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Nebert Daniel W DW Department of Environmental Health, and the Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267-0056, USA. - - 2013
Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH); this ubiquitous environmental carcinogenic agent is found in tobacco smoke, charcoal-grilled foods, and PAH-contaminated surfaces of roofs, playgrounds, and highways. Cytochrome P450 1 wild-type, Cyp1a2(-/-), Cyp1b1(-/-), or Cyp1a2/1b1(-/-) knockouts, and mice with Cyp1a1 expression deleted in hepatocytes can ingest large oral ...
Marker Daniel F DF Centers for Neural Development and Disease, University of Rochester, Rochester, New York 14642, USA. - - 2013
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) is a significant source of disability in the HIV-infected population. Even with stringent adherence to anti-retroviral therapy, >50% of patients living with HIV-1 will develop HAND (Heaton et al., 2010). Because suppression of viral replication alone is not enough to stop HAND progression, ...
Wang Chia-Yih CY Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD, USA. - - 2013
Because of the logistic complexity, excessive respondent burden, and high cost of conducting 24-h urine collections in a national survey, alternative strategies to monitor sodium intake at the population level need to be evaluated. We conducted a calibration study to assess the ability to characterize sodium intake from timed-spot urine ...
Rozen-Zvi Benaya B Dept. of Pediatrics, 310 E. Superior St. Chicago, IL 60611. - - 2013
Transforming growth factor (TGF)-β is a major mediator of kidney fibrosis. In the past decade it was recognized that, besides canonical Smad signaling, many other signaling pathways participate in the process of TGF-β-induced fibrogenesis. One such pathway involves mammalian target of rapamycin complex (mTORC)1. We recently reported that the hypoxia-inducible ...
Morton Paul D PD The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136, - - 2013
Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro. Using a mouse model, we show that nuclear factor κB activation in Schwann cells ...
Housset Michael M Institut de Biologie Valrose, University of Nice Sophia Antipolis, UFR Sciences, Nice F-06108, - - 2013
Photoreceptors are specialized neurons of the retina that receive nursing from the adjacent retinal pigment epithelium (RPE). Frequent in the elderly, photoreceptor loss can originate from primary dysfunction of either cell type. Despite intense interest in the etiology of these diseases, early molecular actors of late-onset photoreceptor degeneration remain elusive, ...
Bodewes Rogier R Department of Viroscience, Erasmus MC, Rotterdam, the - - 2013
Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected ...
Ferguson Brian J BJ Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, - - 2013
Vaccinia virus (VACV) expresses many proteins that are non-essential for virus replication but promote virulence by inhibiting components of the host immune response to infection. These immunomodulators include a family of proteins that have, or are predicted to have, a structure related to the B-cell lymphoma (Bcl)-2 protein. Five members ...
Liu Shijing S Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. - - 2013
Key characteristics of cocaine dependence include attentional bias to cocaine cues and impaired inhibitory control. Studies suggest that serotonin modulates both cocaine cue reactivity and inhibitory control. We investigated effects of the selective serotonin reuptake inhibitor escitalopram on cocaine cue reactivity and inhibitory processes in cocaine-dependent subjects. In a double-blind ...
Ao Mei M Department of Physiology and Biophysics, University of Illinois, Chicago, - - 2013
High levels of chenodeoxycholic acid (CDCA) and deoxycholic acid stimulate Cl(-) secretion in mammalian colonic epithelia. While different second messengers have been implicated in this action, the specific signaling pathway has not been fully delineated. Using human colon carcinoma T84 cells, we elucidated this cascade assessing Cl(-) transport by measuring ...
Huen Sarah C SC Yale Univ. School of Medicine, PO Box 208029, New Haven, CT 06520. - - 2013
Macrophage infiltration is a prominent feature of the innate immune response to kidney injury. The persistence of macrophages is associated with tubulointerstitial fibrosis and progression of chronic kidney disease. Macrophages are known to be major producers of transforming growth factor-β1 (TGF-β1), especially in the setting of phagocytosis of apoptotic cells. ...
Genot Anthony J AJ LIMMS/CNRS-IIS, University of Tokyo, Tokyo, - - 2013
DNA has proved to be an exquisite substrate to compute at the molecular scale. However, nonlinear computations (such as amplification, comparison or restoration of signals) remain costly in term of strands and are prone to leak. Kim et al. showed how competition for an enzymatic resource could be exploited in ...
