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Gallo Sina S School of Dietetics and Human Nutrition, McGill University, Montréal, Québec, - - 2013
Vitamin D supplementation in infancy is required to support healthy bone mineral accretion. A supplement of 400 IU of vitamin D per day is thought to support plasma 25-hydroxyvitamin D (25[OH]D) concentrations between 40 and 50 nmol/L; some advocate 75 to 150 nmol/L for bone health. To investigate the efficacy ...
Wachman Elisha M EM Department of Pediatrics, The Floating Hospital for Children, Tufts Medical Center, 800 Washington St, Boston, MA 02111, - - 2013
Neonatal abstinence syndrome (NAS) caused by in utero opioid exposure is a growing problem; genetic factors influencing the incidence and severity have not been previously examined. Single-nucleotide polymorphisms (SNPs) in the μ-opioid receptor (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated with risk for opioid addiction in adults. ...
Moreno-Smith Myrthala M Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2013
Chronic sympathetic nervous system activation results in increased angiogenesis and tumor growth in orthotopic mouse models of ovarian carcinoma. However, the mechanistic effects of such activation on the tumor vasculature are not well understood. Dopamine (DA), an inhibitory catecholamine, regulates the functions of normal and abnormal blood vessels. Here, we ...
Castaman Giancarlo G Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy. - - 2013
Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in circulation. As a result of von Willebrand factor deficiency or abnormality, levels of factor VIII, the ...
Khanna Savita S Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, - - 2013
Glutathione depletion and 12-lipoxygenase-dependent metabolism of arachidonic acid are known to be implicated in neurodegeneration associated with acute ischemic stroke. The objective of this study was to investigate the significance of miR-29 in neurodegeneration associated with acute ischemic stroke. Neural cell death caused by arachidonic acid insult of glutathione-deficient cells ...
Ma Yafeng Y Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, - - 2013
Fascins, a family of actin-bundling proteins, are expressed in a spatially and temporally restricted manner during development and often in cancer. Fascin 1 has a clear role in cell migration in vitro, but its role in vivo in mammals is not well understood. Here, we investigate the role of fascin ...
Schughart Klaus K 1] Department of Infection Genetics, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany [2] University of Veterinary Medicine Hannover, Germany [3] University of Tennessee Health Science Center, Memphis, TN, - - 2013
Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases ...
Beckmann Manfred M Institute of Biological Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3DA, - - 2013
Although robust associations between dietary intake and population health are evident from conventional observational epidemiology, the outcomes of large-scale intervention studies testing the causality of those links have often proved inconclusive or have failed to demonstrate causality. This apparent conflict may be due to the well-recognised difficulty in measuring habitual ...
Niarchou Maria M Institute of Psychological Medicine and Clinical Neurosciences, MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University, and the Academic Unit of Psychiatry, School of Social and Community Medicine, University of Bristol, - - 2013
Psychotic experiences in children are associated with an elevated risk of developing psychosis. The authors investigated whether the pattern of cognitive deficits present in psychosis also exists in children with psychotic experiences within the general population. The authors examined the longitudinal relationships between key cognitive domains, selected a priori based ...
Seeman Mary V MV Centre for Addiction and Mental Health, Toronto. - - 2013
Sexual dysfunction is common among women with schizophrenia treated with antipsychotic medication. Multiple factors influence sexual function and reproductive health in this patient population, including the effects of medications on prolactin secretion and the complexities of making contraceptive decisions in the context of a serious mental illness. The author explores ...
Lamers Femke F Genetic Epidemiology Research Branch, Intramural ResearchProgram, NIMH, Bethesda, Md, - - 2013
Prolonged fatigue in adolescents has a major impact on social functioning and school attendance. In adults, prolonged fatigue substantially overlaps with mood and anxiety disorders. Extending the data to adolescents, the authors studied the prevalence and correlates of fatigue in a representative U.S. sample. The participants were 10,123 adolescents ages ...
Gallena Sally J K - - 2013
Paradoxical vocal fold motion disorder and nonspecific chronic cough are laryngeal disorders that are newly identified within the speech-language pathologist's scope of practice. Recognizing the signs and symptoms of these disorders and providing practical and evidenced-based treatment is the focus of this article. Defining the role of the speech-language pathologist ...
