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Results 451 - 500 of 2623
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Salvatoni Alessandro - - 2013
BACKGROUND: At the clinical onset of type 1 diabetes mellitus (T1D), enterovirus (EV) infections are suspected to play a role. EVs in blood are seen as a possible biomarker of T1D. EV infections may occur in temporal and geographic clusters and may spread within families. OBJECTIVE: We checked whether EVs ...
Ciogli Alessia - - 2013
Biochemical processes in living organisms rely on a plethora of molecular reactions and interactions involving chiral molecules, and these processes often show different responses to the enantiomers of exogenous or endogenous chemicals. The interaction of enantiomeric drugs with a target receptor is a paradigmatic example of chirality effects on general ...
White Matthew T - - 2013
Biomarkers are often measured with error due to imperfect lab conditions or temporal variability within subjects. Using an internal reliability sample of the biomarker, we develop a parametric bias-correction approach for estimating a variety of diagnostic performance measures including sensitivity, specificity, the Youden index with its associated optimal cut-point, positive ...
Dong Weijie - - 2013
Supported molecular matrix electrophoresis (SMME), in which a hydrophilic polymer such as poly(vinyl alcohol) (PVA) serves as a support within a porous poly(vinylidene difluoride) (PVDF) membrane, was recently developed. This method is similar to cellulose acetate membrane electrophoresis but differs in the compatibility to glycan analysis of the separated bands. ...
Kibirkštis Edmundas - - 2013
To determine whether the geometrical accuracy of small printed elements does not worsen on recycled paper, microscopic analysis of the dot area and the graphic elements raggedness printed on different types of recycled and coated papers at different screen ruling was carried out. Experimental tests have shown that geometrical accuracy ...
Pistone Giuseppe - - 2013
Abstract Purpose: We want to show that there are differences between males and females in the response to drug treatment, and consequently the potential for adverse drugs reactions; it is only fair to take into account the so-called "gender based medicine". Methods: We again selected admission for CADRs, from January ...
de Ory Fernando - - 2013
The aim of this study was to evaluate enzyme immunoassays (EIA) (Euroimmun, Lübeck, Germany) and chemiluminiscent immunoassays (CLIA) (Diasorin, Saluggia, Italy) in their application to detect B19V-IgM and -IgG. For this purpose, one hundred and ninety samples were studied. Of them, 101 came from recent infection cases (B19V-specific IgM (86) ...
McConechy Melissa K - - 2013
Ovarian endometrioid carcinomas and endometrial endometrioid carcinomas share many histological and molecular alterations. These similarities are likely due to a common endometrial epithelial precursor cell of origin, with most ovarian endometrioid carcinomas arising from endometriosis. To directly compare the mutation profiles of two morphologically similar tumor types, endometrial endometrioid carcinomas ...
Li Xin-Hao - - 2013
Porous carbons and porous carbon nitrides are well known support materials. Some of these materials are, however, not only a geometric construct for immobilization, enabling mass transport at the same time, but contribute due to their extended electronic structure to a potential catalytic event as such. When appropriate band schemes ...
Bradbury Sarah - - 2013
The current study aimed to elucidate the role of pharmacokinetic (PK) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4-methylenedioxymethamphetamine (MDMA) self-administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of 1.0 mg/kg MDMA (iv) prior to, and following, the acquisition of ...
Tung Bau-Kuei - - 2013
BACKGROUND: Identification of predictors for permanent facial nerve dysfunction and timing of recovery are important for the management of patients who experience immediate facial nerve dysfunction after parotidectomy. METHODS: In this 6-year retrospective cohort study, 54 such patients were analyzed to determine the associated prognostic factors and timing of recovery. ...
Reyes Ricardo - - 2013
This study aimed to analyze the in vitro and in vivo release kinetics and evaluate the grades of repair induced by either the release of 50 ng of transforming growth factor-β1 or 2.5 or 5 μg of bone morphogenetic protein-2 (BMP-2) from a bilayer scaffold of segmented polyurethane/polylactic-co-glycolic (SPU/PLGA) in ...
Rychen Guido - - 2013
Human activities are emitting persistent organic pollutants (POPs) to the environment. These compounds have raised concerns about the risk of transfer through the food chain via animal products. They are characterized by a strong persistence in environmental matrices and a lipophilicity which may lead to their accumulation in fat tissues. ...
