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Wei Li L Beijing Municipal Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing, - - 2013
Avian metapneumovirus causes acute respiratory tract infection and reductions in egg production in various avian species. We isolated and characterized an increasingly prevalent avian metapneumovirus subgroup C strain from meat-type commercial chickens with severe respiratory signs in China. Culling of infected flocks could lead to economic consequences.
Hingley-Wilson Suzanne M SM Imperial College London, London, UK. - - 2013
Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread ...
Main Penelope A E PA Sansom Institute of Health Research, University of South Australia, North Terrace, Adelaide, - - 2013
Autism spectrum disorders are a heterogeneous group of neurodevelopmental conditions characterised by impairments in reciprocal social interaction, communication and stereotyped behaviours. As increased DNA damage events have been observed in a range of other neurological disorders, it was hypothesised that they would be elevated in lymphoblastoid cell lines (LCLs) obtained ...
Salamon Rachel Schnur RS Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, - - 2013
Class I PI 3-kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid-binding domains. The class I PI 3-kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3-kinases produce ...
Mackway-Jones Kevin C - - 2013
Best Evidence Topic reports (BETs) summarise the evidence pertaining to particular clinical questions. They are not systematic reviews, but rather contain the best (highest level) evidence that can be practically obtained by busy practicing clinicians. The search strategies used to find the best evidence are reported in detail in order ...
Usubalieva Jumagul J Government Sanito-Epidemiology Unit, - - 2013
Human echinococcosis is a reportable disease in Kyrgyzstan. Between 1995 and 2011, human alveolar echinococcosis increased from <3 cases per year to >60 cases per year. The origins of this epidemic, which started in 2004, may be linked to the socioeconomic changes that followed the dissolution of the former Soviet ...
Won Elizabeth E Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2013
Older women with ovarian cancer have increased cancer-related mortality and chemotherapy toxicity. CA125 is a sensitive biomarker for tumor burden. The study evaluates the association between CA125, geriatric assessment (GA), and treatment toxicity. This is a secondary subset analysis of patients 65 years or older with ovarian cancer accrued to ...
Lu Ping P The Wallace H. Coulter Department of Biomedical Engineering, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United - - 2013
This Article describes a facile approach to the synthesis of rutile nanostructures in the form of porous fibers or bundles of nanotubes by maneuvering the surface wettability of yarns made of polystyrene nanofibrils. Specifically, hierarchically porous fibers were obtained by hydrolyzing titanium tetraisopropoxide to form TiO2 nanoparticles in the void ...
Kumara Swamy Shashi K - - 2013
We show how to record and analyze solid-state NMR spectra of organic paramagnetic complexes with moderate hyperfine interactions using the Cu-cyclam complex as an example. Assignment of the (13) C signals was performed with the help of density functional theory (DFT) calculations. An initial assignment of the (1) H signals ...
Parry Alison L AL Department of Chemistry and Biophysical Sciences Institute, Durham University , South Road, Durham, DH1 3LE, - - 2013
Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant mucin glycans. A polymerizable version of ...
Ereifej Evon S - - 2013
The long-term effect of chronically implanted electrodes is the formation of a glial scar. Therefore, it is imperative to assess the biocompatibility of materials before employing them in neural electrode fabrication. Platinum alloy and iridium oxide have been identified as good candidates as neural electrode biomaterials due to their mechanical ...
Xiao Jingbo - - 2013
The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases, and recent clinical trial data has shown benefit in treating acute heart failure. However, the remodelling capacity of these peptide hormones is difficult to study in chronic settings because of their short ...
Hodge Stephen A - - 2013
Previously, reduced single-walled carbon nanotube anions have been used for effective processing and functionalization. Here we report individually separate and distinct (that is, discrete) single-walled carbon nanotube cations, directly generated from a pure anode using a non-aqueous electrochemical technique. Cyclic voltammetry provides evidence for the reversibility of this nanoion electrochemisty, ...
