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Vernon H J HJ McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 North Broadway, BRB 529, Baltimore, MD, 21205, USA, - - 2014
We report an adult male with classic propionic acidemia (PA) who developed chronic kidney disease in the third decade of his life. This diagnosis was recognized by an increasing serum creatinine and confirmed by reduced glomerular filtration on a (99m)Tc-diethylenetriamine pentaacetate (DTPA) scan. Histopathology of the kidney showed moderate glomerulo- ...
Kondera Elżbieta - - 2013
The aim of the present study was to evaluate bioaccumulation of metals in various tissues of the freshwater fish Cyprinus carpio L. exposed to cadmium and copper (a xenobiotic and a microelement). The fish were subjected to short-term (3 h, Cd-S and Cu-S) or long-term (4 weeks, Cd-L and Cu-L) exposures to ...
Mathieu K B KB Department of Bioengineering, Rice University, Houston, TX 77005, - - 2013
We investigated the possibility of reducing radiation dose to the breast tissue of pediatric females by using multiple tube voltages within a single CT examination. The peak kilovoltage (kVp) was adjusted when the x-ray beam was directly exposing the representative breast tissue of a 5-year-old, 10-year-old, and an adult female ...
Seneviratne Chamindi C Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA, 22911, - - 2013
On the basis of the converging evidence showing regulation of drinking behavior by 5-HT3AB receptors and the serotonin transporter, we hypothesized that the interactive effects of genetic variations in the genes HTR3A, HTR3B, and SLC6A4 confer greater susceptibility to alcohol dependence (AD) than do their effects individually. We examined the ...
Zhang Yu - - 2013
Diabetes mellitus is associated with increased risk of osteopenia and bone fracture that may be related to hyperglycemia. However, the mechanisms accounting for diabetic bone disorder are unclear. Here, we showed that high glucose significantly promoted the production of reactive oxygen species (ROS) in rat primary osteoblasts. Most importantly, we ...
Karow Marisa - - 2013
Pericytes, typically attached to the walls of microvessels in almost all organs, interact with endothelial cells and take part in diverse biological processes, e.g. blood vessel regulation and tissue repair. This suggests that pericytes harbor a remarkable degree of cellular plasticity, which could potentially be employed for the treatment of ...
Kapatai G - - 2013
Background:Mutation of the RB1 gene is necessary but not sufficient for the development of retinoblastoma. The nature of events occurring subsequent to RB1 mutation is unclear, as is the retinal cell-of-origin of this tumour.Methods:Gene expression profiling of 21 retinoblastomas was carried out to identify genetic events that contribute to tumorigenesis ...
Valverde Jose M - - 2013
We study in this paper the conversion of CaO-based CO2 sorbents when subjected to repeated carbonation-calcination cycles with a focus on thermally pretreated/doped sorbents. Analytical equations are derived to describe the evolution of conversion with the cycle number from a unifying model based on the balance between surface area loss ...
Guthrie G J K - - 2013
Background:Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have prognostic value in patients with colorectal cancer. However, their relationship with circulating biochemical mediators is unclear. The aim of the present study was to examine the interrelationships between circulating mediators, ...
Jennings Lance C - - 2013
On 14 June 2012, the Asia-Pacific Alliance for the Control of Influenza (APACI) convened the first Antiviral Forum jointly with the Influenza Foundation of Thailand and the Thailand Department of Disease Control. The goals of the meeting were to improve pandemic planning in the region from lessons learned during the ...
Chen Chu-Chih - - 2013
To date, the variant Creutzfeldt-Jakob disease (vCJD) risk assessments that have been performed have primarily focused on predicting future vCJD cases in the United Kingdom, which underwent a bovine spongiform encephalopathy (BSE) epidemic between 1980 and 1996. Surveillance of potential BSE cases was also used to assess vCJD risk, especially ...
Carbajo-Pescador S - - 2013
Background:Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible factor 1 alpha (Hif1α) and signal transducer and activator of transcription (STAT3). Melatonin induces apoptosis in HCC, and shows anti-angiogenic features in several tumours. In ...
Domingues Tatiana M - - 2013
Gomesin is a potent cationic antimicrobial peptide (z = +6) isolated from the Brazilian spider Acanthoscurria gomesiana. The interaction of gomesin with large unilamellar vesicles (LUVs) composed of a 1:1 mixture of zwitterionic (POPC) and anionic (POPG) phospholipids is studied with isothermal titration calorimetry (ITC). In parallel, light scattering and ...
