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Wong Jeffrey L JL Department of Surgery, University of Pittsburgh, Hillman Cancer Center, UPCI Research Pavilion, Room 1.46, 5117 Center Avenue, Pittsburgh, PA 15213-1863, - - 2013
Chemokine-driven interactions of immune cells are essential for effective antitumor immunity. Human natural killer (NK) cells can be primed by the interleukin (IL)-1-related proinflammatory cytokine IL-18 for unique helper activity, which promotes dendritic cell (DC) activation and DC-mediated induction of type-1 immune responses against cancer. Here, we show that such ...
Wanda Paul A PA Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, MO 63130, - - 2013
Humans readily learn to move through direct physical practice and by watching the movements of others. Some researchers have proposed that action observation can inform subsequent changes in control through the acquisition of a neural representation of the novel dynamics, but to date learning following observation has been described by ...
Kim Hanjoo H Department of Electrical and Computer Engineering, Seoul National University, Seoul 151-744, - - 2013
To facilitate the analysis of large-scale high-throughput capillary electrophoresis data, we previously proposed a suite of efficient analysis software named HiTRACE (High Throughput Robust Analysis of Capillary Electrophoresis). HiTRACE has been used extensively for quantitating data from RNA and DNA structure mapping experiments, including mutate-and-map contact inference, chromatin footprinting, the ...
Li Yanhua - - 2013
Nonstructural protein 1beta (nsp1beta) of porcine reproductive and respiratory syndrome virus (PRRSV) contains a papain-like cysteine protease (PLP-beta) domain and was identified to be the main viral protein antagonizing host innate immune response. In this study, nsp1beta was determined to suppress the expression of reporter genes as well as suppress ...
Lei Hanqin H Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, - - 2013
Efficient skeletal muscle repair and regeneration require coordinated remodeling of the extracellular matrix (ECM). Previous reports have indicated that matrix metalloproteinases (MMPs) play the pivotal role in ECM remodeling during muscle regeneration. The goal of the current study was to determine if the interstitial collagenase MMP-13 was involved in the ...
Chouin Nicolas - - 2013
Targeted α-therapy (TAT) appears to be an ideal therapeutic technique for eliminating malignant circulating, minimal residual, or micrometastatic cells. These types of malignancies are typically infraclinical, complicating the evaluation of potential treatments. This study presents a method of ex vivo activity quantification with an α-camera device, allowing measurement of the ...
Tokarz Rafal R Center for Infection and Immunity, Mailman School of Public Health, Columbia University, NY, - - 2013
Coxsackieviruses (CV) A1, CV-A19 and CV-A22 have historically comprised a distinct phylogenetic clade within Enterovirus (EV) C. Several novel serotypes that are genetically similar to these three viruses have been recently discovered and characterized. Here, we report the coding sequence analysis of two genotypes of a previously uncharacterized serotype EV-C113 ...
Cantuti Castelvetri Ludovico L Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois 60612, - - 2013
Loss of function of galactosylceramidase lysosomal activity causes demyelination and vulnerability of various neuronal populations in Krabbe disease. Psychosine, a lipid-raft-associated sphingolipid that accumulates in this disease, is thought to trigger these abnormalities. Myelin-free in vitro analyses showed that psychosine inhibited fast axonal transport through the activation of axonal PP1 ...
Cabrera-Ostertag Ignacio J - - 2013
The 6S RNA is a non-coding small RNA that binds within the active site of housekeeping forms of RNA polymerases (e.g. Eσ(70) in Escherichia coli, Eσ(A) in Bacillus subtilis) and regulates transcription. Efficient release of RNA polymerase from 6S RNA regulation during outgrowth from stationary phase is dependent on use ...
Ravindran Resmi R Center for Comparative Medicine, University of California, Davis, Davis, CA, - - 2013
Host immune responses to Mycobacterium tuberculosis are generally able to contain infection and maintain a delicate balance between protection and immunopathology. A shift in this balance appears to underlie active disease observed in about 10% of infected individuals. Effects of local inflammation, combined with anti-M. tuberculosis systemic immune responses, are ...
Tey Siew Ling - - 2013
Regular nut consumption may improve markers of inflammation and endothelial dysfunction. The quantity of nuts required to achieve these health benefits without compromising body weight and acceptance is unknown. This study compared the effects of incorporating hazelnuts at 2 different doses with a diet without nuts on inflammatory markers, cell ...
