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Lieber Richard L RL Department of Orthopaedic Surgery, University of California San Diego, San Diego, California 92093-0863, USA. - - 2013
Skeletal muscle fibrosis can be a devastating clinical problem that arises from many causes, including primary skeletal muscle tissue diseases, as seen in the muscular dystrophies, or it can be secondary to events that include trauma to muscle or brain injury. The cellular source of activated fibroblasts (myofibroblasts) may include ...
Leyser-Whalen Ophra O Department of Sociology and Anthropology, University of Texas at El Paso, El Paso, Texas 79968, USA. - - 2013
Little is known about Hispanics and their contraceptive choices in general, with some past studies detailing nonconsensual sterilization. This article is based on interviews with a mostly Hispanic sample of 44 women being sterilized at a public clinic in southeast Texas with the Essure device, which entails a new outpatient ...
Wong Jeffrey L JL Department of Surgery, University of Pittsburgh, Hillman Cancer Center, UPCI Research Pavilion, Room 1.46, 5117 Center Avenue, Pittsburgh, PA 15213-1863, - - 2013
Chemokine-driven interactions of immune cells are essential for effective antitumor immunity. Human natural killer (NK) cells can be primed by the interleukin (IL)-1-related proinflammatory cytokine IL-18 for unique helper activity, which promotes dendritic cell (DC) activation and DC-mediated induction of type-1 immune responses against cancer. Here, we show that such ...
Zhang Yaqing Y Department of Surgery, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, - - 2013
Wnt ligand expression and activation of the Wnt/β-catenin pathway have been associated with pancreatic ductal adenocarcinoma, but whether Wnt activity is required for the development of pancreatic cancer has remained unclear. Here, we report the results of three different approaches to inhibit the Wnt/β-catenin pathway in a established transgenic mouse ...
Terry Kathryn L KL Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA 02115, USA. - - 2013
Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with number of genital powder applications and for all histologic types of ovarian cancer ...
Stukalin Evgeny B EB Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218, - - 2013
For symmetrically dividing cells, large variations in the cell cycle time are typical, even among clonal cells. The consequence of this variation is important in stem cell differentiation, tissue and organ size control, and cancer development, where cell division rates ultimately determine the cell population. We explore the connection between ...
Kang Chang-kwon CK Department of Aerospace Engineering, University of Michigan, Ann Arbor, MI 48109, - - 2013
We report a comprehensive scaling law and novel lift generation mechanisms relevant to the aerodynamic functions of structural flexibility in insect flight. Using a Navier-Stokes equation solver, fully coupled to a structural dynamics solver, we consider the hovering motion of a wing of insect size, in which the dynamics of ...
Genot Anthony J AJ LIMMS/CNRS-IIS, University of Tokyo, Tokyo, - - 2013
DNA has proved to be an exquisite substrate to compute at the molecular scale. However, nonlinear computations (such as amplification, comparison or restoration of signals) remain costly in term of strands and are prone to leak. Kim et al. showed how competition for an enzymatic resource could be exploited in ...
Kwon Kyung-Ah KA Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, - - 2013
Blinking is vital to maintain the integrity of the ocular surface and its characteristics such as blink duration and speed can vary significantly, depending on the health of the eyes. The blink is so rapid that special techniques are required to characterize it. In this study, a high-speed camera was ...
Lehnert Matthew S MS School of Agricultural, Forest and Environmental Sciences, Clemson University, Clemson, SC 29634, - - 2013
Mouthparts of fluid-feeding insects have unique material properties with no human-engineered analogue: the feeding devices acquire sticky and viscous liquids while remaining clean. We discovered that the external surface of the butterfly proboscis has a sharp boundary separating a hydrophilic drinking region and a hydrophobic non-drinking region. The structural arrangement ...
Jokiel P L PL Hawaii Institute of Marine Biology, University of Hawaii, , PO Box 1346, Kaneohe, HI 96744, USA. - - 2013
Data on calcification rate of coral and crustose coralline algae were used to test the proton flux model of calcification. There was a significant correlation between calcification (G) and the ratio of dissolved inorganic carbon (DIC) to proton concentration ([DIC] : [H(+)] ratio). The ratio is tightly correlated with [CO3(2-)] ...
Dumas Zoé Z Department of Ecology and Evolution, University of Lausanne, , Biophore Building, 1015 Lausanne, - - 2013
Bacteria often possess multiple siderophore-based iron uptake systems for scavenging this vital resource from their environment. However, some siderophores seem redundant, because they have limited iron-binding efficiency and are seldom expressed under iron limitation. Here, we investigate the conundrum of why selection does not eliminate this apparent redundancy. We focus ...
