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Varadarajan Shankar S MRC Toxicology Unit, University of Leicester, Leicester, - - 2013
Owing to the high levels of antiapoptotic B-cell lymphoma 2 (BCL-2) family members observed in several cancers, there has been a major effort to develop inhibitors of the BCL2-family as chemotherapeutic agents. Of the different members in the BCL-2 family, myeloid cell leukemia sequence 1 (MCL-1) is commonly amplified in ...
Poulter James A - - 2013
The conventional approach to identifying the defective gene in a family with an inherited disease is to find the disease locus through family studies. However, the rapid development and decreasing cost of next generation sequencing facilitates a more direct approach. Here, we report the identification of a frameshift mutation in ...
Gerety Sebastian S SS MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. - - 2013
We have generated an inducible system to control the timing of transgene expression in zebrafish and chick. An estrogen receptor variant (ERT2) fused to the GAL4 transcriptional activator rapidly and robustly activates transcription within 3 hours of treatment with the drug 4-hydroxy-tamoxifen (4-OHT) in tissue culture and transgenic zebrafish. We ...
Li R B RB Physical Measurements Laboratory, National Institute of Standard and Technology, Gaithersburg, Maryland 20899, - - 2013
We demonstrate an optically controlled Kerr phase shifter using a room-temperature 85Rb vapor operating in a Raman gain scheme. Phase shifts from zero to π relative to an unshifted reference wave are observed, and gated operations are demonstrated. We further demonstrate the versatile digital manipulation of encoded signal light with ...
Abràmoff Michael D MD Institute for Vision Research, University of Iowa, Iowa City, IA 52242, - - 2013
Best disease is a macular dystrophy caused by mutations in the BEST1 gene. Affected individuals exhibit a reduced electro-oculographic (EOG) response to changes in light exposure and have significantly longer outer segments (OS) than age-matched controls. The purpose of this study was to investigate the anatomical changes in the outer ...
Kiefer F F Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit, Mannheim, Germany. - - 2013
Reward learning represents a crucial mechanism in the acquisition and maintenance of addictive behavior. The underlying neurobiological foundations and associated neurobiological pathways are identified in this review and similarities between substance abuse and behavioral addictions will be discussed. In the second section current neuroimaging findings on neurobiological mechanisms of pathological ...
Ratzliff Anna D H AD Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 N.E. Pacific St., Seattle, WA 98195-6560, USA. - - 2013
OBJECTIVE This study examined effectiveness of collaborative care for depression among Asians treated either at a community health center that focuses on Asians (culturally sensitive clinic) or at general community health centers and among a matched population of whites treated at the same general community clinics. METHODS For 345 participants ...
Grandner Michael A MA Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk. Cross-sectional. Population-based research. Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults). None. Associations between CRP and self-reported total sleep time (TST) ...
Zhang Xuehong X Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. - - 2013
We assessed the relationship between sleep duration, snoring and colorectal cancer risk. Prospective cohort studies. United States. A total of 30,121 men aged 41 to 79 years in the Health Professionals Follow-up Study and 76,368 women aged 40 to 73 years in the Nurses' Health Study. None. We queried information ...
Jinks-Robertson Sue - - 2013
The Genetics Society of America annually honors members who have made outstanding contributions to genetics. The Thomas Hunt Morgan Medal recognizes a lifetime contribution to the science of genetics. The Genetics Society of America Medal recognizes particularly outstanding contributions to the science of genetics over the past 32 years. The ...
Edwards Stacey L SL Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, - - 2013
Neurons must cope with extreme membrane trafficking demands to produce axons with organelle compositions that differ dramatically from those of the cell soma and dendrites; however, the mechanism by which they accomplish this is not understood. Here we use electron microscopy and quantitative imaging of tagged organelles to show that ...
Cheng Shuna S Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, - - 2013
Fluorescence lifetime imaging (FLIM) offers a noninvasive approach for characterizing the biochemical composition of biological tissue. There has been an increasing interest in the application of multispectral FLIM for medical diagnosis. Central to the clinical translation of FLIM technology is the development of compact and high-speed endoscopy systems. Unfortunately, the ...
Logan Jennifer L JL Oregon Health & Science University, Department of Public Health & Preventive Medicine, Portland, OR 97239, - - 2013
Homeless young adults are exposed to multiple risk factors for HIV infection. We identified HIV risk behaviors and their correlates among homeless young adults in Portland, Oregon. We conducted a community-based, cross-sectional survey of HIV risk behaviors among homeless young adults aged 18-25 years in 2010. Participants completed three study ...
Herrin Jeph J Health Research and Educational Trust, Chicago, IL 60606, USA. - - 2013
The Centers for Disease Control and Prevention recommends HIV screening in U.S. health-care settings unless providers document a yield of undiagnosed HIV infections of <1 per 1,000 population. However, implementation of this guidance has not been widespread and little is known of the characteristics of hospitals with screening practices in ...
