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Results 551 - 600 of 2623
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Li Yuhao - - 2013
Four new heteroleptic cationic Ir(III) complexes bearing benzothiazolylfluorene motif on the bipyridine (N^N) (1 and 2) and phenylpyridine (C^N) (3 and 4) ligands are synthesized and characterized. The influence of the position of the substituent and the extent of π-conjugation on the photophysics of these complexes is systematically investigated by ...
Nie Bei - - 2013
Three-dimensional nanoporous gallium nitride (PGaN) produced by metal-assisted electroless etching is chemically embedded with silver nanoparticles via electroless deposition, forming a metallized semiconductor membrane with large surface area and nanoscale metal features. A new application utilizing the unique chemical and morphological features of these composite nanostructures is described here, laser ...
Yavari Keihann - - 2013
The oxidative photocyclization reactions of olefins that contain 1H-phosphindole or dibenzophosphole substituents have been applied to the synthesis of P/N-bi-heterosubstituted dimeric helicenes, as well as of new [6]- and [8]phosphahelicenes. In these photocyclization processes, the configuration of the stereogenic phosphorus center dictates the sense of helical chirality. Thus, by starting ...
Gulliver John - - 2013
Modelling historic air pollution exposures is often restricted by availability of monitored concentration data. We evaluated back-extrapolation of LUR models for annual mean NO2 concentrations in Great Britain for up to 18 years earlier. LUR variables were created in a GIS using land cover and road network data summarized within ...
Kim-Farley Robert James - - 2013
The progress and setbacks in addressing infectious diseases highlighted in this issue remind us that infectious diseases remain a significant cause of morbidity, disability, and mortality worldwide. Their prevention and control is a constant challenge that faces communities, health workers, and those of us in public health in both developing ...
Zhu Rongshun - - 2013
The kinetics for the thermal unimolecular decomposition of CH3NO2 and its structural isomer CH3ONO have been investigated by statistical theory calculations based on the potential energy surface calculated at the UCCSD(T)/CBS and CASPT3(8, 8)/6-311+G(3df, 2p) levels. Our results show that for the decomposition of CH3NO2 at pressures less than 2 ...
Luo Jinghui - - 2013
Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of Aβ peptide aggregates in the brain. Using ThT fluorescence assays, AFM imaging, NMR and CD spectroscopy, and MD modeling we show that lysozyme - a hydrolytic enzyme abundant in human secretions - completely inhibits the aggregation of Aβ peptides at ...
Jambhekar Supriya K - - 2013
BACKGROUND:: Many pediatric patients need positive airway pressure (PAP) for treatment of obstructive sleep disordered breathing (OSDB). Adherence with use of PAP equipment (defined as percent of nights with nightly use of PAP for more than 4 hours) is often poor and not sustained long- term. With any chronic disease, ...
Sun Xiaolong - - 2013
Integrated and insulated boronate-based fluorescent probes have been evaluated for the detection of hydrogen peroxide in the presence of saccharides.
Schare Mitchell L - - 2013
Four articles examining methodological applications of exposure therapy and its limited dissemination were briefly reviewed. Methodological articles included those by Abramowitz et al., Gryczkowski et al., and Weiner and McKay, which addressed couple-treatment of obsessive compulsive disorder (OCD), modification of evidence-based anxiety treatments for children, and novel exposure methods for ...
Gilburt Helen - - 2013
BACKGROUND: Recovery has become an increasingly prominent concept in mental health policy internationally. However, there is a lack of guidance regarding organisational transformation towards a recovery orientation. This study evaluated the implementation of recovery-orientated practice through training across a system of mental health services. METHODS: The intervention comprised four full-day ...
Houari Ymène - - 2013
Photoacids have a stronger propensity to give protons in their excited state than in their ground state which is a key feature for developing new material properties. Experimentally the determination of the excited state dissociation constants remains challenging as the lifetime of the photoacid, in its excited state, is too ...
Chen Mark Hung-Chih - - 2013
Exposure to benzidine has been known to induce human cancers, particularly bladder carcinomas. In this study, the zebrafish model was used to investigate the developmental toxicity of benzidine. Embryos at 6 h postfertilization (hpf) that were exposed to benzidine exhibited embryonic death in a dose- and time-dependent manner. Benzidine induced ...
