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Results 401 - 450 of 1170
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Sanchez Vega Michelle C - - 2013
Alcohol consumption during pregnancy has deleterious effects on the developing foetus ranging from subtle physical deficits to severe behavioural abnormalities and are encompassed under a broad umbrella term, Foetal Alcohol Spectrum Disorders (FASD). High levels of exposure show distinct effects, whereas the consequences of moderate exposures have been less well ...
Vachel Laura - - 2013
BACKGROUND: TRPC6 has been proposed to be responsible for the abnormal OAG-dependent Ca(2+) influx in cystic fibrosis (CF) cells and we hypothesized that it interacts with CFTR. Here, we investigated how this functional complex operates in CF and non-CF epithelial cells. METHODS: Chinese hamster ovary (CHO) cells stably transfected with ...
Koag Myong Chul - - 2013
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that α7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural ...
Morin Nicolas - - 2013
Metabotropic glutamate 5 (mGlu5) receptor antagonists reduce L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias (LID) in Parkinson's disease (PD). The aim of this study was to investigate the long-term effect of the prototypal mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) on glutamate receptors known to be involved in the development of LID in the de novo ...
Shueh Chong Seng - - 2013
We developed a time-saving and cost-efficient Pulsed Field Gel Electrophoresis (PFGE) method for the typing of Stenotrophomonas maltophilia by modifying the conventional procedures. Our modifications related to the cell suspension preparation, lysis of bacterial cells in plugs, washing steps, and consumption of restriction enzyme. Although few rapid PFGE protocols on ...
Inai Tomomi - - 2013
Inherited loss-of-function mutations in the Rim15p-mediated stress-response pathway contribute to the high fermentation rate of sake yeast strains. In the present study, we found that disruption of the RIM15 gene in ethanol-producing Saccharomyces cerevisiae strain PE-2 accelerated molasses fermentation through enhanced sucrose utilization following glucose starvation.
Pfeifer Alexander - - 2013
The second messenger cyclic guanosine monophosphat (cGMP) mediates the physiological effects of nitric oxide and natriuretic peptides in a broad spectrum of tissues and cells. So far, the major focus of research on cGMP lay on the cardiovascular system. Recent evidence suggests that cGMP also plays a major role in ...
Nakajima Toshiyuki - - 2013
Controversy persists as to whether the acquisition of beneficial metabolic functions via endosymbiosis can occur suddenly on an evolutionary time scale. In this study, an early stage of endosymbiotic associations, which evolved from previously unassociated auto (photo)- and heterotrophic unicellular organisms was analyzed using an experimental ecosystem model, called CET ...
Moghaddasi Mehdi - - 2013
BACKGROUND: Recently, homocysteine (Hcy), folate, and vitamin B12 have been proposed to have several roles on MS pathogenesis. OBJECTIVE: We performed this study to determine the role of serum levels of Hcy, vitamin B12, and folate in patients with relapsing remitting MS (RRMS) and compared them with healthy controls. METHODS: ...
Jupp Bianca - - 2013
This article reviews recent advances in the elucidation of neurobehavioral endophenotypes associated with drug addiction made possible by the translational neuroimaging techniques magnetic resonance imaging (MRI) and positron emission tomography (PET). Increasingly, these non-invasive imaging approaches have been the catalyst for advancing our understanding of the etiology of drug addiction ...
Markou A - - 2013
Deregulation of miRNAs expression levels has been detected in many human tumor types, and recent studies have demonstrated the critical roles of miRNAs in cancer pathogenesis. Numerous recent studies have shown that miRNAs are rapidly released from tissues into the circulation in many pathological conditions. The high relative stability of ...
Salomon Kristen - - 2013
Prior work has repeatedly demonstrated that people who have current major depression exhibit blunted cardiovascular reactivity to acute stressors (e.g., Salomon, et al. 2009). A key question regards the psychobiological basis for these deficits, including whether such deficits are depressed mood-state dependent or whether these effects are trait-like and are ...
Farhad Hoshang - - 2013
During the last forty years tremendous progress has been made in our understanding of coronary atherosclerosis and in the development of methods to characterize atherosclerotic disease burden and risk. Stress testing is designed to elucidate abnormalities in myocardial perfusion during stress due to abnormal coronary vasomotor response. We summarize the ...
