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Zhang Nan N Department of Sociology, Institute for Research on Sexuality and Gender, Renmin University of China, No. 59, Zhongguancun Street, Beijing, 100872, China, - - 2014
Yiyeqing (YYQ) ("one night love", i.e., having sex only once with a non-commercial partner) has increased in China, concomitant with the increase in heterosexual transmission of sexually transmitted infections/human immunodeficiency virus (STI/HIV). Our study explored how participants who had experienced YYQ understood these relationships and characterized YYQ's links to sexual ...
Xu Hao H Department of Orthopaedics, the First Hospital of Wujiang, Jiangsu Province, People's Republic of - - 2013
Anterior lumbar interbody fusion and posterior lumbar interbody fusion with 1 cage have been shown to have similar biomechanics compared with the use of 2 cages. However, there have been no reports on the biomechanical differences between using 1 or 2 cages in transforaminal lumbar interbody fusion (TLIF) surgery. To ...
Matsuo Takeshi T *Department of Neurosurgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan; ‡Department of Physiology, Niigata University School of Medicine, Niigata, Japan; §Department of Ultrastructual Research, National Institute of Neuroscience, Kodaira, Japan; ¶Center for Transdisciplinary Research, Niigata University, Niigata, - - 2013
There has been growing interest in clinical single-neuron recording to better understand epileptogenicity and brain function. It is crucial to compare this new information, single-neuronal activity, with that obtained from conventional intracranial electroencephalography during simultaneous recording. However, it is difficult to implant microwires and subdural electrodes during a single surgical ...
Coburn John A JA *Mayo Medical School, College of Medicine †Department of Psychiatry and Psychology ‡Division of Biostatistics and Informatics §Division of Gastroenterology and Hepatology ‚ą•Division of Transfusion Medicine ¶Division of Anatomic Pathology #Department of Immunology, Mayo Clinic, Rochester, - - 2013
Increasingly, people start a gluten-free diet (GFD) without a clear celiac disease (CD) diagnosis. Human leukocyte antigen (HLA) genotyping is useful in ruling out CD in patients with equivocal results of serologic testing or small-bowel biopsy (SBB), but its utility and the clinical features of patients on self-treated GFD (ST-GFD) ...
Liu Fei F Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, - - 2013
Autophagy is a conserved lysosomal degradation process that has important roles in both normal human physiology and disease. However, the function of autophagy in bone homeostasis is not well understood. Here, we report that autophagy is activated during osteoblast differentiation. Ablation of focal adhesion kinase family interacting protein of 200 ...
Zywiel Michael G MG Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, M5T 2S8, Canada, - - 2013
Advances in the surgical treatment of musculoskeletal conditions have resulted in an interest in better defining and understanding patients' expectations of these procedures, but the best ways to do this remain a topic of considerable debate. (1) What validated instruments for the assessment of patient expectations of orthopaedic surgery have ...
Neuman Arlene C AC Department of Otolaryngology, New York University School of Medicine, New York, NY 10016, USA. - - 2013
The purpose of this study was to determine how the bandwidth of the hearing aid (HA) fitting affects bimodal speech recognition of listeners with a cochlear implant (CI) in one ear and severe-to-profound hearing loss in the unimplanted ear (but with residual hearing sufficient for wideband amplification using National Acoustic ...
Sturm Johannes A JA Akademie der Unfallchirurgie (AUC), Luisenstrasse 58/59, 10117, Berlin, Germany. - - 2013
Development of trauma systems is a demanding process. The United States and Germany both have sophisticated trauma systems. This manuscript is a summary of political, economic, and medical changes that have led to the development of both trauma systems and the current high-quality standards. We specifically asked three questions: (1) ...
Ogasawara Ken K Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, - - 2013
Tacrolimus is an immunosuppressive drug used for the prevention of the allograft rejection in kidney transplant recipients. It exhibits a narrow therapeutic index and large pharmacokinetic variability. Tacrolimus is mainly metabolized by cytochrome P450 (CYP) 3A4 and 3A5 and effluxed via ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp), encoded ...
