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Gulic Tamara - - 2013
Differences in the expression of gp96 and its receptors were analysed in normal and pathological human pregnancy. Immunohistology and immunofluorescence of sections from decidual part of term placenta, first trimester normal decidua, missed abortion and blighted ovum decidua were performed together with reverse transcriptase-quantitative polymerase chain reaction and flow cytometry. ...
Artegiani Benedetta - - 2013
Generation of transgenic mice, in utero electroporation and viral injection are common approaches to manipulate gene expression during embryonic development of the mammalian brain. While very powerful in many contexts, these approaches are each characterized by their own limitations: namely, that generation of transgenic mice is time-consuming and electroporation only ...
Shwartz Arkadi - - 2013
How signal transduction, which is dynamic and fluctuating by nature, is converted into a stable trancriptional response, is an unanswered question in developmental biology. Two ETS-domain transcription factors encoded by the pointed (pnt) locus, PntP1 and PntP2, are universal downstream mediators of EGFR-based signaling in Drosophila. Full disruption of pnt ...
Werner Rachel M RM Center for Health Equity Research and Promotion, Philadelphia VAMC and Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
Changes in resident outcomes may be driven by many factors, including changes in nursing home care processes. Understanding what processes, if any, lead to successful improvements in resident outcomes could create a stronger case for the continued use of these outcome measures in nursing home report cards. To test the ...
Gao Peng P Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, - - 2013
The neocortex plays a key role in higher-order brain functions, such as perception, language and decision-making. Since the groundbreaking work of Ramón y Cajal over a century ago, defining the neural circuits underlying brain functions has been a field of intense study. Here, we review recent findings on the formation ...
Fata Bahar B Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, - - 2013
Delineating the normal postnatal development of the pulmonary artery (PA) and ascending aorta (AA) can inform our understanding of congenital abnormalities, as well as pulmonary and systolic hypertension. We thus conducted the following study to delineate the PA and AA postnatal growth deformation characteristics in an ovine model. MR images ...
Hochgreb-Hägele Tatiana T Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Liver Center and Diabetes Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA. - - 2013
Visceral organs, including the liver and pancreas, adopt asymmetric positions to ensure proper function. Yet the molecular and cellular mechanisms controlling organ laterality are not well understood. We identified a mutation affecting zebrafish laminin β1a (lamb1a) that disrupts left-right asymmetry of the liver and pancreas. In these mutants, the liver ...
Pan Y Albert YA Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. - - 2013
Advances in imaging and cell-labeling techniques have greatly enhanced our understanding of developmental and neurobiological processes. Among vertebrates, zebrafish is uniquely suited for in vivo imaging owing to its small size and optical translucency. However, distinguishing and following cells over extended time periods remains difficult. Previous studies have demonstrated that ...
Arling Greg G Indiana University Center for Aging Research, Regenstrief Institute, Health Information and Translational Sciences Building, Indianapolis, IN 46202-3012, USA. - - 2013
Older people with dementia have increased risk of nursing home (NH) use and higher Medicaid payments. Dementia's impact on acute care use and Medicare payments is less well understood. Identify trajectories of incident dementia and NH use, and compare Medicare and Medicaid payments for persons having different trajectories. Retrospective cohort ...
Shu Cindy - - 2013
Composite agarose (1.2 %) polyacrylamide (0.6 %) gel electrophoresis was used to separate discrete populations of native aggrecan and perlecan in newborn to 10 year old ovine intervertebral discs (IVDs). Semi-dry immunoblotting using core-protein and glycosaminoglycan (GAG) side chain specific monoclonal antibodies in combination with chondroitin ABC lyase demonstrated intra-chain native 7-D-4 chondroitin ...
van den Hoven Andor F - - 2013
Intra-arterial radioembolization with yttrium-90 microspheres is a safe and effective treatment option for patients with unresectable liver tumors. Pretreatment coil embolization of extrahepatic vessels is recommended to avoid extrahepatic deposition of radioactive microspheres. A novel infusion system with an expandable tip, the Surefire Infusion System (SIS), has recently been developed ...
Dohan Anthony - - 2013
OBJECTIVE: This study was designed to determine the incidence of arterial pseudoaneurysm in patients presenting with postpartum hemorrhage (PPH), to analyze the angiographic characteristics of pseudoaneurysms that cause PPH, and to evaluate the effectiveness of pelvic arterial embolization for the treatment of this condition. STUDY DESIGN: Eighteen women with pelvic ...