Royer Dana L DL Department of Earth and Environmental Sciences, Wesleyan University, Middletown, CT 06459, USA. - - 2013
Models generally predict a response in species richness to climate, but strong climate-diversity associations are seldom observed in long-term (more than 10(6) years) fossil records. Moreover, fossil studies rarely distinguish between the effects of atmospheric CO2 and temperature, which limits their ability to identify the causal controls on biodiversity. Plants ...
Mohamed Fawzi Elshaima E Departmento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, - - 2013
Seven 3-month-old, female, helminth-free lambs were immunized intranasally with three doses (1 mg total) of a recombinant part of the catalytic region of the serine/threonine phosphatase 2A (PP2Ar) (group 1 [G1]). In addition, four lambs were used as an adjuvant control group (G2), four as unimmunized, infected controls (G3), and ...
Roy Jeremy W JW Center for Systems Biology/Program in Membrane Biology/Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts; - - 2013
Clear cells express the vacuolar proton-pumping H(+)-ATPase (V-ATPase) and acidify the lumen of the epididymis, a process that is essential for male fertility. The renin-angiotensin-aldosterone system (RAAS) regulates fluid and electrolyte balance in the epididymis, and a previous study showed binding of aldosterone exclusively to epididymal clear cells (Hinton BT, ...
Crossland Randy F RF Department of Anesthesiology, Baylor College of Medicine, Houston, - - 2013
Obstructive sleep apnea (OSA), a condition in which the upper airway collapses during sleep, is strongly associated with metabolic and cardiovascular diseases. Little is known how OSA affects the cerebral circulation. The goals of this study were 1) to develop a rat model of chronic OSA that involved apnea and ...
Pluznick Jennifer L JL Dept. of Physiology, Johns Hopkins Univ. School of Medicine, Baltimore, MD 21205. - - 2013
Studies over the past decade have highlighted important roles played by sensory receptors outside of traditionally sensory tissues; for example, taste receptors participate in pH sensing in the cerebrospinal fluid, bitter taste receptors mediate bronchodilation and ciliary beating in the lung (Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger ...
Wysocki Jan J Div. of Nephrology and Hypertension, Dept. of Medicine, The Feinberg School of Medicine, Northwestern Univ., 320 E. Superior, Chicago, IL 60611. - - 2013
Angiotensin-converting enzyme-2 (ACE2) enhances the degradation of ANG II and its expression is altered in diabetic kidneys, but the regulation of this enzyme in the urine is unknown. Urinary ACE2 was studied in the db/db model of type 2 diabetes and stretozotocin (STZ)-induced type 1 diabetes during several physiological and ...
Ao Mei M Department of Physiology and Biophysics, University of Illinois, Chicago, - - 2013
High levels of chenodeoxycholic acid (CDCA) and deoxycholic acid stimulate Cl(-) secretion in mammalian colonic epithelia. While different second messengers have been implicated in this action, the specific signaling pathway has not been fully delineated. Using human colon carcinoma T84 cells, we elucidated this cascade assessing Cl(-) transport by measuring ...
Park Won Sun WS Department of Physiology, Kangwon National University School of Medicine, Chuncheon, - - 2013
Human adipose tissue-derived mesenchymal stem cells (hASCs) have the power to differentiate into various cell types including chondrocytes, osteocytes, adipocytes, neurons, cardiomyocytes, and smooth muscle cells. We characterized the functional expression of ion channels after transforming growth factor-β1 (TGF-β1)-induced differentiation of hASCs, providing insights into the differentiation of vascular smooth ...
Islam Zinia Z Department of Biological Sciences, Tokyo Institute of Technology, Yokohama, - - 2013
The second most abundant cation in seawater (SW), Mg²⁺, is present at concentrations of ~53 mM. Marine teleosts maintain plasma Mg²⁺ concentration at 1-2 mM by excreting Mg²⁺ into the urine. Urine Mg²⁺ concentrations of SW teleosts exceed 70 mM, most of which is secreted by the renal tubular epithelial ...
Huen Sarah C SC Yale Univ. School of Medicine, PO Box 208029, New Haven, CT 06520. - - 2013
Macrophage infiltration is a prominent feature of the innate immune response to kidney injury. The persistence of macrophages is associated with tubulointerstitial fibrosis and progression of chronic kidney disease. Macrophages are known to be major producers of transforming growth factor-β1 (TGF-β1), especially in the setting of phagocytosis of apoptotic cells. ...
Rozen-Zvi Benaya B Dept. of Pediatrics, 310 E. Superior St. Chicago, IL 60611. - - 2013
Transforming growth factor (TGF)-β is a major mediator of kidney fibrosis. In the past decade it was recognized that, besides canonical Smad signaling, many other signaling pathways participate in the process of TGF-β-induced fibrogenesis. One such pathway involves mammalian target of rapamycin complex (mTORC)1. We recently reported that the hypoxia-inducible ...