Kwon Kyung-Ah KA Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, - - 2013
Blinking is vital to maintain the integrity of the ocular surface and its characteristics such as blink duration and speed can vary significantly, depending on the health of the eyes. The blink is so rapid that special techniques are required to characterize it. In this study, a high-speed camera was ...
Lehnert Matthew S MS School of Agricultural, Forest and Environmental Sciences, Clemson University, Clemson, SC 29634, - - 2013
Mouthparts of fluid-feeding insects have unique material properties with no human-engineered analogue: the feeding devices acquire sticky and viscous liquids while remaining clean. We discovered that the external surface of the butterfly proboscis has a sharp boundary separating a hydrophilic drinking region and a hydrophobic non-drinking region. The structural arrangement ...
Kang Chang-kwon CK Department of Aerospace Engineering, University of Michigan, Ann Arbor, MI 48109, - - 2013
We report a comprehensive scaling law and novel lift generation mechanisms relevant to the aerodynamic functions of structural flexibility in insect flight. Using a Navier-Stokes equation solver, fully coupled to a structural dynamics solver, we consider the hovering motion of a wing of insect size, in which the dynamics of ...
Fernández-Marín Beatriz B Department of Plant Biology and Ecology, University of the Basque Country (UPV/EHU), Aptdo. 644, 48080 Bilbao, Spain. - - 2013
Desiccation-tolerant plants are able to withstand dehydration and resume normal metabolic functions upon rehydration. These plants can be dehydrated until their cytoplasm enters a 'glassy state' in which molecular mobility is severely reduced. In desiccation-tolerant seeds, longevity can be enhanced by drying and lowering storage temperature. In these conditions, they ...
Menguer Paloma K PK Centre for Biological Science, University of Southampton, Life Sciences Building 85, Highfield Campus, Southampton SO17 1B, - - 2013
Heavy metal homeostasis is maintained in plant cells by specialized transporters which compartmentalize or efflux metal ions, maintaining cytosolic concentrations within a narrow range. OsMTP1 is a member of the cation diffusion facilitator (CDF)/metal tolerance protein (MTP) family of metal cation transporters in Oryza sativa, which is closely related to ...
Li Yanping Y Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. - - 2013
To prospectively examine whether men with restless legs syndrome (RLS) had an increased risk of mortality. This was a prospective cohort study of 18,425 US men free of diabetes, arthritis, and renal failure in the Health Professionals Follow-up Study (HPFS). In 2002, RLS was assessed using a set of standardized ...
Kantarci Kejal K Department of Radiology, Mayo Clinic, Rochester, MN, USA. - - 2013
To investigate MRI and proton magnetic resonance spectroscopy (MRS) predictors of mild cognitive impairment (MCI) in cognitively normal older adults. Subjects were cognitively normal older adults (n = 1,156) who participated in the population-based Mayo Clinic Study of Aging MRI/MRS study from August 2005 to December 2010 and had at ...
Wright Kyle T KT Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, - - 2013
Systemic inflammatory response syndrome (SIRS) is associated with the development of severe medical complications, including progression to multiple organ dysfunction syndrome and even death. To date, only marginal improvements in terms of therapeutic options have been established for patients affected by SIRS. Raf kinase inhibitor protein (RKIP) is a regulator ...
Clingan Jonathan M JM Division of Rheumatology, Department of Medicine and Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, - - 2013
The importance for activation of innate immunity by pattern recognition receptors in forming an effective adaptive immune response is well known. TLRs were demonstrated to be critical for Ab responses to a variety of immunizations. In particular, recent evidence suggests that B cell-intrinsic TLR signaling is required for optimal responses ...
Williams Christopher L CL Department of Microbiology and Immunology, Vanderbilt University, Nashville TN 37232, - - 2013
CD4(+) T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN- γ. IL-4-producing Th2 effector cells give rise to a long-lived memory population committed to reactivation of the Th2 cytokine gene expression ...
Šedý John R JR Infectious and Inflammatory Disease Center, Sanford|Burnham Medical Research Institute, La Jolla, CA 92037, - - 2013
Lymphocyte activation is regulated by costimulatory and inhibitory receptors, of which both B and T lymphocyte attenuator (BTLA) and CD160 engage herpesvirus entry mediator (HVEM). Notably, it remains unclear how HVEM functions with each of its ligands during immune responses. In this study, we show that HVEM specifically activates CD160 ...
