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Chul Park Sung - - 2013
Glaucoma is a group of optic neuropathies that have in common a slow progressive degeneration of retinal ganglion cells (RGC) and their axons, resulting in a distinct appearance of the optic disc and a concomitant pattern of visual loss. The lamina cribrosa (LC) is a mesh-like structure at the optic ...
McCartney C A - - 2013
The targeting of mcrA or 16S rRNA genes by quantitative PCR (qPCR) has become the dominant method for quantifying methanogens in rumen. There are considerable discrepancies between estimates based on different primer sets, and the literature is equivocal about the relationship with methane production. There are a number of problems ...
Haworth Elizabeth - - 2013
Outbreaks of infectious diseases that spread via respiratory route, e.g. influenza, are common amongst Hajj congregation in Mecca, Saudi Arabia. The Saudi Arabian authority successfully organized the Hajj 2009 amidst fear of pandemic influenza. While severe influenza A(H1N1)pdm09 was rare, the true burden of pandemic influenza at Hajj that year ...
Sutton Richard - - 2013
This Introduction to the Supplement provides a brief history of remote monitoring, discusses its current status, and indicates the bright future that it possesses with a broad application in many branches of cardiology, at least including arrhythmias, heart failure, and ischaemic heart disease in addition to the management of implantable ...
Rice Kelly A KA Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. - - 2013
Amyloidosis is a progressive and ultimately fatal disease in which amyloid, an insoluble fibrillar protein, is deposited inappropriately in multiple organs, eventually leading to organ dysfunction. Although this condition commonly affects macaques, there is currently no reliable method of early diagnosis. Changes in clinical pathology parameters have been associated with ...
Bruna del Cojo M M Department of Prophylaxis, Paediatric Dentistry and Orthodontics, Complutense University of Madrid, Spain. - - 2013
This was to investigate permanent teeth emergence in children and teenagers of Madrid (Spain) and to compare the data with those reported in the literature. cross-sectional descriptive study. This study comprises data from 752 children and adolescents in Madrid (Spain). Sex, age and present permanent teeth were recorded. In our ...
Sadeghi-Naini Ali A Imaging Research - Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada ; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada ; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada ; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario, - - 2013
Conventional frequency quantitative ultrasound in conjunction with textural analysis techniques was investigated to monitor noninvasively the effects of cancer therapies in an in vivo preclinical model. Conventional low-frequency (∼7 MHz) and high-frequency (∼20 MHz) ultrasound was used with spectral analysis, coupled with textural analysis on spectral parametric maps, obtained from ...
Killer Hanspeter E - - 2013
The function of cerebrospinal fluid (CSF) is to protect the brain and optic nerve from mechanical damage, provide nutrition for axons/neurons, and remove of toxic metabilites. CSF is produced mainly by the choroid plexus epithelium and ependymal cells of the ventricles and flows into interconnecting chambers; namely, the cisterns and ...
Muldowney J - - 2013
With the human population predicted to reach nine billion by 2050, demand for food is predicted to more than double over this time period, a trend which will lead to increased greenhouse gas (GHG) emissions from agriculture. Furthermore, expansion in food production is predicted to occur primarily in the developing ...
Del Prado A - - 2013
The farm level is the most appropriate scale for evaluating options for mitigating greenhouse gas (GHG) emissions, because the farm represents the unit at which management decisions in livestock production are made. To date, a number of whole farm modelling approaches have been developed to quantify GHG emissions and explore ...
Marin Jennifer R JR Division of Emergency Medicine, Children's Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. - - 2013
The objective was to evaluate the test characteristics of clinical examination (CE) with the addition of bedside emergency ultrasound (CE+EUS) compared to CE alone in determining skin and soft tissue infections (SSTIs) that require drainage in pediatric patients. This was a prospective study of CE+EUS as a diagnostic test for ...
Perugia C - - 2013
AIM At present, two different clinical procedures to ensure the adherence of indirect tooth restorations to the dental tissues are available: a traditional method based on a delayed dentin sealing (DDS) and an innovative approach that contemplates an immediate dentin sealing (IDS). In this study the authors highlight the advantages ...
Verway Mark - - 2013
Although vitamin D deficiency is a common feature among patients presenting with active tuberculosis, the full scope of vitamin D action during Mycobacterium tuberculosis (Mtb) infection is poorly understood. As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells ...
