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Pereira Flavia E FE Center for Vascular Biology MC3501, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030-3501, - - 2013
To determine the role of CD13 as an adhesion molecule in trafficking of inflammatory cells to the site of injury in vivo and its function in wound healing following myocardial infarction induced by permanent coronary artery occlusion. Seven days post-permanent ligation, hearts from CD13 knockout (CD13(KO)) mice showed significant reductions ...
Nair R R - - 2013
Control of magnetism by applied voltage is desirable for spintronics applications. Finding a suitable material remains an elusive goal, with only a few candidates found so far. Graphene is one of them and attracts interest because of its weak spin-orbit interaction, the ability to control electronic properties by the electric ...
Ao Mei M Department of Physiology and Biophysics, University of Illinois, Chicago, - - 2013
High levels of chenodeoxycholic acid (CDCA) and deoxycholic acid stimulate Cl(-) secretion in mammalian colonic epithelia. While different second messengers have been implicated in this action, the specific signaling pathway has not been fully delineated. Using human colon carcinoma T84 cells, we elucidated this cascade assessing Cl(-) transport by measuring ...
Sjölander Arvid - - 2013
In observational studies of the effect of an exposure on an outcome, the exposure-outcome association is usually confounded by other causes of the outcome (potential confounders). One common method to increase efficiency is to match the study on potential confounders. Matched case-control studies are relatively common and well covered by ...
Cosman Joshua D - - 2013
Recent studies have demonstrated that brief periods of training facilitate the ability to overcome distraction during future performance of a given task, and researchers have proposed that these effects rely on relational memory systems that enable individuals to link specific attentional states to their learned context. In the current work, ...
Je H Shawn HS Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, and Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland 20892-3714, USA. - - 2013
During development, mammalian neuromuscular junctions (NMJs) transit from multiple-innervation to single-innervation through axonal competition via unknown molecular mechanisms. Previously, using an in vitro model system, we demonstrated that the postsynaptic secretion of pro-brain-derived neurotrophic factor (proBDNF) stabilizes or eliminates presynaptic axon terminals, depending on its proteolytic conversion at synapses. Here, ...
Kratz Mario M Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. - - 2013
Recent studies have indicated that omega-3 (n3) polyunsaturated fatty acids (PUFAs) decrease adipose tissue inflammation in rodents and in morbidly obese humans. We investigated whether a diet rich in n3 PUFAs from both marine and plant sources reduces adipose tissue and systemic inflammation in overweight to moderately obese adults. We ...
Vriet Cécile - - 2013
The plant steroid hormones, brassinosteroids (BRs), and their precursors, phytosterols, play major roles in plant growth, development, and stress tolerance. Here, we review the impressive progress made during recent years in elucidating the components of the sterol and BR metabolic and signaling pathways, and in understanding their mechanism of action ...
Kim Jeongkyun - - 2013
Biological events such as gene expression, regulation, phosphorylation, localization and protein catabolism play important roles in the development of diseases. Understanding the association between diseases and genes can be enhanced with the identification of involved biological events in this association. Although biological knowledge has been accumulated in several databases and ...
Hamilton Kirk L - - 2013
This manuscript highlights the accepted manuscript by He-Ping Ma entitled 'Lovastatin attenuates effects of cyclosporine A on tight junctions and apoptosis in cultured cortical collecting duct principal cells'.
Bodewes Rogier R Department of Viroscience, Erasmus MC, Rotterdam, the - - 2013
Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected ...
Narring Françoise - - 2013
BACKGROUND: To assess the effectiveness of text-messages in reducing the proportion of non-attendance in a youth clinic of a University Hospital. METHODS: Patients who registered for an appointment and provided a mobile phone number were randomly selected to receive or not a text-message reminder before the planned appointment. A 10% ...
Spires Jessica J Departments of Biomedical Engineering, Case Western Reserve Univ., Cleveland, OH 44106-7207, - - 2013
With current techniques, experimental measurements alone cannot characterize the effects of oxygen blood-tissue diffusion on muscle oxygen uptake (Vo₂) kinetics in contracting skeletal muscle. To complement experimental studies, a computational model is used to quantitatively distinguish the contributions of convective oxygen delivery, diffusion into cells, and oxygen utilization to Vo₂ ...
