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Results 251 - 300 of 2623
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Dressler Dirk - - 2013
Botulinum toxin is considered the treatment of choice for axillary hyperhidrosis. Its dosing, however, varies widely. We wanted to study differences in efficacy and adverse effects when Botox(®) 100 MU (B100) or Botox(®) 50 MU (B50) per axilla is applied. In a prospective double blind intraindividual side to side comparison design, we ...
Alexander M S MS Division of Genetics, Program in Genomics, Boston Children's Hospital, Boston, MA, - - 2013
In patients with Duchenne muscular dystrophy (DMD), the absence of a functional dystrophin protein results in sarcolemmal instability, abnormal calcium signaling, cardiomyopathy, and skeletal muscle degeneration. Using the dystrophin-deficient sapje zebrafish model, we have identified microRNAs (miRNAs) that, in comparison to our previous findings in human DMD muscle biopsies, are ...
Coradetti Samuel T - - 2013
Cellulose is recalcitrant to deconstruction to glucose for use in fermentation strategies for biofuels and chemicals derived from lignocellulose. In Neurospora crassa, the transcriptional regulator, CLR-2, is required for cellulolytic gene expression and cellulose deconstruction. To assess conservation and divergence of cellulase gene regulation between fungi from different ecological niches, ...
Antonangelo Ana Teresa B F - - 2013
Although many Brazilian sugar mills initiate the fermentation process by inoculating selected commercial Saccharomyces cerevisiae strains, the unsterile conditions of the industrial sugar cane ethanol fermentation process permit the constant entry of native yeast strains. Certain of those native strains are better adapted and tend to predominate over the initial ...
Lauridsen Carsten - - 2013
To compare computed tomographic colonography (CTC) performance of four trained radiographers with the CTC performance of two experienced radiologists. Four radiographers and two radiologists interpreted 87 cases with 40 polyps ≥6 mm. Sensitivity, specificity, and positive predictive value (PPV) were assessed on a per-patient basis. On a per-polyp basis, sensitivity was ...
Peton M - - 2013
In Reunion Island, the risk of emerging infectious diseases lies mainly in several viral zoonoses: West Nile fever, Sindbis virus, Nipah virus, Wesselsbron virus, Rift Valley fever and Japanese encephalitis. There morbidity and consequences are more or less important but they all have a non-negligible epidemic potential, so they have ...
Kusumanchi P - - 2013
Colorectal cancer cells exhibit limited cytotoxicity towards Tiazofurin, a pro-drug metabolized by cytosolic nicotinamide mononucleotide adenylyltransferase2 (NMNAT2) to thiazole-4-carboxamide adenine dinucleotide, a potent inhibitor of inosine 5'-monophosphate dehydrogenase required for cellular guanylate synthesis. We tested the hypothesis that colorectal cancer cells that exhibit low levels of NMNAT2 and are refractory ...
Palmour Nicole - - 2013
Consumer demand for health information and health services has rapidly evolved to capture and even propel the movement to online health information seeking. Seventeen percent (52 million) of health information internet users will look for information about memory loss, dementia and Alzheimer's disease (AD) (Fox Pew Internet & American life project: ...
Takayama Yohei - - 2013
A total synthesis of ammosamide B (), a member of the pyrroloquinoline alkaloid family isolated from marine Streptomyces, is described. The characteristic core tricyclic structure of was constructed using a novel, tandem Friedel-Crafts reaction sequence to transform the symmetric tetra-amino substituted benzene derivative into the tricyclic pyrroloquinoline product , which ...
Javer Avelino - - 2013
In bacteria, chromosomal architecture shows strong spatial and temporal organization, and regulates key cellular functions, such as transcription. Tracking the motion of chromosomal loci at short timescales provides information related to both the physical state of the nucleo-protein complex and its local environment, independent of large-scale motions related to genome ...
Niesterok C - - 2013
Objective: The aim of our study was to evaluate the value of projection radiography as a standard screening method for the detection of lung nodules compared to computed tomography (CT). Furthermore, we attempted to describe the reasons that might lead to a failed detection of pulmonary nodules in radiography. Materials ...