Zhang Dan D Spine Tumor Center, Changzheng Hospital, Second Military Medical University, Shanghai, - - 2013
A retrospective study of 36 patients with metastatic hepatocellular carcinoma (HCC) of the mobile spine was performed by survival analysis. To discuss the factors that may affect outcomes of patients with HCC spinal metastases. HCC is a rare tumor in Western countries. However, HCC is common in Far East (Taiwan, ...
Hawasli Ammar H AH Departments of Neurosurgery and Biostatistics, Washington University School of Medicine, St. Louis, - - 2013
Brain biopsies of superficial cortex are performed for diagnosis of neurological diseases, but preoperative predictors of successful diagnosis and risks are lacking. We evaluated effectiveness and outcomes of superficial cortical biopsies and determined preoperative predictors of diagnosis, outcomes, morbidities, and mortality. A single-institution retrospective analysis of 170 patients who underwent ...
Takashima Hiroyuki H Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, - - 2013
Prospective study based on magnetic resonance imaging for lumbar disc herniation. In this study, we captured diffusion-weighted imaging (DWI) of dorsal root ganglion (DRG) of the affected nerve root in lumbar disc herniation and examined the relationship between apparent diffusion coefficient (ADC) and clinical symptoms to evaluate the efficacy of ...
Crawford Charles H CH 3rd Norton Leatherman Spine Center, Louisville, KY, - - 2013
Multicenter retrospective analysis of prospectively collected data. Evaluate radiographical and clinical characteristics of patients undergoing a selective thoracic fusion (STF) for Lenke 1C curves. STF of adolescent idiopathic scoliosis has been advocated for the so-called "false double major" curve (Lenke 1C/King type II). Despite these recommendations, many surgeons continue to ...
Esteban Andrés A Hospital Universitario de Getafe & Centro de Investigación Biomédica en red de Enfermedades Respiratorias, Spain. - - 2013
Baseline characteristics and management have changed over time in patients requiring mechanical ventilation; however, the impact of these changes on patient outcomes is unclear. To estimate whether mortality in mechanically ventilated patients has changed over time. Prospective cohort studies conducted in 1998, 2004, and 2010, including patients receiving mechanical ventilation ...
Weenink Robert P RP Diving Medical Center, Royal Netherlands Navy, Den Helder, The Netherlands. - - 2013
Hyperbaric oxygenation is the accepted treatment for cerebral arterial gas embolism. Although earlier start of hyperbaric oxygenation is associated with better outcome, it is unknown how much delay can be tolerated before start of hyperbaric oxygenation. This study investigates the effect of hyperbaric oxygenation on cerebral function in swine when ...
Miller Russell R RR 3rd Division of Pulmonary and Critical Care Medicine, Intermountain Healthcare, Murray, UT, USA. - - 2013
Severe sepsis and septic shock are leading causes of intensive care unit (ICU) admission, morbidity, and mortality. The effect of compliance with sepsis management guidelines on outcomes is unclear. To assess the effect on mortality of compliance with a severe sepsis and septic shock management bundle. Observational study of a ...
Isozaki Takeo T University of Michigan Medical School, Ann Arbor, MI, - - 2013
To examine the possibility that CXCL16 recruits endothelial cells (ECs) to developing neovasculature in rheumatoid arthritis (RA) synovium. We utilized the RA synovial tissue SCID mouse chimera system to examine human microvascular EC (HMVEC) and human endothelial progenitor cell (EPC) recruitment into engrafted human synovium that was injected intragraft with ...
Mittal Sahil S Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX, - - 2013
Hepatocellular carcinoma (HCC) is increasing in incidence and has a very high fatality rate. Cirrhosis due to chronic hepatitis B or hepatitis C is the leading risk factor for HCC. Global epidemiology of HCC is determined by the prevalence of dominant viral hepatitis and the age it is acquired in ...
Griese Matthias M Children's Hospital, Ludwig-Maximilians-University, Munich, Germany. - - 2013
Glutathione is the major antioxidant in the extracellular lining fluid of the lungs and depleted in patients with cystic fibrosis (CF). We aimed to assess glutathione delivered by inhalation as a potential treatment for CF lung disease. This randomized, double-blind, placebo-controlled trial evaluated inhaled glutathione in subjects with CF 8 ...