Javer Avelino - - 2013
In bacteria, chromosomal architecture shows strong spatial and temporal organization, and regulates key cellular functions, such as transcription. Tracking the motion of chromosomal loci at short timescales provides information related to both the physical state of the nucleo-protein complex and its local environment, independent of large-scale motions related to genome ...
Ewert M - - 2013
Objective: The aim of this study was to evaluate factors affecting pregnancy rates in the German Thoroughbred Breed with particular emphasis on optimisation of fertility rates for breeding stallions of older ages. Material and methods: Data from the studbooks of the German Thoroughbred Breeding Association from 1996 to 2009 analysed. ...
Röskes S - - 2013
Objective: To evaluate the influence of a simultaneous injection of GnRH- and PGF2α-analogues at different time points of a cycle on cycle length and on the concentrations of progesterone and oestradiol-17β. Additionally, the length of the following cycles was investigated. Material and methods: In six cows the cycle length was ...
Michaelis I - - 2013
Objective: In context of the study farmers using an automated activity monitoring (AAM) system called Heatime were surveyed on estrus detection practices. The aim of the study was to gain an overview of the usual estrus detection methods and especially to learn about the practical aspects of that system. Material ...
Egloff C - - 2013
A 3-year-old female alpaca was referred to the hospital because of tenesmus. Clinical examination revealed a habitual vaginal prolapse with tenesmus during urination and defecation. On vaginoscopic examination a persistent hymen was detected. Ultrasonography of the caudal abdomen showed an echogenic fluid-filled uterus. A diagnostic laparotomy led to diagnosis of ...
Starke A - - 2013
Objective: The aim of this study was to develop a new radiographic and measurement technique for use in the canine elbow (putting axial load on the joint during radiography and obtaining objective quantification of the resulting joint conformation), assess its reliability in relation to positioning artifacts and repeat measurements as ...
Niesterok C - - 2013
Objective: The aim of our study was to evaluate the value of projection radiography as a standard screening method for the detection of lung nodules compared to computed tomography (CT). Furthermore, we attempted to describe the reasons that might lead to a failed detection of pulmonary nodules in radiography. Materials ...
Münster M - - 2013
Objective: Pathologic gastroesophageal reflux (GER) has been demonstrated experimentally in dogs, and it is suspected to occur naturally in dogs, yet its clinical significance is unknown. The aim of the study was to demonstrate clinical indicators of pathologic GER in dogs with idiopathic esophagopathies. Materials and methods: Dogs with clinical ...
Günther P - - 2013
In a 6-month-old, chronically inappetent Lawsons's Dragon (Pogona henrylawsonii) with stunted growth a hyperdense cardiac region was found using radiology and computed tomography. At necropsy a profound necrosis of the myocardium with dystrophic calcification was diagnosed. In contrast to the frequently seen metastatic mineralisation of soft tissues, mainly due to ...
Brachthäuser L - - 2013
The case of a 5-month-old male Weimaraner dog with severe osteodystrophia fibrosa (rubber jaw) and renal insufficiency is presented. Kidneys were smaller than normal with a granular cortical surface and a histopathological end-stage diagnosis consistent with juvenile nephropathy. Analysis of four described genetic mutations associated with Alport syndrome in dogs ...
Le Bœuf Fabrice - - 2013
Oncolytic viruses are complex biological agents that interact at multiple levels with both tumour and normal tissues. Antiviral pathways induced by interferon are known to have a critical role in determining tumour cell sensitivity and normal cell resistance to infection with oncolytic viruses. Here we pursue a synthetic biology approach ...
Ito Hajime - - 2013
Numerous studies have focused on the mechanical control of solid structures and phase changes in molecular crystals. However, the molecular-level understanding of how macroscopic forces affect the molecules in a solid remains incomplete. Here we report that a small mechanical stimulus or solid seeding can trigger a single-crystal-to-single-crystal transformation from ...
Sunada Yusuke - - 2013
Although discrete nano-sized compounds consisting of a monolayer sheet of multiple atoms have attracted much attention, monolayer transition metal nanosheets are difficult to access. Here we report a template synthesis of the folding metal nanosheet (2) consisting of 11 palladium atoms by treatment of a ladder polysilane, decaisopropylbicyclo[2.2.0]hexasilane (1), with ...
