Search Results
Results 201 - 250 of 2649
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Barratt-Due Andreas - - 2013
Complement and the TLR family constitute two important branches of innate immunity. We previously showed attenuating effects on inflammation and thromogenicity by inhibiting the TLR coreceptor CD14 in porcine sepsis. In the present study, we explored the effect of the C5 and leukotriene B4 inhibitor Ornithodoros moubata complement inhibitor (OmCI; ...
Whelan Donna R - - 2013
The application of FTIR spectroscopy to disease diagnosis requires a thorough knowledge of the spectroscopy associated with the cell cycle to discern disease markers from normal cellular events. We have applied synchrotron FTIR spectroscopy to monitor cells at different phases of the cell cycle namely G1, S and G2 phases. ...
Peng Jing - - 2013
Paired off: The title reaction leads to a series of o-pyridinium phenols (1) and anilines (2). The experimental and computational studies indicate that the key step involves homolytic cleavage to give a radical pair, which undergoes solvent-cage recombination to give the product.
Wusthoff Courtney J - - 2013
The neurological exam can be a challenging part of a newborn's full evaluation. At the same time, the neonatal neurological exam is a useful tool in identifying babies needing closer evaluation for potential problems. The Dubowitz assessment is a standardised approach to the neonatal neurological exam designed for use by ...
Cole Conrad R - - 2013
Appropriate nutrition recommendations are important for the successful management of the infant with an injured gastrointestinal tract postsurgery who is at risk for intestinal failure. Management strategies that can be used to augment successful adaptation and prevent liver disease are summarized in this review. These include appropriate postoperative fluid and ...
Grey Andrew - - 2013
Annual intravenous administration of 5mg zoledronate decreases fracture risk, but the optimal dosing regimen for zoledronate has not been determined. We set out to evaluate the anti-resorptive effects of a single administration of lower doses of zoledronate. 180 postmenopausal women with osteopenia enrolled in a double-blind, randomized, placebo-controlled trial over ...
Rúa Federico - - 2013
This study addressed the hypothesis that epoxidation of the double bound in allylnitrile mediates its vestibular toxicity, directly or after subsequent metabolism by epoxide hydrolases. The potential metabolites 3,4-epoxybutyronitrile and 3,4-dihydroxybutyronitrile were synthesized and characterized. In aqueous solutions containing sodium or potassium ions, 3,4-epoxybutyronitrile rearranged to 4-hydroxybut-2-enenitrile, and this compound ...
Qiu Lianglin - - 2013
Perfluorooctane sulfonate (PFOS) is associated with male reproductive disorders, but its targets and mechanisms are poorly understood. We used in vitro and in vivo models to explore the roles of Sertoli cells and the blood-testis barrier (BTB) in PFOS-induced male reproductive dysfunction. First, we used primary Sertoli cell to estimate ...
Li Xun - - 2013
MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene expression. Previous research has suggested that aberrant miRNA expression often plays a critical role in many types of cancer, including lung cancer. However, the exact miRNAs that are involved in pulmonary carcinogenesis remain unclear. We investigated the miRNA-based molecular changes ...
Jiang Hui-Min - - 2013
BACKGROUND: Granulocyte colony stimulating factor (G-CSF) is a key mediator of neutrophil infiltration and is profibrotic in the liver, lung, and infarcted heart, but its roles in angiotensin II (Ang II)-induced hypertension and cardiac remodeling have not been fully determined. Thus, we sought to investigate the causal relation of G-CSF ...
Kuh Diana - - 2013
There is growing evidence that early growth influences bone mass in later life but most studies are limited to birth weight and/ or early infant growth and DXA measurements. In a British birth cohort study with prospective measures of lifetime height and weight, we investigated the growth trajectory in relation ...
Joskowiak Dominik - - 2013
Background Prolonged intensive care unit (ICU) stay in cardiac surgery patients often results in a poorer clinical course and decreased survival postdischarge. Data on clinical outcomes and prognosis are limited. We aimed to identify perioperative factors that would predict prolonged ICU stay and to evaluate their impact on clinical outcomes.Patients ...
