for the treatment of moderate to severe Alzheimer's disease (AD). Memantine is administered both as a monotherapy and as an add-on therapy in patients already receiving acetylcholinesterase inhibitors. Several meta-analyses have been published that examine the efficacy of memantine in the treatment of ...
Martín-López Alicia - - 2013
The cell growth and monoclonal antibody production of the 55-6 hybridoma cell co-cultured with the murine thymoma cell line EL-4 at different initial 55-6:EL-4 ratios were investigated. Both populations were seeded in co-culture without previous stimulation and therefore with low constitutive CD40 and CD40 ligand (CD154) expression levels, and in ...
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