Search Results
Results 101 - 150 of 2623
1 2 3 4 5 6 7 8 9 10 >
Galván Jose A - - 2013
Objectives: To elucidate the role of epithelial-mesenchymal transition markers in gastroenteropancreatic neuroendocrine tumors (GEP NETs) and the potential usefulness in their clinical management. Methods: One hundred ten GEP NET paraffin-embedded samples were immunohistochemically analyzed for E-cadherin, N-cadherin, β-catenin, vimentin, Snail1, Snail2, Twist, and Foxc2 protein expression. Results: The 5-year survival ...
Axelsson A K - - 2013
Participation is known to be of great importance for children's development and emotional well-being as well as for their families. In the International Classification of Functioning, Disability and Health - Children and Youth version participation is defined as a person's 'involvement in a life situation'. Engagement is closely related to ...
Hingley-Wilson Suzanne M SM Imperial College London, London, UK. - - 2013
Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread ...
King Christopher R - - 2013
Radiotherapy (RT) after prostatectomy may potentially eradicate any residual localized microscopic disease in the prostate bed. The current dilemma is whether to deliver adjuvant RT solely on the basis of high-risk pathology (pT3 or positive margins), but in the absence of measurable prostate-specific antigen, or whether early salvage radiotherapy (SRT) ...
Johnson Barbara S - - 2013
There are currently 22.5 million living U.S. military veterans, and this number is expected to increase dramatically as military personnel return from Iraq and Afghanistan. Although honorably discharged veterans may qualify for health care through the U.S. Department of Veterans Affairs (VA), only about 25% of all veterans take advantage ...
- - 2013
Fuse and mix. In eukaryotes, SNARE-mediated membrane fusion is vital for processes such as vesicle trafficking and secretion. It can be studied using vesicles tagged with different lipid-mixing indicators (represented by the orange and green spheres on the cover). However, as Diao et al. discuss on pages 658-665 of this ...
Shin Dong Hyuk - - 2013
Following a chemical, biological, radiation and nuclear (CBRN) incident, prompt establishment of an advanced airway is required for patients with respiratory failure within the warm zone, while wearing personal protective equipment (PPE). Previous studies reported that intubation attempts were prolonged, and incidence of esophageal intubation was increased with conventional Macintosh ...
Leder Karin - - 2013
Longitudinal data examining travel-associated illness patterns are lacking. To address this need and determine trends and clusters in travel-related illness, we examined data for 2000-2010, prospectively collected for 42,223 ill travelers by 18 GeoSentinel sites. The most common destinations from which ill travelers returned were sub-Saharan Africa (26%), Southeast Asia ...
Agunos Agnes - - 2013
During 2005-2010, the Canadian Integrated Program for Antimicrobial Resistance Surveillance identified increased prevalence of ciprofloxacin (a fluororquinolone) resistance among Campylobacter isolates from retail chicken in British Columbia (4%-17%) and Saskatchewan (6%-11%), Canada. Fluoroquinolones are critically important to human medicine and are not labeled for use in poultry in Canada.
Geurts-Giele Willemina R R - - 2013
Objectives: To address whether successive B-cell lymphomas, diagnosed within a 5- to 15-year interval, are recurrences or unrelated primary lymphomas. Methods: Immunoglobulin heavy and κ light chain gene rearrangements were studied using multiplex polymerase chain reaction fragment assays and sequence analysis in 61 patients. Results: Clonal patterns of the multiple ...
Coster W - - 2013
We compared school participation patterns of students ages 5-17 with and without disabilities and examined whether features of the school environment were perceived to help or hinder their participation. Parents (n = 576) residing in the USA and Canada completed the Participation and Environment Measure for Children and Youth (PEM-CY) ...
Crook Juanita - - 2013
Adenocarcinoma of the prostate is extremely heterogeneous, ranging from an indolent chronic illness to an aggressive rapidly fatal systemic malignancy. The classic prognostic factors of tumor stage, prostate specific antigen level, and Gleason score have been used for over a decade to categorize patients at the time of diagnosis into ...