Johnson Andrew Kelly - - 2013
Treating dissections and dissecting aneurysms requires maintenance of flow through the true lumen and exclusion of the false lumen from the circulation. A dissecting aneurysm of the vertebral artery presented with both a true and false lumen within the aneurysmal sac. Stenting of the true lumen followed by coil embolization ...
Rozen-Zvi Benaya B Dept. of Pediatrics, 310 E. Superior St. Chicago, IL 60611. - - 2013
Transforming growth factor (TGF)-β is a major mediator of kidney fibrosis. In the past decade it was recognized that, besides canonical Smad signaling, many other signaling pathways participate in the process of TGF-β-induced fibrogenesis. One such pathway involves mammalian target of rapamycin complex (mTORC)1. We recently reported that the hypoxia-inducible ...
Clayton Peter E - - 2013
OBJECTIVE: Individual sensitivity to recombinant human growth hormone (r-hGH) is variable. Identification of genetic factors contributing to this variability has potential use for individualization of treatment. The objective of this study was to identify genetic markers and gene expression profiles associated with growth response on r-hGH therapy in treatment-naïve, prepubertal ...
Corman Victor Max - - 2013
Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analyzed fecal, blood and intestine specimens from 1,562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected ...
Kang Chang-kwon CK Department of Aerospace Engineering, University of Michigan, Ann Arbor, MI 48109, - - 2013
We report a comprehensive scaling law and novel lift generation mechanisms relevant to the aerodynamic functions of structural flexibility in insect flight. Using a Navier-Stokes equation solver, fully coupled to a structural dynamics solver, we consider the hovering motion of a wing of insect size, in which the dynamics of ...
Wiggermann Vanessa V UBC MRI Research Centre, University of British Columbia, Vancouver, - - 2013
We investigated the evolution of new multiple sclerosis (MS) lesions over time using frequency shifts of the magnetic resonance (MR) signal. Twenty patients with relapsing-remitting MS were serially scanned for 6 months at 1-month intervals. Maps of MR frequency shifts were acquired using susceptibility-weighted imaging. New lesions were identified by ...
Carr Russell L RL Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762-6100, USA. - - 2013
The endogenous cannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) play vital roles during nervous system development. The degradation of 2-AG and AEA is mediated by monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. These enzymes are inhibited following developmental chlorpyrifos (CPF) exposure. To investigate whether this inhibition is persistent ...
Terry Kathryn L KL Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA 02115, USA. - - 2013
Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with number of genital powder applications and for all histologic types of ovarian cancer ...
Carabellese F F Department of Criminology and Forensic Psychiatry, University of Bari, - - 2013
The aim of this review was to study "female stalking" in the sense of the specific traits characterizing the phenomenon of stalking behaviour committed by women. The main medical databases were searched (Medline, Social Science Research Network, Apa Psyc Net), and 67 articles were selected, reporting studies conducted in clinical ...
Xia Zhibo - - 2013
Glioma-initiating cells (GICs), which are characterized by their self-renewal capacity and tumorigenicity, are a recently identified highly tumorigenic subpopulation of glioblastoma multiform (GBM) and are considered responsible for GBM recurrence and chemo/radiation resistance. In a previous study, we determined that Wnt signaling activation is critical to the self-renewal of GICs. ...
Fortunato Orazio - - 2013
AIMS: Following an acute myocardial infarction (AMI), pro-angiogenic PCs are released from the bone marrow into the circulation and home to the ischemic site attracted by a chemokine gradient. It is unknown if components of this early homeostatic response might help forecast long-term clinical outcome. This study investigates if the ...
Cole Conrad R - - 2013
Appropriate nutrition recommendations are important for the successful management of the infant with an injured gastrointestinal tract postsurgery who is at risk for intestinal failure. Management strategies that can be used to augment successful adaptation and prevent liver disease are summarized in this review. These include appropriate postoperative fluid and ...
Jilka Robert L - - 2013
Skeletal aging is accompanied by decreased cancellous bone mass and increased formation of pores within cortical bone. The latter accounts for a large portion of the increase in non-vertebral fractures after age 65 in humans. We selectively deleted Bak and Bax, two genes essential for apoptosis, in two types of ...
