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Serrano Mario - - 2013
Salicylic acid (SA) is central for the defense of plants to pathogens and abiotic stress. SA is synthesized in chloroplasts from chorismic acid by an isochorismate synthase (ICS1); SA biosynthesis is negatively regulated by auto-inhibitory feedback at ICS1. Genetic studies indicated that the MATE (Multidrug And Toxin Extrusion) transporter EDS5, ...
Yang Hongzhi - - 2013
The first total syntheses of spirobacillenes A and B were achieved concisely. The key transformation leading to spirobacillene A features a biomimetic intramolecular phenol-enol oxidative coupling reaction, and that leading to spirobacillene B highlights a bio-inspired intramolecular indole-ketone enolate oxidative coupling reaction.
Di Alberti L - - 2013
imImmediate loading of dental implants has been defined as a situation where the superstructure is attached to the implants at time of the surgery or however no later than 72 hours after surgery. Micromovements have been deeply studied in dental implants loading but the question of reduction of micromovements has ...
Favretto Filippo - - 2013
Human liver fatty acid binding protein (hL-FABP) has been reported to act as an intracellular shuttle of lipid molecules, thus playing a central role in systemic metabolic homeostasis. The involvement of hL-FABP in the transport of bile salts has been postulated but scarcely investigated. Here we describe a thorough NMR ...
Di Alberti L - - 2013
Several experimental studies have been performed in order to evaluate the behavior of different types of biomaterials involved in the process of tissue and bone regeneration. The guided bone regeneration (GBR) principles are applied in the rebuilding of periodontal tissues, damaged by the periodontal inflammatory process. Since the introduction of ...
Chen Qian - - 2013
Chiral N-tert-butylsulfinyl vinyl aziridine ligands prepared from a readily available (R)-tert-butanesulfinamide have been applied in the rhodium-catalyzed asymmetric 1,4-addition of aryl boronic acids to cyclic enones, which gives high yields and excellent enantioselectivities.
Bertossi D - - 2013
Congenital isolated absent columella is a rare event in population, with an aetiology that is still unclear. Reconstruction remains a challenging problem. A single case is presented with the description of an original single stage surgical technique to restore it.
Bertossi D - - 2013
Third molar displacement into the infratemporal fossa during a surgical extraction is a rare event. Nevertheless, because of the presence of several vascular and neurological trunks through the infratemporal fossa, a correct management of this unusual surgical complication is fundamental in order to avoid many potential serious side effects. In ...
Michaeli Yael - - 2013
Herein we report the specific labelling of the epigenetic modification 5-hydroxymethyl-cytosine along genomic DNA molecules with a fluorescent reporter molecule. Enzymatic glucosylation followed by a click chemistry reaction enables single molecule detection as well as global quantification of 5hmC in genomic DNA.
Antonios Tarek F T - - 2013
BACKGROUND: Preeclampsia is a major cause of maternal and neonatal mortality and morbidity. The incidence of preeclampsia seems to be rising because of increased prevalence of predisposing disorders, such as essential hypertension, diabetes, and obesity, and there is increasing evidence to suggest widespread microcirculatory abnormalities before the onset of preeclampsia. ...
Arslan Hakan - - 2013
Abstract Objective: The aim of this study was to evaluate the effects of different surface treatments on the pushout bond strength of fiber-reinforced posts to composite resin cores. Materials and methods: Twenty-five translucent glass fiber posts were divided into five groups according to surface treatment methods as follows: an untreated ...
Ndisang Joseph Fomusi - - 2013
BACKGROUND: The mechanisms by which heme oxygenase (HO) improves glucose metabolism in essential hypertension are not completely understood. Because dysfunctional insulin signaling is associated with elevated inflammation and high cholesterol and triglycerides, we investigated the effects of HO on the proinflammatory macrophage M1 phenotype and the anti-inflammatory macrophage M2 phenotype ...
Sun Jiaqiang - - 2013
Both blue light (BL) and auxin are essential for phototropism in Arabidopsis thaliana. However, the mechanisms by which light is molecularly linked to auxin during phototropism remain elusive. Here, we report that PHYTOCHROME INTERACTING FACTOR4 (PIF4) and PIF5 act downstream of the BL sensor PHOTOTROPIN1 (PHOT1) to negatively modulate phototropism ...