Drummond Micah J MJ Univ. of Utah, 520 Wakara Way, Salt Lake City, UT 84108-1213, USA. - - 2013
Bed rest induces significant loss of leg lean mass in older adults. Systemic and tissue inflammation also accelerates skeletal muscle loss, but it is unknown whether inflammation is associated to inactivity-induced muscle atrophy in healthy older adults. We determined if short-term bed rest increases toll-like receptor 4 (TLR4) signaling and ...
Henning Oliver - - 2013
BACKGROUND. Epilepsy-related psychoses lie in the border zone between neurology and psychiatry. The aim of this article is to give a brief overview of current knowledge of these psychoses, and to offer recommendations for their treatment.METHOD. The article is based on a discretionary selection of articles found through a search ...
Prameprart Monsikarn - - 2013
The objectives of this study were to investigate the pattern of unintentional drowning deaths and to identify the factors associated with drowning deaths in Thailand from 2000 to 2009. Reported death data were obtained from the Bureau of Health Policy and Strategy, Ministry of Public Health. During the period from ...
Lin Yu-Cheng - - 2013
To examine the potential risk factors for work-related fatigue (WRF) among workers in modern industries, the authors analyzed the records of need-for-recovery questionnaires and health checkup results for 1545 employees. Compared with regular daytime workers, and after adjusting for confounders, the workers adapting to day-and-night rotating shift work (RSW) had ...
Foon Tan Siow - - 2013
This study examines the rate of decline of estimated glomerular filtration rate (eGFR) over a 10-year period and the associated risk factors in type 2 diabetes mellitus (T2DM) patients. Medical records of T2DM patients were randomly selected. The rate of fall in eGFR (simplified modification of diet in renal disease ...
Wang Chenggang - - 2013
The aim of this study is to develop a model that correctly identifies and quantifies the relationship between dengue and meteorological factors in Guangzhou, China. By cross-correlation analysis, meteorological variables and their lag effects were determined. According to the epidemic characteristics of dengue in Guangzhou, those statistically significant variables were ...
Phanthavong Pinkham - - 2013
In spite of being a major public health issue, no data on depression in young people exist in Laos. Decision makers are therefore poorly equipped to define the degree of prioritization of this pathology among their preoccupations. This study aimed at estimating the prevalence of depression among last-year high schools ...
Banala Srinivas - - 2013
A cyclodehydration reaction has been used to synthesize the linear azole-containing peptide plantazolicin A. The target compound was synthesized from two heterocyclic fragments derived from dipeptide building blocks. The acid-labile oxazolines and thiazoles necessitate the use of a Teoc/TMSE-based protection-group strategy which allows structure modification of plantazolicin.
Zemlyak Alla - - 2013
Primary and acquired abdominal pathology accounts for a significant proportion of sepsis and SIRS in the ICU population. Abdominal processes often present a difficult diagnostic dilemma in the truly critically ill patient who, due to hemodynamic instability or severe acute respiratory distress syndrome (ARDS) requiring high-level ventilatory support, is at ...
Pathirage Niroshani A - - 2013
Abnormal trophoblast function is associated with human fetal growth restriction (FGR). Targeted disruption of homeobox gene transforming growth β-induced factor (TGIF-1) results in placental dysfunction in the mouse. The role of human TGIF-1 in placental cell function is unknown. The aims of this study were to determine expression of TGIF-1 ...
Masuda Tsukuru - - 2013
An autonomous functional surface has been designed by using self-oscillating polymers that convert the chemical energy of the Belousov-Zhabotinsky reaction into conformational changes of the polymer chains (see picture: red: hydrophobic/collapsed, green: hydrophilic/extended). Self-oscillating polymer brushes were grafted onto the inner surface of a glass capillary, and autonomous propagation of ...
Zoja Carlamaria - - 2013
The Nrf2/Keap1 system regulates the transcription of antioxidant and cytoprotective genes through direct Nrf2 binding to responsive elements in the promoter region of target genes or via Keap1-induced NF-kB inhibition. The association between oxidative stress and inflammation with progression of chronic kidney diseases (CKDs) directed attention towards bardoxolone methyl and ...
Usvyat Len A - - 2013
BACKGROUND AND OBJECTIVES: In chronic hemodialysis (HD), patients' hospitalizations result in significant costs and affect the quality of life. We aimed at understanding hospitalization rates before death and to identify patterns in clinical and laboratory parameters that precede the first hospitalization. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We conducted two separate ...
Chagas Marcos Hortes N - - 2013
BACKGROUND: depression is common in Parkinson's disease (PD), although frequently under-recognised. Among the scales used to investigate depressive features in PD, the Patient Health Questionnaire-9 (PHQ-9) has been largely used, but no specific cut-off scores for depression have been established thus far, which hinders the use of the PHQ-9 in ...