Masaoka Takashi T RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute , Frederick, Maryland 21702, United - - 2013
The thienopyrimidinone 5,6-dimethyl-2-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4(3H)-one (DNTP) occupies the interface between the p66 ribonuclease H (RNase H) domain and p51 thumb of human immunodeficiency virus reverse transcriptase (HIV RT), thereby inducing a conformational change incompatible with catalysis. Here, we combined biochemical characterization of 39 DNTP derivatives with antiviral testing of selected compounds. In ...
Perera Reshani H RH Department of Radiology, Case Western Reserve University , Cleveland, Ohio , - - 2013
Pluronic block copolymers are non-ionic surfactants with demonstrated sensitizing activity in chemotherapy and hyperthermia in various tumor cell lines. In the current study we investigated the potential activity of Pluronic as a radiosensitizing agent. As a possible mechanism, the effect of Pluronic on Hsp70 and Hsp90 was examined. Gli36 human ...
Gaiter Juarlyn L - - 2013
African American women account for 66% of new HIV infections among U.S. women, and many are not aware of their status. The authors compared three strategies (targeted outreach, alternate venues, and social networks) to recruit African American women for HIV testing in Houston, New York City, Baltimore, and Dayton. A ...
Neyrinck Arne - - 2013
Donor shortage has forced transplant teams to explore new methods to increase the potential donor pool. Donation after circulatory death (DCD) has opened new perspectives and could be a valuable option to expand the brain-dead donors. The purpose of this review is to provide an overview of current practice and ...
van Gemert Caroline - - 2013
Men who have sex with both men and women (behaviorally bisexual men) may be at increased risk of HIV acquisition and transmission due to risky sexual behaviors. We recruited a sexual network comprised of behaviorally bisexual men and their sexual partners in Vientiane, Lao PDR in 2010 to inform our ...
Toleran Daniel E - - 2013
Asian Americans are one of the more under-researched groups in the United States. This holds true with regard to research on risk assessment, screening, and testing for human immunodeficiency virus (HIV) and hepatitis C (HCV). Here, we address that lack by exploring correlates of risk and testing for the two ...
Corton Marlene M - - 2013
A comprehensive knowledge of the boundaries, contents, and interactions between surgical spaces is essential to safely and effectively perform mesh-augmented prolapse repairs and anti-incontinence procedures. This knowledge is also critical when managing intraoperative and postoperative complications such as bleeding, visceral injury, mesh erosion, exposure, or extrusion, and pelvic pain, groin ...
Houtchens Maria - - 2013
Multiple sclerosis (MS) is a chronic neurological illness affecting adults at the time when they are most likely to consider starting a family. It is known that the risk of MS relapse declines during pregnancy but increases in the first 3 to 6 months postpartum. It is also known that ...
Nygaard Ingrid - - 2013
Most marketed devices in the United States, including most used to treat prolapse and incontinence, are marketed without FDA approval; instead, they gain "clearance" as a class II device through premarket notification [also known as the 510(k) process]. Under this process, the manufacturer states that the device is substantially equivalent ...
Ramirez-Valles Jesus - - 2013
Stigma negatively affects the health of people living with HIV/AIDS (PLWHA). Negative attitudes and discriminatory actions towards PLWHA are thought to be based, among other factors, on stigma towards sexual minorities and beliefs about personal responsibility. Yet, there is little evidence to support these linkages and explain how they take ...
Wang Ye Elaine YE University of California, San Francisco, San Francisco, CA 94143, - - 2013
To qualitatively classify and compare types of iris insertion among American Caucasians, American Chinese, and mainland Chinese. Prospective multicenter cross-sectional study. Sex- and age-matched Caucasian, American Chinese, and mainland Chinese cohorts were enrolled. Ultrasound biomicroscopy (UBM) images of the anterior chamber were acquired. Qualitative classification of iris insertion into basal, ...
Zhong Qing Q Kresge Eye Institute, Wayne State University, Detroit, MI, - - 2013
Increase in reactive oxygen species (ROS) is one of the major retinal metabolic abnormalities associated with the development of diabetic retinopathy. NF-E2-related factor 2 (Nrf2), a redox sensitive factor, provides cellular defenses against the cytotoxic ROS. In stress conditions, Nrf2 dissociates from its cytosolic inhibitor, Kelch like-ECH-associated protein 1 (Keap1), ...
