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Results 601 - 650 of 2614
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Lou Hao - - 2013
Abstract Objective: The purpose of this study is to evaluate the influence of sodium iodide, sodium chloride and sodium sulfate on the formation efficiency of sulfamerazine nanocrystals by wet ball milling. Methods: Sulfamerazine was milled using zirconium oxide beads in a solution containing polyvinylpyrrolidone (PVP) and a sodium salt (iodide, ...
Joles Jaap A - - 2013
Chronic heart failure (CHF) can lead to chronic renal injury and loss of renal function. This presentation has been termed cardio-renal syndrome type 2. (1) The presence of proteinuria and histological signs of renal injury in this condition indicates that chronic renal failure is not merely a consequence of reduced ...
Thomson John D - - 2013
Objectives: To report procedural outcome and short-term follow-up data for the Gore Septal Occluder (GSO), a new device for closure of patent foramen ovale (PFO). Background: Transcatheter closure of patent foramen ovale is an established treatment modality but no current device provides a perfect solution. The GORE septal occluder (GSO) ...
Ladam Franck - - 2013
Hox genes encode transcription factors with important roles during embryogenesis and tissue differentiation. Genetic analyses initially demonstrated that interfering with Hox genes has profound effects on the specification of cell identity, suggesting that Hox proteins regulate very specific sets of target genes. However, subsequent biochemical analyses revealed that Hox proteins ...
Mo Junming - - 2013
Without detours: Oxidative catalysis mediated by N-heterocyclic carbenes (NHCs) enables the direct β-carbon functionalization of saturated aldehydes. The reaction proceeds through two sequential oxidative steps to generate α,β-unsaturated triazolium ester equivalents as Michael acceptors, which react with 1,3-diketones and β-ketone esters in an enantioselective manner.
Zhang Bei - - 2013
The aim of the present study was to uncover the mechanism underlying the neuroprotection of Hemin‑mediated neuroglobin (Ngb) in an in vivo model of brain injury. Sixty healthy male Sprague-Dawley rats were randomly divided into 5 groups (n=12, each group): sham surgery, ischemia, Hemin, LY294002 (LY) and Hemin + LY. Focal cerebral ischemia was ...
Yavari Keihann - - 2013
The oxidative photocyclization reactions of olefins that contain 1H-phosphindole or dibenzophosphole substituents have been applied to the synthesis of P/N-bi-heterosubstituted dimeric helicenes, as well as of new [6]- and [8]phosphahelicenes. In these photocyclization processes, the configuration of the stereogenic phosphorus center dictates the sense of helical chirality. Thus, by starting ...
Fujimi Toshio - - 2013
This article proposes a new type of warranty policy that applies the "nudge" concept developed by Thaler and Sunstein to encourage homeowners in Japan to implement seismic retrofitting. Homeowner adaptation to natural disasters through loss reduction measures is known to be inadequate. To encourage proactive risk management, the "nudge" approach ...
Houari Ymène - - 2013
Photoacids have a stronger propensity to give protons in their excited state than in their ground state which is a key feature for developing new material properties. Experimentally the determination of the excited state dissociation constants remains challenging as the lifetime of the photoacid, in its excited state, is too ...
Westermann Robert - - 2013
There is increasing use of three-dimensional (3D) computed tomography (CT) for researching anterior cruciate ligament (ACL) reconstructions and tunnel placement. However, there is limited 3D CT data on the ACL footprint. The purpose of this study is to define the native ACL femoral footprint using 3D surface reconstructions of computed ...
Thevenot Paul - - 2013
BACKGROUND: Chronic alcohol consumption causes persistent oxidative stress in the lung, leading to impaired alveolar macrophage (AM) function and impaired immune responses. AMs play a critical role in protecting the lung from particulate matter (PM) inhalation by removing particulates from the airway and secreting factors which mediate airway repair. We ...
Chen Yang - - 2013
Abstract The highly organized structure of the stratum corneum provides an effective barrier to the drug delivery into or across the skin. To overcome this barrier function, penetration enhancers are always used in the transdermal and dermal drug delivery systems. However, the conventional chemical enhancers are often limited by their ...