Ryu Mikyung - - 2013
OBJECTIVE: this study examined the association of physical activity with sarcopenia and sarcopenic obesity among the community-dwelling Korean elderly. METHODS: subjects consisted of 2,264 aged 65 years or older in the 2008-09 Korea National Health and Nutrition Examination Survey. Sarcopenia was defined as 2 SD below the mean of the ...
Cour M - - 2013
BACKGROUND: /st>Manual changeover of vasoactive drug infusion pumps (CVIP) frequently lead to haemodynamic instability. Some of the newest smart pumps allow automated CVIP. The aim of this study was to compare automated CVIP with manual 'Quick Change' relays. METHODS: /st>We performed a prospective, quasi-experimental study, in a university-affiliated intensive care ...
Lovisetto Alessandro - - 2013
Background and AimsThe evolution of seeds together with the mechanisms related to their dispersal into the environment represented a turning point in the evolution of plants. Seeds are produced by gymnosperms and angiosperms but only the latter have an ovary to be transformed into a fruit. Yet some gymnosperms produce ...
Wang Yi - - 2013
Background and AimsInvasive plants can be released from specialist herbivores and encounter novel generalists in their introduced ranges, leading to variation in defence among native and invasive populations. However, few studies have examined how constitutive and induced indirect defences change during plant invasion, especially during the juvenile stage.MethodsConstitutive extrafloral nectar ...
Waldrop Lindsay D - - 2013
Malacostracan crustaceans such as crabs flick antennae with arrays of olfactory sensilla called aesthetascs through the water to sense odors. Flicking by crabs consists of a quick downstroke, in which aesthetascs are deflected laterally (splayed), and a slower, reversed return stroke, in which aesthetascs clump together. This motion causes water ...
Smutzer Gregory - - 2013
A novel delivery method is described that incorporates taste stimuli into edible strips for determining n-propylthiouracil (PROP) taster status. Edible strips that contained 400 or 600nanomoles of PROP were prepared for psychophysical studies. Using these strips, we measured taste intensity, taste hedonics, and taste quality responses in a sample of ...
McGann John P - - 2013
Presynaptic inhibition is the suppression of neurotransmitter release from a neuron by inhibitory input onto its presynaptic terminal. In the olfactory system, the primary sensory afferents from the olfactory neuroepithelium to the brain's olfactory bulb are strongly modulated by a presynaptic inhibition that has been studied extensively in brain slices ...
Dong Yongqiang - - 2013
Helpful elements: A facile bottom-up method using citric acid and L-cysteine as a precursor has been developed to prepare graphene quantum dots (GQDs) co-doped with nitrogen and sulfur. A new type and high density of surface state of GQDs arises, leading to high yields (more than 70 %) and excitation-independent emission. ...
Bhaskaran Manoj - - 2013
Ricin toxin, a type 2 ribosome-inactivating protein and a category B bioterrorism agent, is produced from the seeds of castor oil plant (Ricinus communis). Chronic pathological changes in survivors of aerosolized ricin exposure have not been reported in primates. Here we compare and contrast the pathological changes manifested between rhesus ...
Vollset Stein Emil - - 2013
Aims: Use time trends in cause-specific middle-age death risk to study differences in mortality patterns among the Nordic countries. Methods: Middle-age (40-69 years) death risk and its decomposition into cause-specific death risks were computed. Results: In 1952, middle-age death risk was highest in Finland and lowest in Norway. For men, ...
Zander Viktoria - - 2013
Background: As dispersed ethnic populations in Swedish society expand, the healthcare system need to adapt rehabilitation services according to their needs. The experiences of trauma and forced resettlement have a continuing impact on health and musculoskeletal pain, as well as the intersecting structures that prerequisite the possibilities in the new ...
Krane Line - - 2013
Aims: Sickness absence is of considerable concern in both Norway and Denmark. Labour Force Surveys indicate that absence in Norway is about twice that in Denmark and twice that of the mean reported by the Organisation for Economic Co-operation and Development. This study compares absence patterns according to age, percentage ...
Elgán Tobias H - - 2013
Aims: The primary aim is to estimate the prevalence of Swedish adolescents who perceive their parent(s) to have alcohol problems. Additional research questions pertain to the prevalence of adolescents who think someone close to them drinks too much alcohol and if this has hurt them or caused them problems. Methods: ...
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