Ugwu Emmanuel Onyebuchi - - 2013
OBJECTIVES: This study aimed at evaluating the effectiveness and safety of membrane stripping at 40-41 weeks of gestation as a means of preventing post-term pregnancy and the need for formal induction of labor in Enugu, Nigeria. METHODOLOGY: A randomized controlled trial of 134 post-date pregnant women at the University of Nigeria ...
Varelogianni Georgia - - 2013
Ambroxol, a mucokinetic anti-inflammatory drug, has been used for treatment of cystic fibrosis (CF). The respiratory epithelium is covered by the airway surface liquid, the thickness and composition of which is determined by Cl(-) efflux via the cystic fibrosis transmembrane conductance regulator (CFTR) and Na(+) influx via the epithelial Na(+) ...
Haab F - - 2013
AIM: NK-1 receptors in sensory nerves, the spinal cord and bladder smooth muscle participate in complex sensory mechanisms that regulate bladder activity. This study was designed to assess the efficacy and safety of a new NK-1 receptor antagonist, netupitant, in patients with OAB. METHODS: This was a phase II, multicenter, ...
Okuyama Kazuaki - - 2013
Coronary artery occlusion during transcatheter aortic valve replacement is a rare complication. However, it is a very severe and life threatening event. Although there are some possible causes of this phenomenon, definite etiologies and predictors are unknown because of the small number. We describe one case of left main coronary ...
Tomai Fabrizio - - 2013
Objectives. To assess coronary plaque composition by virtual histology intravascular ultrasound (VH-IVUS) in young adult recipients and to correlate these findings with time from heart transplant (HTx) and long-term outcomes. Backgroud. Rapid progression of coronary allograft vasculopathy after heart transplantation is a powerful predictor of mortality and clinical events at ...
Nakajima Hiroaki - - 2013
We previously reported that treatment of B16 melanotic melanoma cells with reduced glutathione (GSH) converts them to amelanotic cells without any significant down-regulation of tyrosinase activity. To characterize the cellular mechanism(s) involved, we determined the intracellular distribution of melanocyte-specific proteins, especially in melanin synthesis-specific organelles, termed melanosomes by subcellular fractionation ...
Durand Corentin - - 2013
We report a significant and persistent enhancement of the conductivity in free-standing non-intentionally doped InAs nanowires upon irradiation in ultra-high vacuum. Combining four-point probe transport measurements performed on nanowires with different surface chemistries, field effect based measurements and numerical simulations of the electron density, the change in the conductivity is ...
Chandra-Mouli Venkatraman - - 2013
BACKGROUND: Adolescents in Tanzania require health services that respond to their sexual and reproductive health -- and other -- needs and are delivered in a friendly and nonjudgemental manner. Systematizing and expanding the reach of quality adolescent friendly health service provision is part of the Tanzanian Ministry of Health and ...
Abedalthagafi Malak - - 2013
Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-grade astrocytomas comprise a heterogeneous group of central nervous system tumors. We examined a large cohort of adult (91) and pediatric (n=88) high-grade astrocytomas as well as lower ...
Fritsch Valerie A - - 2013
BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is a rare subtype squamous cell carcinoma (SCC) that frequently occurs in the larynx. BSCC is generally considered an aggressive SCC variant; however, because of its rarity, most studies are underpowered to detect statistical differences in disease-specific survival (DSS). METHODS: Using the Surveillance, Epidemiology, ...
Antanasijević Davor - - 2013
The aims of this study are to create an artificial neural network (ANN) model using non-specific water quality parameters and to examine the accuracy of three different ANN architectures: General Regression Neural Network (GRNN), Backpropagation Neural Network (BPNN) and Recurrent Neural Network (RNN), for prediction of dissolved oxygen (DO) concentration ...
Vaizoglu Ferdi - - 2013
PURPOSE: To determine clinicopathological risk factors associated with lymph node metastasis in endometrial cancer (EC). METHODS: Clinicopathological data of patients who underwent comprehensive surgical staging for clinical early stage EC between 2001 and 2010 at Hacettepe University Hospital was retrospectively reviewed. RESULTS: Two hundred and sixty-one patients were included. There ...