Kim Stanley E - - 2013
The purpose of this retrospective study was to compare the accuracy of computed tomographic angiography (CTA) and abdominal ultrasonography in detecting and characterizing portosystemic shunts (PSS) in dogs. Medical records of 76 dogs that underwent CTA and/or abdominal ultrasonography suspected to have PSS were reviewed. Presence or absence, and characterization ...
Karin A - - 2013
AIMS: To conduct a psychometric analysis to determine the adequacy of instruments that measure cognition in Alzheimer's disease trials. BACKGROUND: Both the Alzheimer's Disease Assessment Scale - Cognition (ADAS-Cog) and the Neuropsychological Test Battery (NTB) are validated outcome measures for clinical trials in Alzheimer's disease and are approved also for ...
Matsumoto Hidetoshi - - 2013
The graphene nanoribbon (GNR)/carbon composite nanofiber yarns were prepared by electrospinning from poly(acrylonitrile) (PAN) containing graphene oxide nanoribbons (GONRs), and successive twisting and carbonization. Electrospinning process can exert directional shear force coupling with external electric field to the flow of spinning solution. During electrospinning, the well-dispersed GONRs were highly oriented ...
Li Li - - 2013
Better than expected: With a regular boronic acid as the functional monomer, a general and facile approach for glycoprotein imprinting exhibited several highly favorable features that are beyond normal expectation, which make the prepared MIPs feasible for the recognition of trace glycoproteins in complicated real samples.
Tunc-Ozcan Elif - - 2013
BACKGROUND: Fetal alcohol spectrum disorder (FASD) is characterized by neurodevelopmental anomalies manifesting in cognitive and behavioral deficits in the offspring with diverse severities. Social behavior is affected in FASD, and these deficits overlap with those of autism spectrum disorder (ASD). Identifying some of the molecular characteristics related to ASD in ...
Vithani K - - 2013
Abstract Sustained release diclofenac sodium (Df-Na) solid lipid matrices with Compritol® 888 ATO were developed in this study. The drug/lipid powders were processed via cold and hot melt extrusion at various drug loadings. The influence of the processing temperatures, drug loading and the addition of excipients on the obtained dissolution ...
Verrotti A - - 2013
The first aim of our study was to analyze the adverse events statistically significantly associated with zonisamide, through a systematic review and meta-analysis of available randomized placebo-controlled trials (RCTs). The second aim was to compare these results with those obtained from an analysis of non-RCTs and observational studies. Randomized controlled ...
Chen Mark Hung-Chih - - 2013
Exposure to benzidine has been known to induce human cancers, particularly bladder carcinomas. In this study, the zebrafish model was used to investigate the developmental toxicity of benzidine. Embryos at 6 h postfertilization (hpf) that were exposed to benzidine exhibited embryonic death in a dose- and time-dependent manner. Benzidine induced ...
Spencer Bryan R - - 2013
BACKGROUND: The association of blood donation-related iron deficiency with pica or restless legs syndrome (RLS) remains poorly elucidated. This study evaluated the prevalence of RLS and pica in blood donors completing the REDS-II Iron Status Evaluation (RISE) study. STUDY DESIGN AND METHODS: RISE enrolled 2425 blood donors in a prospective ...
Eleid Mackram F - - 2013
Retroperitoneal fibrosis is a rare condition characterized by the presence of inflammatory and fibrous retroperitoneal tissue that surrounds and often encases abdominal structures. In this report we describe an unusual presentation of retroperitoneal fibrosis and inferior vena cava (IVC) obstruction that was unidentified by noninvasive testing and ultimately diagnosed using ...
Stevanovic Svetlana - - 2013
Generally, the magnitude of pollutant emissions from diesel engines running on biodiesel fuel is ultimately coupled to the structure of respective molecules that constitutes the fuel. Previous studies demonstrated the relationship between organic fraction of PM and its oxidative potential. Herein, emissions from a diesel engine running on different biofuels ...
Shunatona Hunter P - - 2013
Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.
Takayanagi Toshimitsu - - 2013
OBJECTIVES: To determine the characteristics of the cognitive function in very-low-birth-weight infants (VLBWI) at six years of age and investigate significant factors during NICU admission that affect cognitive outcomes. STUDY SUBJECTS AND PROTOCOL: One hundred and eighty-nine VLBWI (28.4 weeks, 1024 g), including 93 EL infants whose birth weight was ...
