Search Results
Results 301 - 350 of 2650
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Wu Felicia - - 2013
The aflatoxins are a group of fungal metabolites that contaminate a variety of staple crops, including maize and peanuts, and cause an array of acute and chronic human health effects. Aflatoxin B1 in particular is a potent liver carcinogen, and hepatocellular carcinoma (HCC) risk is multiplicatively higher for individuals exposed ...
Sperandio Marcelo - - 2013
Dysplasia grading is widely used to assess risk of transformation in oral potentially malignant disorders despite limited data on predictive value. DNA ploidy analysis has been proposed as an alternative. This study examines the prognostic value for both tests used in a routine diagnostic setting to inform clinical management. A ...
Corral-Martínez Patricia - - 2013
Induction of embryogenesis from isolated microspore cultures is a complex experimental system where microspores undergo dramatic changes in developmental fate. After ~40 years of application of electron microscopy to the study of the ultrastructural changes undergone by the induced microspore, there is still room for new discoveries. In this work, ...
Wang Y Claire - - 2013
BACKGROUND: New York City recently proposed a restriction to cap the portion size of all sugar-sweetened beverages (SSBs) sold in food-service establishments at 16 oz (473 mL). One critical question is whether such a policy may disproportionally affect low-income or overweight individuals.Objective: The objective was to determine the demographic characteristics ...
Mekary Rania A - - 2013
BACKGROUND: Little is known about the association between eating patterns and type 2 diabetes (T2D) risk in women. OBJECTIVE: The objective was to examine prospectively associations between regular breakfast consumption, eating frequency, and T2D risk in women. DESIGN: Eating pattern was assessed in 2002 in a cohort of 46,289 US ...
Savini Sara - - 2013
BACKGROUND: Elevated plasma phytosterol concentrations are an untoward effect of parenteral nutrition (PN) with vegetable oil-based lipid emulsions (LEs). Phytosterols are elevated in neonatal cholestasis, but the relation remains controversial. OBJECTIVE: The objective was to study the effect of 5 LEs on plasma phytosterols in preterm infants. DESIGN: One hundred ...
He Zi-Jun - - 2013
OBJECTIVE: To investigate the working memory of patients with cervicocerebral artery stenosis and its change after stenting. METHODS: 35 patients with cervicocerebral artery stenosis (≥50% with related symptoms of cerebral ischemia, or ≥70% with or without related symptoms of cerebral ischemia) underwent endovascular stenting. Working memory of all 35 patients ...
Johnson Andrew Kelly - - 2013
Treating dissections and dissecting aneurysms requires maintenance of flow through the true lumen and exclusion of the false lumen from the circulation. A dissecting aneurysm of the vertebral artery presented with both a true and false lumen within the aneurysmal sac. Stenting of the true lumen followed by coil embolization ...
Ter-Mikaelian Maria - - 2013
Animal communication sounds contain spectrotemporal fluctuations which provide powerful cues for detection and discrimination. Human perception of speech is influenced both by spectral and temporal acoustic features, but is most critically dependent on low-frequency temporal information. To investigate the neural coding principles underlying the perception of communication sounds, we explored ...
Lebouché Bertrand - - 2013
Early use of highly active antiretroviral treatment (ART) in people living with HIV for HIV prevention has gained legitimacy but remains controversial. Nineteen French HIV experts with diverse specializations (over half of whom were clinicians) were qualitatively interviewed on their views about ART irrespective of CD4 count of more than ...
Crawford Timothy N - - 2013
Objective:The purpose of this study was to evaluate how poor retention in HIV care impacts time to viral suppression after initiating highly active antiretroviral therapy.Methods:A retrospective cohort study design, employing a medical chart review, was conducted at an academic infectious disease clinic at the University of Kentucky. Patients seeking care ...
Yang Xiaofeng - - 2013
BACKGROUND AND OBJECTIVE: Combined magnetic resonance/positron emission tomography (MR/PET) is a relatively new, hybrid imaging modality. MR-based attenuation correction often requires segmentation of the bone on MR images. In this study, we present an automatic segmentation method for the skull on MR images for attenuation correction in brain MR/PET applications. ...