Ying Ge Tong - - 2013
AIMS AND OBJECTIVES.: To describe the level of knowledge, attitudes, and self-reported quality of practice in pain assessment among nurses of Mainland China and explore links with current hospital pain policy and continuing education. BACKGROUND.: Knowledge is necessary for skilled pain assessment among nurses. Little is currently known regarding knowledge, ...
Hansen Anne-Louise S - - 2013
OBJECTIVERegular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis.RESEARCH ...
Gordziel C - - 2013
Background:Aberrant activities of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathways have been implicated in the development and spread of various cancer entities, among them colorectal carcinoma (CRC). Transcription factors STAT3 and STAT1, both downstream effectors of interleukin (IL)-6 and its receptor, are involved in growth and ...
Mawson Kerry - - 2013
The aim of this study was to determine if simulation aided by media technology contributes towards an increase in knowledge, empathy, and a change in attitudes in regards to auditory hallucinations for nursing students. A convenience sample of 60 second-year undergraduate nursing students from an Australian university was invited to ...
Katzmarzyk Peter T - - 2013
OBJECTIVEWe aimed to determine the associations of waist circumference (WC) and BMI with all-cause mortality among patients with diabetes.RESEARCH DESIGN AND METHODSThe sample included 847 white and 553 African American patients (18-69 years of age) with diabetes. Height, weight, and WC were measured, and the BMI (kg/m(2)) was calculated. Cox ...
Giordano Salvatore - - 2013
Background:Antibacterial lavage with topical antibiotics may reduce the occurrence of capsular contracture (CC) in breast augmentation.Objectives:The authors investigate the efficacy of povidone-iodine combined with antibiotic irrigation in reducing the CC rate.Methods:The charts of 333 consecutive women who underwent cosmetic breast augmentation during 2 different periods (group A: 2004-2009, n = ...
Castelló Luis M - - 2013
Chiral complexes formed by phosphoramidites such as (Sa,R,R)-9 and Cu(OTf)2 are excellent catalysts for the general 1,3-dipolar cycloaddition between azomethine ylides and nitroalkenes affording the corresponding tetrasubstituted proline esters mainly as exo-cycloadducts in high er at room temperature. The exo-cycloadducts can be obtained in enantiomerically pure form just after simple ...
Delmont Tom O - - 2013
Metagenomics is a culture- and PCR-independent approach that is now widely exploited for directly studying microbial evolution, microbial ecology, and developing biotechnologies. Observations and discoveries are critically dependent on DNA extraction methods, sequencing technologies, and bioinformatics tools. The potential pitfalls need to be understood and, to some degree, mastered if ...
van Drunen Julia - - 2013
Nickel-based metallic foams are commonly used in electrochemical energy storage devices (rechargeable batteries) as both current collectors and active mass support. These materials attract attention as tunable electrode materials because they are available in a range of chemical compositions, pore structures, pore sizes and densities. This contribution presents structural, chemical, ...
Sherr Jennifer L - - 2013
OBJECTIVEAfternoon exercise increases the risk of nocturnal hypoglycemia (NH) in subjects with type 1 diabetes. We hypothesized that automated feedback-controlled closed-loop (CL) insulin delivery would be superior to open-loop (OL) control in preventing NH and maintaining a higher proportion of blood glucose levels within the target blood glucose range on ...
Mangili G - - 2013
Objective:The aim of this study is to evaluate the long-term outcome of granulosa cell tumour (GCT) of the ovary in a large series of patients treated in MITO centres (Multicentre Italian Trials in Ovarian Cancer) and to define prognostic parameters for relapse and survival.Methods:A retrospective multi-institutional review of patients with ...
Sandison Harriet E - - 2013
AIMS: Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell ...
Schriver Maria - - 2013
Anticorrosion and antioxidation surface treatments such as paint or anodization are a foundational component in nearly all industries. Graphene, a single-atom-thick sheet of carbon with impressive impermeability to gases, seems to hold promise as an effective anticorrosion barrier, and recent work supports this hope. We perform a complete study of ...