Eppinger Ben B Princeton Neuroscience Institute, Green Hall, Princeton University, Princeton, New Jersey 08544, USA. - - 2013
We examined whether older adults differ from younger adults in how they learn from rewarding and aversive outcomes. Human participants were asked to either learn to choose actions that lead to monetary reward or learn to avoid actions that lead to monetary losses. To examine age differences in the neurophysiological ...
Kwon Kyung-Ah KA Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, - - 2013
Blinking is vital to maintain the integrity of the ocular surface and its characteristics such as blink duration and speed can vary significantly, depending on the health of the eyes. The blink is so rapid that special techniques are required to characterize it. In this study, a high-speed camera was ...
Jokiel P L PL Hawaii Institute of Marine Biology, University of Hawaii, , PO Box 1346, Kaneohe, HI 96744, USA. - - 2013
Data on calcification rate of coral and crustose coralline algae were used to test the proton flux model of calcification. There was a significant correlation between calcification (G) and the ratio of dissolved inorganic carbon (DIC) to proton concentration ([DIC] : [H(+)] ratio). The ratio is tightly correlated with [CO3(2-)] ...
Vaaramo Kalle - - 2013
BACKGROUND: It is not known whether alcohol-related head trauma predicts the new-onset seizures, particularly alcohol-related seizures. OBJECTIVE: We investigated risk factors for new-onset seizures in a cohort of 739 head trauma subjects. METHODS: All subjects with head trauma attending Oulu University Hospital during 1999, including children and very old people ...
Kanekiyo Kenji - - 2013
In demyelinating diseases such as multiple sclerosis, a critical problem is failure of remyelination, which is important for protecting axons against degeneration and restoring conduction deficits. However, the underlying mechanism of demyelination/remyelination remains unclear. N-acetylglucosaminyltransferase-IX (GnT-IX; also known as GnT-Vb) is a brain-specific glycosyltransferase that catalyzes the branched formation of ...
Li Xun - - 2013
MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene expression. Previous research has suggested that aberrant miRNA expression often plays a critical role in many types of cancer, including lung cancer. However, the exact miRNAs that are involved in pulmonary carcinogenesis remain unclear. We investigated the miRNA-based molecular changes ...
Jessen Leon Eyrich - - 2013
Identifying which mutation(s) within a given genotype is responsible for an observable phenotype is important in many aspects of molecular biology. Here, we present SigniSite, an online application for subgroup-free residue-level genotype-phenotype correlation. In contrast to similar methods, SigniSite does not require any pre-definition of subgroups or binary classification. Input ...
Blanco Gustavo G Dept. of Molecular and Integrative Physiology, 3901 Rainbow Blvd., Kansas City, KS 66160. - - 2013
The classic role of the Na-K-ATPase is that of a primary active transporter that utilizes cell energy to establish and maintain transmembrane Na(+) and K(+) gradients to preserve cell osmotic stability, support cell excitability, and drive secondary active transport. Recent studies have revealed that Na-K-ATPase located within cholesterol-containing lipid rafts ...
Mimic Branko - - 2013
OBJECTIVES: The study aimed to evaluate the results following complete repair of tetralogy of Fallot (TOF) in relation to age at surgery and to assess the role of palliation in the current era. METHODS: A retrospective review of 251 consecutive patients with TOF repaired between 2003 and 2011 at the ...
Corneil Brian D - - 2013
Adaptive adjustments of strategies help optimize behavior in a dynamic and uncertain world. Previous studies in the countermanding (or stop-signal) paradigm have detailed how reaction times (RTs) change with trial sequence, demonstrating adaptive control of movement generation. Comparatively little is known about the adaptive control of movement cancellation in the ...
Bungay Vicky - - 2013
I present the findings from a study that explored the experiences and decision making of street-involved women navigating the health care system. Data were drawn from a larger qualitative study situated in a western Canadian inner-city neighborhood that examined the health-management strategies of street-involved women with a history of crack ...
Dryanovski Dilyan I DI Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, - - 2013
The core motor symptoms of Parkinson's disease (PD) are attributable to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial oxidant stress is widely viewed a major factor in PD pathogenesis. Previous work has shown that activity-dependent calcium entry through L-type channels elevates perinuclear mitochondrial oxidant ...
Crossland Randy F RF Department of Anesthesiology, Baylor College of Medicine, Houston, - - 2013
Obstructive sleep apnea (OSA), a condition in which the upper airway collapses during sleep, is strongly associated with metabolic and cardiovascular diseases. Little is known how OSA affects the cerebral circulation. The goals of this study were 1) to develop a rat model of chronic OSA that involved apnea and ...