Zhao Chengquan - - 2013
Objectives: To document screening test histories of women with histopathologic cervical glandular neoplasia (CGN) in a large integrated health system using new methods of cervical screening. Methods: Cervical screening test results were reviewed for 265 patients with histopathologic diagnoses of CGN, including 168 adenocarcinoma in situ, 80 invasive cervical adenocarcinoma, ...
Montag Judith - - 2013
To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected.
Groppi Diane E - - 2013
Objectives: To describe our experience, both in meeting challenges and in reporting outcomes, of the consolidation of anatomic pathology services in the North Shore-LIJ Health System in February 2011. Methods: We addressed issues of governance, personnel, physical plant, quality programming, connectivity, and education. Conclusions: The highly regulated nature of the ...
Bourke-Taylor H - - 2013
The Assistance to Participate Scale (APS) was designed to measure the primary carer's estimate of the amount of assistance that their school-aged child with a disability requires to participate in play and leisure activities. Previous research suggests that the 8-item APS has good internal consistency. The construct validity of the ...
Mahamat Aba - - 2013
Acute Q fever is an emergent and severe disease in French Guiana. We obtained 5 Coxiella burnetii isolates from samples of patients from Cayenne and found an epidemic clone circulating in Cayenne. This clone has caused pneumonia and endocarditis and seems to be more virulent than previously described strains.
Ansumana Rashid - - 2013
We diagnosed 400 possible IgM-positive cases of chikungunya virus in Bo, Sierra Leone, during July 2012-January 2013 by using lateral flow immunoassays. Cases detected likely represent only a small fraction of total cases. Further laboratory testing is required to confirm this outbreak and characterize the virus.
Denham James W - - 2013
The optimal duration of hormonal therapy when combined with radiation for men with high-risk and locally advanced prostate cancer remains under active study. Based on the results of randomized controlled trials, durations of androgen suppression therapy of at least 6 months have been shown to prolong survival in men with ...
Khetani M - - 2013
We examined activity-specific patterns and child, family and environmental correlates of participation restriction in nine community-based activities among preschoolers with disabilities who have received Part C early intervention services. Data were gathered from a subsample of 1509 caregivers whose children (mean age = 67.7 months) had enrolled in the National ...
Tuffrey C - - 2013
The concept of participation was introduced by the World Health Organisation in the International Classification of Functioning, Disability and Health, 2001. Instruments to measure participation have been developed for children and adults, but none specifically for adolescents. Adolescence is a life stage with distinct patterns of participation, and previous research ...
Gaze William H - - 2013
The clinical failure of antimicrobial drugs that were previously effective in controlling infectious disease is a tragedy of increasing magnitude that gravely affects human health. This resistance by pathogens is often the endpoint of an evolutionary process that began billions of years ago in non-disease-causing microorganisms. This environmental resistome, its ...
Voruganti Sudhakar S Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078, - - 2013
AUY922 is a potent synthetic Hsp90 antagonist that is moving steadily through clinical trials against a small range of cancers. To identify protein markers that might measure the drug's effects, and to gain understanding of mechanisms by which AUY922 might inhibit the proliferation of leukemia cells, we characterized AUY922's impacts ...
Lu Ping P The Wallace H. Coulter Department of Biomedical Engineering, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United - - 2013
This Article describes a facile approach to the synthesis of rutile nanostructures in the form of porous fibers or bundles of nanotubes by maneuvering the surface wettability of yarns made of polystyrene nanofibrils. Specifically, hierarchically porous fibers were obtained by hydrolyzing titanium tetraisopropoxide to form TiO2 nanoparticles in the void ...
Kumara Swamy Shashi K - - 2013
We show how to record and analyze solid-state NMR spectra of organic paramagnetic complexes with moderate hyperfine interactions using the Cu-cyclam complex as an example. Assignment of the (13) C signals was performed with the help of density functional theory (DFT) calculations. An initial assignment of the (1) H signals ...
Liu Chien-Liang - - 2013
In vivo imaging of insulin metabolism is realized by T.-M. Liu, P.-T. Chou and co-workers using synthesized human insulin-Au nanodots (NDs). Benefiting from its efficient red to near infrared emission, deep tissue subcellular uptake of insulin-Au NDs can be evaluated with a nonlinear optical microscope. On page 2103, insulin-Au NDs ...