Wen Donghai D Dept. of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198-5850. - - 2013
In the distal nephron, the large-conductance Ca-activated K (BK) channel, comprised of a pore-forming-α (BK-α) and the BK-β4 subunit, promotes K excretion when mice are maintained on a high-K alkaline diet (HK-alk). We examined whether BK-β4 and the acid-base status regulate apical membrane expression of BK-α in the cortical (CCD) ...
Bi J J Dept. of Cell and Developmental Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210. - - 2013
Glomerular visceral epithelial cells, also known as podocytes, are critical to both normal kidney function and the development of kidney disease. Podocyte actin cytoskeleton and their highly specialized cell-cell junctions (also called slit diaphragm complexes) play key roles in controlling glomerular filtration. Myosin 1e (myo1e) is an actin-based molecular motor ...
Zhou Hua H Renal Diagnostics and Therapeutics Unit, NIDDK, National Institutes of Health, 10 Center Dr., Bldg 10, Rm. 3N108, Bethesda, MD 20892-1268. - - 2013
Renal Wilms' tumor-1 (WT-1) staining is used to detect podocyte loss in kidney biopsies. We aimed to determine if urinary exosomal WT-1 could serve as a noninvasive biomarker of podocyte injury. We examined WT-1 by Western blot in a human podocyte-like cell line, a mouse model of podocyte injury, and ...
Marker Daniel F DF Centers for Neural Development and Disease, University of Rochester, Rochester, New York 14642, USA. - - 2013
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) is a significant source of disability in the HIV-infected population. Even with stringent adherence to anti-retroviral therapy, >50% of patients living with HIV-1 will develop HAND (Heaton et al., 2010). Because suppression of viral replication alone is not enough to stop HAND progression, ...
Henning Oliver - - 2013
BACKGROUND. Epilepsy-related psychoses lie in the border zone between neurology and psychiatry. The aim of this article is to give a brief overview of current knowledge of these psychoses, and to offer recommendations for their treatment.METHOD. The article is based on a discretionary selection of articles found through a search ...
Prameprart Monsikarn - - 2013
The objectives of this study were to investigate the pattern of unintentional drowning deaths and to identify the factors associated with drowning deaths in Thailand from 2000 to 2009. Reported death data were obtained from the Bureau of Health Policy and Strategy, Ministry of Public Health. During the period from ...
Lin Yu-Cheng - - 2013
To examine the potential risk factors for work-related fatigue (WRF) among workers in modern industries, the authors analyzed the records of need-for-recovery questionnaires and health checkup results for 1545 employees. Compared with regular daytime workers, and after adjusting for confounders, the workers adapting to day-and-night rotating shift work (RSW) had ...
Foon Tan Siow - - 2013
This study examines the rate of decline of estimated glomerular filtration rate (eGFR) over a 10-year period and the associated risk factors in type 2 diabetes mellitus (T2DM) patients. Medical records of T2DM patients were randomly selected. The rate of fall in eGFR (simplified modification of diet in renal disease ...
Wang Chenggang - - 2013
The aim of this study is to develop a model that correctly identifies and quantifies the relationship between dengue and meteorological factors in Guangzhou, China. By cross-correlation analysis, meteorological variables and their lag effects were determined. According to the epidemic characteristics of dengue in Guangzhou, those statistically significant variables were ...
Phanthavong Pinkham - - 2013
In spite of being a major public health issue, no data on depression in young people exist in Laos. Decision makers are therefore poorly equipped to define the degree of prioritization of this pathology among their preoccupations. This study aimed at estimating the prevalence of depression among last-year high schools ...
Banala Srinivas - - 2013
A cyclodehydration reaction has been used to synthesize the linear azole-containing peptide plantazolicin A. The target compound was synthesized from two heterocyclic fragments derived from dipeptide building blocks. The acid-labile oxazolines and thiazoles necessitate the use of a Teoc/TMSE-based protection-group strategy which allows structure modification of plantazolicin.
Zemlyak Alla - - 2013
Primary and acquired abdominal pathology accounts for a significant proportion of sepsis and SIRS in the ICU population. Abdominal processes often present a difficult diagnostic dilemma in the truly critically ill patient who, due to hemodynamic instability or severe acute respiratory distress syndrome (ARDS) requiring high-level ventilatory support, is at ...
Pathirage Niroshani A - - 2013
Abnormal trophoblast function is associated with human fetal growth restriction (FGR). Targeted disruption of homeobox gene transforming growth β-induced factor (TGIF-1) results in placental dysfunction in the mouse. The role of human TGIF-1 in placental cell function is unknown. The aims of this study were to determine expression of TGIF-1 ...