Lee Hedwig H University of Washington, Department of Sociology, Seattle, WA 98195, USA. - - 2013
Consistent findings show that black Americans have high rates of cardiovascular disease (CVD) and related behavioral risk factors. Despite this body of work, studies on black Americans are generally limited to the 50 U.S. states. We examined variation in CVD and related risk factors among black Americans by comparing those ...
Tong Van T VT Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Reproductive Health, Atlanta, GA 30341, USA. - - 2013
We compared three measures of maternal smoking status--prepregnancy, during pregnancy, and smoking cessation during pregnancy-between the Pregnancy Risk Assessment Monitoring System (PRAMS) questionnaire and the 2003 revised birth certificate (BC). We analyzed data from 10,485 women with live births in eight states from the 2008 PRAMS survey, a confidential, anonymous ...
Seib Katherine K Emory University, Rollins School of Public Health, Hubert Department of Global Health, Atlanta, GA 30322, USA. - - 2013
Emergency response involving mass vaccination requires the involvement of traditional vaccine providers as well as other health-care providers, including pharmacists, obstetricians, and health-care providers at correctional facilities. We explored differences in provider experiences administering pandemic vaccine during a public health emergency. We conducted a cross-sectional survey of H1N1 vaccine providers ...
Curtis Amy B AB Western Michigan University, College of Health & Human Services, Interdisciplinary Health Sciences, Kalamazoo, MI 49008, USA. - - 2013
To efficiently help communities prevent and manage diabetes, health departments need to be able to target populations with high risk but low resources. To aid in this process, we mapped county-level diabetes-related rates and resources/use using publicly available secondary data to identify Michigan counties with high diabetes prevalence and low ...
Geraghty Estella M EM University of California, Davis, Division of General Medicine, Sacramento, CA 95817, USA. - - 2013
Insecticides reduce vector-borne pathogen transmission but also pose health risks. In August 2005, Sacramento County, California, underwent emergency aerial ultralow-volume (ULV) application of pyrethrin insecticide to reduce the population of West Nile virus (WNV)-infected mosquitoes and thereby interrupt enzootic and tangential transmission. We assessed the association between aerially applied pyrethrin ...
Duina Andrea A AA Biology Department, Hendrix College, Conway, Arkansas 72032, USA. - - 2013
An article from Alan Hinnebusch's laboratory in the March 2013 issue of GENETICS establishes an exciting new link between proteins with well-established roles in the endomembrane system and the process of transcription elongation. This Primer article provides tools needed for students to fully appreciate, analyze, and critically evaluate the experiments ...
Hopper Anita K AK Department of Molecular Genetics, Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA. - - 2013
Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis employs a specialized RNA polymerase that generates initial transcripts that must be subsequently altered via a multitude of post-transcriptional steps before the tRNAs beome mature molecules that function in protein synthesis. Genetic, genomic, biochemical, and cell biological approaches ...
Backer Adam S AS Institute of Computational and Mathematical Engineering, Stanford, California 94305, - - 2013
This Letter presents a means of measuring the dipole orientation of a fluorescent, orientationally fixed single molecule, which uses a specially designed phase mask, termed a "quadrated pupil," conjugate to the back focal plane of a conventional wide-field microscope. The method leverages the spatial anisotropy of the far-field emission pattern ...
Goldberg Shoshana S University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Maternal and Child Health, Chapel Hill, NC 27599, USA. - - 2013
We examined associations between two definitions of sexual minority status (SMS) and substance abuse and/or dependence among young adults in a national population. A total of 14,152 respondents (7,529 women and 6,623 men) interviewed during wave four of the National Longitudinal Study of Adolescent Health were included in the study ...
Hered Robert W RW Eye Physicians of Central Florida, Maitland, FL 32751, USA. - - 2013
We determined the efficacy of pediatric-based preschool vision screening, as knowledge of vision screening effectiveness in primary care pediatrics is incomplete. Pediatricians and staff at nine primary care pediatric practices were trained in vision screening, and practices screened children aged 3-5 years from May 2007 through July 2008. Children failing ...
Godfrey Anna L AL Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Cambridge, - - 2013
Subclones homozygous for JAK2V617F are more common and larger in patients with polycythemia vera compared to essential thrombocythemia, but their role in determining phenotype remains unclear. We genotyped 4564 erythroid colonies from 59 patients with polycythemia vera or essential thrombocythemia to investigate whether the proportion of JAK2V617F -homozygous precursors, compared ...
Gorrepati Lakshmi L Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, - - 2013
The C. elegans seam cells are lateral epithelial cells arrayed in a single line from anterior to posterior that divide in an asymmetric, stem cell-like manner during larval development. These asymmetric divisions are regulated by Wnt signaling; in most divisions, the posterior daughter in which the Wnt pathway is activated ...
