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Results 501 - 550 of 2613
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Nikiforov Andrey I - - 2013
Rebaudioside D (Reb D) is one of the several glycosides found in the leaves of Stevia rebaudiana (Bertoni) Bertoni (Compositae) which has been identified as a potential sweetener. The metabolism of Reb A and Reb D was evaluated in various in vitro matrices (simulated gastrointestinal fluids, rat liver microsomes, and ...
Silvestre Daniel Meneszes - - 2013
The development of methods for direct determinations of Al, Cd and Pb in rice by SS-GF AAS is presented. Heating program optimization associated with the use of an adequate chemical modifier containing Pd + Mg allowed direct analysis against aqueous calibrations. The obtained LOD were 114.0 µg kg-1, 3.0 µg ...
Sekiguchi Kazutaka - - 2013
Abstract 1. The drug metabolism and pharmacokinetics of S-777469 were investigated in in vitro (rat, dog and human) and in in vivo (rats and dogs). 2. S-777469 was rapidly and well absorbed, with bioavailability values ranging from 50 to 70% in rats and dogs, almost all drug radioactivity was excreted into the ...
Costescu Dustin Jw - - 2013
BACKGROUND: Completion of a randomised controlled trial is one way by which the resident research requirement can be met in Canadian obstetrics and gynaecology programmes. However, little is known about the specific challenges of performing clinical trials within the specialty, let alone as a resident project. PURPOSE: A resident-led randomised ...
Nisbet R M - - 2013
Anti-amyloid-β immunotherapies are a promising therapeutic approach for the treatment and prevention of Alzheimer's disease (AD). Single chain antibody fragments (scFv) are an attractive alternative to whole antibodies due to their small size, single polypeptide format and inability to stimulate potentially undesirable Fc-mediated immune effector functions. We have generated the ...
Schare Mitchell L - - 2013
Four articles examining methodological applications of exposure therapy and its limited dissemination were briefly reviewed. Methodological articles included those by Abramowitz et al., Gryczkowski et al., and Weiner and McKay, which addressed couple-treatment of obsessive compulsive disorder (OCD), modification of evidence-based anxiety treatments for children, and novel exposure methods for ...
Sebera Jakub - - 2013
A reaction mechanism that describes the substitution of two imino protons in a thymine:thymine (T:T) mismatched DNA base pair with a Hg(II) ion, which results in the formation of a (T)N3-Hg(II) -N3(T) metal-mediated base pair was proposed and calculated. The mechanism assumes two key steps: The formation of the first ...
Sarapatkova Hana - - 2013
BACKGROUND: Thyroid gland disturbances are the most common endocrine disorders in pregnancy. There are some particular recommendations for the investigation of women in risk groups, but no consensus guidelines for general screening exists at present in the Czech Republic. AIM: The aim of our study was to determine whether universally ...
Cambon A - - 2013
Amphiphilic polymeric micelles greatly improve the solubilization and sustained release of hydrophobic drugs and provide a protective environment for the cargo molecules in aqueous media, which favors lower drug administration doses, reduces adverse side effects, increases in blood circulation times and passive targeting to specific cells. These capabilities depend, amongst ...
Park Seung-Jung - - 2013
The anatomical SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and Cardiac Surgery) score is a stratification score illustrating the complexity of angiographic stenosis. It was considered a surrogate for poor prognosis following percutaneous coronary intervention (PCI).(1) Accordingly, in patients with a high baseline SYNTAX score (bSS) requiring coronary revascularization, ...
Price Christopher P - - 2013
The purpose of laboratory medicine is to facilitate better decision making in clinical practice and healthcare delivery. Decision making implies an unresolved issue, problem or unmet need. The most important criterion for any investigation to be of value in clinical practice is that it addresses an unmet need. The different ...
Hoàng Thu Hà - - 2013
BACKGROUND: Alpha 1 antitrypsin (A1AT) is the major plasma serine protease inhibitor that is produced in liver cells. A1AT deficiency is recognized globally as a common genetic cause of liver disease in children, which results from mutations in the SERine Protease INhibitor A1 (SERPINA1) gene. The importance of A1AT deficiency ...
Tintoré Maria - - 2013
The folding of DNA molecules by DNA origami is used in a nanosensor to analyze enzymatic DNA repair activity of hAGT. The method uses conformational changes that condition α-thrombin interaction with DNA aptamers, and illustrates the use of DNA origami as a protein recognition biosensor.