Gramss Gerhard - - 2013
Several fungal species are notorious for the preferential acquisition of toxicants such as AsCdHgPbU in their wild-grown basidiomes, but it is not known how, or whether at all, mineral uptake is regulated. In this study, basidiomes of Kuehneromyces mutabilis, Pleurotus ostreatus, and Hypholoma fasciculare were grown on Fagus sylvatica logs ...
Tournus Magali - - 2013
We developed a mathematical model of calcium (Ca(2+)) transport along the rat nephron to investigate the factors that promote hypercalciuria. The model is an extension of the flat medullary model of Hervy and Thomas (Am J Physiol Renal Physiol 284: F65-F81, 2003). It explicitly represents all the nephron segments beyond ...
Carabellese F - - 2013
The aim of this review was to study "female stalking" in the sense of the specific traits characterizing the phenomenon of stalking behaviour committed by women. The main medical databases were searched (Medline, Social Science Research Network, Apa Psyc Net), and 67 articles were selected, reporting studies conducted in clinical ...
Bungay Vicky - - 2013
I present the findings from a study that explored the experiences and decision making of street-involved women navigating the health care system. Data were drawn from a larger qualitative study situated in a western Canadian inner-city neighborhood that examined the health-management strategies of street-involved women with a history of crack ...
Ben David Alon - - 2013
The receptor binding domain of botulinum neurotoxin (BoNT), also designated HC fragment, is a promising vaccine candidate against botulism. In this study a highly efficient expression system for the protein was developed in E. coli, which provided yields that are an order of magnitude higher than those reported to date ...
Piazza Elise A - - 2013
In vision, humans use summary statistics (e.g., the average facial expression of a crowd) to efficiently perceive the gist of groups of features. Here, we present direct evidence that ensemble coding is also important for auditory processing. We found that listeners could accurately estimate the mean frequency of a set ...
Cosman Joshua D - - 2013
Recent studies have demonstrated that brief periods of training facilitate the ability to overcome distraction during future performance of a given task, and researchers have proposed that these effects rely on relational memory systems that enable individuals to link specific attentional states to their learned context. In the current work, ...
Baumert Anna - - 2013
Moral courage is characterized as a bystander intervention against the norm violations of a perpetrator despite the potential for negative consequences for oneself. We tested a comprehensive set of potential personality determinants of moral courage derived from a model of helping. In Study 1, we used a vignette to assess ...
Tiwari Sapana - - 2013
Brucellosis is an important zoonotic infectious disease of human and livestock with worldwide distribution and is caused by the bacteria of genus Brucella. The diagnosis of brucellosis always required laboratory confirmation either by isolation of pathogen or by detection of specific antibody. The conventional serological tests available for diagnosis of ...
Vaaramo Kalle - - 2013
BACKGROUND: It is not known whether alcohol-related head trauma predicts the new-onset seizures, particularly alcohol-related seizures. OBJECTIVE: We investigated risk factors for new-onset seizures in a cohort of 739 head trauma subjects. METHODS: All subjects with head trauma attending Oulu University Hospital during 1999, including children and very old people ...
Xia Zhibo - - 2013
Glioma-initiating cells (GICs), which are characterized by their self-renewal capacity and tumorigenicity, are a recently identified highly tumorigenic subpopulation of glioblastoma multiform (GBM) and are considered responsible for GBM recurrence and chemo/radiation resistance. In a previous study, we determined that Wnt signaling activation is critical to the self-renewal of GICs. ...
Kimura Toru - - 2013
OBJECTIVES: Although video-assisted thoracoscopic thymectomy (VATS-Tx) for thymoma has been introduced, its oncological outcome remains unclear. Our institutional experience with early-stage thymoma was retrospectively reviewed to evaluate the oncological feasibility of thoracoscopic thymectomy. METHODS: A retrospective review consisting of 74 patients with Masaoka Stage I and II thymomas who had ...
Cercamondi Colin I - - 2013
Home fortification with lipid-based nutrient supplements (LNSs) is a promising approach to improve bioavailable iron and energy intake of young children in developing countries. To optimize iron bioavailability from an LNS named complementary food fortificant (CFF), 3 stable isotope studies were conducted in 52 young Beninese children. Test meals consisted ...
