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Memtsoudis Stavros G SG Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY, 10021, USA, - - 2014
Total knee arthroplasty (TKA) can be associated with considerable postoperative pain. Ischemic preconditioning of tissue before inducing procedure-related underperfusion may reduce the postoperative inflammatory response, which further may reduce associated pain. In this prospective, randomized study, we aimed at evaluating the impact of ischemic preconditioning on postoperative pain at rest ...
De Walt Patrick S - - 2013
This manuscript theoretically explores the application of a stretched expanded nigrescence theory (NT-E) by making notions of consciousness explicit, thereby building on the research involving first generation U.S.-born Africans (FGAs). In taking this approach, a theoretical framework of a diasporic consciousness emerged an alternative for exploring the identity development of ...
Iizuka Toshihiko - - 2013
Telomeres are repetitive nucleotide sequences that cap the end of eukaryotic chromosomes. Attrition of these structures has been associated with carcinogenesis in many tissues, and therefore, they are essential for chromosome stabilization. Telomeres are maintained by telomerase complexes, of which human telomerase reverse transcriptase (hTERT) is an essential component. A ...
John Esther M - - 2013
Data on body size and postmenopausal breast cancer in Hispanic and African American women are inconsistent, possibly due to the influence of modifying factors. We examined associations between adiposity and risk of breast cancer defined by hormone receptor status in a population-based case-control study conducted from 1995-2004 in the San ...
Muhle Claus - - 2013
The aim of the study was to evaluate whether MR Imaging of the knee at 30° and 55° of flexion can improve the diagnosis of anterior cruciate ligament and menisci injuries compared to arthroscopy and imaging during extension of the knee joint. Knee joints from 40 patients with clinical suspicion ...
Kušar Janez - - 2013
Project management of product/service orders has become a mode of operation in many companies. Although these are mostly cyclically recurring projects, risk management is very important for them. An extended risk-analysis model for new product/service projects is presented in this paper. Emphasis is on a solution developed in the Faculty ...
Pond Amber L AL Anatomy Department, Southern Illinois University School of Medicine, 2080 Life Sciences III, 1135 Lincoln Drive, Carbondale, Illinois, 62901, USA; Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana, - - 2014
We investigated the mechanism by which the MERG1a K+ channel increases ubiquitin proteasome proteolysis (UPP). Hindlimb suspension and electro-transfer of Merg1a cDNA into mouse gastrocnemius muscles induced atrophy. Atrophic gastrocnemius muscles of hindlimb-suspended mice express Merg1a, Murf1, and Mafbx genes. Electrotransfer of Merg1a significantly decreases muscle fiber size (12.6%) and ...
Agcaoglu Serife - - 2013
Stress fractures are frequently observed in physically active populations, and they are believed to be associated with microcrack accumulation. There are not many tools for real-time monitoring of microdamage formation during fatigue of bone, in vivo or in vitro. Acoustic emission (AE) based detection of stress waves resulting from microdamage ...
Galldiks Norbert - - 2013
AbstractAntiangiogenic treatment using bevacizumab in brain tumor patients may cause difficulties in the diagnosis of tumor progression (ie, nonenhancing tumor progression). Newly defined criteria for treatment assessment and diagnosis of tumor progression (ie, RANO [Response Assessment in Neuro-Oncology] criteria) have implemented signal alterations on T2/fluid-attenuated inversion recovery (FLAIR) sequences to ...
Lamare Frederic - - 2013
AbstractBrain anatomy variability is a major problem in quantifying functional images in nuclear medicine, in particular relative to aging and neurodegenerative diseases. The aim of this study was to compare affine and elastic model-based methods for magnetic resonance imaging (MRI) to brain atlas registration and to assess their impact on ...
Fuchs Kerstin - - 2013
AbstractThe aim of this study was to evaluate the impact of different anesthetics on 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) uptake in carcinomas and arthritic ankles. To determine the amount of [18F]FLT uptake in subcutaneous CT26 colon carcinomas or arthritic ankles, spontaneously room air/medical air-breathing mice were anesthetized with isoflurane, a combination of medetomidine/midazolam, ...