Sakamaki I - - 2013
Immunomodulatory drugs (IMiDs) are effective therapeutic agents with direct inhibitory effects on malignant B- and plasma cells and immunomodulatory effects on the T cell activation. This dual function of IMiDs makes them appealing candidates for combination with a cancer vaccine. We investigated the immune stimulatory effects of lenalidomide, administrated to ...
Petersen John W - - 2013
BACKGROUND: Standard measures of left ventricular systolic and diastolic function often fail to identify left ventricular dysfunction in patients with heart failure and do not correlate with measures of functional capacity.Aim: To determine if speckle tracking echocardiography (STE)--determined measures of global and regional myocardial contractility have a linear association with ...
Park Chul Hwan - - 2013
This study evaluates the clinical usefulness of T2 mapping for the detection of myocardial edema in the re-perfused acute myocardial infarction (MI). Cardiac MRIs were reviewed in 20 patients who had acute MI after reperfusion therapy. The regional T2 values and T2-weighted image (T2WI) signal intensities (SI) were measured in ...
Vicini Claudio - - 2013
BACKGROUND: Transoral robotic surgery (TORS) for obstructive sleep apnea-hypopnea syndrome is a relatively young technique principally devised for managing apneas in the tongue base (TB) area and supraglottic larynx. This procedure is included in the so-called "multilevel surgery" often including a palatal and nasal surgery. METHODS: We carried out a ...
Jivrajka R V RV Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, - - 2013
The purpose of this study was to measure macular sensitivity using microperimetry in patients on Plaquenil therapy without evidence of retinopathy as assessed by recommended screening standards. Sixteen patients from a clinical practice treated with 200 or 400 mg/day of Plaquenil for more than 5 years, without visual complaints (visual acuity ...
Sánchez-Gordo F - - 2013
Two novels alleles were A*01:128 and. HLA-C*05:88 characterized.
Murphy T W - - 2013
Lunar laser ranging has provided many of the best tests of gravitation since the first Apollo astronauts landed on the Moon. The march to higher precision continues to this day, now entering the millimeter regime, and promising continued improvement in scientific results. This review introduces key aspects of the technique, ...
Angeletti Chiara - - 2013
Low back pain is usually self-limited. The transition from acute to chronic LBP is influenced by physical and psychological factors. Identification of all contributing factors, in a mass emergency setting, differentiating primary and secondary life-threatening forms of LBP, is the best approach for success. Aims of the present report were ...
Jung Peter - - 2013
BACKGROUND: Nailfold capillaroscopy of fingers is an important tool for diagnosis and monitoring of collagen-vascular diseases. However, little is known about capillaroscopy of toes. PATIENTS AND METHODS: Capillaroscopy of the first and second toe was performed in 50 healthy volunteers and 67 patients with chronic venous insufficiency (n = 22), ...
Karimi Leila - - 2013
AIMS: To investigate the extent to which emotional labour and emotional intelligence are associated with well-being and job-stress among a group of Australian community nurses. The moderating role of emotional intelligence was evaluated as a key factor in the rescue of healthcare workers from job-stress, thus increasing job retention. BACKGROUND: ...
Ikeda Naoto - - 2013
AIM: In chronic liver disease associated with hepatitis C virus (HCV), a low platelet count is a major obstacle in carrying out interferon (IFN) treatment. We used a questionnaire to clarify the extent to which splenectomy/partial splenic embolization (PSE) is performed before IFN treatment, as well as the efficacy and ...
Ding Shiming - - 2013
We report a highly promising technique for the high-resolution imaging of labile phosphorus (P) in sediments and soils in combination with the diffusive gradients in thin films (DGT). This technique was based on the surface coloration of the Zr-oxide binding gel using the conventional molybdenum blue method following the DGT ...
George Michael - - 2013
BACKGROUND: Our objectives were to assess the evidence of preservation of the greater auricular nerve in parotidectomy with regard to morbidity and quality of life. METHODS: This was a systematic review. Inclusion criteria were: English literature, prospective and retrospective studies. Exclusion criteria were: single case reports, "teaching" reviews. Outcome measures ...
Wei Wei - - 2013
Iodine is essential for the biosynthesis of thyroid hormones, including triiodothyronine and thyroxine. Thyroid hormones are important for central nervous system development. Mild maternal iodine deficiency (ID)-induced hypothyroxinemia causes neurological deficits and mental retardation of fetus. However, the detailed mechanism underlying these deficits is still largely unknown. Given that the ...