Koukounas Vasileios - - 2013
PURPOSE: This study was designed to investigate the incidence of arterial embolization using a peripheral protection filter device in a series of patients undergoing percutaneous mechanical thrombectomy for the management of thrombosed hemodialysis arteriovenous grafts (AVGs). METHODS: This prospective, single-center study included all eligible patients presenting during an 18-month period ...
Liu Ake - - 2013
Helix-loop-helix (bHLH) proteins play essential regulatory roles in a variety of biological processes. These highly conserved proteins form a large transcription factor superfamily, and are commonly identified in large numbers within animal, plant, and fungal genomes. The bHLH domain has been well studied in many animal species, but has not ...
Thakur Jitendra Kumar - - 2013
The KIX domain, which mediates protein-protein interactions, was first discovered as a motif in the large multidomain transcriptional activator histone acetyltransferase p300/CBP. Later, the domain was also found in Mediator subunit MED15, where it interacts with many transcription factors. In both proteins, the KIX domain is a target of activation ...
Francis Wendy S - - 2013
Repetition priming was used to assess how proficiency and the ease or difficulty of lexical access influence bilingual translation. Two experiments, conducted at different universities with different Spanish-English bilingual populations and materials, showed repetition priming in word translation for same-direction and different-direction repetitions. Experiment 1, conducted in an English-dominant environment, ...
Tamplin Andrea K - - 2013
Research in narrative comprehension has repeatedly shown that when people read about characters moving in well-known environments, the accessibility of object information follows a spatial gradient. That is, the accessibility of objects is best when they are in the same room as the protagonist, and it becomes worse the farther ...
Evers Patrick D - - 2013
OBJECTIVE: Radical cystectomy (RC) can provide a survival advantage in patients with urothelial carcinoma of the bladder, but not without significant morbidity rates. Whether the ability of preoperative comorbidity or performance status metrics can stratify patients to overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) following RC is ...
Sockalingam Sanjeev - - 2013
BACKGROUND: Attendance at bariatric surgery follow-up appointments has been associated with bariatric surgery outcomes. In this prospective study, we sought to examine psychosocial predictors of attendance at post-operative follow-up appointments. METHODS: Consecutive bariatric surgery patients (n = 132) were assessed pre-surgery for demographic variables, depressive symptoms, and relationship style. Patients were followed ...
Vercelino Rafael - - 2013
New approaches based on topical treatments are needed for treating pain and impaired dermal blood flow. We used a topical Pluronic F127 hydrogel containing S-nitrosoglutathione (GSNO) as a prodrug to generate free NO, an effector molecule that exerts both dermal vasodilation and antinociceptive effects. GSNO-containing hydrogels underwent gelation above 12 °C ...
Ditsawanon Panida - - 2013
Structural and functional peritoneal membrane changes are associated with long-term peritoneal dialysis. These changes can lead to ultrafiltration failure and peritoneal fibrosis, reducing the efficacy of the peritoneal membrane to remove waste and balance fluid and electrolytes. The loss of mesothelial cells from the basement membrane is one of the ...
Morais D S - - 2013
A novel hydrogel, based on an alginate/hyaluronate mixture and Ce(III) ions, with effective bioactive and antimicrobial ability was developed to be used as vehicle of a synthetic bone substitute producing an injectable substitute (IBS). Firstly, three different IBSs were prepared using three developed alginate-based hydrogels, the hydrogel Alg composed by ...
Schnuerch Robert - - 2013
Temporal orienting-that is, selective attention to instants in time-has been shown to modulate performance in terms of faster responses in a variety of paradigms. Electrophysiological recordings have shown that temporal orienting modulates neural processing at early, probably perceptual, and late, probably decision- or response-related, stages. Recently, it was shown that ...
Riva N - - 2013
The term unusual site venous thrombosis defines uncommon clinical manifestations of venous thromboembolism occurring in sites different from the lower limbs or the lungs, with peculiar pathophysiological features and clinical history. Information on long-term outcomes of unusual site thrombosis is generally scant, because most studies are small and usually retrospective. ...
Withagen Ans - - 2013
The study examined exploratory procedures (EPs) of congenitally blind and sighted children and adults on a haptic match-to-sample task. The aim was to examine the influence of age, visual status, and familiarity on the use of EPs when people haptically examine the object properties of weight, size, exact shape, and ...