Eun Kim Jung - - 2013
AbstractThe purpose of this study was to investigate in vivo monitoring of hair follicle stem cells (newborn mouse fibroblasts [NFs]) expressing enhanced firefly luciferase (effluc) (NF-effluc) using noninvasive bioluminescence imaging (BLI). Effluc gene transduction into NFs was performed by retroviral vector, and effluc messenger ribonucleic acid expression and function were ...
Shi Jiyun - - 2013
AbstractThere is a critical need to develop diagnostic procedures enabling early detection of tumors while at a curable stage. Technetium 99m (99mTc)-labeled VQ peptide (99mTc-HYNIC-VQ) identified through screening phage display peptide libraries against fresh human colonic adenomas was prepared and evaluated for tumor detection. 99mTc-HYNIC-VQ was prepared by a non-SnCl2 ...
Watanabe Hiroyuki - - 2013
AbstractThe formation of β-amyloid (Aβ) plaques is a critical neurodegenerative change in Alzheimer disease (AD). We designed and synthesized novel boron dipyrromethane (BODIPY)-based Aβ probes (BAPs) and evaluated their utility for near-infrared fluorescence imaging of Aβ plaques in the brain. In binding experiments in vitro, BAPs showed high affinity for ...
Rubin Mark N - - 2013
Telemedicine for acute stroke care is supported by a literature base. It remains unclear whether or not the use of telemedicine for other phases of stroke care is beneficial. The authors conducted a systematic review of the published literature on telemedicine for the purposes of providing post-stroke care. Studies were ...
Hankey Graeme J - - 2013
Three novel oral anticoagulants (NOACS)-dabigatran etexilate, rivaroxaban, and apixaban-have been approved in many countries for stroke prevention in atrial fibrillation, because they are associated with the same or lower rates of stroke, bleeding (particularly intracranially) and death compared with warfarin; and unlike warfarin, they can be given in fixed doses ...
Miyasaki Janis M - - 2013
Palliative care for Parkinson disease (PD) is a new concept in neurodegenerative care. Abundant evidence exists supporting PD as increasing risk of death, most commonly from aspiration pneumonia despite improvements in motor and non-motor symptom management. Palliative care emphasizes an interdisciplinary and holistic approach to symptom management. In the following, ...
Průša Vít - - 2013
Practically all experimental measurements related to the response of nonlinear bodies that are made within a purely mechanical context are concerned with inhomogeneous deformations, though, in many experiments, much effort is taken to engender homogeneous deformation fields. However, in experiments that are carried out in vivo, one cannot control the ...
Rzany Berthold - - 2013
Acne is a complex disease ranging from mild to very severe. Quality of life can be considerably affected although the impact on the quality of life does not necessarily correlate with the severity of the disease. To show how good external evidence can be used in individual treatment decisions. Description ...
Baykan Betul - - 2013
Juvenile myoclonic epilepsy (JME) is among the most common types of genetic epilepsies, displaying a good prognosis when treated with appropriate drugs, but with a well-known tendency to relapse after withdrawal. The majority of patients with JME have continuing seizures after a follow-up of two decades. However, 17% are able ...
Genton Pierre - - 2013
Juvenile myoclonic epilepsy (JME) has been the subject of intensive research over the past 25years. It was discovered stepwise in Switzerland and France in the 19th century, adequately described in Germany and Uruguay in the 1950s, and rediscovered in North America in the early 1980s. Juvenile myoclonic epilepsy represents the ...
Craiu Dana - - 2013
Juvenile myoclonic epilepsy (JME) involves cortico-thalamo-cortical networks. Thalamic, frontal gray matter, connectivity, and neurotransmitter disturbances have been demonstrated by structural/functional imaging studies. Few patients with JME show mutations in genes coding ion channels or GABAA (gamma-aminobutyric acid) receptor subunits. Recent research points to EFHC1 gene mutations leading to microdysgenesis and ...
Yamakawa Kazuhiro - - 2013
Mutations in EFHC1 gene cause juvenile myoclonic epilepsy (JME). We previously showed that myoclonin1 protein encoded by EFHC1 is expressed in prenatal choroid plexus and postnatal ependymal cell cilia but may not be in neurons. However, another group reported that myoclonin1 is expressed in neurons and at mitotic spindle, and ...
de Araujo Filho Gerardo Maria - - 2013
Juvenile myoclonic epilepsy (JME) is a well-defined age-related idiopathic epilepsy syndrome. Past studies have emphasized the difficulties in the treatment of patients with JME, which have been attributed to some specific psychiatric, psychological, and psychosocial characteristics. These aspects have aroused a significant amount of interest in the last two decades. ...