Zhang Yaqing Y Department of Surgery, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, - - 2013
Wnt ligand expression and activation of the Wnt/β-catenin pathway have been associated with pancreatic ductal adenocarcinoma, but whether Wnt activity is required for the development of pancreatic cancer has remained unclear. Here, we report the results of three different approaches to inhibit the Wnt/β-catenin pathway in a established transgenic mouse ...
Pearce Allison A Department of Computer Science, University of Pennsylvania, Philadelphia, Pennsylvania, - - 2013
High-frequency (100-500 Hz) oscillations (HFOs) recorded from intracranial electrodes are a potential biomarker for epileptogenic brain. HFOs are commonly categorized as ripples (100-250 Hz) or fast ripples (250-500 Hz), and a third class of mixed frequency events has also been identified. We hypothesize that temporal changes in HFOs may identify ...
Makita Yuko - - 2013
Positional MEDLINE (PosMed; http://biolod.org/PosMed) is a powerful Semantic Web Association Study engine that ranks biomedical resources such as genes, metabolites, diseases and drugs, based on the statistical significance of associations between user-specified phenotypic keywords and resources connected directly or inferentially through a Semantic Web of biological databases such as MEDLINE, ...
Khalifeh M S - - 2013
CD40 and CD40L interactions have costimulatory effects as part of a complex series of events in host immunity. In this study, expression of CD40 and CD40L on peripheral blood mononuclear cells (PBMCs) isolated from cattle with Johne's disease was measured on freshly isolated PBMCs and after culture of cells for ...
Potter Rachel R Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, - - 2013
Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40 in the central nervous system (CNS). This ...
Schiroli Davide - - 2013
Dysregulated expression of the AGXT2L1 gene has been associated to neuropsychiatric disorders. Recently the gene product was shown to possess O-phosphoethanolamine phospho-lyase activity. We here analyze the specificity of AGXT2L1 in terms of both reaction and substrate. We show that the enzyme, despite having evolved from a transaminase ancestor, is ...
Chakraborty Sumit - - 2013
Nick of time: The nickel cyanomethyl complex 1 catalyzes the room temperature coupling of aldehydes with acetonitrile under base-free conditions. The catalytic system is long-lived and remarkably efficient with high turnover numbers (TONs) and turnover frequencies (TOFs) achieved. The mild reaction conditions allow a wide variety of aldehydes, including base-sensitive ...
Lee Ho-Sun HS International Agency for Research on Cancer, Lyon, - - 2013
Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism ...
Tournus Magali - - 2013
We developed a mathematical model of calcium (Ca(2+)) transport along the rat nephron to investigate the factors that promote hypercalciuria. The model is an extension of the flat medullary model of Hervy and Thomas (Am J Physiol Renal Physiol 284: F65-F81, 2003). It explicitly represents all the nephron segments beyond ...
Vazquez Alberto L - - 2013
Hemodynamic responses are commonly used to map brain activity; however, their spatial limits have remained unclear because of the lack of a well-defined and malleable spatial stimulus. To examine the properties of neural activity and hemodynamic responses, multiunit activity, local field potential, cerebral blood volume (CBV)-sensitive optical imaging, and laser ...
Zhang Yuhua - - 2013
Atherosclerosis is accelerated in diabetes mellitus mainly due to the reduced availability and function of endothelial progenitor cells (EPCs). The purpose of this study was to determine the protective effects of the anthocyanin cyanidin-3-O-β-glucoside (C3G) on EPC function and endothelial repair in diabetic apolipoprotein E-deficient (apoE(-/-)) mice. Diabetes mellitus was ...
Hsu Chia-Hsin CH Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan, Republic of - - 2013
Protein domain architectures (PDAs), in which single domains are linked to form multiple-domain proteins, are a major molecular form used by evolution for the diversification of protein functions. However, the design principles of PDAs remain largely uninvestigated. In this study, we constructed networks to connect domain architectures that had grown ...
Edwards Ian J IJ School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United - - 2013
The Na(+)/K(+) ATPase (NKA) is an essential membrane protein underlying the membrane potential in excitable cells. Transmembrane ion transport is performed by the catalytic α subunits (α1-4). The predominant subunits in neurons are α1 and α3, which have different affinities for Na(+) and K(+), impacting on transport kinetics. The exchange ...
Stukalin Evgeny B EB Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218, - - 2013
For symmetrically dividing cells, large variations in the cell cycle time are typical, even among clonal cells. The consequence of this variation is important in stem cell differentiation, tissue and organ size control, and cancer development, where cell division rates ultimately determine the cell population. We explore the connection between ...