Whalin Matthew K - - 2013
BACKGROUND AND PURPOSE: There have been reports that general anesthesia (GA) is associated with worse clinical outcomes during intra-arterial treatment (IAT) for stroke. Since traditional sedatives carry the risk of respiratory depression, this retrospective study was designed to compare sedation with the α2 adrenergic agonist dexmedetomidine (DEX) and with GA ...
Takemi Mitsuaki - - 2013
There is increasing interest in electroencephalogram (EEG)-based brain-computer interface (BCI) as a tool for rehabilitation of upper limb motor functions in hemiplegic stroke patients. This type of BCI often exploits EEG mu and beta oscillations recorded over the sensorimotor areas, and their event-related desynchronization (ERD) following motor imagery is believed ...
Jilka Robert L - - 2013
Skeletal aging is accompanied by decreased cancellous bone mass and increased formation of pores within cortical bone. The latter accounts for a large portion of the increase in non-vertebral fractures after age 65 in humans. We selectively deleted Bak and Bax, two genes essential for apoptosis, in two types of ...
Gad Parag - - 2013
The rat spinal cord isolated from supraspinal control via a complete low- to mid-thoracic spinal cord transection produces locomotor-like patterns in the hindlimbs when facilitated pharmacologically and/or by epidural electrical stimulation. To evaluate the role of epidural electrical stimulation in enabling motor control (eEmc) for locomotion and posture, we recorded ...
Yamamoto Junpei - - 2013
It takes two (photons) to tango: Single-turnover flash experiments showed that the flavoenzyme (6-4) photolyase uses a successive two-photon mechanism to repair the UV-induced T(6-4)T lesion in DNA. The intermediate (X) formed by the first photoreaction is likely to be the oxetane-bridged dimer T(ox)T. The enzyme could stabilize the normally ...
Fujiyama Hakuei - - 2013
A disruptive transcranial magnetic stimulation (TMS) approach was used to determine whether the increased frontal activation and reduced hemispheric laterality brain activation patterns observed in older adults during motor tasks play a functional role. Young and older adults abducted their left index finger as soon as possible following a visual ...
Pourmemari Mohammad-Hossein - - 2013
Introduction: We assessed the association between smoking and carpal tunnel syndrome (CTS) and estimated the magnitude of the association with meta-analysis. Methods: The PubMed, Embase, Scopus, and SciVerse databases were searched through December 2012. Thirteen studies were included in the meta-analysis. Results: Cross sectional studies reported an association between current ...
Urquhart D S - - 2013
OBJECTIVES: To describe breathing patterns in infants with Prader-Willi Syndrome (PWS), as well as the effects of supplemental oxygen (O2) on breathing patterns. Children with PWS commonly have sleep-disordered breathing, including hypersomnolence and obstructive sleep apnoea, as well as central sleep breathing abnormalities that are present from infancy. DESIGN: Retrospective ...
Lendrem Dennis - - 2013
OBJECTIVES: EuroQoL-5 dimension (EQ-5D) is a standardised preference-based tool for measurement of health-related quality of life and EQ-5D utility values can be converted to quality-adjusted life years (QALYs) to aid cost-utility analysis. This study aimed to evaluate the EQ-5D utility values of 639 patients with primary Sjögren's syndrome (PSS) in ...
Saito Ken - - 2013
Activation of the epidermal growth factor receptor (EGFR) has been observed in many malignant tumors and its constitutive signal transduction facilitates the proliferation of tumors. EGFR-tyrosine kinase inhibitors, such as gefitinib, are widely used as a molecular-targeting agent for the inactivation of EGFR signaling and show considerable therapeutic effect in ...
Filardo Giuseppe - - 2013
BACKGROUND:Osteochondritis dissecans (OCD) is an acquired lesion of the subchondral bone that may result in separation and instability of the overlying articular cartilage. Unstable lesions must be treated surgically to reestablish the joint surface as anatomically as possible.Hypothesis/ PURPOSE:The aim of this study was to evaluate the potential of a ...
Stauber Martin - - 2013
Efforts in finding independent measures for accurate and reliable prediction of trabecular bone failure have led to the development of a number of morphometric indices characterizing trabecular bone microstructure. Generally, these indices assume a high homogeneity within the bone specimen. However, in the present study we showed that the variance ...