Matsuba Yuki - - 2013
Functional gene clusters, containing two or more genes encoding different enzymes for the same pathway, are sometimes observed in plant genomes, most often when the genes specify the synthesis of specialized defensive metabolites. Here, we show that a cluster of genes in tomato (Solanum lycopersicum; Solanaceae) contains genes for terpene ...
Kelly Katherine J - - 2013
Despite advances in the treatment of diabetic nephropathy (DN), currently available therapies have not prevented the epidemic of progressive chronic kidney disease (CKD). The morbidity of CKD, and the inexorable increase in the prevalence of end stage renal disease, demands more effective approaches to prevent and treat progressive CKD. We ...
Muratsugu Satoshi - - 2013
Ru nanoclusters (average diameter = 1.3 ± 0.3 nm) were successfully prepared by using a Ru3 cluster Ru3O(CH3COO)6(H2O)3·(CH3COO) grafted on a pyridine-functionalized SiO2 surface. The pyridine moiety dispersed on the SiO2 surface spread the Ru3 cluster, controlling its surface density, and the nanoclusterization of the Ru cluster proceeded on the ...
Correr Cassyano Januario - - 2013
BACKGROUND:The complexity of clinical pharmacy services usually leads to an inconsistent or even poor description of their interventions in scientific reports. To ensure comparability and reproducibility of the evidence, an in-depth description of pharmacist interventions is required.OBJECTIVE:To validate a new tool called DEPICT (Descriptive Elements of Pharmacist Intervention Characterization Tool) ...
Rosenthal E - - 2013
Although preliminary studies showed that preexposure prophylaxis (PrEP) lowers the HIV transmission in individuals with HIV, confirmative trials are ongoing and PrEP is not routinely recommended. The aim of this study was to assess whether individuals with HIV share antiretroviral (ARV) drugs for PrEP and to describe awareness and discussion ...
Karger Amy B - - 2013
Background: Renal coloboma syndrome (RCS) is a rare inherited disorder caused by mutations in the PAX2 gene. Clinical testing is currently performed by bidirectional Sanger sequencing of all 12 coding exons of the PAX2 gene, which detects point mutations or small insertion/deletion mutations. Large genomic deletions of PAX2 have been ...
Sinha Mahua - - 2013
Cell-free Epstein-Barr viral (EBV) DNA is detectable in plasma of patients with EBV-related lymphomas. The aim of this study was to evaluate the utility of plasma EBV DNA as a biomarker of EBV association in childhood Hodgkin lymphoma (HL). Furthermore, an attempt was made to evaluate the effectiveness of viral ...
Grabowsky Jennifer A - - 2013
OBJECTIVE:To evaluate everolimus drug-drug and drug-food interactions, with an emphasis on patients with cancer.DATA SOURCES:Literature was accessed through PubMed (1990-March 2013) using Boolean combinations of the terms drug interactions, herb-drug interactions, food-drug interactions, everolimus, antineoplastic agents, hormonal, and breast neoplasms. In addition, reference citations from publications and the prescribing information ...
Carnevale Santino D - - 2013
Polarization-induced nanowire light emitting diodes (PINLEDs) are fabricated by grading the Al composition along the c-direction of AlGaN nanowires grown on Si substrates by plasma-assisted molecular beam epitaxy (PAMBE). Polarization-induced charge develops with a sign that depends on the direction of the Al composition gradient with respect to the [0001] ...
Ikai Saeko - - 2013
OBJECTIVE:To report on a patient who was successfully rechallenged with clozapine after perforation of the large intestine and pulmonary embolism post operatively, and provide a literature review on clozapine rechallenge.CASE SUMMARY:A 46-year-old Japanese man with treatment-resistant schizophrenia developed constipation and slight abdominal discomfort while taking clozapine 275 mg/day. He developed ...