Fasula Amy M AM Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, in Atlanta, Georgia 30333, USA. - - 2013
Incarcerated women are a critical population for targeted HIV/STI prevention programming; however, there is a dearth of evidence-based, genderspecific behavioral interventions for this population. Systematically adapting existing evidence-based interventions (EBIs) can help fill this gap. We illustrate the adaptation of the HIV/STI prevention EBI, Project Safe, for use among incarcerated ...
Luis Leonel L Health Sciences Institute, Portuguese Catholic University, Lisbon, Portugal. - - 2013
To evaluate the clinical pathophysiology of oculomotor changes in a patient presenting with a spontaneous semicircular horizontal canal plug. A 42-year-old man with acute spontaneous vertigo with spinning and persistent left-horizontal nystagmus, intensity but not direction dependent on head orientation with respect to gravity, indicating a benign paroxysmal positional vertigo ...
Grear Karrie E KE Department of Neurology, Wake Forest School of Medicine, Winston Salem, North Carolina, - - 2013
Stroke is a neurological emergency that carries a risk of morbidity and mortality. Recent studies have shown that the incidence of stroke, although rare, is increasing in pregnant females. In this review, stroke and other vasculopathies in the pregnant and postpartum female are examined. A discussion of the symptoms and ...
Bilger Marcel M Health Services and Systems Research Program, Duke-NUS Graduate Medical School, Singapore. - - 2013
To test whether overweight or obese employees who achieve clinically significant weight loss of ≥ 5% have reduced medical expenditures, absenteeism, presenteeism, and/or improved Health-Related Quality Of Life (HRQOL). The sample analyzed combines data from full-time overweight or obese employees who took part in one of the WAY to Health ...
Camlin Carol S CS Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, 50 Beale St., Suite 1200, San Francisco, CA 94105, USA. - - 2013
In Nyanza Province, Kenya, HIV incidence is highest (26.2%) in the beach communities along Lake Victoria. Prior research documented high mobility and HIV risks among fishermen; mobility patterns and HIV risks faced by women in fishing communities are less well researched. This study aimed to characterize forms of mobility among ...
Dhal Pradeep K PK Polymer & Biomaterial R&D, Sanofi-Genzyme R&D Center, Genzyme Corporation-A Sanofi Company, 270 Albany Street, Cambridge, Massachusetts 02139, United States. - - 2013
Syntheses and characterization of aminooxy terminated polymers of N-(2-hydroxyproyl) methacrylamide (HPMA) of controlled molecular weight and narrow molecular weight distribution are presented here. Design of a chain transfer agent (CTA) containing N-tert-butoxycarbonyl (t-Boc) protected aminooxy group enabled us to use reversible addition-fragmentation (RAFT) polymerization technique to polymerize the HPMA monomer. ...
Palacios Manuel A MA Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United - - 2013
Single molecule detection schemes promise that one has the ability to reach the ultimate limit of detection: one molecule. In this paper, we use the stochastic luminescence of single semiconductor nanocrystals (quantum dots, QDs) to detect and localize particles as digital counts. These digital counts can be correlated to the ...
Vasiljevik Tamara T Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas 66045, - - 2013
Attenuation of increased endocannabinoid signaling with a CB1R neutral antagonist might offer a new therapeutic direction for treatment of alcohol abuse. We have recently reported that a monohydroxylated metabolite of the synthetic aminoalkylindole cannabinoid JHW-073 (3) exhibits neutral antagonist activity at CB1Rs and thus may serve as a promising lead ...
Kannan Rama R Department of Biochemistry, University of Missouri , Columbia, Missouri 65211, United - - 2013
Formation of protein aggregates in the aging eye lens has been shown to correlate with progressive accumulation of specific low-molecular weight (LMW) peptides derived from crystallins. Prominent among the LMW fragments is αA66-80, a peptide derived from αA-crystallin and present at higher concentrations in the water-insoluble nuclear fractions of the ...