Lubbock Alexander L R - - 2013
Tissue microarrays (TMAs) allow multiplexed analysis of tissue samples and are frequently used to estimate biomarker protein expression in tumour biopsies. TMA Navigator (www.tmanavigator.org) is an open access web application for analysis of TMA data and related information, accommodating categorical, semi-continuous and continuous expression scores. Non-biological variation, or batch effects, ...
Kannan Sankaranarayanan S Cardiac Aging and Redox Signaling Laboratory, RM # 4A100, Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, - - 2013
Mutant protein aggregation (PA) cardiomyopathy (MPAC) is characterized by reductive stress (RS), PA (of chaperones and cytoskeletal components), and ventricular dysfunction in transgenic mice expressing human mutant CryAB (hmCryAB). Sustained activation of nuclear erythroid-2 like factor-2 (Nrf2) causes RS, which contributes to proteotoxic cardiac disease. The goals of this pre-clinical ...
Hattori Naoko - - 2013
Combinations of histone modifications have significant biological roles, such as maintenance of pluripotency and cancer development, but cannot be analyzed at the single cell level. Here, we visualized a combination of histone modifications by applying the in situ proximity ligation assay, which detects two proteins in close vicinity (∼30 nm). ...
Ben David Alon - - 2013
The receptor binding domain of botulinum neurotoxin (BoNT), also designated HC fragment, is a promising vaccine candidate against botulism. In this study a highly efficient expression system for the protein was developed in E. coli, which provided yields that are an order of magnitude higher than those reported to date ...
Cercamondi Colin I - - 2013
Home fortification with lipid-based nutrient supplements (LNSs) is a promising approach to improve bioavailable iron and energy intake of young children in developing countries. To optimize iron bioavailability from an LNS named complementary food fortificant (CFF), 3 stable isotope studies were conducted in 52 young Beninese children. Test meals consisted ...
Merriam Elisha P EP Center for Neural Science, New York University, New York, New York 10003, USA. - - 2013
To locate visual objects, the brain combines information about retinal location and direction of gaze. Studies in monkeys have demonstrated that eye position modulates the gain of visual signals with "gain fields," so that single neurons represent both retinotopic location and eye position. We wished to know whether eye position ...
Drummond Micah J MJ Univ. of Utah, 520 Wakara Way, Salt Lake City, UT 84108-1213, USA. - - 2013
Bed rest induces significant loss of leg lean mass in older adults. Systemic and tissue inflammation also accelerates skeletal muscle loss, but it is unknown whether inflammation is associated to inactivity-induced muscle atrophy in healthy older adults. We determined if short-term bed rest increases toll-like receptor 4 (TLR4) signaling and ...
Kantarci Kejal K Department of Radiology, Mayo Clinic, Rochester, MN, USA. - - 2013
To investigate MRI and proton magnetic resonance spectroscopy (MRS) predictors of mild cognitive impairment (MCI) in cognitively normal older adults. Subjects were cognitively normal older adults (n = 1,156) who participated in the population-based Mayo Clinic Study of Aging MRI/MRS study from August 2005 to December 2010 and had at ...
Selvaraju Ram K - - 2013
The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of Langerhans and is therefore an attractive target for imaging of the β-cell mass. In the present study, (68)Ga-labeled exendin-4 was evaluated for PET imaging and quantification of GLP-1R in the pancreas. METHODS: Dose escalation studies ...
Ferguson Brian J BJ Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, - - 2013
Vaccinia virus (VACV) expresses many proteins that are non-essential for virus replication but promote virulence by inhibiting components of the host immune response to infection. These immunomodulators include a family of proteins that have, or are predicted to have, a structure related to the B-cell lymphoma (Bcl)-2 protein. Five members ...
Clingan Jonathan M JM Division of Rheumatology, Department of Medicine and Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, - - 2013
The importance for activation of innate immunity by pattern recognition receptors in forming an effective adaptive immune response is well known. TLRs were demonstrated to be critical for Ab responses to a variety of immunizations. In particular, recent evidence suggests that B cell-intrinsic TLR signaling is required for optimal responses ...