Joseph Nerine T - - 2013
Diverse external and internal environmental factors are integrated in the hypothalamus to regulate the reproductive system. This is mediated through the pulsatile secretion of GnRH into the portal system to stimulate pituitary gonadotrophin secretion, which in turn regulates gonadal function. A single subpopulation of neurons termed 'KNDy neurones' located in ...
Lei Jing - - 2013
In conscious rats, intramuscular injection of 2.5% formalin into the gastrocnemius muscle, at volumes between 25-200μl, evoked dose-dependent biphasic persistent flinching activities: phase 1 (0-10min) and phase 2 (10-60min). During this intramuscular formalin-induced ipsilateral muscle nociception, bilateral secondary mechanical hyperalgesia and heat hypoalgesia assessed by measuring thresholds of paw withdrawal ...
Monsiváis-Urenda Adriana - - 2013
Dendritic cells (DCs) play an important role in inducing immune tolerance. Inhibitory receptors, such as ILT2/CD85j, are involved in the tolerogenic effect of DCs and previous studies have indicated the important role of these receptors on the pathogenesis of autoimmune diseases. The aim of this study was to evaluate the ...
Zhang Yanping - - 2013
Mutations in gap junction (GJ) family of proteins, especially in the connexin (Cx) 26, are responsible for causing severe congenital hearing loss in a significant portion of patients (30-50% in various ethnic groups). Substitution of glycine at the position 45 of Cx26 to glutamic acid (p.G45E mutation) causes the Keratitis-ichthyosis-deafness ...
Kim Song E - - 2013
OBJECTIVE: To investigate spatiotemporal characteristics and functional correlates of evoked oscillations (EOs) at different frequency bands in human visual cortex. METHODS: Flash visual evoked potentials (FVEPs) were recorded from 11 epilepsy patients with intracranial electrodes placed over the occipital and adjacent cortices. Spatiotemporal characteristics of spectral powers and correlation with ...
Dullaart Robin P F - - 2013
BACKGROUND: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) mass predicts future cardiovascular events in the non-acute setting. We tested the extent to which Lp-PLA2 is elevated in patients with acute coronary syndrome. METHODS: 231 consecutive patients referred for acute chest pain participated. 144 were diagnosed with myocardial infarction (MI; 100 were classified ...
Pezeshki Abdul Mohammad - - 2013
HLA-DO (H2-O in mice) is an intracellular non-classical MHC class II molecule (MHCII). It forms a stable complex with HLA-DM (H2-M in mice) and shapes the MHC class II-associated peptide repertoire. Here, we tested the impact of HLA-DO and H2-O on the binding of superantigens (SAgs), which has been shown ...
Tsoutsman Tatiana - - 2013
Hypertrophic cardiomyopathy (HCM) is the most common inherited primary myocardial disorder. HCM is characterized by interstitial fibrosis and excessive accumulation of extracellular matrix (ECM) proteins. Fibrosis in HCM has been associated with impaired cardiac function and heart failure, and has been considered a key substrate for ventricular arrhythmias and sudden ...
Miyata Ryohei - - 2013
Exposure to ambient air particulate matter (particles less than 10μm or PM10) has been shown to be an independent risk factor for the development and progression of atherosclerosis. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have well-established anti-inflammatory properties. The aim of this study was to determine the impact of ...
Kazancioglu H O - - 2013
OBJECTIVE: To investigate the occurrence of MDR1 C3435T gene polymorphisms in the Turkish renal transplant patients treated with cyclosporine (CsA), and correlate these findings with prevalence and degree of gingival hyperplasia (GH). METHODS: Before to renal transplantation, dental treatment and oral hygiene education of 300 renal disease patients was completed. ...
Sahin Mehmet - - 2013
Epigenetics has been gaining great attention as a therapeutic target in cancer. The cancer genome usually contains both hyper- and hypo-methylated genes to increase invasion, proliferation and metastasis. These cells not only operate their own growth, but also develop various strategies to escape from immune surveillance, and for this aim, ...
Zhang Guo-Liang - - 2013
Aging is usually associated with a progressive disruption of the redox balance leading to recurrent damage resulting from oxidative stress. Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of motor behavior disorders. Therefore, antioxidant therapies have received considerable attention in motor behavior defects ...
Heaner Martica K - - 2013
During the last 25years, the careful examination of the eating behavior of individuals with eating disorders has provided critical insights into the nature of these disorders. Crucially, studies investigating components of different eating behaviors have documented that Anorexia Nervosa (AN), Bulimia Nervosa (BN), and Binge Eating Disorder (BED) are characterized ...