Vielhauer George A GA Department of Urology, University of Kansas Medical Center, Kansas City, KS, USA. - - 2013
In treating cancer with clinically approved chemotherapies, the high systemic toxicity and lack of selectivity for malignant cells often result in an overall poor response rate. One pharmacological approach to improve patient response is to design targeted therapies that exploit the cancer milieu by reductively activating prodrugs, which results in ...
Ellis-Behnke Rutledge G - - 2013
Microglial cells function as first responders to signal inflammation, react to injuries by creating a wall to block invaders, and clear debris from the site. To better understand the modulation of microglia in inflammation and injury of eye and brain, we developed a morphological and orienting classification system of each ...
Clough T J - - 2013
Nitrous oxide (N2O) is a potent greenhouse gas and the dominant anthropogenic stratospheric ozone-depleting emission. The tropospheric concentration of N2O continues to increase, with animal production systems constituting the largest anthropogenic source. Stable isotopes of nitrogen (N) provide tools for constraining emission sources and, following the temporal dynamics of N2O, ...
Cobo Roxana - - 2013
Patients coming from Latin America are also known as mestizos or Hispanics. They are a combination of different ethnic groups where predominant facial features will vary depending on where the patient is coming from. A structural approach to the nose will be presented showing how techniques using sutures and grafts ...
Ghiso Jorge A JA Department of Pathology, New York University Langone Medical Center, New York, NY, - - 2013
Alzheimer's disease (AD) is the most common form of dementia. Intraneuronal neurofibrillary tangles, extracellular Aβ amyloid deposits in the form of amyloid plaques and cerebral amyloid angiopathy, and synaptic and neuronal loss co-exist in the brain parenchyma, with the limbic areas being the most severely affected. The classic clinical findings ...
Beaudoin Francesca L - - 2013
The primary objective was to compare the efficacy of ultrasound (US)-guided three-in-one femoral nerve blocks to standard treatment with parenteral opioids for pain control in elderly patients with hip fractures in the emergency department (ED). A randomized controlled trial was conducted at a large urban academic ED over an 18-month ...
Botta Cirino C Medical Oncology Unit, Campus Salvatore Venuta, Department of Experimental and Clinical Medicine, Magna Graecia University and Tommaso Campanella Cancer Center, Catanzaro, - - 2013
Bevacizumab is a humanized anti-VEGF monoclonal antibody able to produce clinical benefit in advanced non-squamous non-small-cell lung cancer (NSCLC) patients when combined to chemotherapy. At present, while there is a rising attention to bevacizumab-related adverse events and costs, no clinical or biological markers have been identified and validated for baseline ...
Carr Robert - - 2013
The past decade has seen the development of a network of specialist teenage and young adult cancer centres across the UK. These provide expertise in treatment across the spectrum of malignancies that occur in young adults, supported by multi-disciplinary teams that are able to provide the psycho-social support so necessary ...
Addison Ben - - 2013
Urinary retention is a common acute presentation for men in their later decades. Potential contributing pathologies are numerous. We report an unusual case of acute urinary retention requiring catheterisation secondary to sacral herpes zoster reactivation (S2-4) in an 88-year-old man with minimal preceding obstructive symptoms.
Abraham William T - - 2013
Heart failure represents a major public health concern, associated with high rates of morbidity and mortality. A particular focus of contemporary heart failure management is reduction of hospital admission and readmission rates. While optimal medical therapy favourably impacts the natural history of the disease, devices such as cardiac resynchronization therapy ...
d'Offay Jean M JM Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. - - 2013
Two young female baboons naturally infected with simian T-lymphotropic virus type 1 (STLV1) were euthanized due to chronic respiratory disease that was unresponsive to treatment. Massive lymphocytic infiltration of the lung interstitium suggested a diagnosis of STLV-associated lymphoma. In each case, the diagnosis was confirmed through inverse PCR (IPCR) that ...
Hussein A S - - 2013
AIM To assess the salivary levels of Copper (Cu), Zinc (Zn), Manganese (Mn) and Iron (Fe) obtained from children of different ethnic backgrounds in Shah Alam, Malaysia and investigate the possible relationships with caries. MATERIALS AND METHODS One hundred and twenty primary school children were included. They were divided into ...