Guo Wen-Yong - - 2013
After its introduction into North America, Euro-Asian Phragmites australis became an aggressive invasive wetland grass along the Atlantic coast of North America. Its distribution range has since expanded to the middle, south and southwest of North America, where invasive P. australis has replaced millions of hectares of native plants in ...
Bryant R V - - 2013
BACKGROUND: There is a paucity of data on body composition in patients with inflammatory bowel disease (IBD). Alterations of fat and muscle may affect bone health, muscle performance, quality of life (QoL) and overall morbidity. AIMS: To systematically review the literature on body composition in adults with IBD, and to ...
Chen Rui-Qiang - - 2013
PURPOSE: Although the occurrence and progression of AIS has been linked to low bone mineral density (BMD), the relationships between spinal curvature and bilateral differences in proximal femur BMD are controversial. Few correlation studies have stratified patients by curve type. The purpose of this study was to evaluate the relationships ...
Zhang Yali V YV Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, - - 2013
Below a certain level, table salt (NaCl) is beneficial for animals, whereas excessive salt is harmful. However, it remains unclear how low- and high-salt taste perceptions are differentially encoded. We identified a salt-taste coding mechanism in Drosophila melanogaster. Flies use distinct types of gustatory receptor neurons (GRNs) to respond to ...
Muruganandan Shanmugam - - 2013
Bone is a dynamic tissue that is continuously remodelled through the action of formative osteoblasts and resorptive osteoclasts. Chemerin is a secreted protein that activates chemokine-like receptor 1 (CMKLR1), a G protein-coupled receptor expressed by various cell types including adipocytes, osteoblasts, mesenchymal stem cells, and macrophages. Previously, we identified chemerin ...
Goldin Laura J - - 2013
Employees in nail salons, largely Vietnamese immigrant women in Boston, are exposed to a range of volatile organic chemicals from the products used in salons, including solvents, glues and polishes. Some of these chemicals have the potential to cause short and long-term adverse health effects. Only limited research has been ...
Pi Y - - 2013
In this study, microstructural characterization of Ti-6Al-4V alloy, subjected to the duplex surface mechanical attrition treatment (SMAT)/nitriding treatment, leading to improve its mechanical properties, was carried out through novel and original samples preparation methods. Instead of acid etching which is limited for morphological characterization by scanning electron microscopy (SEM), an ...
Elfarra Hamdi - - 2013
A case of pacemaker electrode infection with Staphylococcus aureus is presented. In order to avoid sternotomy, the right ventricular pacemaker lead, which had been implanted for 15 years, was successfully extracted using a laser sheath despite large endocarditic vegetations on the pacemaker lead. After completion of a 6-week course of antibiotics, ...
Lin Hui-Hao - - 2013
Different stimulus intensities elicit distinct perceptions, implying that input signals are either conveyed through an overlapping but distinct subpopulation of sensory neurons or channeled into divergent brain circuits according to intensity. In Drosophila, carbon dioxide (CO2) is detected by a single type of olfactory sensory neuron, but information is conveyed ...
Hao Ge-Fei - - 2013
Gibberellins (GAs) are phytohormones essential for many developmental processes in plants. In this work, fundamental mechanism of hormone perception by receptor GID1 has been studied by performing computational simulations, revealing a new GA-binding channel of GID1 and a novel hormone perception mechanism involving only one conformational state of GID1. The ...
Lassaline-Utter Mary - - 2013
OBJECTIVE: To review the signalment, clinical characteristics, treatment, and outcome of equine EK cases in the Mid-Atlantic United States; to evaluate the effects of topical or systemic corticosteroid treatment, oral cetirizine treatment and secondary corneal infection on disease duration; and to evaluate the association between corticosteroid and cetirizine treatment and ...
Wan Xiao-Ming - - 2013
The frequent co-existence of arsenic (As) and lead (Pb) necessitates the investigation of clean-up technologies for multi-metal(loid)s. Field survey and hydroponic experiments were conducted to elucidate the co-accumulation of As and Pb in Pteris vittata L. The P. vittata population isolated from a Pb-Zn mine in Yunnan province, China is ...
