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Xue Xinying - - 2013
Gefitinib-induced interstitial lung disease (ILD) is a rare but lethal drug adverse event, which usually leads to the withdrawal of gefitinib and causes complications with anticancer treatment. In this study, gefitinib administration combined with prednisolone in a female with stage IIIb non-small cell lung cancer (NSCLC) produced a good outcome ...
Pezzuto Aldo - - 2013
This study aimed to present the atypical clinical presentation and management of a metastatic lung cancer that had spread to an atypical location. Lung cancer is the most common cause of cancer-related mortality worldwide. The brain, liver, adrenal glands and bone are the most common sites of metastatic disease in ...
Altun Insaf - - 2013
To identify university students' hygiene behaviour using a hygiene behaviour inventory in a Turkish sample. The cross-sectional study was conducted with 353 randomly selected university students aged 17-24 years in Kocaeli, Turkey. Data were collected in December 2009 using a socio-demographic form and the Turkish version of the Hygiene Behaviour ...
Moore Raeanne C RC Department of Psychiatry, HIV Neurobehavioral Research Program, University of California, San Diego, - - 2013
There is a growing public health interest in the aging human immunodeficiency virus (HIV)-infected (HIV+) population, although there is a dearth of research on successful aging with HIV. This study aimed to understand the risk and protective factors associated with self-rated successful aging (SRSA) with HIV. Cross-sectional, case-controlled. HIV Neurobehavioral ...
Sakaguchi Kazuhiko K Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan. - - 2013
We developed a system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET). Sweat contamination during interstitial fluid glucose (IG) extraction affects the accuracy of glucose AUC measurement, because this technology uses extracted sodium ion levels as an internal standard. Therefore, we developed ...
Lorvik Kristina Berg - - 2013
The central role of tumor-specific TH1 cells in anticancer immune responses is becoming increasingly appreciated. However, little is known about how these cells are generated in vivo. Here, we used flow cytometry and gene expression microarrays to characterize the primary activation and TH1 differentiation of naïve tumor-specific CD4(+) T cells ...
Visnyei Koppany - - 2013
Squamous cell carcinoma of the external auditory canal, middle ear and temporal bone is a rare and unusual malignancy. The lack of a unifying classification system in the past, along with the rarity of the disease has made the development of clear treatment guidelines difficult. In this report, we describe ...
Resztak Matylda - - 2013
A stereospecific capillary zone electrophoresis (CZE) method was developed for the determination of verapamil (VER) and its main metabolite norverapamil (NOR) in human plasma. Optimal temperature, cyclodextrin selectors (CDs), pH of background electrolyte (BGE) and voltage were established to obtain complete separation of the chiral analytes and clopidogrel internal standard ...
Sting Reinhard - - 2013
In a seven year study, 235 lizards, 193 snakes and 111 chelonians were tested for the occurrence of Salmonella enterica. The material for analysis consisted of 251 faecal samples from reptiles suffering from diarrhoea and 288 carcasses of perished or euthanized reptiles. The carcasses were dissected and examined pathohistologically. A ...
Gupta Vijay - - 2013
Background & objectives: HIV/AIDS patients may have renal involvement also, however, Indian data are sparse. The present study was done to find the spectrum of renal diseases in HIV/AIDS patients in north India. Methods: In this prospective pilot study, HIV positive patients aged >18 yr were screened for renal involvement ...
Pai Sara I - - 2013
Human papillomavirus (HPV) types associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for ...
Jamrógiewicz Marzena - - 2013
Near infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode at-line evaluation. In this, the content of pharmaceutical ...
Qin Wen-Bo - - 2013
To study the changes in the activities of carbon monoxide (CO) and heme oxygenase 2 (HO-2) in ED rats with hyperhomocysteinemia (HHcy). This study included 40 male Wistar rats weighing 280 - 310 g, 10 as normal controls (group A). HHcy models were made in the other 30 by giving ...