Leitgeb J - - 2013
To analyse the association between the Glasgow Coma Scale (GCS) score at intensive care unit (ICU) discharge and the 1-year outcome of patients with severe traumatic brain injury (TBI). Retrospective analysis of prospectively collected observational data. Between 01/2001 and 12/2005, 13 European centres enrolled 1,172 patients with severe TBI. Data ...
Saleh M - - 2013
AIM To determine the degree of pain and discomfort during the orthodontic treatment of skeletal Class III malocclusion using the Removable Mandibular Retractor (RMR). MATERIALS AND METHODS The sample consisted of 33 skeletal Class III patients (17 males and 16 females; average age: 7.5 ± 1.33 years) who had been ...
Richards Michael R MR School of Public Health, Yale University, CT 06510, USA. - - 2013
American obesity rates continue to escalate, but an effective policy response remains elusive. Specific changes to the Supplemental Nutrition Assistance Program (SNAP) have been proposed as one way to improve nutrition and combat obesity among lower-income populations. While current SNAP proposals hold promise, some important challenges still remain. We discuss ...
Sapkota Gopal P GP MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. - - 2013
The signalling pathways downstream of the transforming growth factor beta (TGFβ) family of cytokines play critical roles in all aspects of cellular homeostasis. The phosphorylation and activation of p38 mitogen-activated protein kinase (MAPK) has been implicated in TGFβ-induced epithelial-to-mesenchymal transition and apoptosis. The precise molecular mechanisms by which TGFβ cytokines ...
De Moraes Carlos Gustavo - - 2013
The axons of the retinal ganglion cells form the optic nerve. The two optic nerves meet at the optic chiasm, where the nerve fibers originating in the nasal retina of each eye decussate to join the temporal fibers of the fellow eye. From the chiasm, the same axons continue on ...
Sarkar Pamela - - 2013
Junior doctors frequently experience delays in routine ward-based procedures. There is little published data on this subject, but it is clear that such delays can have implications in terms of costs, efficiency, length of patient stay, team working and patient safety and experience. We formulated an anonymous online survey to ...
Cobo Roxana - - 2013
In an effort to try to define the tendencies in the practice of facial plastic surgery in the different countries of Latin America, a survey was conducted from June 2012 to August 2012. Questionnaires were sent to specialists in otolaryngology and facial plastic surgery in the countries of Colombia, Brazil, ...
Shin J H - - 2013
BACKGROUND This article describes the management of a complicated crown root fracture. CASE REPORT A young patient presented with a crown root fracture of the maxillary left central incisor with an oblique subgingival fracture line. A multidisciplinary treatment approach including endodontic treatment, orthodontic extrusion, surgical extraction and intra-alveolar repositioning was ...
Lewallen Michelle - - 2013
Retinal neuronal death causes a severe and irreversible loss of visual function in the patients of retinitis pigmentosa, age-related macular degeneration and glaucoma, but these degenerative diseases currently still lack effective medical treatments. The restorative properties of stem cells hold the promise in the treatment of these retinal degenerative diseases. ...
Seymour Christopher W CW Department of Critical Care and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. - - 2013
Emergency medical services (EMS) personnel commonly use systolic blood pressure (sBP) to triage and treat acutely ill patients. The definition of prehospital hypotension and its associated outcomes are poorly defined. The authors sought to determine the discrimination of prehospital sBP thresholds for 30-day mortality and to compare patient classification by ...
Frise Charlotte J - - 2013
Gastrointestinal (GI) conditions are common in women of childbearing age. They often present before pregnancy but can arise de novo during pregnancy. The physiological changes that occur during pregnancy can influence the differential diagnosis of common GI presentations, affect the interpretation of diagnostic tests and restrict the use of diagnostic ...
Martin Sally - - 2013
Munc18-1 plays a dual role in transporting syntaxin-1A (Sx1a) to the plasma membrane and regulating SNARE-mediated membrane fusion. As impairment of either function leads to a common exocytic defect, assigning specific roles for various Munc18-1 domains has proved difficult. Structural analyses predict that a loop region in Munc18-1 domain 3a ...
Lin J - - 2013
Internet-based health interventions (IHIs) provide a way to treat people via the Internet. The spectrum is wide, comprising interventions for mental disorders and somatic diseases as well as health and risk behavior change interventions. Numerous international studies have demonstrated the efficacy of IHIs for the aforementioned areas. Through the resource-saving ...
