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Bastin Julien - - 2013
Many high-level visual regions exhibit complex patterns of stimulus selectivity that make their responses difficult to explain in terms of a single cognitive mechanism. For example, the parahippocampal place area (PPA) responds maximally to environmental scenes during fMRI studies but also responds strongly to nonscene landmark objects, such as buildings, ...
Mimic Branko - - 2013
OBJECTIVES: The study aimed to evaluate the results following complete repair of tetralogy of Fallot (TOF) in relation to age at surgery and to assess the role of palliation in the current era. METHODS: A retrospective review of 251 consecutive patients with TOF repaired between 2003 and 2011 at the ...
Narring Françoise - - 2013
BACKGROUND: To assess the effectiveness of text-messages in reducing the proportion of non-attendance in a youth clinic of a University Hospital. METHODS: Patients who registered for an appointment and provided a mobile phone number were randomly selected to receive or not a text-message reminder before the planned appointment. A 10% ...
da Costa C A S - - 2013
The excessive fat intake generally might induce obesity and metabolic disturbances. Thus, the goal of the study was to assess the role of high-fat diets containing soybean or canola oil on intra-abdominal adiposity and pancreatic morphology and function of young rats. After weaning, rats were fed with a control diet ...
Loopstra Rachel - - 2013
Cross-sectional studies have established a relationship between poverty and food insecurity, but little is known about the acute changes within households that lead to changes in food insecurity. This study examined how changes in income, employment status, and receipt of welfare related to change in severity of food insecurity during ...
Vandenheede Hadewijch - - 2013
BACKGROUND: Diabetes prevalence is high worldwide, affecting entire populations. Yet some population groups are more susceptible than others. In contemporary western societies, socioeconomically disadvantaged groups are disproportionally affected. The pattern is less clear for diabetes mortality. Researchers argue increasingly in favour of looking beyond individual socioeconomic position (SEP). In light ...
Balarajan Yarlini - - 2013
Improving maternal nutrition is an important step toward reducing low birth weight (LBW) and its sequelae. In India, an estimated 7.5 million babies are born each year with LBW, which accounts for more than one-third of the global burden. In this context, little is known about the population-level association of ...
Corman Victor Max - - 2013
Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analyzed fecal, blood and intestine specimens from 1,562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected ...
Pereira Flavia E - - 2013
AIMS: To determine the role of CD13 as an adhesion molecule in trafficking of inflammatory cells to the site of injury in-vivo and its function in wound healing following myocardial infarction induced by permanent coronary artery occlusion.Methods and ResultsSeven days post-permanent ligation, hearts from CD13(KO) mice showed significant reductions in ...
Kannan Sankaranarayanan - - 2013
AIMS: Mutant protein aggregation cardiomyopathy (MPAC) is characterized by reductive stress (RS), protein aggregation (of chaperones and cytoskeletal components) and ventricular dysfunction in transgenic mice expressing human mutant CryAB (hmCryAB). Sustained activation of Nrf2 causes reductive stress, which contributes to proteotoxic cardiac disease. The goals of this pre-clinical study were ...
Herrmann Stefan - - 2013
AIMS: The complex molecular mechanisms underlying spontaneous cardiac pacemaking are not fully understood. Recent findings point to a coordinated interplay between intracellular Ca(2+) cycling and plasma membrane localized cation transport determining the origin and periodicity of pacemaker potentials. The sodium-calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance ...
Alemán Gabriela - - 2013
Body nitrogen retention is dependent on the amount of dietary protein consumed, as well as the fat and carbohydrate content in the diet, due to the modulation of amino acid oxidation. PPARα is a transcription factor involved in the upregulation of the expression of enzymes of fatty acid oxidation. However, ...
Davis-Macnevin Parnell L - - 2013
Systemic administration of the noncompetitive N-methyl-D-aspartate (NMDA)- receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia. Evidence has shown that MK-801 increases the probability of operant responding during extinction, possibly modeling perseveration, as would be seen in patients with schizophrenia. This ...