Koepke Tyson T Department of Horticulture, Washington State University, Pullman, WA, USA; Molecular Plant Sciences Graduate Program, Washington State University, Pullman, WA, - - 2013
Prunus is an economically important genus with a wide range of physiological and biological variability. Using the peach genome as a reference, sequencing reads from four almond accessions and one sweet cherry cultivar were used for comparative analysis of these three Prunus species. Reference mapping enabled the identification of many ...
Liu Yi - - 2013
Methylmercury (MeHg+) is a strong liposoluble ion, which can be accumulated in the organs of animals and can cause prenatal nervous system and visceral damage. Therefore, the efficient and sensitive monitoring of MeHg+ in organisms is of great im-portance. Upconversion luminescence (UCL) detection based on rare-earth upconversion nanophosphors (UCNPs) as ...
Bajelani Kourosh - - 2013
We present a novel, low complexity method for the detection of the first and second of heart sounds (S1 and S2, respectively) and the periods of systole and diastole without using an electrocardiogram reference. The algorithm uses a technique called empirical mode decomposition to produce intensity envelopes of the main ...
Volkovova Katarina - - 2013
Abstract The study determined the effect of i.v. administration of acutely toxic or sub-lethal doses of Na-oleate coated Fe3O4 (OC-Fe3O4) NPs on liver structure and function in Wistar rats, compared to TiO2 NPs and saline injected controls. The acute study, using a modified OECD 425 progressive dosing procedure, found LD50 ...
Jardim Bruna Victorasso - - 2013
The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 women diagnosed with invasive ...
Redmond Eileen M EM Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA. - - 2013
To determine the role of patched receptor (Ptc)-1 in mediating pulsatile flow-induced changes in vascular smooth muscle cell growth and vascular remodeling. In vitro, human coronary arterial smooth muscle cells were exposed to normal or pathological low pulsatile flow conditions for 24 hours using a perfused transcapillary flow system. Low ...
Thomson John D - - 2013
Objectives: To report procedural outcome and short-term follow-up data for the Gore Septal Occluder (GSO), a new device for closure of patent foramen ovale (PFO). Background: Transcatheter closure of patent foramen ovale is an established treatment modality but no current device provides a perfect solution. The GORE septal occluder (GSO) ...
Bhabhe Ashutosh - - 2013
We follow the freezing of heavy water (D2O) nanodroplets formed in a supersonic nozzle apparatus using position resolved pressure trace measurements, Fourier transform infra-red spectroscopy and small angle X-ray scattering. For these 3 nm to 9 nm radii droplets, freezing starts between 223 K and 225 K, at volume based ...
Habisreutinger Severin N - - 2013
Rising atmospheric levels of carbon dioxide and the depletion of fossil fuel reserves raise serious concerns about the ensuing effects on the global climate and future energy supply. Utilizing the abundant solar energy to convert CO2 into fuels such as methane or methanol could address both problems simultaneously as well ...
Zhao Yanying - - 2013
Reactions of the ground state titanium and zirconium monoxide and dioxide molecules with monochloromethane in excess argon matrices have been investigated in solid argon by infrared absorption spectroscopy and density functional theoretical calculations. The results show that the ground state MOx (M=Ti, Zr; x=1, 2) molecules react with CH3Cl to ...
Li Wing-Yan - - 2013
Abstract Context: The poor prognostic outcome of breast cancer is largely due to its resistance to cancer therapies. Development of therapeutic agents that can inhibit growth and induce apoptosis in breast cancer cells can help solve the problem. Emodin is an active anthraquinone that has been reported to have diverse ...
Fox Elizabeth - - 2013
PURPOSE: Medullary thyroid carcinoma (MTC) is a manifestation of multiple endocrine neoplasia type 2 (MEN2) syndromes caused by germline, activating mutations in the RET proto-oncogene. Vandetanib, a VEGF and EGF receptor inhibitor, blocks RET tyrosine kinase activity and is active in adults with hereditary MTC. EXPERIMENTAL DESIGN: We conducted a ...
Ogunyemi Omolola O Center for Biomedical Informatics, Charles Drew University of Medicine and Science, Lynwood, CA 90262, USA. - - 2013
Teleretinal screening with nonmydriatic cameras has been presented as a means of increasing the number of patients assessed for diabetic retinopathy in urban safety net clinics. It has been hypothesized that automated nonmydriatic cameras may improve screening rates by reducing the learning curve for camera use. In this article, we ...
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