Velasco Ines - - 2013
Background The effects of moderate variations in dietary iodine intake on maternal and fetal thyroid function are poorly understood. Recent studies question the usefulness of neonatal screening of congenital hypothyroidism as a tool for monitoring iodine deficiency. We proposed to test the hypothesis of an association between iodine intake during ...
Reside Jonathan - - 2013
PURPOSE: This pilot study evaluated the molecular, histologic, and radiographic healing of bone to instrumentation with piezoelectric or high speed rotary (R) devices over a 3-week healing period. MATERIAL AND METHODS: Fourteen Sprague-Dawley rats (Charles River Laboratories International, Inc., Wilmington, MA, USA) underwent bilateral tibial osteotomies prepared in a randomized ...
Viruthagiri G - - 2013
Studies have been planned to obtain activity and associated radiation hazards in ceramic raw materials (quartz, feldspar, clay, zircon, kaolin, grog, alumina bauxite, baddeleyite, masse, dolomite and red mud) and end products (ceramic brick, glazed ceramic wall and floor tiles) as the activity concentrations of uranium, thorium and potassium vary ...
Yoo Song Jae - - 2013
For assessment of external doses from the ground contaminated with radionuclides, the dose-rate conversion factors (DCFs) prescribed in FGR (Federal Guidance Report) 12 have been used. Recently, significant changes were made by International Commission on Radiological Protection in dosimetric models and parameters, which include use of Reference Phantoms and revised ...
Candell-Riera Jaume - - 2013
BACKGROUND: -The incremental prognostic value of myocardial perfusion gated-SPECT (MPGS) over exercise test has not yet been properly evaluated. METHODS AND RESULTS: -5,672 consecutive patients with known or suspected coronary disease undergoing exercise MPGS between 1,997 and 2,007 were included. Three years predictive models for total death and death from ...
Thévenod Frank - - 2013
The polyspecific organic cation transporter Oct2 from rat (gene Slc22A2) has been previously shown to transport Cs+. Here we report that human OCT2 (hOCT2) is able to transport Cd2+ showing substrate saturation with a Michaelis Menten contant (Km) value of 54 + 5.8 µM. Cd2+ uptake by hOCT2 was inhibited ...
Christensen Anne Illemann - - 2013
BACKGROUND: While face-to-face interviews are considered the gold standard of survey modes, self-administered questionnaires are often preferred for cost and convenience. This article examines response patterns in two general population health surveys carried out by face-to-face interview and self-administered questionnaire, respectively. METHOD: Data derives from a health interview survey in ...
Zahedifar M - - 2013
Nanoparticles of Cu-doped calcium fluoride were synthesised by using the hydrothermal method. The structure of the prepared nanomaterial was characterised by the X-ray diffraction (XRD) pattern and energy dispersive spectrometer. The particle size of 36 nm was calculated from the XRD data. Its shape and size were also observed by ...
Borah Basanta K - - 2013
Plant viruses, possessing a bacilliform shape and containing double-stranded DNA, are emerging as important pathogens in a number of agricultural and horticultural crops in the tropics. They have been reported from a large number of countries in African and Asian continents, as well as from islands from the Pacific region. ...
Utendale William T - - 2013
Polyvagal theory provides a framework for understanding connections between children's autonomic regulation, cognitive functioning, and behavioral adjustment. Parasympathetic regulation has been associated with executive functions and externalizing problems (EP), and children with EP demonstrate deficits in inhibition of prepotent responding, or inhibitory control (IC). We examined parasympathetic regulation of cardiac ...
Pica Monica - - 2013
Gels of α-type zirconium(IV) phosphate alkylphosphonates, ZP(Cn)x, were prepared by reacting, at room temperature, propanol intercalated nanosized α-zirconium phosphate (α-ZrP) with propanol solutions of alkylphosphonic acids (H2Cn, n = number of carbon atoms in the alkyl chain = 4, 5, 6), with (H2Cn/Zr) molar ratios in the range 0.4-4.0. (31)P ...
Mazairac Albert H A - - 2013
BACKGROUND: Despite the growing interest in haemodiafiltration (HDF), there is no information on the costs and cost-utility of this dialysis modality yet. It was therefore our objective to study the cost-utility of HDF versus haemodialysis (HD). METHODS: A cost-utility analysis was performed using a Markov model. It included data from ...