Natarajan Chandrasekhar - - 2013
Epistatic interactions between mutant sites in the same protein can exert a strong influence on pathways of molecular evolution. We performed protein engineering experiments that revealed pervasive epistasis among segregating amino acid variants that contribute to adaptive functional variation in deer mouse hemoglobin (Hb). Amino acid mutations increased or decreased ...
Rummer Jodie L - - 2013
The Root effect is a pH-dependent reduction in hemoglobin-O2 carrying capacity. Specific to ray-finned fishes, the Root effect has been ascribed specialized roles in retinal oxygenation and swimbladder inflation. We report that when rainbow trout are exposed to elevated water carbon dioxide (CO2), red muscle partial pressure of oxygen (PO2) ...
Lin Hui-Hao - - 2013
Different stimulus intensities elicit distinct perceptions, implying that input signals are either conveyed through an overlapping but distinct subpopulation of sensory neurons or channeled into divergent brain circuits according to intensity. In Drosophila, carbon dioxide (CO2) is detected by a single type of olfactory sensory neuron, but information is conveyed ...
Hoops M - - 2013
The number of New World camelids in Germany is increasing. Owners and breeders are usually well educated regarding their animals. For practitioners, this means being up-to-date with respect to their veterinary knowledge. This includes the physiology and pathology of reproduction. Specifics of reproduction in domesticated New World camelids are an ...
Ganter M - - 2013
The epidemic occurrence of the Schmallenberg virus has induced numerous congenital malformations in small ruminants. Because of this high incidence of malformed lambs, an overview of the different causes of congenital malformations is provided. The most frequent infectious and physical causes as well as mineral and vitamin deficiencies and toxic ...
Hildebrandt L - - 2013
The case report describes a narrowing of the spinal canal in the lumbar and sacroiliac regions with entailing acute recumbency in a nearterm 17-year-old Welsh B Pony mare. The reason for recumbency was metastases of a malignant melanoma in the spinal canal of the lumbo-sacral region, where the tumour had ...
Strube C - - 2013
The zoonotic roundworm Toxocara canis is considered one of the most common gastrointestinal helminths in dogs in Europe. Infection occurs via embryonated eggs from the environment or the ingestion of paratenic hosts. Pups become infected via intrauterine or lactogenic transmission of larvae from the bitch. Prenatal infection results in major ...
Mirceta Scott - - 2013
Extended breath-hold endurance enables the exploitation of the aquatic niche by numerous mammalian lineages and is accomplished by elevated body oxygen stores and adaptations that promote their economical use. However, little is known regarding the molecular and evolutionary underpinnings of the high muscle myoglobin concentration phenotype of divers. We used ...
Schäfers A - - 2013
Objective: The aim of the study was to establish reference values for haematological and clinical-chemical parameters in adult dogs and to evaluate whether they are influenced by age, sex and feeding. Material and methods: The study population consisted of 508 clinically healthy dogs of both genders and different breeds aged ...
Lee Helen H - - 2013
BACKGROUND: Inadequate access to oral health care places children at risk of caries. Disease severity and inability to cooperate often result in treatment with general anesthesia (GA). Sedation is increasingly popular and viewed as lower risk than GA in community settings. Currently, few data are available to quantify pediatric morbidity ...
Yang Lin - - 2013
Abstract The major aim of this study is to elucidate the hypocholesterolemic mechanism exerted by rice protein (RP) in adult rats under cholesterol-enriched dietary condition. Compared with casein, the cholesterol levels in plasma and the liver were significantly reduced by RP, accompanying significant inhibition of cholesterol absorption. RP increased the ...
Greenhouse Ian - - 2013
Preparing to stop may "prime" the neural mechanism for stopping and alter brain activity at the time of stopping. Much electroencephalography (EEG) research has studied the N2/P3 complex over frontocentral electrodes during outright stopping. Here, we used differential reward of the stop and go processes in a stop signal task ...