Pop-Busui Rodica - - 2013
OBJECTIVEThe Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial demonstrated similar long-term clinical effectiveness of insulin-sensitizing (IS) versus insulin-providing (IP) treatments for type 2 diabetes on cardiovascular outcomes in a cohort with documented coronary artery disease. We evaluated the effects of randomized glycemic control strategy (IS vs. IP) on ...
Ernst Jennifer - - 2013
Purpose: Functional electrical stimulation represents an alternative to conventional and passive ankle foot orthosis (AFO) for the treatment of stroke-related drop foot. We evaluated the implantable 4-channel stimulator ActiGait, which selectively and directly stimulates the peroneal nerve. In addition, it bypasses the need for surface electrodes and cables. Methods: Walking ...
Takagi K - - 2013
Background:Estrogens have important roles in ductal carcinoma in situ (DCIS) of the breast. However, the significance of presurgical aromatase inhibitor treatment remains unclear. Therefore, we examined intratumoral concentration of estrogens and changes of clinicopathological factors in DCIS after letrozole treatment.Methods:Ten cases of postmenopausal oestrogen receptor (ER)-positive DCIS were examined. They ...
Kulkarni Smita R - - 2013
OBJECTIVETo study the relationship between maternal circulating fuels and neonatal size and compare the relative effects of glucose and lipids.RESEARCH DESIGN AND METHODSThe Pune Maternal Nutrition Study (1993-1996) investigated the influence of maternal nutrition on fetal growth. We measured maternal body size and glucose and lipid concentrations during pregnancy and ...
Feeney Erin J - - 2013
Purpose: Transgenic manipulation of mouse physiology facilitates the preclinical study of genetic risk factors, neural plasticity, and reactive processes accompanying Alzheimer's disease. Alternatively, entorhinal cortex lesions (ECLs) model pathophysiological denervation and axonal sprouting in rat. Given reports of anatomical differences between the mouse and rat hippocampus, application of the ECL ...
Clarke C A - - 2013
Background:Solid organ transplant recipients have high risk of lymphomas, including non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). A gap in our understanding of post-transplant lymphomas involves the spectrum and associated risks of their many histologic subtypes.Methods:We linked nationwide data on solid organ transplants from the US Scientific Registry of Transplant ...
Cooper W A - - 2013
AIM: We assessed the diagnostic accuracy of epidermal growth factor receptor (EGFR) mutant-specific antibodies for detecting two common activating EGFR mutations. METHODS: Immunohistochemical expression of mutation-specific antibodies against EGFR exon 19 deletion E746-A750 ((c.2235_2249del15 or c.2236_2250del15, p. Glu746_Ala750del) and exon 21 L858R point mutation (c.2573T>G, p.Leu858Arg) were assessed in a ...
Clark David M - - 2013
This is the first in a series of articles describing the application of Lean management systems to Laboratory Medicine. Lean is the term used to describe a principle-based continuous quality improvement (CQI) management system based on the Toyota production system (TPS) that has been evolving for over 70 years. Its ...
Lee Cheol Whan - - 2013
BACKGROUND: Stanniocalcin-1 (STC1) is involved in fundamental biological processes such as angiogenesis, inflammation and wound healing, but little is known about its expression in human coronary atherosclerotic plaques or its relationship to plaque instability. OBJECTIVE: STC1 expression was examined in the culprit coronary plaques of 70 patients with acute myocardial ...
Vestberg Daniel - - 2013
OBJECTIVETo investigate the potential relationship between overweight, obesity, and severe obesity and the risk of hospitalization for heart failure (HF) in patients with type 1 diabetes.RESEARCH DESIGN AND METHODSWe studied patients with type 1 diabetes included in the Swedish National Diabetes Register during 1998-2003, and they were followed-up until hospitalization ...
Akkoc H - - 2013
The goal of this study was to investigate whether the combination of the Poly(ADP-ribose) polymerase inhibitor 5-aminoisoquinolinone (5-AIQ) and the Na+-H+ exchanger inhibitor zoniporide (ZN) provides increased protection against ischemia-reperfusion (I/R) injury. Rats were separated into 5 groups (n=8): Group 1: Control group, Group 2: I/R, Group 3: 5-AIQ, Group ...