Diss Lucy B LB School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United - - 2013
Constipation and fecal impaction are conditions of the bowel whose prevalence increases with age. Limited information is known about how these conditions manifest; however, functional deficits are likely to be due to changes in signaling within the bowel. This study investigated the effects of age on colonic mucosal melatonin (MEL) ...
Hu Chun-Rui CR Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science, University of Science and Technology of Science, Hefei 230027, - - 2013
We demonstrate a low-cost-stimulated Raman scattering (SRS) microscope using continuous-wave (cw) lasers as excitation sources. A dual modulation scheme is used to remove the electronic background. The cw-SRS imaging of lipids in fatty liver is demonstrated by excitation of C─H stretch vibration.
Jadeja Shalini S MRC Human Genetics Unit, MRC Institute of Genetics & & Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United - - 2013
A mouse mutant identified during a recessive N-ethyl-N-nitrosourea (ENU) mutagenesis screen exhibited ocular hemorrhaging resulting in a blood-filled orbit, and hence was named "redeye." We aimed to identify the causal mutation in redeye, and evaluate it as a model for diabetic retinopathy (DR). The causative gene mutation in redeye was ...
Khan Amjad P AP Michigan Center for Translational Pathology, Ann Arbor, MI, - - 2013
Metabolomic profiling of prostate cancer (PCa) progression identified markedly elevated levels of sarcosine (N-methyl glycine) in metastatic PCa and modest but significant elevation of the metabolite in PCa urine. Here, we examine the role of key enzymes associated with sarcosine metabolism in PCa progression. Consistent with our earlier report, sarcosine ...
Kuna Samuel T ST University of Pennsylvania, Philadelphia, PA, USA. - - 2013
To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years. Randomized controlled trial with follow-up at 1, 2, and 4 years. 4 Look AHEAD clinical centers. Two hundred sixty-four obese adults with type 2 diabetes and OSA. ...
Coyne Claire A CA cavoyne@indiana.eduIndiana University, Bloomington, IN 47405, - - 2013
Teenage motherhood is associated with poor offspring outcomes but these associations may be influenced by offspring birth year because of substantial social changes in recent decades. Existing research also has not examined whether these associations are due to the specific effect of mother's age at childbirth or factors shared by ...
Cunha-Cruz Joana J Department of Oral Health Sciences, School of Dentistry, University of Washington, Box 357475, Seattle, Wash. 98195-7475, USA. - - 2013
Saliva is one of the intraoral host factors that influence caries development. The authors conducted a study to investigate whether salivary characteristics are associated with recent dental caries experience. Dentist-investigators and dental staff members collected data pertaining to a two-year cumulative incidence of dental caries (previous 24 months) and salivary ...
Atif S M - - 2013
Toll-like receptor 5 (TLR5) has been widely studied in an inflammatory context, but the effect of TLR5 on the adaptive response to bacterial flagellin has received considerably less attention. Here, we demonstrate that TLR5 expression by dendritic cells (DCs) allows a 1,000-fold enhancement of T-cell sensitivity to flagellin, and this ...
Yadeau J T JT Hospital for Special Surgery, New York, New York 10021, USA. - - 2013
In a randomised controlled pragmatic trial we investigated whether local infiltration analgesia would result in earlier readiness for discharge from hospital after total knee replacement (TKR) than patient-controlled epidural analgesia (PCEA) plus femoral nerve block. A total of 45 patients with a mean age of 65 years (49 to 81) ...
Chi Donald L DL Department of Oral Health Sciences, School of Dentistry, University of Washington, Box 357475, Seattle, Wash. 98195, USA. - - 2013
The authors examined the correlates of root caries experience for middle-aged adults (aged 45-64 years) and older adults (65 years and older) to test the hypothesis that the factors related to root caries are different for middle-aged adults than they are for older adults. The authors conducted an observational cross-sectional ...
Sundeen Sandra J SJ Department of Psychiatry, University of Maryland School of Medicine, 1501 South Edgewood St., Suite L, Baltimore, MD 21227, USA. - - 2013
The Practice Research Network (PRN) in Maryland, funded by a grant from the National Institute of Mental Health, extends the historically close collaborative relationship between the Department of Psychiatry at the University of Maryland and the Maryland Mental Hygiene Administration. The PRN focuses on the relationship between university-based investigators and ...
Shimamura Munehisa M Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, - - 2013
Cyclooxygenase-2-derived prostaglandin E2 (PGE2) contributes to excitotoxic and ischemic neuronal cell death by engaging neuronal PGE2 type 1 receptors (EP1R). Our previous studies have shown that EP1R signaling resulted in disturbances of intracellular Ca(2+) homeostasis and suppression of the pro-survival protein kinase AKT. The aim of this study was to ...