Mense Lars - - 2013
Objective Positive effects of breast milk feeding for preterm newborns have been demonstrated but bacterial contamination of mechanically expressed breast milk may cause neonatal sepsis. Pasteurizing breast milk reduces the bacterial count but impairs helpful nutrients. The aim of the study was (1) to analyze bacterial concentration in expressed breast ...
Lofrumento Dario D - - 2013
In the present study we used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model to analyze resveratrol neuroprotective effects. The MPTP-induced PD model is characterized by chronic inflammation, oxidative stress and loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). We observed that resveratrol treatment significantly ...
Chen Yu - - 2013
Spiro compounds: An iodine monochloride-induced intramolecular cyclization of 1-[4'-methoxy(1,1'-biphenyl)2-yl]alkynones has been developed. An electrophilic iodocyclization selectively takes place at the ipso position (versus the ortho electrophilic aromatic substitution) to afford 4'H-spiro(cyclohexa[2,5]diene-1,1'-naphthalene)-4,4'-diones, a new group of spiroconjugated compounds.
Sutkuvienė Simona - - 2013
Multidrug efflux pump inhibitors have a great potential as pharmacological agents that increase the drug susceptibility of bacterial pathogens. Our study was focused on the synthesis and evaluation of the efficiency of resistance-nodulation-division (RND) family efflux pump inhibitors. The efficiency of these inhibitors was investigated on Salmonella enterica ser. Typhimurium ...
Zhuang Jiaming J Department of Chemistry, University of Massachusetts, Amherst, MA 01003, - - 2013
In this review, we outline examples that illustrate the design criteria for achieving macromolecular assemblies that incorporate a combination of two or more chemical, physical or biological stimuli-responsive components. Progress in both fundamental investigation into the phase transformations of these polymers in response to multiple stimuli and their utilization in ...
Viruthagiri G - - 2013
Studies have been planned to obtain activity and associated radiation hazards in ceramic raw materials (quartz, feldspar, clay, zircon, kaolin, grog, alumina bauxite, baddeleyite, masse, dolomite and red mud) and end products (ceramic brick, glazed ceramic wall and floor tiles) as the activity concentrations of uranium, thorium and potassium vary ...
Lo Hung-Kai - - 2013
Background Unrecognized or untreated injury in patients with ankylosing spondylitis (AS) may develop anterior column spinal pseudoarthrosis with an open wedge bone defect. The methods of surgical treatment are controversial. Combined anterior and posterior stabilizations or posterior instrumentation with osteoclasis are beneficial as shown in an existing literature review.Case Report ...
Kavala Miroslav - - 2013
A comparison set of mono-/biradical TEMPO derivatives was prepared, novel compounds were fully characterized, and their physicochemical properties were determined. Cyclic voltammetry revealed reversible redox behavior for all studied nitroxides. Moreover, the electron-withdrawing substituents increased the oxidation potential of the respective nitroxides in comparison to electron-donating groups. While EPR spectra ...
Escaja Núria - - 2013
Some DNA oligonucleotides can fold back and self-associate forming dimeric structures stabilized by intermolecular base pairs. The resulting antiparallel dimer is a tightly packed four-stranded structure formed by a core of minor groove tetrads connected by short loops of unpaired nucleotides. We have explored the sequential requirements for the loop ...
Gater Deborah L DL Institut de Pharmacologie et de Biologie Structurale, UMR 5089, CNRS - Université de Toulouse, UPS BP 64182, 205 route de Narbonne, 31077 Toulouse, Cedex04, - - 2013
The addition of cholesterol to the monoolein-based lipidic cubic phase (LCP) has been instrumental in obtaining high-resolution crystal structures of several G protein-coupled receptors. Here, we report the use of high-resolution magic angle spinning NMR spectroscopy to record and assign the isotropic (13)C chemical shifts of cholesterol in lipidic lamellar ...
Li Zhenjun - - 2013
The interactions of ethylene glycol with a partially reduced rutile TiO2(110) surface have been studied using temperature programmed desorption (TPD). The saturation coverage on surface Ti rows is determined to be 0.43 monolayer (ML), slightly less than one ethylene glycol per two Ti sites. Most of the adsorbed ethylene glycol ...