Hu Xiaoge - - 2013
Multifunctional nanoparticles with integrated magnetic, optical, and targeting properties enable simultaneous trapping and ultrasensitive detection of rare circulating tumor cells in blood vessels. On page 2046, photoacoustic imaging shows how the nanoprobes detect the cells at the single-cell-per-milliliter level, capturing two thirds of the labeled cells in just one pass. ...
Parry Alison L AL Department of Chemistry and Biophysical Sciences Institute, Durham University , South Road, Durham, DH1 3LE, - - 2013
Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant mucin glycans. A polymerizable version of ...
Ereifej Evon S - - 2013
The long-term effect of chronically implanted electrodes is the formation of a glial scar. Therefore, it is imperative to assess the biocompatibility of materials before employing them in neural electrode fabrication. Platinum alloy and iridium oxide have been identified as good candidates as neural electrode biomaterials due to their mechanical ...
Pitt T L - - 2013
Several antimicrobial cocktail solutions of differing composition and concentrations are widely used to decontaminate viable banked tissue allografts at different temperatures and times of exposure. We compared the efficiency of four cocktails comprising nine antimicrobials to kill suspensions of a panel of 27 strains of 13 bacterial species, and 3 ...
Villesen T F - - 2013
This paper presents a novel method for the self-assembly of aluminum nanoparticles on Si and fused silica. Due to high reactivity with oxygen, ex-vacuo annealing of thin deposited metal films, a method used extensively with other metals, does not work with aluminum. In the present experiment this problem was overcome ...
Lithgow Trevor T Department of Biochemistry & Molecular Biology, Monash University, Melbourne, - - 2013
The EMBO conference 'From Structure to Function of Translocation Machines' took place in April 2013 in Dubrovnik, Croatia. The meeting brought together a mix of established and aspiring researchers to discuss a wealth of unpublished data and ideas in a lively scientific programme of talks designed to shatter the established ...
Procino Alfredo - - 2013
Fat distribution is associated with metabolic risk; differences in cellular characteristics and metabolic functions of these depots have been described, but the molecular mechanisms involved are not understood. The pathogenesis and pathophysiology of metabolic disease can well be understood by studying the molecular mechanisms that control the development and function ...
Garrido Carolina E - - 2013
A total of 89 freshly harvested soybean seed samples (Roundup Ready [transgenic] soybean cultivars) from the 2010/2011 crop season were collected from five locations in the Northern Pampean Region II, Argentina. These samples were analyzed for internal mycoflora, toxin production of isolated fungi, and for a range of mycotoxins. Mycotoxin ...
Xie Guoxiang G Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 28081, - - 2013
Chronic ethanol consumption is associated with not only the alteration of metabolic profiles in biofluids but also the composition of the gut microbiome. Our understanding of the importance of the intestinal microbiota as well as the disturbances elicited by ethanol intervention is limited by the fact that previous analyses have ...
Harada Kenichi - - 2013
BACKGROUND: Primary biliary cirrhosis (PBC), characterized by cholangitis and loss of intrahepatic small bile ducts, predominantly affects middle-aged females. We have reported that fractalkine expression associated with chronic inflammation is observed in the damaged bile ducts and periductal vessels of PBC patients, which is closely associated with chronic cholangitis. AIMS: ...
Casuso Rafael A - - 2013
Abstract Quercetin is suggested as a nitric oxide regulator which may in turn influence blood parameters and weight gain. Wistar rats were classified as: quercetin-exercise training, QT; placebo-exercise training, PT; quercetin-sedentary, QS; and placebo sedentary, PS. After 6 weeks of treatment with quercetin and/or exercise, an incremental test was run ...
Castro Ana Paula Pereira - - 2013
PURPOSE: Evidence suggests that plasma retinol-binding protein 4 (RBP4) and insulin resistance are related to body fat (BF). We aimed to assess the relationship between RBP4 and insulin resistance with obesity in a mixed (skin color) cohort of the Brazilian population. METHODS: A nested case-control study was conducted in 227 ...
Mantripragada Venkata P VP Biomedical Engineering Program, The University of Toledo, Toledo, Ohio, - - 2013
Great deal of research is still going on in the field of orthopedic and craniofacial implant development to resolve various issues being faced by the industry today. Despite several disadvantages of the metallic implants, they continue to be used, primarily because of their superior mechanical properties. In order to minimize ...