Graves Alexandra - - 2013
INTRODUCTION:: Intravenous (IV) recombinant tissue plasminogen activator (rt-PA) is the standard of care for patients exhibiting signs of acute ischemic stroke. IV rt-PA uses weight-based dosing, and often an estimated weight is used. The clinical effects of using estimated weight in dosing IV rt-PA remain unclear. The goal of this ...
Schut Christina - - 2013
It is known that itch is associated with psychological variables, but it is not known whether personality characteristics, depression or anxiety are predictors of experimentally induced itch in patients with atopic dermatitis (AD). In this study itch was induced in 27 patients with AD and 28 healthy controls by the ...
Pacan Przemysław - - 2013
Onychophagia is defined as chronic nail biting behaviour, which usually starts during childhood. Onychotillomania results from recurrent picking and manicuring of the fingernails and/or toenails, leading to visual shortening and/or estraction of nails. The aim of this study was to assess the prevalence of onychophagia and onychotillomania in young adults, ...
Killen Shaun S SS Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, Graham Kerr Building, University of Glasgow, G12 8QQ, Glasgow, UK. Electronic address: - - 2013
Although correlations have frequently been observed between specific physiological and behavioural traits across a range of animal taxa, the nature of these associations has been shown to vary. Here we argue that a major source of this inconsistency is the influence of environmental stressors, which seem capable of revealing, masking, ...
Costello Mark J MJ Institute of Marine Science, University of Auckland, Auckland, 1142, New Zealand. - - 2013
Concerns over data quality impede the use of public biodiversity databases and subsequent benefits to society. Data publication could follow the well-established publication process: with automated quality checks, peer review, and editorial decisions. This would improve data accuracy, reduce the need for users to 'clean' the data, and might increase ...
Ohmatsu Hanako - - 2013
Primary cutaneous follicular helper T (TFH)-cell lym-phoma has recently been proposed, and is characterized by proliferation of malignant T cells expressing TFH-cell markers, such as CXCL13, accompanied by numerous reactive B cells. We report here a patient whose skin histology showed massive infiltration of both T and B cells, with ...
Robertson Bruce A BA Division of Science, Mathematics, and Computing, Bard College, Annandale-on-Hudson, NY 12504, USA. - - 2013
Human-induced rapid environmental change (HIREC; e.g., climate change or exotic species) has caused global species declines. Although behavioral plasticity has buffered some species against HIREC, maladaptive behavioral scenarios called 'evolutionary traps' are increasingly common, threatening the persistence of affected species. Here, we review examples of evolutionary traps to identify their ...
Christensen Shawna B SB Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101, - - 2013
To investigate the prevalence of polycystic ovary syndrome (PCOS) in adolescents and its association with obesity. Cross-sectional study using electronic medical records. Not applicable. Adolescents aged 15-19 years (n = 137,502). None. PCOS diagnosed or defined according to National Institutes of Health (NIH) criteria. The prevalence of a confirmed diagnosis ...
Perera Minoli A MA Section of Genetic Medicine, Department of Medicine, University of Chicago, IL, - - 2013
VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. We did a genome-wide association study of discovery and ...
Lee Suzanne R SR Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: - - 2013
In the cell, mRNAs and non-coding RNAs exist in association with proteins to form ribonucleoprotein (RNP) complexes. Regulation of RNP stability and function is achieved by alterations to the RNP through poorly understood mechanisms into which recent studies have now begun to provide insight. This emerging body of work points ...
Chen Mingsheng - - 2013
OBJECTIVE: The purpose of this study was to reveal the effectiveness of non-thermal atmospheric plasma brush in surface wettability and modification of four dental substrates. METHODS: Specimens of dental substrates including dentin, enamel, and two composites Filtek Z250, Filtek LS Silorane were prepared (~2mm thick, ~10mm diameter). The prepared surfaces ...
Brojmohun Archana A Department of Psychiatry and Psychology, Cleveland Clinic Foundation, Cleveland, OH, - - 2013
Consultation-liaison (C-L) psychiatrists are frequently asked to initiate and manage psychotropic drugs, some of which can delay cardiac repolarization, prolong the QT interval, and increase the risk of torsades de pointes (TdP). This task is complicated by the growing number of patients with cardiovascular implantable electronic devices (CIED) [i.e., permanent ...