Kim Jiseon - - 2013
Bacterial infection can cause inflammatory bone diseases accompanied by the bone destruction due to excess generation of osteoclasts. Although lipoproteins are one of the major immuno-stimulating components of bacteria, little is known about their effects on bone metabolism. In this study, we investigated the role of lipoproteins in bacteria-induced bone ...
Ferreiro-Rangel Carlos A - - 2013
Structural and mechanical properties of silica aerogels are studied using a flexible coarse-grained model and a variety of simulation techniques. The model, introduced in a previous study (J. Phys. Chem. C vol. 111 [2007] 15792), consists of spherical "primary" gel particles which interact through weak non-bonded forces and through microscopically-motivated ...
Ginzburg Karni - - 2013
Sensitivity to bodily signals is the tendency to be aware of bodily states and to identify subtle bodily reactions to internal and environmental conditions. Monitoring these signals is a top-down process, describing individuals' tendency to actively scan their bodies in order to detect cues for their physical condition. Two studies ...
Záliš Stanislav - - 2013
X-ray absorption spectra of fac-[ReBr(CO)3(bpy)] near the Re L3- and Br K-edges were measured in a steady-state mode as well as time-resolved at 630 ps after 355 nm laser pulse excitation. Relativistic spin-orbit time-dependent density functional theory (TD-DFT) calculations account well for the shape of the near-edge absorption (the ″white ...
Dwight Trisha - - 2013
Context:Reports of the coexistence of pituitary adenomas and pheochromocytoma/paraganglioma are uncommon. Recently germline mutations in 2 of the genes encoding succinate dehydrogenase, SDHC and SDHD, were associated with pituitary tumors.Objective:Our aim was to determine whether the development of a pituitary adenoma was associated with SDHA mutation.Patients:A 46-year-old female presented with ...
Benedek Tibor - - 2013
Nowadays, because of substantial use of petroleum-derived fuels the number and extension of hydrocarbon polluted terrestrial ecosystems is in growth worldwide. In remediation of aforementioned sites bioremediation still tends to be an innovative, environmentally attractive technology. Although huge amount of information is available concerning the hydrocarbon degradation potential of cultivable ...
Morleo Michela - - 2013
BACKGROUND: Developing timely and effective strategies for preventing alcohol misuse in young people is required in order to prevent related harms since, worldwide, alcohol consumption was associated with 320,000 deaths amongst 15--29 year olds in 2004. Providing guidance and advice to parents is essential if alcohol misuse is to be ...
Ozcan Kursat Murat - - 2013
To our knowledge, no studies up to date have investigated the correlation of rapid eye movement (REM) dependent obstructive sleep apnea syndrome (OSAS) and Muller maneuver. The aim of this study is to investigate whether REM-dependent OSAS is predicted by the findings of the Muller maneuver. The study was conducted ...
Sefidbakht Yahya - - 2013
We designed a rectangular waveguide exposure system to study the effects of mobile phone frequency (940 MHz) electromagnetic fields (EMF) on luciferase structure and activity. The luciferase activity of exposed samples was significantly higher than that of unexposed samples. Dynamic light scattering of the exposed samples showed smaller hydrodynamic radii compared ...
Rouen Alexandre - - 2013
STUDY QUESTION: Can the proportion of unbalanced spermatozoa in chromosomal rearrangement carriers be decreased through the use of discontinuous gradient centrifugation (DGC)? SUMMARY ANSWER: DGC significantly decreases the proportion of genetically unbalanced spermatozoa in chromosomal rearrangement carriers. WHAT IS KNOWN ALREADY: Chromosomal rearrangement carriers present with a certain proportion of ...
Liang Hong-Wei - - 2013
Abstract In this study, the complete mitochondrial DNA (mtDNA) sequence of Pseudobagrus truncatus (Siluriformes: Bagridae) was determined. The complete mtDNA genome sequence of P. truncatus is 16,533 bp in size. It consists of 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes and one non-coding control region. The ...
Pearce Ruth - - 2013
Using environmental scanning Kelvin probe microscopy we show that the position of the Fermi level of single layer graphene is more sensitive to chemical gating than that of double layer graphene. We calculate that the difference in sensitivity to chemical gating is not entirely due to the difference in band ...
Kim Min Kyoung - - 2013
The self-assembly of multi-component monolayers with designed patterns requires molecular recognition among components. Dipolar interactions have been found to influence morphologies of self-assembled monolayers and can affect molecular recognition functions. Ketone groups have large dipole moments (2.6 D) and are easily incorporated into molecules. The potential of ketone groups for ...