Nanatani Kei - - 2013
Synechocystis sp strain PCC 6803 contains one gene encoding a putative large conductance mechanosensitive channel homolog [named SyMscL (slr0875)]. However, it is unclear whether SyMscL contributes to the adaptation to hypoosmotic stress in Synechocystis. Here we report the in vivo characteristics of SyMscL. SyMscL was mainly expressed in the plasma ...
Dai Fei - - 2013
Background Desvenlafaxine succinate (DVS) is a novel SNRI. The aim of this study was to investigate the effects of DVS on visceral hypersensitivity and solid gastric emptying in a rodent model of gastric hyperalgesia. Methods Twenty eight gastric hyperalgesia rats and 20 control rats were used. Visceral sensitivity during gastric ...
Noh Young-Woock - - 2013
Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity.
Thomas Melanie R MR University of California, San Francisco, San Francisco, CA, USA. - - 2013
To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. Data from 38 HIV-positive and 29 HIV-negative children born to seropositive women were obtained. Measures included family adversity questionnaires, ...
Huggins David John - - 2013
Accurate prediction of hydration free energies is a key objective of any free energy method that is applied to modelling and understanding interactions in the aqueous phase. Inhomogeneous fluid solvation theory (IFST) is a statistical mechanical method for calculating solvation free energies by quantifying the effect of a solute acting ...
Takayanagi Toshimitsu - - 2013
OBJECTIVES: To determine the characteristics of the cognitive function in very-low-birth-weight infants (VLBWI) at six years of age and investigate significant factors during NICU admission that affect cognitive outcomes. STUDY SUBJECTS AND PROTOCOL: One hundred and eighty-nine VLBWI (28.4 weeks, 1024 g), including 93 EL infants whose birth weight was ...
Xiao Jingnan - - 2013
BACKGROUND: Primary effusion lymphoma (PEL) is a rare subtype of large B-cell lymphoma that arises in body cavities without detectable tumor masses. PEL is universally associated with Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus-8 (HHV8). Despite overlapping features, KSHV/HHV8-negative effusion-based lymphoma is a distinct entity from PEL. To date, 52 cases have ...
Irwig Michael S - - 2013
BACKGROUND: There is a robust literature in rodents, but not in humans, on the interaction between finasteride and alcohol, particularly as it relates to neurosteroids. Finasteride has been shown to reduce alcohol intake and suppress alcohol preference in male mice. This study examines the role of finasteride in alcohol consumption ...
Blachier Martin - - 2013
Objective. To assess whether factors such as inflammation by laboratory tests and MRI differ between early axial SpA with and without radiographic lesions.Methods. Cross-sectional analysis of baseline data from Devenir des Spondylarthropathies Indifferenciées Récentes (DESIR) cohort patients having recent-onset inflammatory back pain and meeting Assessment of SpondyloArthritis international Society criteria. ...
Basu Anirban - - 2013
In the outcomes research and comparative effectiveness research literature, there are strong cautionary tales on the use of instrumental variables (IVs) that may influence the newly initiated to shun this premier tool for casual inference without properly weighing their advantages. It has been recommended that IV methods should be avoided ...
Li Jiang - - 2013
Self-assembled DNA nanostructures have emerged as a type of nano-biomaterials with precise structures, versatile functions and numerous applications. One particularly promising application of these DNA nanostructures is to develop universal nanocarriers for smart and targeted drug delivery. DNA is the genetic material in nature, and inherently biocompatible. Nevertheless, cell membranes ...
Alagappan Dhivyaa - - 2013
We recently established that the epidermal growth factor receptor (EGF-R) is an essential regulator of the reactive expansion of subventricular zone (SVZ) neural precursors (NPs) that occurs during recovery from hypoxic-ischemic brain injury. The purpose of the current studies was to identify the conditions and the transcription factor (s) responsible ...
Rignot E - - 2013
We compare the volume flux divergence of Antarctic ice shelves in 2007-2008 with 1979-2010 surface accumulation and 2003-2008 thinning to determine their rates of melting and mass balance. Basal melt of 1325 ± 235 gigatons per year (Gt/year) exceeds a calving flux of 1089 ± 139 Gt/year, making ice shelf ...