Szabadi Elemer - - 2013
The central noradrenergic neurone, like the peripheral sympathetic neurone, is characterized by a diffusely arborizing terminal axonal network. The central neurones aggregate in distinct brainstem nuclei, of which the locus coeruleus (LC) is the most prominent. LC neurones project widely to most areas of the neuraxis, where they mediate dual ...
Turner Helen E - - 2013
BACKGROUND: Spurious hyperkalaemia is a relatively common occurrence in samples originating from primary care. Failure to identify spurious hyperkalaemia carries a significant risk of patient mismanagement. We have carried out a retrospective evaluation to review the impact of the use of centrifuges in primary care for biochemistry blood samples on ...
Owen Laura J - - 2013
BACKGROUND: LC-MS/MS is rapidly becoming the technology of choice for measuring steroid hormones. We have developed a rapid LC-MS/MS assay for the routine analysis of serum cortisol. We have used this assay to investigate the effects of gender and exogenous steroid interference on the immunoassay measurement of serum cortisol. METHODS: ...
Levin Mattias - - 2013
Detailed understanding of how Abs of the IgE isotype interact with allergen at the onset of an allergic reaction is of great importance for deciphering mechanisms involved in the development of disease and may aid in the design of hypoallergenic variants. In this study, we have used a set of ...
Schiroli Davide - - 2013
Dysregulated expression of the AGXT2L1 gene has been associated to neuropsychiatric disorders. Recently the gene product was shown to possess O-phosphoethanolamine phospho-lyase activity. We here analyze the specificity of AGXT2L1 in terms of both reaction and substrate. We show that the enzyme, despite having evolved from a transaminase ancestor, is ...
Li Anyin - - 2013
Rapid qualitative and quantitative analysis of 4-methylimidazole (4-MEI) in caramel and beverage samples is demonstrated using the paper spray form of ambient ionization mass spectrometry. The minimum level of pure 4-MEI detectable using multiple reaction monitoring (MRM) in a triple quadrupole instrument was 3 pg μL(-1) in neat solvent and ...
Dou Ying - - 2013
The hERG potassium channel has unusual functional characteristics in that the rates of channel activation and deactivation are much slower than inactivation, which is attributed to specific structural elements within the N-terminus and the S1-S4 voltage-sensing domains (VSD). Although the charged residues in the VSD have been extensively modified and ...
Taketani Akinori - - 2013
The aim of the present study is to evaluate the capability of a miniaturized Raman endoscope (mRE) system to monitor the advancement of colorectal tumors in model mice as a method that is noninvasive to the tumor itself. Nevertheless, the endoscope is narrow enough to observe the inside of the ...
Prieto-Alhambra D - - 2013
Although oral bisphosphonates (BP) are highly effective in preventing fractures, some patients will fracture while on treatment. We identified predictors of such fractures in a population-based cohort of incident users of oral BP. We screened the SIDIAP database to identify new users of oral BP in 2006-2007. SIDIAP includes pharmacy ...
Chakraborty Sumit - - 2013
Nick of time: The nickel cyanomethyl complex 1 catalyzes the room temperature coupling of aldehydes with acetonitrile under base-free conditions. The catalytic system is long-lived and remarkably efficient with high turnover numbers (TONs) and turnover frequencies (TOFs) achieved. The mild reaction conditions allow a wide variety of aldehydes, including base-sensitive ...
Nunes Kevin L - - 2013
We examined the relationship between self-reported sexual aggression and implicit and explicit attitudes towards rape in a sample of 86 male heterosexual university students. Large, significant group differences were found between the most sexually aggressive participants and the nonaggressive participants, with the most sexually aggressive group showing less negative implicit ...
Karim Md Rezaul - - 2013
Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosis have not yet been fully documented. The aim of this study was to investigate the associations of circulating molecules involved in atherosclerosis with arsenic exposure in ...
Sperandio Marcelo - - 2013
Dysplasia grading is widely used to assess risk of transformation in oral potentially malignant disorders despite limited data on predictive value. DNA ploidy analysis has been proposed as an alternative. This study examines the prognostic value for both tests used in a routine diagnostic setting to inform clinical management. A ...