Tey Siew Ling - - 2013
Regular nut consumption may improve markers of inflammation and endothelial dysfunction. The quantity of nuts required to achieve these health benefits without compromising body weight and acceptance is unknown. This study compared the effects of incorporating hazelnuts at 2 different doses with a diet without nuts on inflammatory markers, cell ...
Boudry Gaëlle - - 2013
The interplay between the colonic microbiota and gut epithelial and immune cells during the neonatal period, which establishes the structure of the microbiota and programs mucosal immunity, is affected by the diet. We hypothesized that protein-enriched milk formula would disturb this interplay through greater flux of protein entering the colon, ...
Martin Lena - - 2013
High dietary zinc concentrations are used to prevent or treat diarrhea in piglets and humans, but long-term adaptation to high zinc supply has yet not been assessed. Intestinal zinc uptake is facilitated through members of zinc transporter families SLC30 (ZnT) and SLC39 (ZIP). Whereas in rodents, regulation of zinc homeostasis ...
Li Yanhua - - 2013
Nonstructural protein 1beta (nsp1beta) of porcine reproductive and respiratory syndrome virus (PRRSV) contains a papain-like cysteine protease (PLP-beta) domain and was identified to be the main viral protein antagonizing host innate immune response. In this study, nsp1beta was determined to suppress the expression of reporter genes as well as suppress ...
Yu Chulang - - 2013
Emaravirus is a recently described genus of negative-strand RNA plant viruses. Emaravirus P4 protein localizes to plasmodesmata, suggesting that it could be a viral movement protein (MP). In the current study, we showed that the P4 protein of Raspberry leaf blotch emaravirus (RLBV) rescues the cell-to-cell movement of a defective ...
Griffiths Peter C - - 2013
Development of transgenic mouse models expressing heterologous prion proteins (PrP) has facilitated and advanced in vivo studies of prion diseases affecting humans and animals. Here, novel transgenic mouse lines expressing a chimeric murine/ovine (Mu/Ov) PrP transgene, including amino acid residues alanine, histidine and glutamine at ovine polymorphic codons 136, 154 ...
Fortunato Orazio - - 2013
AIMS: Following an acute myocardial infarction (AMI), pro-angiogenic PCs are released from the bone marrow into the circulation and home to the ischemic site attracted by a chemokine gradient. It is unknown if components of this early homeostatic response might help forecast long-term clinical outcome. This study investigates if the ...
Wei Li-Hua - - 2013
AIMS: Smad7 plays a negative regulatory role in many inflammatory diseases, but its effect on hypertensive disease remains unknown. The present study tested the hypothesis that overexpression of Smad7 may have therapeutic potential for angiotensin II (Ang II) - mediated hypertensive cardiac remodeling.Methods and ResultsHypertensive heart disease was induced in ...
Maoz Hagai - - 2013
Impairments in 'theory of mind' (ToM) were linked to social cognition and reciprocal relationships deficits in children with attention deficit/hyperactivity disorder (ADHD). Twenty-four children with ADHD (13 with inattentive type and 11 with combined type, mean age 10.2 years) completed the Interpersonal Reactivity Index (IRI), a self-reported empathy questionnaire. All ...
Vriet Cécile - - 2013
The plant steroid hormones, brassinosteroids (BRs), and their precursors, phytosterols, play major roles in plant growth, development, and stress tolerance. Here, we review the impressive progress made during recent years in elucidating the components of the sterol and BR metabolic and signaling pathways, and in understanding their mechanism of action ...
Gallagher Christopher J - - 2013
There is limited information on the effects of vitamin D on serum 25 hydroxyvitamin D in young people and none on African Americans. The main objective of this trial was to measure the effect of different doses of Vitamin D3 on serum 25 hydroxyvitamin D (25OHD) and serum PTH (parathyroid ...
Mohajeri Arezoo - - 2013
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm displaying variable morphologic and clinical features. To identify pathogenetically important genetic rearrangements, 44 SFTs were analyzed using a variety of techniques. Chromosome banding and fluorescence in situ hybridization (FISH) showed recurrent breakpoints in 12q13, clustering near the NAB2 and STAT6 genes, and ...