Halko Mark A MA Department of Neurology, Bereson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, - - 2013
There are currently two techniques to manipulate brain function non-invasively: transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). These brain stimulation techniques work to cause long-term change within the brain. We have been combining noninvasive brain stimulation with functional magnetic resonance imaging (fMRI) to investigate the plasticity of ...
Lawrence Julia A JA Wake Forest University Comprehensive Cancer Center, Winston Salem, NC, USA. - - 2013
The vitamin D hormone, [1,25(OH) 2D, calcitriol], inhibits proliferation and angiogenesis in breast cancer but its therapeutic use is limited by hypercalcemia. Synthetic analogs of 1,25(OH) 2D that are less calcemic, such as paricalcitol (19-nor-1,25-Dihydroxyvitamin D 2), are used to treat hyperparathyroidism associated with chronic kidney disease. We sought to ...
Macgowan Alasdair - - 2013
The need to use front-line antibiotics wisely has never been greater. Antibiotic resistance and multi-drug resistant infection, driven by antibiotic use, remain major public health and professional concerns. To overcome these infection problems, use of older antibiotics active against multi drug-resistant pathogens is increasing - for example, colistin, fosfomycin, pivmecillinam, ...
Marelli-Berg Federica M FM William Harvey Research Institute, Barts' and The London School of Medicine, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK. - - 2013
Although it is expressed by all leukocytes, including T-, B-lymphocytes and dendritic cells, the immunoglobulin-like receptor CD31 is generally regarded by immunologists as a marker of endothelial cell lineage that lacks an established functional role in adaptive immunity. This perception has recently been challenged by studies that reveal a key ...
Theissing J - - 2013
Obese patients were coached after inpatient medical rehabilitation with a 6 units comprehensive multimodal Liveonline aftercare program. In the randomized controlled study design, significant improvements in all outcome criteria were found both in treatment and control group. The improvements in the treatment group, however, were only partially superior to the ...
Barboza Nora N University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, New Brunswick, NJ, - - 2013
PDCD2 is an evolutionarily conserved eukaryotic protein with unknown function. The Drosophlia PDCD2 ortholog Zfrp8 has an essential function in fly hematopoiesis. Zfrp8 mutants exhibit marked lymph gland hyperplasia that results from increased proliferation of partially differentiated hemocytes, suggesting Zfrp8 may participate in cell growth. Based on the above observations ...
Evans Kate - - 2013
An increasing number of people with type 1 diabetes mellitus are using insulin pump therapy, also known as continuous subcutaneous insulin infusion therapy (CSII). Most patients using pumps are safest remaining on CSII if admitted to hospital, unless incapacitated. This review provides the generalist physician with a framework to guide ...
Click Robert E RE University of Minnesota; Minneapolis, MN, USA. - - 2013
There seems to be little doubt that organosulfur compounds have enormous benefits for biological processes, especially those of diseases like cancer. The preliminary results herein define a cancer model in which benefits/mechanisms of multitudes of xenobiotic and nature's organosulfurs could easily be compared. Mice from three strains with a high ...
Crowley Rachel - - 2013
The management of patients with hypercalcaemia should be informed by the patient's symptoms and signs, by the degree of elevation of calcium, by the underlying mechanism by which calcium has been elevated and by the disease process underlying the presentation. Regardless of diagnosis, all significantly hypercalcaemic patients should be rendered ...
Castro-Govea Yanko - - 2013
Background Many people today are looking to preserve their youthful appearance for as long as possible. Current techniques of facial rejuvenation consist of superficial muscular aponeurotic system and/or deep tissue manipulation to relocate the tissues to their former positions. Scars continue to be a limiting factor for many patients who ...
Papour Asael A University of California Los Angeles, Department of Electrical Engineering, Los Angeles, CA 90095, - - 2013
An autofluorescence lifetime wide-field imaging system that can generate contrast in underlying tissue structures of normal and malignant brain tissue samples with video rate acquisition and processing time is presented. Images of the investigated tissues were acquired with high resolution (∼35 μm) using an algorithm to produce contrast based on ...
Billett Amy L - - 2013
A number of pediatric collaborative improvement networks have demonstrated improved care and outcomes for children. Regionally, Cincinnati Children's Hospital Medical Center Physician Hospital Organization has sustained key asthma processes, substantially increased the percentage of their asthma population receiving "perfect care," and implemented an innovative pay-for-performance program with a large commercial ...
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