Ozguner Ismet F - - 2013
Background/Purpose The aim of the study is to evaluate the diagnostic value of interleukin-6 (IL-6) level and neutrophil cluster of differentiation 64 (CD64) expression in diagnosis of acute appendicitis (AA).Methods A prospective controlled trail was performed. Children who were hospitalized with a diagnosis of right lower quadrant pain were our ...
Li Wenhao - - 2013
Large A- and small B-starch granules separated from hard red and soft red winter wheat grains were investigated their morphological, structural and physicochemical properties. A-granules displayed a disk or lenticular shape, and B-granules showed a spherical or polygonal shape according to SEM. XRD analysis showed that both A- and B- ...
Paterson Ross W - - 2013
BACKGROUND: Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations including limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. However, there are patients with positive levels in whom the significance is uncertain. OBJECTIVE: To evaluate the clinical significance associated with positive (>100 pM) VGKC-complex antibodies. ...
Norwood Fiona - - 2013
A national UK workshop to discuss practical clinical management issues related to pregnancy in women with myasthenia gravis was held in May 2011. The purpose was to develop recommendations to guide general neurologists and obstetricians and facilitate best practice before, during and after pregnancy. The main conclusions were (1) planning ...
Di Alberti L - - 2013
Atrophy of the alveolar processes of the jaws, as a result of edentulism, often cannot allow a prosthetic rehabilitation, also if it only consists of a total removable prosthesis - for the inadequate base support - and also if it is backed by implants, because the small residual thickness bone ...
Bertossi D - - 2013
Le Fort I osteotomy of the maxilla continues to be one of the most common techniques used in the surgical correction of a variety of dento-midfacial deformities. Occasionaly, however, surgeons may encounter difficulties during three-pieces Le Fort I procedures because the surgical movements are also prone to adverse movement and ...
Sateriale Adam - - 2013
OBJECTIVE: To identify potential opportunities for drug repurposing by developing an automated approach to pre-screen the predicted proteomes of any organism against databases of known drug targets using only freely available resources. MATERIALS AND METHODS: We employed a combination of Ruby scripts that leverage data from the DrugBank and ChEMBL ...
Chiba Junya - - 2013
We propose linear end-to-end assemblies of short DNA duplexes based on β-cyclodextrin-adamantane complexation. The assembled duplexes exhibited increased Tm values compared with those of the corresponding natural hybrids. Competition experiments with external guest molecules showed a substantial decrease in Tm of the terminal modified duplexes, suggesting the viability of inter-duplex ...
Kong Ping - - 2013
As a typical matricellular protein, Thrombospondin (TSP)-1, binds to the structural matrix and regulates cellular behavior by modulating growth factor and cytokine signaling. Obesity and diabetes are associated with marked upregulation of TSP-1 in adipose tissue. We hypothesized that endogenous TSP-1 may play an important role in the pathogenesis of ...
Lang Charles H - - 2013
Muscle disuse atrophy is routinely observed in patients recovering from traumatic injury and can be either generalized resulting from extended bed rest or localized resulting from single limb immobilization. The present study addressed the hypothesis that a diet containing 5% alpha-hydroxyisocaproic acid (αHICA), a leucine (Leu) metabolite, will slow the ...
Zhang Xiao-Ling - - 2013
Hepatocellular carcinoma (HCC) is a highly invasive type of cancer. Metastasis is the leading cause of mortality of advanced HCC patients. In the metastasis cascade, cancer cells undergo epithelial-mesenchymal transition resulting in the loss of cell‑to‑cell adhesion, migration and invasion into the stroma. Loss of E-cadherin expression is a key ...
Adjeitey Cyril Nii-Klu - - 2013
Enhancement of proton leaks in muscle tissue represents a potential target for obesity treatment. In this study, we examined the bioenergetic and physiologic implications of increased proton leak in skeletal muscle. To induce muscle-specific increases in proton leak we used mice that selectively express uncoupling protein-1 (UCP1) in skeletal muscle ...
Xu Lirong - - 2013
In this work we provide a systematic scanning tunneling microscopy (STM) study on the self-assembling and mixing behavior of Arylene Ethynylene Macrocycles (AEMs) containing 1,4-phenylene, 1,4-naphthylene or 9,10-anthrylene substituents at the solid/liquid interface. The effect of bulky substituents on the self-assembly structure was investigated and we found that 1,4-phenylene ethynylene ...
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