Pompili Maurizio - - 2013
OBJECTIVE: Suicidal behavior is a major public health problem worldwide, and its prediction and prevention represent a challenge for everyone, including clinicians. The aim of the present paper is to provide a systematic review of the existing literature on the epidemiology of completed suicides in adult patients with bipolar disorder ...
Kidoh Masafumi - - 2013
OBJECTIVE: To evaluate the effect of a newly developed connecting tube, which generates a spiral flow of saline, on aortic and hepatic contrast enhancement during hepatic-arterial phase (HAP) and portal venous phase (PVP) computed tomography (CT). METHODS: Eighty patients were randomly assigned to one of two protocols: with a new ...
Li Xin - - 2013
Activation of Wnt5a-Ror2 signaling has been shown to be associated with epithelial-to-mesenchymal transition (EMT) of epidermoid carcinoma cells via induction of matrix metalloproteinase-2 (MMP-2). Because EMT has also been implicated in the progression of tissue fibrosis, we examined the possible association of Wnt5a-Ror2 signaling with renal fibrosis. Here, we show ...
Ogbonna Kelechi C - - 2013
Atrial fibrillation (AF) is one of the most common cardiac arrhythmias seen in clinical practice. Stroke risk in patients diagnosed with AF increases from 1.5% in the fifth decade of life to 23.5% in patients older than 80, emphasizing the need for effective and appropriate therapies. Over the past 50 ...
Rosenkrantz Andrew B - - 2013
OBJECTIVES: To investigate the impact of prostate computed diffusion-weighted imaging (DWI) on image quality and tumour detection. METHODS: Forty-nine patients underwent 3-T magnetic resonance imaging using a pelvic phased-array coil before prostatectomy, including DWI with b values of 50 and 1,000 s/mm(2). Computed DW images with b value 1,500 s/mm(2) were generated ...
Tomoi Yusuke - - 2013
To investigate the efficacy of statin treatment after endovascular therapy (EVT) for isolated below-the-knee (BTK) lesions in patients with critical limb ischemia (CLI). From March 2004 to June 2011, 812 patients (984 limbs, 69.0 % male, 71.6 ± 10.0 years old) with CLI underwent successful EVT for de novo isolated BTK lesions at 11 ...
Lameris A L L - - 2013
Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, used by millions of patients suffering from gastric acid-related complaints. Although PPIs have an excellent safety profile, an increasing number of case reports describe patients with severe hypomagnesemia due to long-term PPI use. As there is no evidence of ...
Fang Jing - - 2013
OBJECTIVE: Chronic hepatitis B virus (HBV) carrier status has a critical impact on clinical management of patients with IgA nephropathy (IgAN) who are treated with corticosteroids, because corticosteroids may enhance HBV replication. This study compared corticosteroids and antivirals combined therapy with corticosteroids monotherapy on patients of IgAN who were also ...
Guillot Mathieu - - 2013
The purposes of this work are to assess the performance of a 2D plastic scintillation detectors array prototype for quality assurance in intensity-modulated radiation therapy (IMRT) and to determine its sensitivity and specificity to positioning errors of one multileaf collimator (MLC) leaf and one MLC leaf bank by applying the ...
Trapp Oliver - - 2013
The investigation of the molecular dynamics of stereoisomers is of fundamental interest in chemistry, biochemistry, medicine, and related areas. In recent years enantioselective dynamic chromatography and enantioselective dynamic capillary electrophoresis (DCE) have been established as versatile tools to investigate the kinetics of interconversions of stereoisomers. The term dynamic chromatography and ...
Liu Yun - - 2013
Restoration of vegetation is the most viable management approach for restoring ecological functions in the drawdown zone (hydro-fluctuation belt) of the Three Gorges Reservoir. The selection of plants for this purpose is therefore critically important. Most indigenous plants are not adapted, however, to the counter-seasonal fluctuation of water levels and ...
Sow Ai Yin - - 2013
The present study investigates the concentration of Pb, Cd, Ni, Zn, and Cu in the paddy field soils collected from Tumpat, Kelantan. Soil samples were treated with sequential extraction to distinguish the anthropogenic and lithogenic origin of Pb, Cd, Ni, Zn, and Cu. ELFE and oxidizable-organic fractions were detected as ...