Corral-Martínez Patricia - - 2013
Induction of embryogenesis from isolated microspore cultures is a complex experimental system where microspores undergo dramatic changes in developmental fate. After ~40 years of application of electron microscopy to the study of the ultrastructural changes undergone by the induced microspore, there is still room for new discoveries. In this work, ...
Wang Y Claire - - 2013
BACKGROUND: New York City recently proposed a restriction to cap the portion size of all sugar-sweetened beverages (SSBs) sold in food-service establishments at 16 oz (473 mL). One critical question is whether such a policy may disproportionally affect low-income or overweight individuals.Objective: The objective was to determine the demographic characteristics ...
Savini Sara - - 2013
BACKGROUND: Elevated plasma phytosterol concentrations are an untoward effect of parenteral nutrition (PN) with vegetable oil-based lipid emulsions (LEs). Phytosterols are elevated in neonatal cholestasis, but the relation remains controversial. OBJECTIVE: The objective was to study the effect of 5 LEs on plasma phytosterols in preterm infants. DESIGN: One hundred ...
He Zi-Jun - - 2013
OBJECTIVE: To investigate the working memory of patients with cervicocerebral artery stenosis and its change after stenting. METHODS: 35 patients with cervicocerebral artery stenosis (≥50% with related symptoms of cerebral ischemia, or ≥70% with or without related symptoms of cerebral ischemia) underwent endovascular stenting. Working memory of all 35 patients ...
Johnson Andrew Kelly - - 2013
Treating dissections and dissecting aneurysms requires maintenance of flow through the true lumen and exclusion of the false lumen from the circulation. A dissecting aneurysm of the vertebral artery presented with both a true and false lumen within the aneurysmal sac. Stenting of the true lumen followed by coil embolization ...
Lebouché Bertrand - - 2013
Early use of highly active antiretroviral treatment (ART) in people living with HIV for HIV prevention has gained legitimacy but remains controversial. Nineteen French HIV experts with diverse specializations (over half of whom were clinicians) were qualitatively interviewed on their views about ART irrespective of CD4 count of more than ...
Crawford Timothy N - - 2013
Objective:The purpose of this study was to evaluate how poor retention in HIV care impacts time to viral suppression after initiating highly active antiretroviral therapy.Methods:A retrospective cohort study design, employing a medical chart review, was conducted at an academic infectious disease clinic at the University of Kentucky. Patients seeking care ...
Yang Xiaofeng - - 2013
BACKGROUND AND OBJECTIVE: Combined magnetic resonance/positron emission tomography (MR/PET) is a relatively new, hybrid imaging modality. MR-based attenuation correction often requires segmentation of the bone on MR images. In this study, we present an automatic segmentation method for the skull on MR images for attenuation correction in brain MR/PET applications. ...
Gramss Gerhard - - 2013
Several fungal species are notorious for the preferential acquisition of toxicants such as AsCdHgPbU in their wild-grown basidiomes, but it is not known how, or whether at all, mineral uptake is regulated. In this study, basidiomes of Kuehneromyces mutabilis, Pleurotus ostreatus, and Hypholoma fasciculare were grown on Fagus sylvatica logs ...
Tournus Magali - - 2013
We developed a mathematical model of calcium (Ca(2+)) transport along the rat nephron to investigate the factors that promote hypercalciuria. The model is an extension of the flat medullary model of Hervy and Thomas (Am J Physiol Renal Physiol 284: F65-F81, 2003). It explicitly represents all the nephron segments beyond ...
Carabellese F - - 2013
The aim of this review was to study "female stalking" in the sense of the specific traits characterizing the phenomenon of stalking behaviour committed by women. The main medical databases were searched (Medline, Social Science Research Network, Apa Psyc Net), and 67 articles were selected, reporting studies conducted in clinical ...
Bungay Vicky - - 2013
I present the findings from a study that explored the experiences and decision making of street-involved women navigating the health care system. Data were drawn from a larger qualitative study situated in a western Canadian inner-city neighborhood that examined the health-management strategies of street-involved women with a history of crack ...