Hussain Qurban - - 2013
To observe the changes in Doppler waveform of hepatic vein after the administration of terlipressin, and to assess indirectly the efficacy of the drug to reduce the Hepatic Vein Pressure Gradient and portal pressure. The quasi-experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from April 1 to ...
Denzin Nicolai - - 2013
Hepatitis E Virus (HEV) may cause acute hepatitis in humans. In industrialised countries, acute hepatitis E generally occurs only sporadically. However, in recent years an increase in the number of reported cases has been observed. Concerning autochthonous, non-travel-associated cases, a zoonotic transmission, particularly from the animal reservoirs of domestic pig ...
Stevens Hanne - - 2013
Violence and criminality are adverse outcomes for some persons who develop psychotic illnesses. The extent to which treatment can reduce offending has rarely been studied. The aim of this study was to evaluate whether assertive specialized treatment would reduce the rate of crime in patients with a first episode of ...
Gunn Cameron A CA Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand. - - 2013
STAR (stochastic targeted) is a glycemic control model-based framework for critically ill neonates that has shown benefits in reducing hypoglycemia and hyperglycemia. STAR uses a stochastic matrix method to forecast future changes in a patient's insulin sensitivity and then applies this result to a physiological model to select an optimal ...
Morrison-Beedy Dianne D University of South Florida, College of Nursing, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA. - - 2013
The purpose of this study was to invite girls who participated in a gender-specific sexual risk-reduction intervention to describe their experiences and identify program characteristics most or least beneficial to their involvement. Semistructured interviews were completed with 26 African American, low-income girls aged 15 to 19 years who had participated ...
Gallimore Awen - - 2013
Recently, a number of studies have documented the presence of high endothelial venules in both mouse and human tumors. The significance of these highly specialized blood vessels within neoplastic lesions, and notably their capacity to influence anticancer immune responses and tumor progression, remains to be fully understood.
Derer Stefanie - - 2013
Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting ...
Mo Min-Li - - 2013
Similarly to the Wnt protein palmitoyltransferase, porcupine (PPN) is essential to the activation of the Wnt/β-catenin signaling pathway. However, little is known about the role of PPN activity in human gastric cancer, one of the most common causes of cancer-related mortality. Real-time quantitative PCR was used to detect the expression ...
Plaze Marion - - 2013
The first shock therapies date back to 1933 with the Sakel therapy. Electric induction experiments led to electroconvulsive therapy first used by Ugo Cerletti and Lucio Bini in 1938. Today, transcranial magnetic stimulation offers new therapeutic perspectives for the treatment of mental disorders. Similarly, deep brain stimulation techniques have been ...
Withers Amy C - - 2013
Although studies have linked childhood trauma to depression resembling the atypical subtype, a majority of these studies did not use DSM-IV criteria for atypical features nor assess trauma both before and after depression onset. This study examined the relationship between atypical depression and lifetime trauma with the hypothesis that atypically ...
Cortez-Retamozo Virna - - 2013
The communication between tumor and host cells involves signals that act across extended distances in the body. Recent evidence indicates that the hormone angiotensin II is overproduced by lung adenocarcinoma to remotely expand bone marrow-derived hematopoietic stem cells. This process amplifies the supply of tumor-associated macrophages, which promote disease progression.
Naz Ayesha Saba - - 2013
To identify and compare awareness of intellectual wellness in male and female medical students of Karachi. The cross-sectional questionnaire-based survey comprised randomly selected 800 medical students of both gender. It was conducted from January to December 2010 in 8 medical colleges of Karachi. Responses--never, sometimes, mostly and always (numbered 0-4)--were ...
Ströhle Alexander - - 2013
The consumption of micronutrient-supplements by the general public has become widespread; between 25 and more than 40% of individuals questioned in western developed nations confirm to regularly consume such products. In principle, there are two product categories for micronutrient-supplements - medicinal products (drugs) and foodstuffs. The latter are marketed as ...