Sjölander Arvid - - 2013
In observational studies of the effect of an exposure on an outcome, the exposure-outcome association is usually confounded by other causes of the outcome (potential confounders). One common method to increase efficiency is to match the study on potential confounders. Matched case-control studies are relatively common and well covered by ...
Hamilton Kirk L - - 2013
This manuscript highlights the accepted manuscript by He-Ping Ma entitled 'Lovastatin attenuates effects of cyclosporine A on tight junctions and apoptosis in cultured cortical collecting duct principal cells'.
Galloway Johanna M - - 2013
In a world with ever decreasing natural reserves, researchers are striving to find sustainable methods of producing components for technology. Bioinspired, biokleptic and biomimetic materials can be used to form a wide range of technologically relevant materials under environmentally friendly conditions. Here we investigate a range of biotemplated and bioinspired ...
Alexander R Todd - - 2013
Sodium-proton exchange activity in the apical membrane of the proximal tubule is fundamental to the reabsorption of sodium and water from the filtrate. The role of this exchange process in bicarbonate reclamation and consequently the maintenance of acid-base homeostasis has been appreciated for at least half a century and remains ...
Rebolj Kodre Anamarija - - 2013
With changing the age distribution at the time of cancer diagnosis, the administrative censoring due to study end may be informative. This problem has been mentioned frequently in the relative survival field, and an estimator aiming to correct this problem has been developed. In this paper, we review the existing ...
Karger Christian - - 2013
Renin expressing cells in the kidney normally appear as mural cells of developing preglomerular vessels and finally impose as granulated juxtaglomerular cells in adult kidneys. The differentiation of renin expressing cells from the metanephric mesenchyme in general, and the potential role of special precursor stages in special, is not well ...
Sokalski Dg - - 2013
A 23-year-old African-American woman with a history of recurrent pneumonias presented to the hospital with 2 weeks of shortness of breath, chest pain, fevers, and lightheadedness. The histologic diagnosis proved to be lupus aortitis. Optimal Framingham risk factor management by itself may not be a completely successful approach in diminishing ...
Taylor Judy - - 2013
In regional Australia "communities of place," defined as bounded geographic locations with a local society, undertake community-wide primary prevention programs. In helping to prevent chronic illness, communities provide valuable resources to the health system. To understand the role of community-health sector partnerships for primary prevention and the community contextual factors ...
Khairullah S - - 2013
Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythematosus (SLE). Fewer than 30 cases of CIPO secondary ...
Su Min - - 2013
We previously showed that mitochondrial dysfunction (MtD) is involved in an aldosterone-induced podocyte injury. Here, the potential role of MtD in the initiation of podocyte damage was investigated. We detected the dynamic changes of urinary protein, urinary F2-isoprostane and renal malondialdehyde levels, kidney ultrastructure morphology, mitochondrial DNA (mtDNA) copy number, ...
Vazquez Alberto L - - 2013
Hemodynamic responses are commonly used to map brain activity; however, their spatial limits have remained unclear because of the lack of a well-defined and malleable spatial stimulus. To examine the properties of neural activity and hemodynamic responses, multiunit activity, local field potential, cerebral blood volume (CBV)-sensitive optical imaging, and laser ...
Giufrè Maria - - 2013
The introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines has changed the epidemiology of invasive H. influenzae disease with a shift in the predominant serotype from Hib to nonencapsulated (ncHi). The objective of this study was to identify the genotypes/clones associated with invasive H. influenzae disease in Italy. Eighty-seven ...
Pillaud Vincent - - 2013
We tested whether individuals can exert control over the expression of attitudinal ambivalence and if this control is exerted with self-presentational concerns. Using the self-presentation paradigm, participants reported more ambivalence about Genetically Modified Organisms (GMOs) in a standard and a self-enhancement (present yourself positively) conditions than in a self-depreciation (present ...
Liu Ping - - 2013
A live-attenuated vaccine candidate strain (M2) of human metapneumovirus (hMPV) was generated by removing the N-linked carbohydrate at amino acid 172 in the F protein. Previously, replication of M2 in the mouse lungs could be detected by molecular assays but not by viral titration. In the present study, the protective ...