Prasad Aditya - - 2013
Objective: To compare the use of regadenoson to adenosine for measurement of fractional flow reserve (FFR). Background: FFR is an accepted method to assess the functional significance of intermediate coronary artery stenoses and uses adenosine to induce maximal hyperemia. The use of the selective A2a receptor agonist regadenoson for FFR ...
Dubar Faustine - - 2013
Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(.) in the acidic and oxidizing environment of ...
Gulliver John - - 2013
Modelling historic air pollution exposures is often restricted by availability of monitored concentration data. We evaluated back-extrapolation of LUR models for annual mean NO2 concentrations in Great Britain for up to 18 years earlier. LUR variables were created in a GIS using land cover and road network data summarized within ...
Struik Fransien M - - 2013
BACKGROUND: Non-invasive positive pressure ventilation (NIPPV) is effective in treating acute exacerbations of chronic obstructive pulmonary disease (COPD). Nocturnal non-invasive positive pressure ventilation (nocturnal-NIPPV) has been proposed as an intervention for stable hypercapnic patients with COPD. OBJECTIVES: To assess the effects of nocturnal-NIPPV at home via nasal mask or face ...
Lieberman Lani - - 2013
BACKGROUND: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. The majority of the literature involves adult patients. The main objective of this study was to characterize the demographic features, clinical presentation, patient outcomes, and antibody profiles of TRALI patients reported to the Canadian Blood Service (CBS) ...
Maniruzzaman Mohammed - - 2013
Abstract The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs is a major challenge in the development of such oral dosage forms. Taste assessment is an important quality-control parameter for evaluating taste-masked formulations of any new ...
Habisreutinger Severin N - - 2013
Rising atmospheric levels of carbon dioxide and the depletion of fossil fuel reserves raise serious concerns about the ensuing effects on the global climate and future energy supply. Utilizing the abundant solar energy to convert CO2 into fuels such as methane or methanol could address both problems simultaneously as well ...
Polonais Valérie - - 2013
Microsporidia are obligate intracellular eukaryotic parasites with a broad host spectrum characterized by a unique and highly sophisticated invasion apparatus, the polar tube. In a previous study, two polar tube proteins, named AlPTP1 (50 kDa) and AlPTP2 (35 kDa), were identified in Antonospora locustae, an orthoptera parasite that is used ...
Rajagopal Aditya - - 2013
We present a novel method for the encoding and decoding of multiplexed biochemical assays. The method enables a theoretically unlimited number of independent targets to be detected and uniquely identified in any combination in the same sample. For example, the method offers easy access to 48-plex PCR assays, as contrasted ...
Xiao Jingnan - - 2013
BACKGROUND: Primary effusion lymphoma (PEL) is a rare subtype of large B-cell lymphoma that arises in body cavities without detectable tumor masses. PEL is universally associated with Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus-8 (HHV8). Despite overlapping features, KSHV/HHV8-negative effusion-based lymphoma is a distinct entity from PEL. To date, 52 cases have ...
Chatterjee Nivedita - - 2013
Bio-oils, which are multicomponent mixtures, were produced from two different biomass (rice straw (rice oil) and sawdust of oak tree (oak oil)) by using the slow pyrolysis process, and chemical compositional screening with GC-MS detected several hazardous compounds in both bio-oil samples. The two bio-oils vary in their chemical compositional ...
Couteau C - - 2013
Abstract The relationship between skin cancer and exposure to the sun is now clearly established. It is therefore necessary to ensure that consumers have effective sun protection. The effectiveness of the anti-solar products is quantified using a universal indicator, the SPF (sun protection factor). This value can be given in ...
Gooderham Spencer E - - 2013
The present article examines the lateralization of hand use throughout the lifespan with an emphasis on aging beyond adulthood. The experimental paradigm utilizes a novel observational method to determine the effects of task complexity, a currently misunderstood factor in hand selection. Current literature is contradictory in that some suggest an ...