Borregales Leonardo D - - 2013
To determine the extent of variability in the definitions of the 'trifecta' after radical prostatectomy (undetectable PSA, urinary continence and potency) to be found in the literature. To establish a consensus definition of the trifecta in an effort to standardize criteria and reporting. A systematic review of published articles found ...
D'Arcy Yvonne - - 2013
Among the questions raised about patient-controlled analgesia (PCA) by proxy are as follows: What are the safety issues related to PCA by proxy? Should another type of pain management be used for patients who can not activate the PCA button? This article focuses on safe PCA use and authorized agent-controlled ...
Lian Jin Xiong - - 2013
This article focuses on translating arterial blood gas information into clinical benefits, with 3 case scenarios that focus on using arterial blood gases to manage mechanical ventilation.
Hulmani Manjunath - - 2013
Most of the misnomers encountered in dermatology have arisen from lack of understanding of the underlying etiopathogenesis, histopathology and/or concepts. Some misnomers are due to imprecise translations from word of origin, etymological bungles and/or factual errors. It is very important for the residents and practitioners of dermatology to update and ...
Al-Mutairi Nawaf - - 2013
Background: During the last decade, a lot of co-morbidities (diabetes, obesity, heart disease, etc.) have been described to be associated with psoriasis, but the exact link at the molecular level is not well-known. Researchers have shown molecular level changes in vitamin D pathway and its relationship to cathelicidin. Aims: To ...
Shah Nidhi - - 2013
Background: A distinct morphological pattern of photodermatosis has been observed with shiny skin colored to hypopigmented tiny papules, discrete or coalescing to form plaques. Aims: To study the clinico-pathological features of patients presenting with these lesions. Methods: A total of 72 patients were recruited. Clinical examination and skin biopsy was ...
Jagadeesan Soumya - - 2013
Background: Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with high mortality. Though different modalities of treatment are advocated, there is no consensus regarding specific therapy. Corticosteroids have shown conflicting results and for high dose intravenous immunoglobulins (IVIG), cost is a limiting factor. Aim: To find out ...
Shetty Vanaja P - - 2013
Background: Leprosy has been a major public-health problem in many developing countries for centuries. According to the National Leprosy Elimination Programme report of March 2012, there were a total of about 0.13 million cases of leprosy in India, 9.7% of which were children. Numerous studies have investigated child leprosy amongst ...
Bansal Shuchi - - 2013
Paget's disease of the breast is an uncommon form of breast cancer presenting as an eczematous eruption over the nipple and/or areola. The diagnosis remains elusive with varied presentations, mimicking many benign skin diseases, the awareness of which is indispensable for diagnosis and minimizing morbidity. Most of the cases have ...
Sun Z - - 2013
In assessing patients with headaches, general practitioners (GPs) play an important role in determining which patients require computed tomography (CT) scans. The purpose of this study was to identify factors that influence GPs' decisions to refer CT scans for patients with headaches. A self-administered survey was presented to GPs in ...
Sinha R - - 2013
The population in developed countries is ageing. Cancer is a disease of ageing, and this is likely to lead to an increase in the number of older patients diagnosed with cancer with significant implications for resource allocation and research priorities. Breast Cancer in older women presents a number of challenges. ...
Hofmann Volker - - 2013
Goal-directed behavior in most cases is composed of a sequential order of elementary motor patterns shaped by sensorimotor contingencies. The sensory information acquired thus is structured in both space and time. Here we review the role of motion during the generation of sensory flow focusing on how animals actively shape ...
Neveln Izaak D - - 2013
Weakly electric knifefish have intrigued both biologists and engineers for decades with their unique electrosensory system and agile swimming mechanics. Study of these fish has resulted in models that illuminate the principles behind their electrosensory system and unique swimming abilities. These models have uncovered the mechanisms by which knifefish generate ...