Couto Narciso - - 2013
Glr1 (glutathione reductase) is a low abundance protein involved in defense mechanisms against reactive oxygen species. Expressed on cytosolic ribosomes, the same gene, GLR1, uses alternative start codons to generate two forms of Glr1. Translation from the first AUG codon generates the mitochondrial form incorporating a presequence necessary for import; ...
Jensen Morten Hasselstrøm - - 2013
Abstract Background: Hypoglycemia is a potentially fatal condition. Continuous glucose monitoring (CGM) has the potential to detect hypoglycemia in real time and thereby reduce time in hypoglycemia and avoid any further decline in blood glucose level. However, CGM is inaccurate and shows a substantial number of cases in which the ...
Seres Adrienn B - - 2013
Abstract Numerous honeybee products are used in medicine, but the literature furnishes no information concerning the effects of the drone milk (DM), although drone brood, which is similar to DM, was reported to elicit a hormone-like strengthening effect. In certain countries, DM is traditionally used to treat infertility and to ...
Wu Qinghao - - 2013
Measuring average quantities in complex mixtures can be challenging for mass spectrometry, as it requires ionization and detection with nearly equivalent cross-section for all components, minimal matrix effect, and suppressed signal from fragments and aggregates. Fragments and aggregates are particularly troublesome for complex mixtures, where they can be incorrectly assigned ...
Saito Kenji - - 2013
A visible-light-absorbing SnNb2O6 shell with high crystallinity was successfully fabricated on a NaNbO3 nanowire through a molten salt treatment of the NaNbO3 nanowire of the starting material with SnCl2, whereas the fabrication was not successful on the TT phase of a niobia nanowire. The difference will come from the formation ...
Linhares A G - - 2013
A method of extracting membranes from red blood cells (RBCs) is described, which were in turn used to assay acetylcholinesterase (AChE) activity. The evidence for the enzyme activity was established by selective inhibition using 1,5-bis(4-allyldimethylammoniumphenyl) pentan-3-one dibromide, tetraisopropyl pyrophosphoramide and neostigmine. Blood samples were exposed to three organophosphorus (dichlorvos, chlorpyrifos ...
Ragsdale Kathleen - - 2013
To expand the scant research on sexual expectancies development among non-sexually active adolescents, we examined the relationship between adolescents' exposure to four socializing agents-mother/female guardian, father/male guardian, peers, and television programs with high sexual content-and their endorsement of four sexual expectancies: social benefit, pleasure, social risk, and health risk. Data ...
Issurin Vladimir B - - 2013
Training transfer as an enduring, multilateral, and practically important problem encompasses a large body of research findings and experience, which characterize the process by which improving performance in certain exercises/tasks can affect the performance in alternative exercises or motor tasks. This problem is of paramount importance for the theory of ...
Oyama Hiroyuki - - 2013
Conventional immunization-based antibodies are not always applicable to monitor trace amounts of clinical biomarkers due to insufficient antigen-binding affinity. The development of in vitro affinity maturation for native antibodies has paved the way to solve this problem, but there has been minimal success in obtaining improved antibody mutants for small ...
Downard Kevin M - - 2013
The influenza virus is one of the most deadly infectious agents known to man and has been responsible for the deaths of some hundred million lives throughout human history. The need to rapidly and reliably survey circulating virus strains down to the molecular level is ever present. This tutorial describes ...
Wang Lihua - - 2013
INTRODUCTION AND HYPOTHESIS: Patients with pelvic organ prolapse (POP) have lower pelvic floor muscle (PFM) function. We hypothesized that pelvic reconstructive surgery could improve PFM function and strength. METHODS: The controlled, nonrandomized study recruited 37 POP patients in the Prolift group and 30 non-POP patients in the control group. Two ...
Atsumi Michiko - - 2013
The electronic configuration of the electronic ground and low-lying doublet excited states of neutral metal dihalides BrMCl (M = Cu, Ag, Au) has been investigated on the basis of CASSCF/CASPT2 methods taking into account scalar relativistic effects. A preliminary study of the electronic problem in BrAgCl, based on DFT and ...
Lee Jae-Ho - - 2013
Dysregulated BMPs expression may contribute to the development and progression of renal cell carcinoma (RCC). Herein, we report that bone morphogenetic protein-6 (BMP-6) promotes the proliferation of RCC cells by IL-10-mediated polarization of tumor-associated macrophages (TAM). IL-10 secretion from macrophages stimulated by BMP-6 required nuclear interaction between Smad5 and STAT3. ...