Driscoll Kimberly A KA Florida State University, College of Medicine, Department of Medical Humanities and Social Sciences, 1115 W. Call St., Tallahassee, FL 32306, USA. - - 2013
Insulin bolusing calculators alleviate the burden of having to calculate insulin bolus doses for patients with type 1 diabetes mellitus (T1DM). Three important pieces of information are needed: a blood glucose monitoring (BGM) result, carbohydrates to be consumed, and the amount of insulin bolus delivered. The purpose of this study ...
Shirokawa Y Y Department of Systems Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. - - 2013
Sex allocation is one of the most successful applications of evolutionary game theory. This theory has usually been applied to multicellular organisms; however, conditional sex allocation in unicellular organisms remains an unexplored field of research. Observations at the cellular level are indispensable for an understanding of the phenotypic sex allocation ...
Schmiedel Benjamin Joachim - - 2013
Receptor activator of NFκB ligand (RANKL) is mainly known for its role in bone metabolism, constituting a target for therapeutic interventions. Increasing evidence suggests that RANKL is also involved in oncogenesis and tumor progression, including a prominent role in host-tumor interaction. Our data suggest that targeting RANKL may reinforce natural ...
Abbes Ilham Ben IB Supelec/I.E.T.R., Avenue de la Boulaie, Cesson-Sévigné Cedex, France. - - 2013
Most closed-loop insulin delivery systems rely on model-based controllers to control the blood glucose (BG) level. Simple models of glucose metabolism, which allow easy design of the control law, are limited in their parametric identification from raw data. New control models and controllers issued from them are needed. A proportional ...
Walsh Linda V - - 2013
Heath promotion has become recognized as a vital component of health care delivery. It is well known that the traditional model of medical care delivery is limited by its focus on diagnosis of illness and treatment. The integration of public health concepts of prevention and health promotion offers depth and ...
Cooper Zachary A - - 2013
The combination of BRAF-targeted agents with immune checkpoint inhibitors represents a recent advance in the treatment of melanoma, even though each of these therapeutic approaches alone has specific limitations. Increasing evidence suggests indeed the existence of a synergistic interaction between these therapeutic modalities.
Improta Giuseppina - - 2013
Evaluation of the mutational status of KRAS is a crucial step for the correct therapeutic approach in treating advanced colorectal cancer as the identification of wild-type KRAS tumors leads to more specific and less toxic treatments for patients. Although several studies have highlighted the differences between primary and metastatic tumors, ...
Leung Janice M JM Critical Care Medicine Department, National Institute of Health, Bethesda, Maryland 20892, USA. - - 2013
The inherent limitations of spirometry and clinical history have prompted clinicians and scientists to search for surrogate markers of airway diseases. Although few biomarkers have been widely accepted into the clinical armamentarium, the authors explore three sources of biomarkers that have shown promise as indicators of disease severity and treatment ...
Krasny Marta - - 2013
In view of high availability and diversity of non-steroidal anti-inflammatory drugs (NSAIDs) on Polish market it is important for orthodontists to be aware of NSAID effect on the range of orthodontic tooth movement as well as the risk of root resorption in the moved teeth and other adverse effects, which ...
Turankar A V - - 2013
Background & objectives: Regular practice of slow breathing has been shown to improve cardiovascular and respiratory functions and to decrease the effects of stress. This pilot study was planned to evaluate the short term effects of pranayama on cardiovascular functions, pulmonary functions and galvanic skin resistance (GSR) which mirrors sympathetic ...
Schnurr Max - - 2013
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5'-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth factor β silencing with RIG-I activation to break tumor-induced ...
Ren Yan-Feng - - 2013
To assess the reliability and validity of the Aging Males' Symptoms (AMS) scale in the male population of Shanghai. We enrolled 973 males aged 40 years and over in a community of Shanghai, China. Using the AMS scale, we calculated the split-half reliability coefficient and Cronbach's alpha coefficient, assessed the ...