Politano A - - 2013
High-resolution electron energy loss spectroscopy is used to study the electronic properties of thin Ag layers on Ni(111). In addition to the ordinary surface plasmon at 3.8 eV, we observe a broad feature at 7-8 eV, whose nature is investigated as a function of scattering geometry and primary electron beam energy. Loss ...
Schüler Herwig - - 2013
ADP-ribosylation of proteins is emerging as a very versatile post-translational modification in various signaling pathways. Poly(ADP-ribosyl)ation, with the massive charge accumulation that it confers, can break up chromatin structure by interfering with protein-DNA interactions, and alter the surface properties of substrate proteins. Mono-ADP-ribosylation can alter the chemistry of specific protein ...
Flowers Chris I - - 2013
The aim of this study is to evaluate Breast Imaging Reporting and Data Systems (BI-RADS) 4A/B subcategory risk estimates for ductal carcinoma in situ (DCIS) and invasive cancer (IC), determining whether changing the proposed cutoffs to a higher biopsy threshold could safely increase cancer-to-biopsy yields while minimizing false-positive biopsies. A ...
Arihara Fumitaka - - 2013
Myeloid-derived suppressor cells (MDSCs) are known as key immune regulators in various human malignancies, and it is reported that CD14(+)HLA-DR(-/low) MDSCs are increased in hepatocellular carcinoma (HCC) patients. However, the host factors that regulate the frequency and the effect on the prognosis of HCC patients are still unclear. We investigated ...
Francius Cédric - - 2013
Understanding how thousands of different neuronal types are generated in the CNS constitutes a major challenge for developmental neurobiologists and is a prerequisite before considering cell or gene therapies of nervous lesions or pathologies. During embryonic development, spinal motor neurons (MNs) segregate into distinct subpopulations that display specific characteristics and ...
Akar Servet - - 2013
We evaluated the relationship between the baseline sacroiliac joint (SIJ) magnetic resonance imaging (MRI) findings and the development of radiographic sacroiliitis and tested their prognostic significance in cases of ankylosing spondylitis. Patients who had undergone an SIJ MRI at the rheumatology department were identified. Individuals for whom pelvic X-rays were ...
Loiselle Andrea - - 2013
Iatrogenic pneumothorax has become an increasingly recognized complication of routine outpatient procedures, such as transthoracic needle biopsies of the lung and transbronchial lung biopsies. Patients with clinically significant pneumothorax are typically managed with evacuation via a percutaneously placed catheter or chest tube. Tube thoracotomy and chest tube management have traditionally ...
Bruma A - - 2013
In this study we report a direct, atomic-resolution imaging of calcined Au24Pd1 clusters supported on multiwall carbon nanotubes by employing aberration-corrected scanning transmission electron microscopy. Using gold atoms as mass standards, we confirm the cluster size to be 25 ± 2, in agreement with the Au24Pd1(SR)18 precursor used in the ...
Kamban Sólrún W - - 2013
AIMS AND OBJECTIVES: To measure the benefit of a short-family therapeutic conversation (STC) intervention in an acute paediatric unit. BACKGROUND: Studies of children with bronchiolitis caused by respiratory syncytial virus (RSV) have shown that this virus may have an impact on their respiratory system in the form of a wheezing ...
Neri Piergiorgio - - 2013
To report a case of overlapping choriocapillaritis that initially presented as multifocal choroiditis (MFC) but later showed features compatible with acute zonal occult outer retinopathy (AZOOR) resistant to standard immunosuppression that responded only to adalimumad therapy. A 41-year-old patient presented with multiple small, discrete yellow-whitish spots in both eyes, compatible ...
Wenger Seth J - - 2013
Forecasts of species distributions under future climates are inherently uncertain, but there have been few attempts to describe this uncertainty comprehensively in a probabilistic manner. We developed a Monte Carlo approach that accounts for uncertainty within generalized linear regression models (parameter uncertainty and residual error), uncertainty among competing models (model ...
Vizzardi Enrico - - 2013
Tako-Tsubo cardiomyopathy is a transient left ventricular apical ballooning syndrome also known as stress-induced cardiomyopathy. This reversible cardiomyopathy without epicardial coronary artery disease mimics acute myocardial infarction. Right ventricular involvement, which has been infrequently reported, is present in about a quarter of cases of Tako-Tsubo cardiomyopathy and is associated with ...