Ben David Alon - - 2013
The receptor binding domain of botulinum neurotoxin (BoNT), also designated HC fragment, is a promising vaccine candidate against botulism. In this study a highly efficient expression system for the protein was developed in E. coli, which provided yields that are an order of magnitude higher than those reported to date ...
Piazza Elise A - - 2013
In vision, humans use summary statistics (e.g., the average facial expression of a crowd) to efficiently perceive the gist of groups of features. Here, we present direct evidence that ensemble coding is also important for auditory processing. We found that listeners could accurately estimate the mean frequency of a set ...
Cosman Joshua D - - 2013
Recent studies have demonstrated that brief periods of training facilitate the ability to overcome distraction during future performance of a given task, and researchers have proposed that these effects rely on relational memory systems that enable individuals to link specific attentional states to their learned context. In the current work, ...
Baumert Anna - - 2013
Moral courage is characterized as a bystander intervention against the norm violations of a perpetrator despite the potential for negative consequences for oneself. We tested a comprehensive set of potential personality determinants of moral courage derived from a model of helping. In Study 1, we used a vignette to assess ...
Tiwari Sapana - - 2013
Brucellosis is an important zoonotic infectious disease of human and livestock with worldwide distribution and is caused by the bacteria of genus Brucella. The diagnosis of brucellosis always required laboratory confirmation either by isolation of pathogen or by detection of specific antibody. The conventional serological tests available for diagnosis of ...
Vaaramo Kalle - - 2013
BACKGROUND: It is not known whether alcohol-related head trauma predicts the new-onset seizures, particularly alcohol-related seizures. OBJECTIVE: We investigated risk factors for new-onset seizures in a cohort of 739 head trauma subjects. METHODS: All subjects with head trauma attending Oulu University Hospital during 1999, including children and very old people ...
Xia Zhibo - - 2013
Glioma-initiating cells (GICs), which are characterized by their self-renewal capacity and tumorigenicity, are a recently identified highly tumorigenic subpopulation of glioblastoma multiform (GBM) and are considered responsible for GBM recurrence and chemo/radiation resistance. In a previous study, we determined that Wnt signaling activation is critical to the self-renewal of GICs. ...
Kimura Toru - - 2013
OBJECTIVES: Although video-assisted thoracoscopic thymectomy (VATS-Tx) for thymoma has been introduced, its oncological outcome remains unclear. Our institutional experience with early-stage thymoma was retrospectively reviewed to evaluate the oncological feasibility of thoracoscopic thymectomy. METHODS: A retrospective review consisting of 74 patients with Masaoka Stage I and II thymomas who had ...
Cercamondi Colin I - - 2013
Home fortification with lipid-based nutrient supplements (LNSs) is a promising approach to improve bioavailable iron and energy intake of young children in developing countries. To optimize iron bioavailability from an LNS named complementary food fortificant (CFF), 3 stable isotope studies were conducted in 52 young Beninese children. Test meals consisted ...
Tey Siew Ling - - 2013
Regular nut consumption may improve markers of inflammation and endothelial dysfunction. The quantity of nuts required to achieve these health benefits without compromising body weight and acceptance is unknown. This study compared the effects of incorporating hazelnuts at 2 different doses with a diet without nuts on inflammatory markers, cell ...
Boudry Gaëlle - - 2013
The interplay between the colonic microbiota and gut epithelial and immune cells during the neonatal period, which establishes the structure of the microbiota and programs mucosal immunity, is affected by the diet. We hypothesized that protein-enriched milk formula would disturb this interplay through greater flux of protein entering the colon, ...
Martin Lena - - 2013
High dietary zinc concentrations are used to prevent or treat diarrhea in piglets and humans, but long-term adaptation to high zinc supply has yet not been assessed. Intestinal zinc uptake is facilitated through members of zinc transporter families SLC30 (ZnT) and SLC39 (ZIP). Whereas in rodents, regulation of zinc homeostasis ...
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