Yao Tao - - 2013
Only the half of it: A modified intercalation-deintercalation strategy that takes advantage of the characteristic thermally induced phase transition of monoclinic VO2 has been developed for the preparation of ultrathin VO2 nanosheets. The resultant nanosheets exhibit half-metallic character and a temperature-dependent phase transition. The half-metallicity could lead to applications in ...
Gourlan Mathieu - - 2013
Using self-determination theory (SDT) as an explanatory framework, this randomised-controlled study evaluates the effect of a motivational interviewing (MI)-based intervention as an addition to a standard weight loss programme (SWLP) on physical activity (PA) practice in obese adolescents over a six-month period. Fifty-four obese adolescents (mean age = 13 years, mean BMI = 29.57 kg/m²) were ...
Thoresen Christian - - 2013
Introduction. Impaired monitoring of internally generated information has been proposed to be one component in the development and maintenance of delusions. The present study investigated the neural correlates underlying the monitoring processes and whether they were associated with delusions. Methods. Twenty healthy controls and 19 patients with schizophrenia spectrum disorders ...
Bui Linh - - 2013
Take the straight path: Furfural was converted into γ-valerolactone (GVL) through sequential transfer-hydrogenation and hydrolysis reactions catalyzed by zeolites with Lewis and Brønsted acid sites. Together, Zr-Beta and Al-MFI nanosheets generated GVL in 78 % yield without the use of precious metals or molecular H2 . This system offers an attractive ...
Zhao Zilong - - 2013
This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the ...
Shao Changzhun - - 2013
Self-assembly: A tweezer-type perylene bisimide (PBI) dyad self-assembles into a defined bimolecular complex composed of a quadruple PBI π stack with remarkable kinetic stability, which is unprecedented for π-stacked dye aggregates. These persistent supramolecular species are of considerable interest for the elucidation of functional properties of dye aggregates.
Beloqui Ana - - 2013
Ligand libraries can be printed onto a sandwich composed of activated lipids embedded in a hydrophobic layer conjugated to an indium-tin oxide (ITO) surface. Arrays produced this way can be analyzed by fluorescence spectroscopy and mass spectrometry. Applications include the assignment of enzyme specificity, the profiling of glycoforms and the ...
Zhao Kai - - 2013
DREB2-type transcription factors play a critical role in the stress-related regulation network in plants. In this study, we isolated and characterized a DREB2 homolog from Malus sieversii Roem., designated MsDREB2C (GenBank Accession No. JQ790526). MsDREB2C localized to the nucleus and transactivated reporter genes in yeast strain YGR-2. Quantitative real-time PCR ...
Verset L - - 2013
Background:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC).Methods:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistochemistry for FHL2 ...
Sharma Ketki - - 2013
Neutron imaging is presented as a tool for quantifying the diffusion of ions inside porous materials, such as carbon electrodes used in the desalination process via capacitive deionization and in electrochemical energy-storage devices. Monolithic mesoporous carbon electrodes of ∼10 nm pore size were synthesized based on a soft-template method. The ...
Saha Manik Lal - - 2013
Over years, mathematicians, biologists and chemists have capitalised on the highly useful concept of orthogonality for developing sophisticated complex systems. The use of orthogonal pairs ensures that any modification made on one pair does not propagate any effect onto the other. While the concept equally pertains to dynamic supramolecular interactions, ...
Tseng Shiojenn - - 2013
The influence of boundary shape on electrophoresis is modeled by considering a soft spherical particle comprising a positively charged rigid core and an uncharged membrane layer on the axis of a necked cylindrical pore with its throat positively charged. The presence of the throat makes the associated flow and electric ...
Zhou Bing - - 2013
A Rh(III)-catalyzed direct aldehyde C-H amidation from aldehydes and N-chloroamines, prepared in situ from amines, has been developed via C-H bond activation under very mild reaction conditions. A variety of primary and secondary amines were used to afford the corresponding amides in moderate to excellent yields.
Feng Chen-Guo - - 2013
A Pd(II)-catalyzed C-H phosphorylation reaction has been developed using heterocycle-directed ortho-palladation. Both dialkyl phosphites and diaryl phosphine oxides are suitable coupling partners for this reaction.