Ghijselings Ines - - 2013
Objectives:To examine the relationship between normative and self-perceived treatment need assessed by different measures, comprising two Oral Health-Related Quality of Life (OHRQoL) scales. Subjects and Methods:This cross-sectional observational study comprised 386 children aged 11-16 years registered for a first consultation at the Orthodontic Department of the University Hospitals of Leuven ...
Nakatsuka Takashi - - 2013
Betalains are one of the major plant pigment groups found in some higher plants and higher fungi. They are not produced naturally in any plant species outside of the order Caryophyllales, nor are they produced by anthocyanin-accumulating Caryophyllales. Here, we attempted to reconstruct the betalain biosynthetic pathway as a self-contained ...
Jessen Leon Eyrich - - 2013
Identifying which mutation(s) within a given genotype is responsible for an observable phenotype is important in many aspects of molecular biology. Here, we present SigniSite, an online application for subgroup-free residue-level genotype-phenotype correlation. In contrast to similar methods, SigniSite does not require any pre-definition of subgroups or binary classification. Input ...
Esque Jérémy - - 2013
Protein structures are an ensemble of atoms determined experimentally mostly by X-ray crystallography or Nuclear Magnetic Resonance. Studying 3D protein structures is a key point for better understanding protein function at a molecular level. We propose a set of accurate tools, for analysing protein structures, based on the reliable method ...
Makita Yuko - - 2013
Positional MEDLINE (PosMed; http://biolod.org/PosMed) is a powerful Semantic Web Association Study engine that ranks biomedical resources such as genes, metabolites, diseases and drugs, based on the statistical significance of associations between user-specified phenotypic keywords and resources connected directly or inferentially through a Semantic Web of biological databases such as MEDLINE, ...
Basha Omer - - 2013
Genome sequencing and transcriptomic profiling are two widely used approaches for the identification of human disease pathways. However, each approach typically provides a limited view of disease pathways: Genome sequencing can identify disease-related mutations but rarely reveals their mode-of-action, while transcriptomic assays do not reveal the series of events that ...
Lubbock Alexander L R - - 2013
Tissue microarrays (TMAs) allow multiplexed analysis of tissue samples and are frequently used to estimate biomarker protein expression in tumour biopsies. TMA Navigator (www.tmanavigator.org) is an open access web application for analysis of TMA data and related information, accommodating categorical, semi-continuous and continuous expression scores. Non-biological variation, or batch effects, ...
Kim Hanjoo - - 2013
To facilitate the analysis of large-scale high-throughput capillary electrophoresis data, we previously proposed a suite of efficient analysis software named HiTRACE (High Throughput Robust Analysis of Capillary Electrophoresis). HiTRACE has been used extensively for quantitating data from RNA and DNA structure mapping experiments, including mutate-and-map contact inference, chromatin footprinting, the ...
Roche Daniel B - - 2013
The FunFOLD2 server is a new independent server that integrates our novel protein-ligand binding site and quality assessment protocols for the prediction of protein function (FN) from sequence via structure. Our guiding principles were, first, to provide a simple unified resource to make our function prediction software easily accessible to ...
Kim Jeongkyun - - 2013
Biological events such as gene expression, regulation, phosphorylation, localization and protein catabolism play important roles in the development of diseases. Understanding the association between diseases and genes can be enhanced with the identification of involved biological events in this association. Although biological knowledge has been accumulated in several databases and ...
Lissouba Pascale - - 2013
OBJECTIVES: To conduct a systematic review and a meta-analysis of epidemiological studies investigating the association of genital human papillomavirus (HPV) infection and HIV acquisition. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Scientific databases and conference abstracts were systematically searched to identify all relevant studies published up to 31 January 2012. ...
Orelle Cédric - - 2013
Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery. Because cells have many different RS, usually one for each amino acid, identification of the specific enzyme targeted by a new natural or synthetic inhibitor can be cumbersome. We describe ...
Ren Xianwen - - 2013
Gene expression profiling has gradually become a routine procedure for disease diagnosis and classification. In the past decade, many computational methods have been proposed, resulting in great improvements on various levels, including feature selection and algorithms for classification and clustering. In this study, we present iPcc, a novel method from ...
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