Nie Shu - - 2013
We study how the (100) surface of magnetite undergoes oxidation by monitoring its morphology during exposure to oxygen at ~650 ˚C. Low-energy electron microscopy (LEEM) reveals that magnetite's surface steps advance continuously. This growth of Fe3O4 crystal occurs by the formation of bulk Fe vacancies. Using Raman spectroscopy, we identify ...
Kirschner Benny - - 2013
OBJECTIVE: Human papillomavirus (HPV) genotype distributions in invasive cervical cancers may differ by geographic region. The primary objective of this study was to estimate HPV-genotype distribution in Danish women with diagnosis of invasive cervical cancer. DESIGN: Observational, cross-sectional. POPULATION: Danish data from a multi-center study undertaken in 12 European countries. ...
Volkovova Katarina - - 2013
Abstract The study determined the effect of i.v. administration of acutely toxic or sub-lethal doses of Na-oleate coated Fe3O4 (OC-Fe3O4) NPs on liver structure and function in Wistar rats, compared to TiO2 NPs and saline injected controls. The acute study, using a modified OECD 425 progressive dosing procedure, found LD50 ...
Agusti Alvar - - 2013
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifies patients with COPD into four groups (A to D).We explored the characteristics, stability and relationship to outcomes of these groups within the ECLIPSE study (n=2101).Main results showed that: (1) these groups differed in several clinical, functional, imaging and biological ...
Podlekareva Daria N - - 2013
Mortality of HIV/TB patients in Eastern Europe (EE) is high. Little is known about their causes of death (COD).To assess and compare mortality rates and COD in HIV/TB patients across EE and Western Europe and Argentina (WEA) in an international cohort study.Mortality rates and COD were analysed by time from ...
Van Waes Vincent - - 2013
There is a growing use of psychostimulants, such as methylphenidate (Ritalin; dopamine re-uptake inhibitor), for medical treatments and as cognitive enhancers in the healthy. Methylphenidate is known to produce some addiction-related gene regulation. Recent findings in animal models show that selective serotonin re-uptake inhibitors (SSRIs), including fluoxetine, can potentiate acute ...
Goel Neha - - 2013
A 21-year-old woman presented with acute decreased vision due to massive subretinal haemorrhage with macular exudation in the right eye and vitreous haemorrhage in the left eye. Haematological work-up revealed thrombocytopenia (platelets 14,000/μl) with anaemia (haemoglobin 6.3 gm/100 ml). A diagnosis of idiopathic thrombocytopenic purpura (ITP) was confirmed by a haematologist. Systemic ...
Choi Hoo-Kyun - - 2013
Our previous studies have shown that multidrug resistance protein 2 (MRP2) is overexpressed in tamoxifen-resistant MCF-7 breast cancer cells (TAMR-MCF-7 cells) and forkhead box-containing protein, O subfamily1 (FoxO1), functions as a key regulator of multidrug resistance 1 (MDR1) gene transcription. This study aimed to investigate the role of FoxO1 in ...
Berti Francesco - - 2013
The reductive cleavage of nitrosobenzene-derived cycloadducts with appropriately protected 1,2-dihydropyridines allows a novel and simple obtainment of substituted N-[1-(1-phenyl-1H-pyrrol-2-yl)alkylamides. This synthesis can also be carried out in a very simple, mild and practical one-pot procedure without isolation of the corresponding nitrosobenzene cycloadduct.
Bagnasco Annamaria - - 2013
AIM: To describe a protocol for a quantitative systematic review, to identify critique and summarize factors that influence self-management education. BACKGROUND: Self-management education enables patients to manage their condition successfully and it is associated with better self-care, good control over lifestyle and leading the best possible quality of life, notwithstanding ...
Chen Yufeng - - 2013
A new composite based on polymolybdate incorporated in layered magadiite has been synthesized via a exfoliation/self-assembly process. Various techniques, including X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy coupled with energy-dispersive X-ray analysis (SEM-EDX), Raman spectroscopy, thermogravimetric (TG) analysis, UV-vis spectroscopy, and transmission electron microscopy (TEM), have been ...
Jardim Bruna Victorasso - - 2013
The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 women diagnosed with invasive ...
Braemswig Tim Bastian - - 2013
BACKGROUND AND PURPOSE: New diffusion-weighted imaging (DWI) lesions are common in patients with acute ischemic stroke. They are associated with an initial nonsingle lesion pattern. Previous studies have not analyzed this association in detail. We differentiated nonsingle lesions in 1 vascular supply territory only (scattered lesion pattern) from nonsingle lesions ...