Ruscher Karsten K Laboratory for Experimental Brain Research, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden. - - 2013
After stroke, brain inflammation in the ischemic hemisphere hampers brain tissue reorganization and functional recovery. Housing rats in an enriched environment (EE) dramatically improves recovery of lost neurologic functions after experimental stroke. We show here that rats housed in EE after stroke induced by permanent occlusion of the middle cerebral ...
Ord Emily N J EN Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, - - 2013
We hypothesized that targeting key points in the ischemic cascade with combined neuroglobin (Ngb) overexpression and c-jun N-terminal kinase (JNK) inhibition (SP600125) would offer greater neuroprotection than single treatment after in vitro hypoxia/reoxygenation and in a randomized, blinded in vivo experimental stroke study using a clinically relevant rat strain. Male ...
Liew Wendy K M WK Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, USA and Neurology service, Department of Paediatric Medicine, KK Women's and Children's Hospital, - - 2013
Pediatric neuromuscular disorders comprise a large variety of disorders that can be classified based on their neuroanatomical localization, patterns of weakness, and laboratory test results. Over the last decade, the field of translational research has been active with many ongoing clinical trials. This is particularly so in two common pediatric ...
Westmore G C GC School of Agricultural Science/Tasmanian Institute of Agriculture, University of Tasmania, Hobart Tas, - - 2013
Of eight thelytokous populations of onion thrips (Thrips tabaci) collected from potato (three populations), onion (four) or Chrysanthemum (one) hosts from various regions of Australia, only those from potato were capable of transmitting Tomato spotted wilt virus (TSWV) in controlled transmission experiments. Genetic differentiation of seven of these eight populations, ...
Peischl S S Section of Integrative Biology, University of Texas at Austin, Austin, TX, USA. - - 2013
Chromosomal inversions are common in natural populations and are believed to be involved in many important evolutionary phenomena, including speciation, the evolution of sex chromosomes and local adaptation. While recent advances in sequencing and genotyping methods are leading to rapidly increasing amounts of genome-wide sequence data that reveal interesting patterns ...
Itokawa K K Department of Medical Entomology, National Institute of Infectious Diseases, Tokyo, - - 2013
Insecticide resistance develops as a genetic factor (allele) conferring lower susceptibility to insecticides proliferates within a target insect population under strong positive selection. Intriguingly, a resistance allele pre-existing in a population often bears a series of further adaptive allelic variants through new mutations. This phenomenon occasionally results in replacement of ...
Mathot K J KJ Evolutionary Ecology of Variation Group, Max Planck Institute for Ornithology, Seewiesen, Germany. - - 2013
Quantitative genetic analyses of basal metabolic rate (BMR) can inform us about the evolvability of the trait by providing estimates of heritability, and also of genetic correlations with other traits that may constrain the ability of BMR to respond to selection. Here, we studied a captive population of zebra finches ...
Besson Morgane M Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, - - 2013
Impulsivity shares high comorbidity with substance abuse in humans, and high impulsivity (HI) in rats has been identified as a predictive factor for cocaine addiction-like behavior. Despite the evidence that high impulsivity is associated with altered function of corticostriatal networks, the specific neural substrates underlying the increased vulnerability of impulsive ...
Tarapore Rohinton S RS Department of Medicine, Gastroenterology Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6144, - - 2013
Esophageal cancer is the eighth most common cancer in the world and has an extremely dismal prognosis, with a 5-year survival of less than 20%. Current treatment options are limited, and thus identifying new molecular targets and pathways is critical to derive novel therapies. Worldwide, more than 90% of esophageal ...
Dobson Simon R M SR Department of Pediatrics, University of British Columbia, Vancouver, Canada. - - 2013
Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible. To determine whether mean antibody levels to HPV-16 and HPV-18 among girls receiving 2 doses was noninferior to women receiving 3 doses. Randomized, phase 3, postlicensure, multicenter, ...
Lowenthal Elizabeth D ED Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. - - 2013
Worldwide, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) efavirenz and nevirapine are commonly used in first-line antiretroviral regimens in both adults and children with human immunodeficiency virus (HIV) infection. Data on the comparative effectiveness of these medications in children are limited. To investigate whether virological failure is more likely among children ...
Serenius Fredrik F Department of Women's and Children's Health, Section for Pediatrics, Uppsala University, S-751 85 Uppsala, Sweden. - - 2013
Active perinatal care increases survival of extremely preterm infants; however, improved survival might be associated with increased disability among survivors. To determine neurodevelopmental outcome in extremely preterm children at 2.5 years (corrected age). Population-based prospective cohort of consecutive extremely preterm infants born before 27 weeks of gestation in Sweden between ...
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