Wang M - - 2013
BACKGROUND AND PURPOSE: This study aims to evaluate the effect of genistein on glucose homeostasis and underlying mechanisms under normal and insulin resistant conditions. EXPERIMENTAL APPROACH: To induced insulin resistance, mice or differentiated 3T3-L1 adipocytes were treated with macrophage-derived conditioned medium. Glucose tolerance test was used to investigate the effect ...
Kohan A A - - 2013
OBJECTIVES: Evaluate the performance of PET/MRI at tissue interfaces with different attenuation values for detecting lymph node (LN) metastases and for accurately measuring maximum standardised uptake values (SUVmax) in lung cancer patients. MATERIALS AND METHOD: Eleven patients underwent PET/CT and PET/MRI for staging, restaging or follow-up of suspected or known ...
Philippart F - - 2013
PURPOSE: To assess preferences among individuals aged ≥80 years for a future hypothetical critical illness requiring life-sustaining treatments. METHODS: Observational cohort study of consecutive community-dwelling elderly individuals previously hospitalised in medical or surgical wards and of volunteers residing in nursing homes or assisted-living facilities. The participants were interviewed at their ...
Shen Yu-Chu - - 2013
PURPOSE: Episiotomy is one of the most commonly performed procedures among women of childbearing age in the United States. In 2005, a major systematic review conducted by Hartmann and colleagues recommended against routine use of episiotomy and was widely covered in the media. We assessed the impact of the Hartman ...
Alegria-Barrero Eduardo - - 2013
Aims: Percutaneous edge-to-edge mitral valve repair with the MitraClip® was shown to be a safe and feasible alternative compared to conventional surgical mitral valve repair. We analyse the concept of the central clip and the predictors for the need of more than one MitraClip® in our high-risk surgical population with ...
Rodríguez-Vela Javier - - 2013
PURPOSE: Supporters of minimally invasive approaches for transforaminal lumbar interbody fusion (TLIF) have reported short-term advantages associated with a reduced soft tissue trauma. Nevertheless, mid- and long-term outcomes and specifically those involving physical activities have not been adequately studied. The aim of this study was to compare the clinical outcomes ...
Bhana Saheel - - 2013
Aim: To develop a simple assay for the capture and detection of rare cancer cells in whole blood using iron oxide-gold (IO-Au) nanoparticles. Materials & methods: IO-Au nanoovals (NOVs) were synthesized, coated with Raman tags and linked with antibodies targeting breast cancer. An integrated system was constructed for on-line magnetic ...
Hanson Erik A - - 2013
OBJECTIVE: Multispectral, multichannel, or time series image segmentation is important for image analysis in a wide range of applications. Regularization of the segmentation is commonly performed using local image information causing the segmented image to be locally smooth or piecewise constant. A new spatial regularization method, incorporating non-local information, was ...
Georgin-Lavialle S - - 2013
BACKGROUND: Mastocytosis is a heterogeneous disease whose different subtypes also vary in aggressivity. Children typically present with cutaneous mastocytosis. We identified, in our previous work, a peripheral CD34-c-Kit+mast cell precursor by flow cytometry in systemic forms but not in cutaneous forms of adult mastocytosis. OBJECTIVES: We wanted to know if ...
Iacobas D A - - 2013
Prenatal exposure to corticosteroids has long-term postnatal somatic and neurodevelopmental consequences. Animal studies indicate that corticosteroid exposure-associated alterations in the nervous system include hypothalamic function. Infants with infantile spasms, a devastating epileptic syndrome of infancy with characteristic spastic seizures, chaotic irregular waves on interictal electroencephalogram (EEG; hypsarhythmia) and mental deterioration, ...
Griese Daniel P - - 2013
Objectives Aim of this study was to analyse feasibility, efficacy and safety of a double-ProGlide preclose-technique for access site closure after transfemoral transcatheter aortic valve implantation (TAVI). Background An effective and safe transcutaneous closure device is advantageous in transfemoral TAVI to avoid surgical cut down of the large calibre sheath ...
1 2 3 4 5 6 7 8 9 10 >