Baker Clare V H - - 2013
Electroreception is an ancient vertebrate sense with a fascinating evolutionary history involving multiple losses as well as independent evolution at least twice within teleosts. We review the phylogenetic distribution of electroreception and the morphology and innervation of electroreceptors in different vertebrate groups. We summarise recent work from our laboratory that ...
Wang Tao - - 2013
UVR is one of the major risk factors for melanoma development. However, the mechanisms by which UVR leads to the development of melanoma are not fully understood. Handoko et al. (this issue) explicitly indicate that macrophages are essential for UVR-induced melanocyte proliferation and migration using a neonatal mouse model. Although ...
Rünger Thomas M - - 2013
Data on the wavelength dependence of UV-induced formation of DNA damage and skin cancer have been available for quite some time, but a detailed in vivo action spectrum of mutation formation has not yet been reported so far. This important information gap is filled by Ikehata et al. in this ...
Hovnanian Alain - - 2013
In this issue, Woodley et al. report restoration of anchoring fibril formation and dermal-epidermal adherence in a murine model of recessive dystrophic epidermolysis bullosa (RDEB) by intravenous injection of recombinant human type VII collagen. This work follows a previous report by the same group of the surprising capability of intradermally ...
Kasperova Alena - - 2013
Abstract Cysteine dioxygenase (CDO, EC 1.13.11.20) is a key enzyme involved in the homeostatic regulation of cysteine level and in production of important oxidized metabolites of cysteine such as pyruvate, sulphite, sulphate, hypotaurine, and taurine in all eukaryotic cells. The intracellular CDO concentration is regulated at both transcriptional and posttranslational ...
Meyer Barbara J - - 2013
The aim of this study was to explore the associations between incidence of depression and dietary intakes of foods and fatty acids in adult Australians. Data from the 1995 Australian National Nutrition Survey (NNS), the 1995 Australian National Health Survey (NHS) and an updated fatty acid database were merged and ...
Oztürk Serkan - - 2013
Objectives: It is well known that inflammation plays a key role in both initiation and propagation of acute coronary syndrome (ACS). White blood cell (WBC) and its subtypes are an indicator of inflammation in patients with ACS. We aimed to evaluate the WBC and its subtypes in patients aged <45 ...
Büyükkaya Eyüp - - 2013
Objectives: Cardiac syndrome X (CSX) is a clinical entity that is defined as normal coronary arteries with angina pectoris and objective sins of ischemia. The correlation between CSX and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) is well established, however an association with pentraxin-3 (PTX-3) has not been examined. ...
Oto Ali - - 2013
Objectives: Pulmonary vein (PV) isolation with cryothermal energy is a recently introduced technique in patients with atrial fibrillation (AF). It may reduce procedural times and serious complications associated with radiofrequency (RF) ablation. We aimed to present the baseline characteristics and follow-up data of our study population undergoing cryoballoon AF ablation. ...
Brown Sara - - 2013
ABCC11 genotype affects apocrine secretory cell function and determines individual body odor phenotype. Rodriguez et al. have applied genetic epidemiology using predetermined phenotype data to demonstrate an association between a single-nucleotide polymorphism (rs17822931) and the human behavior of deodorant application. Individuals with the ABCC11 genotype predicting a nonodorous phenotype report ...
Val Gonzalo Moreno Del - - 2013
This study was undertaken to refine the techniques of in vivo collection of sperm in the mouse. The principal objective was to offer a viable, safe and reliable method for serial collection of in vivo epididimary sperm through the direct puncture of the epididymis. Six C57Bl/6J males were subjected to the whole ...
Thaete Larry G - - 2013
Common anaesthetic and analgesic agents used during pregnancy in mice have been observed to cause fetal growth restriction. We investigated the impact of therapeutic doses of three anaesthetics (ketamine/xylazine, isoflurane, and tribromoethanol) and two analgesics (buprenorphine and meloxicam) on fetal and placental growth. Pregnant mice were treated with one of ...
Sánchez-Lara Karla - - 2013
The aim of this study was to examine the brain activity manifested while non-small cell lung cancer (NSCLC) patients with and without anorexia were exposed to visual food stimuli. We included 26 treatment-naïve patients who had been recently diagnosed with advanced NSCLC. Patients with brain metastasis were excluded. The patients ...
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