Liu Jian - - 2013
To explore the efficacy and safety of 980 nm diode laser vaporization in the treatment of benign prostatic hyperplasia (BPH). We treated 92 BPH patients by 980 nm diode laser vaporization. The patients were aged 65 - 89 years, with a mean prostate volume of (50.1 +/- 13.0) ml. We ...
Kamijo Atsushi - - 2013
Introduction: Up to 30% of the Japanese population suffers from Japanese cedar pollinosis, and some of these patients also have severe perennial allergies or other pollen allergies. Posterior nasal neurectomy has recently been reported as effective treatment for severe perennial allergic and intrinsic rhinitis. However, the efficacy of this surgery ...
Peng Jing - - 2013
To evaluate the effect of daily low-dose tadalafil on erectile dysfunction (ED) induced by pelvic fracture urethral disruption (PFUD). This study included 46 cases of PFUD-induced ED treated from Jan 2008 to Dec 2011. The patients were aged 33.9 +/- 7.2 years (range 25 -51 yr), and the interval between ...
Shivers Joseph P JP Sansum Diabetes Research Institute, 2219 Bath St., Santa Barbara, CA 93105, - - 2013
Safe and widespread use of diabetes technology is constrained by alarm fatigue: when someone receives so many alarms that he or she becomes less likely to respond appropriately. Alarm fatigue and related usability issues deserve consideration at every stage of alarm system design, especially as new technologies expand the potential ...
Scheper Wouter - - 2013
Human γδ T cells possess broad antitumor reactivity and are involved in the control of viral infections. We have recently described multifunctional γδ T cells induced by cytomegalovirus after allogenic stem cell transplantation, placing γδ T cells and their receptors in the spotlight for the development of novel anticancer immunotherapies.
Glas Michael - - 2013
The advancement of well known techniques in Point-of-Care coagulation diagnostics (e.g. thromboelastography/-metry) has lead to further distribution in perioperative coagulation management. By increasing user friendliness these devices have helped to expand the spectrum of coagulation diagnostics in daily clinical routine. But can they really be considered as the ne plus ...
Marya Charu Mohan - - 2013
The study was conducted to investigate the extent to which students of two dental schools in northern India make use of internet during their undergraduate course and to assess their attitude towards the internet in general. All undergraduate students were assessed using a specially designed, self-administered questionnaire. Overall, 470 (88.84%) ...
von Altrock Alexandra - - 2013
Skin tumors are rarely observed in pigs, and, in particular, only a few cases of squamous cell carcinoma have been reported. The present case report describes the occurrence of a squamous cell carcinoma located in the skin at the center of the udder of a 14-year-old German Landrace sow. The ...
Kitabayashi Taeru - - 2013
We experienced a 10-year-old boy who had anaphylaxis after eating rose-flavored soft-serve ice cream. The patient felt a sense of discomfort in his throat when eating apple, peach, loquat, Japanese pear, and kiwi fruit. Therefore, we measured specific IgE antibodies to allergen components by ImmunoCAP ISAC. Consequently, the patient gave ...
Patrick Kevin K Department of Family and Preventive Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0811, USA. - - 2013
Obese adolescents are at risk for type 2 diabetes mellitus (T2DM). Obesity interventions delivered through media, such as the web and text messages [short message service (SMS)] may be beneficial when targeting obese adolescents.. A randomized controlled trial, Pace-Internet for Diabetes Prevention Intervention (PACEi-DP), compared three forms of an obesity ...
Koutsampasopoulos Konstantinos - - 2013
Neuroendocrine tumors (NETs) frequently metastasize to the liver, but it is rare to find them there as primary tumors. Isolated polycystic liver disease (PCLD) is a rare autosomal dominant disease. There is no known association between polycystic liver disease and neuroendocrine or other tumors. We report a case of a ...
Jiang Jing - - 2013
Gastric cancer remains the fourth most commonly diagnosed cancer and is the second leading cause of cancer-related mortality worldwide. The aim of this study was to investigate the effects of canolol on the proliferation and apoptosis of SGC-7901 human gastric cancer cells and its relevant molecular mechanisms. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ...
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