Saini S - - 2013
Earlier, we reported an association of A-kinase anchor protein 4 (AKAP4) expression in cervical cancer patient specimens, indicating its implications as an immunotherapeutic target. In this study, we investigated the possible role of AKAP4 in cervical carcinogenesis. AKAP4 messenger RNA and protein expression was assessed in four cervical cancer cell ...
Wang Jinpeng - - 2013
Novel luminescent dense nano-silica hybrid materials (DNSS) modified with different amounts of (3-aminopropyl)triethoxysilane (APTES) and 1,8-naphthalic anhydride (NA) were successfully synthesized via two steps combined with post-grafting methods. Powder X-ray diffraction (XRD), N2 -sorption analysis, Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), photoluminescence (PL) spectroscopy ...
Peng Z Z Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, - - 2013
It is recognized now that intrinsically disordered proteins (IDPs), which do not have unique 3D structures as a whole or in noticeable parts, constitute a significant fraction of any given proteome. IDPs are characterized by an astonishing structural and functional diversity that defines their ability to be universal regulators of ...
Pickard Amelia - - 2013
Myotonic dystrophy type 1 (MD1) is the commonest muscular dystrophy found in adults; however, it may present in the neonatal period with hypotonia, talipes, poor feeding, and respiratory failure. Inheritance is autosomal dominant with a defect in the DMPK gene found on the long arm of chromosome 19 with variable ...
Jin Jun - - 2013
Interleukin (IL)-17A is a highly inflammatory cytokine and is known to be produced by Th17 cells. The importance of IL-17A expression in nasal epithelial cells is not well understood. The goal of this study is to explore the expression of IL-17A in nasal epithelial cells in vivo and in vitro. ...
Pieters Jean - - 2013
Recent work has implicated members of the evolutionarily conserved family of coronin proteins - in particular coronin 1 - in immune homeostasis. Coronins are involved in processes as diverse as pathogen survival in phagocytes and homeostatic T cell signalling. Notably, in both mice and humans, coronin mutations are associated with ...
Li Wen - - 2013
AIM: The aim of the present study was to evaluate the effectiveness of chlorhexidine (CHX) with an antidiscoloration system (ADS) on stain, plaque accumulation, and gingivitis. METHODS: A randomized, controlled clinical trial was conducted in 26 students. After a preparatory period, the students were randomly assigned to either group P ...
van Wilgen B W - - 2013
Globally, invasions by alien plants are rapidly increasing in extent and severity, leading to large-scale ecosystem degradation. Weed biological control offers opportunities to arrest or even reverse these trends and, although it is not always effective or appropriate as a management strategy, this practice has an excellent record of safety ...
Yu Yong - - 2013
Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) shares much similarity to the cancer initiation process, and the molecular mechanisms underlying both processes remain to be elucidated. Here, we report that a tumor- or embryonic stem cell(ESC)-specific Ras gene ERas, which encodes a constitutively active form of GTPase, ...
Ramakrishnan Yujay - - 2013
BACKGROUND: The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer. METHODS: The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at ...
Raynor L A - - 2013
Many of the genetic variants identified via genome-wide association studies (GWAS) appear to have larger parameter estimates for younger onset cancers compared with adult onset cancers. We used data from the National Human Genome Research Institute (NHRGI) Catalog of Published GWAS to test the hypothesis that the magnitude of the ...
Mirceta Scott - - 2013
Extended breath-hold endurance enables the exploitation of the aquatic niche by numerous mammalian lineages and is accomplished by elevated body oxygen stores and adaptations that promote their economical use. However, little is known regarding the molecular and evolutionary underpinnings of the high muscle myoglobin concentration phenotype of divers. We used ...
Califano Daniela - - 2013
HMGA2 is a small, non-histone, chromatin-associated protein with a key role in tumorigenesis and adipogenesis. Indeed, HMGA2 overexpression has been frequently detected in several malignant neoplasms and inhibition of its expression prevents thyroid cell transformation. Moreover, HMGA2 null mice show a pigmy phenotype with a great reduction in fat tissue. ...
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