Wu Chuntao C Department of Public Health Sciences, Penn State Hershey College of Medicine, Hershey, PA, - - 2013
The association between incomplete revascularization (IR) and long-term mortality after stenting in the era of drug-eluting stents is not well understood. In the present study, we test the hypothesis that IR is associated with a greater risk of long-term (5-year) mortality after stenting for multivessel coronary disease. Using data from ...
Li H-J - - 2013
The factor associated suicide (Fas) and its ligand (FasL) signaling is an important regulatory pathway of apoptosis in mammalian follicles. However, whether apoptosis in bovine oocytes is regulated by the Fas-FasL signaling pathway remains unknown. In this study, localization of Fas and FasL in immature oocytes and FasL in cumulus ...
Steinberger Jutta J Max F. Perutz Laboratories, Medical University of Vienna, Department of Medical Biochemistry, Dr. Bohr-Gasse 9/3, A-1030 Vienna, - - 2013
The foot-and-mouth disease virus leader proteinase (Lb(pro)) cleaves itself off the nascent viral polyprotein. NMR studies on the monomeric variant Lb(pro) L200F provide structural evidence for intramolecular self-processing. (15)N-HSQC measurements of Lb(pro) L200F showed specifically shifted backbone signals in the active and substrate binding sites compared to the monomeric variant ...
Panchal Hemang B - - 2013
The purpose of this meta-analysis was to compare postprocedural mortality and major adverse cardiovascular and cerebrovascular events between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic stenosis. Seventeen studies (n = 4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End points were ...
Min Byung-Il - - 2013
Radionuclides were released into the atmosphere and ocean due to an accident in the Fukushima Daiichi Nuclear Power Plant (NPP) in March 2011. Numerical simulations were carried out to evaluate the distribution of (137)Cs in the ocean considering both direct releases to the sea and deposition from the atmosphere as ...
Sarkis Sarkis - - 2013
BACKGROUND: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological inflammatory disease associated with a predominant infiltration of CD4+ T lymphocytes, which are the main subset of HTLV-1-infected cells. It has been demonstrated that in cell line the viral Tax protein transcriptionnally regulate expression of osteopontin, an inflammatory cytokine associated with ...
Kim Insoo - - 2013
Inhalable highly porous large PLGA microparticles with incorporated doxorubicin and surface-attached with TRAIL (TRAIL/Dox PLGA MP) were fabricated using a w/o/w double emulsification method using ammonium bicarbonate as a gas-foaming agent for the treatment of lung cancer. The TRAIL/Dox PLGA MP produced were highly porous and 11.5 ± 0.4 μm in diameter, and ...
Luc Michael - - 2013
We tested the clinically relevant diagnostic accuracy of a new electrocardiographic (ECG) recording system incorporating all 10 ECG electrodes in a single-size glove worn on the patient's left arm and placed on the chest. The PhysioGlove (PG) was designed to allow fast, reproducible, electrode placement with only minimal training. The ...
Ferrari Silvia - - 2013
BACKGROUND: Comorbidity between vestibular and psychiatric disorders in predisposed individuals is underestimated, untreated, and may result in chronicization and poor quality of life. There are few studies concerning the type and the prevalence of psychiatric-psychosomatic distress in patients with benign paroxysmal positional vertigo (BPPV). OBJECTIVE: The aim of this study ...
Susaya Janice - - 2013
Ground-level ozone (O3) is a well-known atmospheric pollutant with its adverse impacts on the environment and human health. Here, the tropospheric O3 concentrations monitored in seven major cities in Korea at monthly intervals over a 22-year period (1989-2010) are presented, and their long-term variability examined. The analysis of annual mean ...
Agathocleous Michalis M Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: - - 2013
Stem and progenitor cells proliferate and give rise to other types of cells through differentiation. Deregulation of this process can lead to many diseases including cancer. Recent evidence suggests that an extensive metabolic reconfiguration of cancer cells allows them to sustain pathological growth by providing anabolic intermediates for biosynthesis. This ...
Ruiz-Alonso Maria - - 2013
OBJECTIVE: To demonstrate the clinical value of the endometrial receptivity array (ERA) in patients with repeated implantation failure (RIF), for guiding their personalized embryo transfer (pET) as a novel therapeutic strategy. DESIGN: Prospective interventional multicenter clinical trial. SETTING: University-affiliated infertility and private clinics. PATIENT(S): Eighty-five RIF patients and 25 comparison ...
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