Qiu Lianglin - - 2013
Perfluorooctane sulfonate (PFOS) is associated with male reproductive disorders, but its targets and mechanisms are poorly understood. We used in vitro and in vivo models to explore the roles of Sertoli cells and the blood-testis barrier (BTB) in PFOS-induced male reproductive dysfunction. First, we used primary Sertoli cell to estimate ...
Gramss Gerhard - - 2013
Several fungal species are notorious for the preferential acquisition of toxicants such as AsCdHgPbU in their wild-grown basidiomes, but it is not known how, or whether at all, mineral uptake is regulated. In this study, basidiomes of Kuehneromyces mutabilis, Pleurotus ostreatus, and Hypholoma fasciculare were grown on Fagus sylvatica logs ...
Katnani Husam A HA Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, - - 2013
Whether allocation of visuospatial attention can be divorced from saccade preparation has been the subject of intense research efforts. A variant of the visual search paradigm, in which a feature singleton indicates that the correct saccade should be directed to it (prosaccade) or to the opposite distractor (antisaccade), has been ...
Nakatsuka Takashi - - 2013
Betalains are one of the major plant pigment groups found in some higher plants and higher fungi. They are not produced naturally in any plant species outside of the order Caryophyllales, nor are they produced by anthocyanin-accumulating Caryophyllales. Here, we attempted to reconstruct the betalain biosynthetic pathway as a self-contained ...
Taketani Akinori - - 2013
The aim of the present study is to evaluate the capability of a miniaturized Raman endoscope (mRE) system to monitor the advancement of colorectal tumors in model mice as a method that is noninvasive to the tumor itself. Nevertheless, the endoscope is narrow enough to observe the inside of the ...
Wu Felicia F Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, - - 2013
The aflatoxins are a group of fungal metabolites that contaminate a variety of staple crops, including maize and peanuts, and cause an array of acute and chronic human health effects. Aflatoxin B1 in particular is a potent liver carcinogen, and hepatocellular carcinoma (HCC) risk is multiplicatively higher for individuals exposed ...
Péré Christelle C CABI, 2800 Delémont, - - 2013
How global warming will affect insect parasitoids and their role as natural enemies of insect pests is difficult to assess within a short period of time. Considering that elevation gradients can be used as analogues for global warming, we carried out meta-analyses of 27 correlations between parasitoid richness and elevation ...
Ramaker Jenna M JM Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon 97239, - - 2013
Amyloid precursor protein (APP) belongs to a family of evolutionarily conserved transmembrane glycoproteins that has been proposed to regulate multiple aspects of cell motility in the nervous system. Although APP is best known as the source of β-amyloid fragments (Aβ) that accumulate in Alzheimer's disease, perturbations affecting normal APP signaling ...
Grey Andrew - - 2013
Annual intravenous administration of 5mg zoledronate decreases fracture risk, but the optimal dosing regimen for zoledronate has not been determined. We set out to evaluate the anti-resorptive effects of a single administration of lower doses of zoledronate. 180 postmenopausal women with osteopenia enrolled in a double-blind, randomized, placebo-controlled trial over ...
Crawford Timothy N - - 2013
Objective:The purpose of this study was to evaluate how poor retention in HIV care impacts time to viral suppression after initiating highly active antiretroviral therapy.Methods:A retrospective cohort study design, employing a medical chart review, was conducted at an academic infectious disease clinic at the University of Kentucky. Patients seeking care ...
Durán Elisa - - 2013
Although protein recognition of DNA motifs in promoter regions has been traditionally considered as a critical regulatory element in transcription, the location of promoters, and in particular transcription start sites (TSSs), still remains a challenge. Here we perform a comprehensive analysis of putative core promoter sequences relative to non-annotated predicted ...
Crook Robyn J - - 2013
Bodily injury in mammals often produces persistent pain that is driven at least in part by long-lasting sensitization and spontaneous activity (SA) in peripheral branches of primary nociceptors near sites of injury. While nociceptors have been described in lower vertebrates and invertebrates, outside of mammals there is limited evidence for ...
Karim Md Rezaul - - 2013
Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosis have not yet been fully documented. The aim of this study was to investigate the associations of circulating molecules involved in atherosclerosis with arsenic exposure in ...
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