Barnes D R - - 2013
Background:Pedigrees with multiple genotyped family members have been underutilised in breast cancer (BC) genetic-association studies. We developed a pedigree-based analytical framework to characterise single-nucleotide polymorphism (SNP) associations with BC risk using data from 736 BC families ascertained through multiple affected individuals. On average, eight family members had been genotyped for ...
Lee Pearl G - - 2013
OBJECTIVETo describe the prevalence of physical function limitations among a nationally representative sample of adults with prediabetes.RESEARCH DESIGN AND METHODSWe performed a cross-sectional analysis of 5,991 respondents ≥53 years of age from the 2006 wave of the Health and Retirement Study. All respondents self-reported physical function limitations and comorbidities (chronic ...
Avalos Gloria E - - 2013
OBJECTIVEThe optimal screening regimen for gestational diabetes mellitus (GDM) remains controversial. Risk factors used in selective screening guidelines vary. Given that universal screening is not currently adopted in our European population, we aimed to evaluate which selective screening strategies were most applicable.RESEARCH DESIGN AND METHODSBetween 2007 and 2009, 5,500 women ...
Rasmussen Stephanie B - - 2013
BACKGROUND: Dexamethasone, when added to local anesthetics, has been shown to prolong the duration of peripheral nerve blocks; however, there are limited studies utilizing large numbers of patients. The purpose of this study was to examine the effect of adding dexamethasone to ropivacaine on duration of nerve blocks of the ...
Khara Basile - - 2013
Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels.
Lajous Martin - - 2013
OBJECTIVEThe objective of this study was to evaluate the relationship between childhood and adult secondhand smoke and type 2 diabetes.RESEARCH DESIGN AND METHODSWe conducted a prospective cohort study among 37,343 French women from the E3N-EPIC (Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale-European Prospective Investigation into ...
Vequi-Suplicy Cíntia C - - 2013
The fluorescent probe Prodan (2-dimethylamino-6-propionylnaphthalene) has been widely used in biological systems, mainly due to the high sensitivity of its emission spectrum to the medium polarity. Though mostly used as a membrane probe, in lipid dispersions Prodan partitions in water, mainly in the presence of gel-phase bilayers. Here, optical properties ...
Shang Haihong - - 2013
NAC domain proteins are plant-specific transcription factors known to play diverse roles in various plant developmental processes. In the present study, we performed the first comprehensive study of the NAC gene family in Gossypium raimondii Ulbr., incorporating phylogenetic, chromosomal location, gene structure, conserved motif, and expression profiling analyses. We identified ...
Wheeler B W - - 2013
Background:This study investigates the geography of non-melanoma skin cancer (NMSC) in England, and ecological associations with three widespread environmental hazards: radon, arsenic and ultraviolet radiation from the sun.Methods:Age-/sex-standardised registration rates of NMSC were mapped for local authority (LA) areas (n=326), along with geographical data on bright sunshine, household radon and ...
Newsom Sean A - - 2013
OBJECTIVEThe purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults.RESEARCH DESIGN AND METHODSEleven sedentary obese adults (male/female: 3/8; BMI 37 ± 1 kg/m(2); peak oxygen uptake [VO2peak] 20 ± 1 ...
He Jibin - - 2013
The starchy endosperm is the major storage tissue in the mature wheat grain and exhibits quantitative and qualitative gradients in composition, with the outermost cell layers being rich in protein, mainly gliadins, and the inner cells being low in protein but enriched in HMW subunits of glutenin. We have used ...
Lv Yunhe - - 2013
An efficient Cu-catalyzed synthesis of quinazolines via the C-N bond formation reactions between N-H bonds of amidines and C(sp(3))-H bonds adjacent to sulfur or nitrogen atoms in the commonly used solvents, such as DMSO, DMF, DMA, NMP or TMEDA, followed by intramolecular C-C bond formation reactions was developed for the ...
Di Alberti L - - 2013
This study evaluated the clinical performance of screwed customized zirconia abutments. Additionally, the marginal fit between the selected implant components was measured and the clinical gingival response was monitored. Thirty patients were consecutively selected for a prospective study of 30 implant-supported restorations. Customized zirconia abutment complexes were prepared, then ceramic ...
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