Wang Jeh-Jeng - - 2013
A novel series of bicyclic[1,2,3]triazoles (4, 7, 11, 15) has been synthesized using one-pot metal free strategy with high structural diversity as a photoprotective agents and delineated their effect on UVA-induced senescence in human dermal fibroblast cells (FB) and the associated mechanism. 11d plus UVA can induce a decrease in ...
Kim Rebeca J - - 2013
Acute left main coronary occlusion secondary to a periaortic root hematoma secondary to annular rupture during transcatheter heart valve deployment. © 2013 Wiley Periodicals, Inc.
Beaudry Jacqueline L - - 2013
Corticosterone (CORT) and other glucocorticoids cause peripheral insulin resistance and compensatory increases in β-cell mass. A prolonged high-fat diet (HFD) induces insulin resistance and impairs β-cell insulin secretion. This study examined islet adaptive capacity in rats treated with CORT and a HFD. Male Sprague-Dawley rats (age6 weeks) were given exogenous ...
Maruo Takuya - - 2013
An ideal head-immobilization method provides a high level of accuracy and reproducibility in the immobilization. Various head-immobilization methods for radiotherapy have been published and are excellent in terms of accuracy; however, these methods are complicated to use, and labor intensive. The present study describes two new bite block-type head-immobilization devices ...
Castelnuovo Paolo - - 2013
ObjectiveTo describe the different surgical techniques for nasopharyngeal endoscopic resection (NER) and to support the efficacy of the endoscopic endonasal approach in the management of selected primary and locally recurrent nasopharyngeal tumors (NPTs).Study DesignCase series with chart review.SettingPatients affected by NPTs who underwent NER from 1997 to 2011 at two ...
Hiraumi Harukazu - - 2013
ObjectiveTo evaluate the prevalence of the persistent petrosquamosal venous sinus in patients with chronic otitis media using a high-resolution CT scan.Study DesignRetrospective chart review.SettingTertiary referral center.Subjects and MethodsEighty-four patients older than 6 years of age underwent surgery (in a total of 92 ears) for chronic otitis media at Kyoto University ...
Viney Rosalie - - 2013
Conventionally, generic quality-of-life health states, defined within multi-attribute utility instruments, have been valued using a Standard Gamble or a Time Trade-Off. Both are grounded in expected utility theory but impose strong assumptions about the form of the utility function. Preference elicitation tasks for both are complicated, limiting the number of ...
Sherman Susan G - - 2013
The recent article by Schwartz et al. addresses the intersection of two important public health issues: opiate substitution therapy and fatal heroin overdose.(1) In the United States, drug overdose is responsible for more than 36 000 deaths annually(2) and is the leading cause of death among illicit drug users. Baltimore, Maryland, ...
Shargorodsky Josef - - 2013
ObjectiveThis study explored the outcomes of epistaxis treatment modalities to optimize management and enable the development of a therapeutic algorithm.Study DesignCase series with chart review.SettingTertiary care hospital.Subjects and MethodsAdult patients presenting between 2005 and 2011 with epistaxis underwent cauterization, tamponade, and/or proximal vascular control. Outcomes of treatment modalities were compared. ...
Irwig Michael S - - 2013
BACKGROUND: There is a robust literature in rodents, but not in humans, on the interaction between finasteride and alcohol, particularly as it relates to neurosteroids. Finasteride has been shown to reduce alcohol intake and suppress alcohol preference in male mice. This study examines the role of finasteride in alcohol consumption ...
You Jeong Soon - - 2013
To evaluate the extent to which fat mass contributes to serum osteopontin (OPN) concentration, we investigated whether serum OPN levels are decreased by exercise-induced fat mass loss and whether they are associated with body fat percentage in obese humans. Twenty‑three female college students were recruited to participate in an 8‑week ...
Tan Li-Lin - - 2013
Starburst triarylamine-based organic dyes (, , and ) have been synthesized. For the three designed dyes, the starburst triarylamine group, thiophene (or 3,4-ethylenedioxythiophene), and cyanoacetic acid take the role of electron donor, π-conjugation bridge, and electron acceptor, respectively. These compounds are characterized by photophysical, electrochemical, and theoretical computational methods. Nanocrystalline ...
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