Tintoré Maria - - 2013
The folding of DNA molecules by DNA origami is used in a nanosensor to analyze enzymatic DNA repair activity of hAGT. The method uses conformational changes that condition α-thrombin interaction with DNA aptamers, and illustrates the use of DNA origami as a protein recognition biosensor.
Desikan R S - - 2013
SUMMARY:Alzheimer disease affects millions of people worldwide. The neuropathologic process underlying this disease begins years, if not decades, before the onset of memory decline. Recent advances in neuroimaging suggest that it is now possible to detect Alzheimer-associated neuropathologic changes well before dementia onset. Here, we evaluate the role of recently ...
Verrotti A - - 2013
The first aim of our study was to analyze the adverse events statistically significantly associated with zonisamide, through a systematic review and meta-analysis of available randomized placebo-controlled trials (RCTs). The second aim was to compare these results with those obtained from an analysis of non-RCTs and observational studies. Randomized controlled ...
Couteau C - - 2013
Abstract The relationship between skin cancer and exposure to the sun is now clearly established. It is therefore necessary to ensure that consumers have effective sun protection. The effectiveness of the anti-solar products is quantified using a universal indicator, the SPF (sun protection factor). This value can be given in ...
Egami Hiromichi - - 2013
A multitalented system: N-Migratory oxytrifluoromethylation and one-pot three-component reactions of allylamines as well as the aminotrifluoromethylation of alkenyl amines all proceeded efficiently in the presence of the Togni reagent (1) and CuI to afford a variety of β-trifluoromethylamine derivatives.
Wang Fangfang - - 2013
The quantum Monte Carlo method is used to calculate the binding energy of an (H2O)16 cluster that has been the subject of several recent theoretical studies. The resulting interaction energy, -165.1(8) kcal/mol, is very close to our MP2 complete basis set limit interaction energy of -164.1 kcal/mol. Comparison of these ...
Ito Shigekazu - - 2013
Catenation of stable 1,3-diphopsphacyclobutane-2,4-diyl units with biphenyl-, diphenyl ether-, and diphenylmethane-based bridging groups were utilized for evaluation of the distinct through-space interaction between the electron-donating P-heterocyclic biradical chromophores. Structural properties of the oligo(biradicals), characterized by X-ray crystallography and DFT calculation, suggest a possible distance between the biradical units for the ...
Yoo Seungmin - - 2013
Down to the wire: Three-dimensional interconnected Si-based nanowires are produced through the combination of thermal decomposition of SiO and a metal-catalyzed nanowire growth process. This low-cost and scalable approach provides a promising candidate for high-capacity anodes in lithium-ion batteries.
Sheath Karen L - - 2013
The aim of the present study was to evaluate the use of KaryoLite™ bacterial artificial chromosomes (BACs)‑on‑Beads™ (BoBs) technology for the rapid screening of products of conception (POC). Validation and prospective studies were carried out on 85 and 95 patient samples, respectively. Validation studies had previously been analyzed using routine culture ...
Fujimoto Kenzo - - 2013
3-Cyanovinylcarbazole nucleoside ((CNV)K), which can quickly photocrosslink to the pyrimidine base in the DNA double strand, was incorporated into a triplex forming oligonucleotide (TFO). We successfully demonstrated that (CNV)K in TFO can photocrosslink to the thymine base in Watson-Crick double-stranded DNA via anti-Hoogsteen base pairing with a few seconds of ...
Wilson A M - - 2013
Although the cheetah is recognised as the fastest land animal, little is known about other aspects of its notable athleticism, particularly when hunting in the wild. Here we describe and use a new tracking collar of our own design, containing a combination of Global Positioning System (GPS) and inertial measurement ...
Gupta Subash C SC Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
Extensive research over the past decade has revealed that the proinflammatory microenvironment plays a critical role in the development of colorectal cancer. Whether nimbolide, a limonoid triterpene, can inhibit the growth of colorectal cancer was investigated in the present study. The effect of nimbolide on proliferation of colorectal cancer cell ...
Yoo Song Jae - - 2013
For assessment of external doses from the ground contaminated with radionuclides, the dose-rate conversion factors (DCFs) prescribed in FGR (Federal Guidance Report) 12 have been used. Recently, significant changes were made by International Commission on Radiological Protection in dosimetric models and parameters, which include use of Reference Phantoms and revised ...
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