Mauseth Siri A - - 2013
OBJECTIVE: To investigate the pattern of use of anticholinergic drugs for overactive bladder among women in Norway with regard to persistence, adherence and switch rates. DESIGN: Observational study. SETTING AND SAMPLE: Data from the Norwegian Prescription Database on prescriptions for tolterodine, solifenacin, darifenacin and fesoterodine filled in Norwegian pharmacies from ...
Babauta Jerome T - - 2013
Cathodic reactions in biofilms employed in sediment microbial fuel cells is generally studied in the bulk phase. However, the cathodic biofilms affected by these reactions exist in microscale conditions in the biofilm and near the electrode surface that differ from the bulk phase. Understanding these microscale conditions and relating them ...
De Silva Nuwan - - 2013
Excited state enol to keto tautomerization of 7-hydroxy-4-methyl-coumarin (C456) with three water molecules (C456:3H2O), is theoretically investigated using time-dependent density functional theory (TDDFT) combined with the polarizable continuum model and 200 waters explicitly modeled with the effective fragment potential. The tautomerization of C456 in the presence of three water molecules ...
Chiu Cindy H - - 2013
Objectives. We describe the demographics of the decedents from the tornado outbreak in Alabama on April 27, 2011; examine the circumstances of death surrounding these fatalities; and identify measures to prevent future tornado-related fatalities. Methods. We collected information about the decedents from death certificates, disaster-related mortality surveillance, and interview data ...
Schumacher Andreas - - 2013
Swapping N,P for C,N: Iridium complexes of bidentate pyridine-based C,N ligands with an N-heterocylic carbene (NHC) unit proved to be efficient and highly enantioselective hydrogenation catalysts. As a result of the lower acidity of iridium hydride intermediates produced from NHC-based complexes, these catalysts are much better suited than analogous N,P-ligand ...
Moon Hee-Won - - 2013
We evaluated the performance of the VITEK MS for identification of Gram-positive cocci routinely isolated in clinical microbiology laboratories. With a total of 424 well-characterized isolates, the results of the VITEK MS were compared to those of conventional methods and 16S rRNA gene sequencing. The VITEK MS correctly identified 97.9% ...
Lee Antonio S J - - 2013
Background: Vertebrate muscles are defined and patterned at the stage of primary myotube formation, but there is no clear description of how these cells form in vivo. Of particular interest is whether primary myotubes are 'seeded' by a unique myoblast population that differentiates as mononucleated myocytes, similar to the founder ...
Chen Yi-Hao - - 2013
Purpose:  To investigate the effect of silibinin in myofibroblast transdifferentiation and in animal trabeculectomy models. Methods:  The effect of silibinin on the expression of α-smooth muscle actin (α-SMA) and vimentin in response to transforming growth factor-β1 (TGF-β1) was determined in human tenon fibroblasts (HTFs). Cell migration and collagen contraction arrays ...
Kerékgyártó Márta - - 2013
The analysis and polyclonal antibody response for newly synthesized maltose - BSA conjugate neoglycoproteins is described. In this first, proof of concept study a simple carbohydrate antigen, maltose, was linked to bovine serum albumin by reductive amination. An aglycone spacer was utilized to conserve the intact annular maltose structure and ...
Iversen Jenny - - 2013
Objectives. We examined trends in HCV incident infection among injection drug users (IDUs) attending needle and syringe programs (NSPs) in Australia in 1995 to 2010. Methods. We created a passive retrospective cohort of 724 IDUs who tested negative for HCV antibodies by a simple deterministic method linking partial identifiers to ...
Rapues Jenna - - 2013
Objectives. We evaluated the use of respondent-driven sampling (RDS) among a high-risk population of transfemales. We also obtained up-to-date epidemiological data on HIV infection and related correlates among this population. Methods. We evaluated the utility of RDS in recruiting a sample of 314 transfemales in San Francisco, California, from August ...
Reid Marion E - - 2013
BACKGROUND: Anti-Lan has been implicated in hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. The LAN blood group system is encoded by ABCB6, whose gene product, ABCB6, belongs to the ATP-binding cassette (ABC) efflux transporter superfamily. The purpose of this study was to characterize additional alleles by ...
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