Royer Dana L DL Department of Earth and Environmental Sciences, Wesleyan University, Middletown, CT 06459, USA. - - 2013
Models generally predict a response in species richness to climate, but strong climate-diversity associations are seldom observed in long-term (more than 10(6) years) fossil records. Moreover, fossil studies rarely distinguish between the effects of atmospheric CO2 and temperature, which limits their ability to identify the causal controls on biodiversity. Plants ...
Levin Mattias - - 2013
Detailed understanding of how Abs of the IgE isotype interact with allergen at the onset of an allergic reaction is of great importance for deciphering mechanisms involved in the development of disease and may aid in the design of hypoallergenic variants. In this study, we have used a set of ...
Yang Xiaofeng X Department of Radiology and Imaging Sciences, Center for Systems Imaging, Emory University, Atlanta, Georgia, - - 2013
Combined magnetic resonance/positron emission tomography (MR/PET) is a relatively new, hybrid imaging modality. MR-based attenuation correction often requires segmentation of the bone on MR images. In this study, we present an automatic segmentation method for the skull on MR images for attenuation correction in brain MR/PET applications. Our method transforms ...
Alexander R Todd - - 2013
Sodium-proton exchange activity in the apical membrane of the proximal tubule is fundamental to the reabsorption of sodium and water from the filtrate. The role of this exchange process in bicarbonate reclamation and consequently the maintenance of acid-base homeostasis has been appreciated for at least half a century and remains ...
Shaban Kholoud - - 2013
Besides being the world's most widely used vaccine directed against tuberculosis, Mycobacterium bovis BCG is the most controversial vaccine in current use. Its protective efficacy varies widely in different parts of the world. One approach to improve the current BCG vaccine could be to produce recombinant BCG strains that express ...
Dumas Zoé Z Department of Ecology and Evolution, University of Lausanne, , Biophore Building, 1015 Lausanne, - - 2013
Bacteria often possess multiple siderophore-based iron uptake systems for scavenging this vital resource from their environment. However, some siderophores seem redundant, because they have limited iron-binding efficiency and are seldom expressed under iron limitation. Here, we investigate the conundrum of why selection does not eliminate this apparent redundancy. We focus ...
Owen Laura J - - 2013
BACKGROUND: LC-MS/MS is rapidly becoming the technology of choice for measuring steroid hormones. We have developed a rapid LC-MS/MS assay for the routine analysis of serum cortisol. We have used this assay to investigate the effects of gender and exogenous steroid interference on the immunoassay measurement of serum cortisol. METHODS: ...
Li Yanping Y Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. - - 2013
To prospectively examine whether men with restless legs syndrome (RLS) had an increased risk of mortality. This was a prospective cohort study of 18,425 US men free of diabetes, arthritis, and renal failure in the Health Professionals Follow-up Study (HPFS). In 2002, RLS was assessed using a set of standardized ...
Nebert Daniel W DW Department of Environmental Health, and the Center for Environmental Genetics, University of Cincinnati Medical Center, P.O. Box 670056, Cincinnati, OH 45267-0056, USA. - - 2013
Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH); this ubiquitous environmental carcinogenic agent is found in tobacco smoke, charcoal-grilled foods, and PAH-contaminated surfaces of roofs, playgrounds, and highways. Cytochrome P450 1 wild-type, Cyp1a2(-/-), Cyp1b1(-/-), or Cyp1a2/1b1(-/-) knockouts, and mice with Cyp1a1 expression deleted in hepatocytes can ingest large oral ...
Menguer Paloma K PK Centre for Biological Science, University of Southampton, Life Sciences Building 85, Highfield Campus, Southampton SO17 1B, - - 2013
Heavy metal homeostasis is maintained in plant cells by specialized transporters which compartmentalize or efflux metal ions, maintaining cytosolic concentrations within a narrow range. OsMTP1 is a member of the cation diffusion facilitator (CDF)/metal tolerance protein (MTP) family of metal cation transporters in Oryza sativa, which is closely related to ...
Stauber Martin - - 2013
Efforts in finding independent measures for accurate and reliable prediction of trabecular bone failure have led to the development of a number of morphometric indices characterizing trabecular bone microstructure. Generally, these indices assume a high homogeneity within the bone specimen. However, in the present study we showed that the variance ...
Takahashi Melissa K - - 2013
Antisense RNA transcription attenuators are a key component of the synthetic biology toolbox, with their ability to serve as building blocks for both signal integration logic circuits and transcriptional cascades. However, a central challenge to building more sophisticated RNA genetic circuitry is creating larger families of orthogonal attenuators that function ...
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