Bouwman R W - - 2013
The recent introduction of digital breast tomosynthesis into clinical practice requires quality control procedures. In this study we have investigated whether the assessment of the average glandular dose for modelled standard breasts can be performed using a combination of polymethyl methacrylate (PMMA) and polyethylene (PE) slabs that matches standard breast ...
Fomin Yu D - - 2013
We report a molecular dynamics study of the transport coefficients and the infinite frequency shear modulus of liquid iron at high temperatures and high pressures. We observe a simultaneous rise of both the shear viscosity and the diffusion coefficient along the melting line and estimate whether liquid iron can vitrify ...
Nestel Paul J - - 2013
The association between consumption of full-fat dairy foods and CVD may depend partly on the nature of products and may not apply to low-fat dairy foods. Increased circulating levels of inflammatory biomarkers after consumption of dairy product-rich meals suggest an association with CVD. In the present study, we tested the ...
Naghmouchi Karim - - 2013
The ability of Paenibacillus polymyxa to inhibit the growth of Escherichia coli generic ATCC 25922 (Escherichia coli ATCC 25922) and to adhere to monolayers of the enterocyte-like human cell line Caco-2 was evaluated. P. polymyxa JB-0501 (P. polymyxa JB-0501), found in a livestock feed probiotic supplement, was compared to P. ...
Mumbo John - - 2013
3-Chlorocarbazole, 3,6-dichlorocarbazole, dibromocarbazole, and 1,3,6,8-tetrabromocarbazole are emerging environmental contaminants which have been detected recently in water, sediment, and soil samples. However, their sources and occurrence have not been explained. Here, we report an enzymatic synthesis of bromo- and chlorocarbazoles by chloroperoxidase from Caldariomyces fumago in water. Density functional theory (DFT) ...
Mukherjee Prajna - - 2013
We have carried out density functional theory based calculations for understanding the structural, electronic and magnetic properties of pristine and transition metal (TM) doped ZnTe nanowires. Pristine ZnTe nanowires (NWs) turn out to be semiconducting in nature, with the band gap varying with the diameter of the NWs. In Mn-doped ...
Gouk Shiou Wah - - 2013
The present study aimed to determine the effect of positional distribution of long-chain SFA in TAG, especially at the sn-1, 3 positions, on fat deposition using the C57BL/6 mouse model. Throughout the 15 weeks of the study, mice were fed with diets fortified with palm olein (POo), chemically interesterified POo ...
Terentyev D - - 2013
The understanding of radiation-induced strengthening in ferritic FeCr-based steels remains an essential issue in the assessment of materials for fusion and fission reactors. Both early and recent experimental works on Fe-Cr alloys reveal Cr segregation on radiation-induced nanostructural features (mainly dislocation loops), whose impact on the modification of the mechanical ...
Kodet Ondřej - - 2013
Malignant melanoma is a highly aggressive tumor with increasing incidence and high mortality. The importance of immunohistochemistry in diagnosis of the primary tumor and in early identification of metastases in lymphatic nodes is enormous; however melanoma phenotype is frequently variable and thus several markers must be employed simultaneously. The purposes ...
Nishikawa Masaki - - 2013
Successful derivations of specific neuronal and glial cells from embryonic stem cells have enormous potential for cell therapies and regenerative medicine. However, the low efficiency, the complexity of induction method, and the need for purification represent obstacles that make their application impractical. In this study, we found that PDGFRα(+) cells ...
Yanykin D V - - 2013
It has been shown that removal of manganese from the water-oxidizing complex (WOC) of photosystem II (PSII) leads to flash-induced oxygen consumption (FIOC) which is activated by low concentration of Mn(2+) (Yanykin et al., Biochim Biophys Acta 1797:516-523, 2010). In the present work, we examined the effect of transition and ...
Karabulut Sedat - - 2013
Glucopyranose is the most stable form of glucose in solution. Identification of molecular structure of glucopyranose is very important because of its biological and synthetic significance; it is not an easy task because of the large number of possible configurations. Relative energies of exocyclic hydroxymethyl rotamers and α-β anomers of ...
Hamahata Atsumori - - 2013
BACKGROUND: Various studies have indicated a worldwide increase in the number of immediate breast reconstruction surgeries. However, breast reconstruction should not delay or prevent postoperative cancer therapeutics such as adjuvant chemotherapy and radiotherapy. In response to these developments, our team researched the impact of immediate breast reconstruction on postoperative adjuvant ...
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