Janowski Pawel A PA Department of Chemistry and Chemical Biology and BioMaPS Institute, Rutgers University, Piscataway, New Jersey 08854, - - 2013
Molecular dynamics simulations of biomolecular crystals at atomic resolution have the potential to recover information on dynamics and heterogeneity hidden in X-ray diffraction data. We present here 9.6 μs of dynamics in a small helical peptide crystal with 36 independent copies of the unit cell. The average simulation structure agrees ...
Jin Yonghao Y Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, - - 2013
New series of pyrrolidine mercaptosulfide, 2-mercaptocyclopentane arylsulfonamide, and 3-mercapto-4-arylsulfonamidopyrrolidine matrix metalloproteinase inhibitors (MMPIs) were designed, synthesized, and evaluated. Exhibiting unique properties over other MMPIs (e.g., hydroxamates), these newly reported compounds are capable of modulating activities of several MMPs in the low nanomolar range, including MMP-2 (~2 to 50 nM), MMP-13 ...
Kjaergaard Christian H CH Department of Chemistry, Stanford University , Stanford, California 94305, United - - 2013
Multicopper oxidases (MCOs) carry out the most energy efficient reduction of O2 to H2O known, i.e., with the lowest overpotential. This four-electron process requires an electron mediating type 1 (T1) Cu site and an oxygen reducing trinuclear Cu cluster (TNC), consisting of a binuclear type 3 (T3)- and a mononuclear ...
Sims Patrick C PC Department of Physics and Astronomy, University of California, Irvine, California 92697, - - 2013
Single-molecule studies of enzymes open a window into their dynamics and kinetics. A single molecule of the catalytic domain of cAMP-dependent protein kinase A (PKA) was attached to a single-walled carbon nanotube device for long-duration monitoring. The electronic recording clearly resolves substrate binding, ATP binding, and cooperative formation of PKA's ...
Olsen Tivoli J TJ Department of Chemistry, University of California, Irvine, California 92697, - - 2013
Bioconjugating single molecules of the Klenow fragment of DNA polymerase I into electronic nanocircuits allowed electrical recordings of enzymatic function and dynamic variability with the resolution of individual nucleotide incorporation events. Continuous recordings of DNA polymerase processing multiple homopolymeric DNA templates extended over 600 s and through >10,000 bond-forming events. ...
Huang Jing J Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United - - 2013
Surface properties, as well as inherent physicochemical properties, of the engineered nanomaterials play important roles in their interactions with the biological systems, which eventually affect their efficiency in diagnostic and therapeutic applications. Here we report a new class of MRI contrast agent based on milk casein protein-coated iron oxide nanoparticles ...
Joshi Pratixa P PP Department of Biomedical Engineering and §Texas Materials Institute, University of Texas at Austin, Austin, Texas 78712, United - - 2013
Anisotropic gold nanorods provide a convenient combination of properties, such as tunability of plasmon resonances and strong extinction cross sections in the near-infrared to red spectral region. These properties have created significant interest in the development of antibody conjugation methods for synthesis of targeted nanorods for a number of biomedical ...
Liang Yong Y Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United - - 2013
A stereoselective radical-mediated hydrogermylation of the protected 5-ethynyluracil nucleosides with trialkyl-, triaryl,- or tris(trimethylsilyl)germanes gave (Z)-5-(2-germylvinyl)uridine, 2'-deoxyuridine, or ara-uridine as major products. Reaction of the β-triphenylgermyl vinyl radical intermediate with oxygen and fragmentation of the resulting peroxyradical provided also 5-[2-(triphenylgermyl)acetyl]pyrimidine nucleosides in low to moderate yields. Thermal isomerization of the ...
Ruthstein Sharon S Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United - - 2013
Double quantum coherence (DQC) ESR spectroscopy is applied to measure the Cu(2+)-Cu(2+) distance in the EcoRI-DNA complex. A simple method is proposed to reduce the contribution of nuclear hyperfine and quadrupole interactions to such data. The effects of such interactions between the electron spin of Cu(2+) and neighboring nuclei on ...
Ashida T - - 2013
In this study, we fabricated a Cr2O3 (0001) film without and with a Pt buffer layer and investigated its effect on perpendicular exchange coupling in a Cr2O3/Co3Pt interface. The results showed that the exchange bias field (μ0Hex) and blocking temperature (TB) of a Cr2O3 film without and with Pt were ...
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