Bengtsson Håkan - - 2013
BACKGROUND:Player activities in soccer matches are influenced by the match result and match venue. It is not known whether injury rates are influenced by these factors. PURPOSE:To investigate whether there are associations between injury rates and the match result, venue, and type of competition in male soccer. STUDY DESIGN:Cohort study; ...
Straatmann Caroline - - 2013
BACKGROUND: Idiopathic nephrotic syndrome (NS) in children is classified as steroid sensitive or steroid resistant. Steroid sensitivity typically portends a low risk of permanent renal failure. However, some initially steroid-sensitive patients later develop steroid resistance. These patients with late steroid resistance (LSR) are often treated with immunosuppressant medications, but the ...
Zirngibl R A - - 2013
We sought to determine whether the estrogen receptor-related receptor gamma (mEsrrg) regulated the Osteopontin (Opn) promoter through the same AP1/CAAT box element that we have previously described for mEsrra. In HeLa cells mEsrrg used an additional site present in the 5'UTR, while in ROS17/2.8 cells the AP1/CAAT site was not ...
Günther S - - 2013
The NO + H2 reaction on a potassium promoted Rh(110) surface is shown to sustain the formation of spatio-temporal periodic patterns leading to mass transport phenomena. The excitation of pulses and the mass transport mechanism are studied in the 10(-7) and 10(-6) mbar pressure range, with the potassium coverage varying ...
Tanjasiri Sora Park - - 2013
There is growing interest in understanding individual and environmental influences on youth risk behaviors, including tobacco use. The purpose of this article is to describe the processes and findings from a study that sought to increase the capacity of Asian American and Pacific Islander (AAPI) community-based organizations to understand and ...
Pratt Alexandra - - 2013
Dexmedetomidine has become a popular sedative in the intensive care unit for patients undergoing mechanical ventilation because of its highly selective α-2 agonism, which exerts a combination of anesthetic, analgesic, and anxiolytic effects. Bradycardia and hypotension have been reported as the most common side effects of its use in large ...
Mosqueira Matias - - 2013
Duchenne muscular dystrophy (DMD) affects young boys and is characterized by the absence of dystrophin, a large cytoskeletal protein present in skeletal and cardiac muscle cells and neurons. The heart and diaphragm become necrotic in DMD patients and animal models of DMD, resulting in cardiorespiratory failure as the leading cause ...
Marek Aleš - - 2013
Gas-phase conformations and electron transfer dissociations of pentapeptide ions containing the photo-Leu residue (L*) were studied. Exhaustive conformational search including molecular dynamics force-field, semi-empirical, ab initio, and density functional theory calculations established that the photo-Leu residue did not alter the gas-phase conformations of (GL*GGK  +  2H)(2+) and (GL*GGK-NH2 + H)(+) ions, which ...
Ribas Adriana Danmvolf - - 2013
American cutaneous leishmaniasis (ACL) shows a wide spectrum of clinical and immunopathological manifestations. The CCR5 chemokine receptor directs the immune response to a Th1 pattern and the mutant allele of this genotype (Δ32/Δ32) results in a less effective response, thus leading to a milder inflammation. The objective of the present ...
Le-Ha Chi - - 2013
Background:High-density lipoprotein-cholesterol (HDL-C) levels are influenced by gender and by genetic and environmental factors. We aimed to assess the impact of passive smoking exposure since birth on HDL-C levels of nonsmoking adolescents at age 17 years and to determine whether there was a gender difference in the relationship between smoking ...
Güdücü N - - 2013
The aim of this study was to understand the relationship of retinol-binding protein 4 (RBP4) with hormonal and biochemical parameters in pre- and postmenopausal women. We included 69 postmenopausal women and 27 regularly menstruating premenopausal women. Postmenopausal women had statistically significantly higher RBP4 levels when compared to premenopausal women. RBP4 ...
Koffarnus Robin L - - 2013
OBJECTIVE:To review the pharmacology, pharmacokinetics, efficacy, and safety of the thiazolidinedione rivoglitazone, a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, to determine its potential role in the treatment of type 2 diabetes mellitus.DATA SOURCES:A MEDLINE search (1966-February 2013) was conducted for English-language studies in humans, using the terms rivoglitazone and CS011. Abstracts ...
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