Huopio Hanna - - 2013
OBJECTIVE: The aim of this study was to investigate the association of risk variants for type 2 diabetes (T2D) and hyperglycemia with gestational diabetes (GDM). DESIGN AND METHODS: 533 Finnish women who were diagnosed with GDM and 407 controls with normal glucose tolerance during the pregnancy were genotyped for 69 ...
Minekawa Takayuki - - 2013
Hepatitis B virus (HBV) infections are sometimes overlooked when using commercial kits to measure hepatitis B surface antigen (HBsAg) due to their low sensitivity and hyporeactivity to mutant strains of various genotypes. We developed an ultrasensitive bioluminescent enzyme immunoassay (BLEIA) for HBsAg using firefly luciferase, which is adaptable to a ...
Chouin Nicolas - - 2013
Targeted α-therapy (TAT) appears to be an ideal therapeutic technique for eliminating malignant circulating, minimal residual, or micrometastatic cells. These types of malignancies are typically infraclinical, complicating the evaluation of potential treatments. This study presents a method of ex vivo activity quantification with an α-camera device, allowing measurement of the ...
Khalifeh M S - - 2013
CD40 and CD40L interactions have costimulatory effects as part of a complex series of events in host immunity. In this study, expression of CD40 and CD40L on peripheral blood mononuclear cells (PBMCs) isolated from cattle with Johne's disease was measured on freshly isolated PBMCs and after culture of cells for ...
Selvaraju Ram K - - 2013
The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of Langerhans and is therefore an attractive target for imaging of the β-cell mass. In the present study, (68)Ga-labeled exendin-4 was evaluated for PET imaging and quantification of GLP-1R in the pancreas. METHODS: Dose escalation studies ...
Shaban Kholoud - - 2013
Besides being the world's most widely used vaccine directed against tuberculosis, Mycobacterium bovis BCG is the most controversial vaccine in current use. Its protective efficacy varies widely in different parts of the world. One approach to improve the current BCG vaccine could be to produce recombinant BCG strains that express ...
Pyysalo Mikko J - - 2013
BACKGROUND: Patients with ruptured saccular intracranial aneurysms have excess long-term mortality due to cerebrovascular and cardiovascular diseases compared with general population. Chronic inflammation is detected in ruptured intracranial aneurysms, abdominal aortic aneurysms and coronary artery plaques. Bacterial infections have been suggested to have a role in the aetiology of atherosclerosis. ...
Badiane Aida S - - 2013
Plasmodium falciparum utilizes multiple ligand-receptor interactions for invasion. The invasion ligand EBA-175 is being developed as a major blood-stage vaccine candidate. EBA-175 mediates parasite invasion of host erythrocytes in a sialic acid-dependent manner through its binding to the erythrocyte receptor glycophorin A. In this study, we address the ability of ...
Hara Azusa - - 2013
The incidence of gastric cancer throughout the world is ∼2-3 times higher in men than in women. Previous research suggested that isoflavones, which are structurally similar to 17β-estradiol, may prevent gastric cancer. Based on a large, population-based, prospective study, we recently reported a null association between dietary isoflavone intake and ...
Szabó Gábor - - 2013
OBJECTIVES: Constrictive pericarditis is the result of a spectrum of primary cardiac and non-cardiac conditions. Few data exist on the preoperative risk specific to survival after pericardiectomy. This study was designed to compare the association of aetiology of constrictive pericarditis and other clinical variables, with long-term survival after total pericardiectomy. ...
Zhang Yuhua - - 2013
Atherosclerosis is accelerated in diabetes mellitus mainly due to the reduced availability and function of endothelial progenitor cells (EPCs). The purpose of this study was to determine the protective effects of the anthocyanin cyanidin-3-O-β-glucoside (C3G) on EPC function and endothelial repair in diabetic apolipoprotein E-deficient (apoE(-/-)) mice. Diabetes mellitus was ...
Qiu Tian-Ming - - 2013
OBJECTIVE: Peripheral nerve injury can induce immediate and long-standing remodelling of the brain cortex, which may affect outcomes of nerve repair. This study examined changes of corresponding cortical representations in patients with brachial plexus injuries. METHODS: Resting-state fMRI was acquired for 13 adult patients with total brachial plexus root avulsion, ...
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