Alvarez Marisa Claudia - - 2013
BACKGROUND: Helicobacter pylori infection is usually acquired in childhood and persists into adulthood if untreated. The bacterium induces a chronic inflammatory response, which is associated with epigenetic alterations in oncogenes, tumor-suppressor genes, cell-cycle regulators, and cell-adhesion molecules. AIM: The aim of this study was to analyze the effect of H. ...
Harada Kenichi - - 2013
BACKGROUND: Primary biliary cirrhosis (PBC), characterized by cholangitis and loss of intrahepatic small bile ducts, predominantly affects middle-aged females. We have reported that fractalkine expression associated with chronic inflammation is observed in the damaged bile ducts and periductal vessels of PBC patients, which is closely associated with chronic cholangitis. AIMS: ...
Bartkiene Elena - - 2013
Abstract The effect of supplementing wheat flour at a level of 15% with lupine (Lupinus angustifolius L.) wholemeal fermented by different lactic acid bacteria on acrylamide content in bread crumb as well as on bread texture and sensory characteristics was analysed. The use of fermented lupine resulted in a lower ...
Satoh Hiroshi - - 2013
BACKGROUND/AIMS: The effects of feeding conditions (fasted or fed) and dietary fiber (DF) in the diet on gastrointestinal (GI) damage induced by aspirin (ASA) were examined in cats. METHODS: Plain ASA (P-ASA, 20 mg/kg) or one enteric-coated ASA tablet (EC-ASA, containing 100 mg ASA) was administered p.o. once daily for 3 or ...
Hao Ge-Fei - - 2013
Gibberellins (GAs) are phytohormones essential for many developmental processes in plants. In this work, fundamental mechanism of hormone perception by receptor GID1 has been studied by performing computational simulations, revealing a new GA-binding channel of GID1 and a novel hormone perception mechanism involving only one conformational state of GID1. The ...
McConechy Melissa K - - 2013
Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endometrioid carcinomas arising from endometriosis. To directly compare the mutation profiles of two morphologically similar tumor types, endometrial endometrioid carcinomas ...
Idrees Muhammad T - - 2013
We investigated the role of OCT4 immunohistochemical staining in detecting germ cell tumor lymph node metastases. Retroperitoneal lymph node dissection is important for staging and treatment of testicular germ cell tumors, and OCT4 is sensitive and specific for pluripotent testicular germ cell tumors; however, micrometastases, particularly from seminoma, can be ...
Abedalthagafi Malak - - 2013
Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-grade astrocytomas comprise a heterogeneous group of central nervous system tumors. We examined a large cohort of adult (91) and pediatric (n=88) high-grade astrocytomas as well as lower ...
Pan Chin-Chen - - 2013
Specialized stromal tumors of the prostate encompass stromal sarcoma and stromal tumors of uncertain malignant potential (STUMP). The molecular signature associated with stromal sarcoma and STUMP has not been unraveled. The study was conducted to detect the chromosomal imbalances in stromal sarcoma and STUMP by using array comparative genomic hybridization ...
Pinto Alvaro P - - 2013
As life expectancy lengthens, cases of non-viral-associated vulvar squamous cell carcinoma and its precursor lesion, so-called differentiated vulvar intraepithelial neoplasia (VIN), continue to increase in frequency. Differentiated VIN often is difficult to recognize and failure to detect it before invasion results in morbidity and mortality. Thus, identification of a reliable ...
Casuso Rafael A - - 2013
Abstract Quercetin is suggested as a nitric oxide regulator which may in turn influence blood parameters and weight gain. Wistar rats were classified as: quercetin-exercise training, QT; placebo-exercise training, PT; quercetin-sedentary, QS; and placebo sedentary, PS. After 6 weeks of treatment with quercetin and/or exercise, an incremental test was run ...
Brenner Isabel - - 2013
The expression of IgG4 in malignant B-cell lymphomas has only partially been studied. Recent reports described single cases of marginal zone lymphomas arising in the ocular adnexae that express IgG4. Moreover, a subset of dura-associated marginal zone lymphomas appear to express IgG4 as well. We investigated IgG4 expression in a ...
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