Masuda Tsukuru - - 2013
An autonomous functional surface has been designed by using self-oscillating polymers that convert the chemical energy of the Belousov-Zhabotinsky reaction into conformational changes of the polymer chains (see picture: red: hydrophobic/collapsed, green: hydrophilic/extended). Self-oscillating polymer brushes were grafted onto the inner surface of a glass capillary, and autonomous propagation of ...
Zoja Carlamaria - - 2013
The Nrf2/Keap1 system regulates the transcription of antioxidant and cytoprotective genes through direct Nrf2 binding to responsive elements in the promoter region of target genes or via Keap1-induced NF-kB inhibition. The association between oxidative stress and inflammation with progression of chronic kidney diseases (CKDs) directed attention towards bardoxolone methyl and ...
Usvyat Len A - - 2013
BACKGROUND AND OBJECTIVES: In chronic hemodialysis (HD), patients' hospitalizations result in significant costs and affect the quality of life. We aimed at understanding hospitalization rates before death and to identify patterns in clinical and laboratory parameters that precede the first hospitalization. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We conducted two separate ...
Chagas Marcos Hortes N - - 2013
BACKGROUND: depression is common in Parkinson's disease (PD), although frequently under-recognised. Among the scales used to investigate depressive features in PD, the Patient Health Questionnaire-9 (PHQ-9) has been largely used, but no specific cut-off scores for depression have been established thus far, which hinders the use of the PHQ-9 in ...
Ryu Mikyung - - 2013
OBJECTIVE: this study examined the association of physical activity with sarcopenia and sarcopenic obesity among the community-dwelling Korean elderly. METHODS: subjects consisted of 2,264 aged 65 years or older in the 2008-09 Korea National Health and Nutrition Examination Survey. Sarcopenia was defined as 2 SD below the mean of the ...
Cour M - - 2013
BACKGROUND: /st>Manual changeover of vasoactive drug infusion pumps (CVIP) frequently lead to haemodynamic instability. Some of the newest smart pumps allow automated CVIP. The aim of this study was to compare automated CVIP with manual 'Quick Change' relays. METHODS: /st>We performed a prospective, quasi-experimental study, in a university-affiliated intensive care ...
Waldrop Lindsay D - - 2013
Malacostracan crustaceans such as crabs flick antennae with arrays of olfactory sensilla called aesthetascs through the water to sense odors. Flicking by crabs consists of a quick downstroke, in which aesthetascs are deflected laterally (splayed), and a slower, reversed return stroke, in which aesthetascs clump together. This motion causes water ...
Smutzer Gregory - - 2013
A novel delivery method is described that incorporates taste stimuli into edible strips for determining n-propylthiouracil (PROP) taster status. Edible strips that contained 400 or 600nanomoles of PROP were prepared for psychophysical studies. Using these strips, we measured taste intensity, taste hedonics, and taste quality responses in a sample of ...
McGann John P - - 2013
Presynaptic inhibition is the suppression of neurotransmitter release from a neuron by inhibitory input onto its presynaptic terminal. In the olfactory system, the primary sensory afferents from the olfactory neuroepithelium to the brain's olfactory bulb are strongly modulated by a presynaptic inhibition that has been studied extensively in brain slices ...
Dong Yongqiang - - 2013
Helpful elements: A facile bottom-up method using citric acid and L-cysteine as a precursor has been developed to prepare graphene quantum dots (GQDs) co-doped with nitrogen and sulfur. A new type and high density of surface state of GQDs arises, leading to high yields (more than 70 %) and excitation-independent emission. ...
Bhaskaran Manoj - - 2013
Ricin toxin, a type 2 ribosome-inactivating protein and a category B bioterrorism agent, is produced from the seeds of castor oil plant (Ricinus communis). Chronic pathological changes in survivors of aerosolized ricin exposure have not been reported in primates. Here we compare and contrast the pathological changes manifested between rhesus ...
Vollset Stein Emil - - 2013
Aims: Use time trends in cause-specific middle-age death risk to study differences in mortality patterns among the Nordic countries. Methods: Middle-age (40-69 years) death risk and its decomposition into cause-specific death risks were computed. Results: In 1952, middle-age death risk was highest in Finland and lowest in Norway. For men, ...
Zander Viktoria - - 2013
Background: As dispersed ethnic populations in Swedish society expand, the healthcare system need to adapt rehabilitation services according to their needs. The experiences of trauma and forced resettlement have a continuing impact on health and musculoskeletal pain, as well as the intersecting structures that prerequisite the possibilities in the new ...
Krane Line - - 2013
Aims: Sickness absence is of considerable concern in both Norway and Denmark. Labour Force Surveys indicate that absence in Norway is about twice that in Denmark and twice that of the mean reported by the Organisation for Economic Co-operation and Development. This study compares absence patterns according to age, percentage ...
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