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Results 301 - 350 of 2813
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Zhang Xuehong X Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. - - 2013
We assessed the relationship between sleep duration, snoring and colorectal cancer risk. Prospective cohort studies. United States. A total of 30,121 men aged 41 to 79 years in the Health Professionals Follow-up Study and 76,368 women aged 40 to 73 years in the Nurses' Health Study. None. We queried information ...
Kousin-Ezewu Onajite - - 2013
Alemtuzumab was first used in multiple sclerosis in 1991. It is a monoclonal antibody which is directed against CD52, a protein of unknown function on lymphocytes. Alemtuzumab causes a lymphopenia, following which homeostatic reconstitution leads to prolonged alteration of the immune repertoire. This reduces the risk of relapse and disability ...
Mairs Katie - - 2013
ABSTRACT Rates of HIV (human immunodeficiency virus) and sexual-risk behaviour for those aged 50 and over in the United States are highest and increasing in Florida, where many Canadian "snowbirds" winter. This pilot study examined the sexual-risk behaviour and predictors of HIV testing in a convenience sample of Canadian snowbirds ...
Kulkarni K - - 2013
Background: In the general surgical and anaesthetic literature, there has been a decline in research output originating from the UK. This study analysed the 10 globally leading and 2 UK leading otorhinolaryngology journals to determine whether this trend was also reflected within otorhinolaryngology. Methods: Citable research output was analysed from ...
Knotts Derek - - 2013
In accordance with Boyle's law (as barometric pressure decreases, gas volume increases), thoracostomy is often recommended for patients with pneumothoraces before helicopter EMS (HEMS) transport. We sought to characterize altitude-related volume changes in a pneumothorax model, aiming to improve clinical decisions for preflight thoracostomy in HEMS patients. This prospective study ...
Chin K F - - 2013
We investigated the predictive value of intra-operative neurophysiological investigations in obstetric brachial plexus injuries. Between January 2005 and June 2011 a total of 32 infants of 206 referred to our unit underwent exploration of the plexus, including neurolysis. The findings from intra-operative electromyography, sensory evoked potentials across the lesion and ...
Needleman Ian - - 2013
BACKGROUND: and overview. This article describes the different types of reviews of research that are available in the literature: systematic reviews and traditional reviews. Systematic reviews have become the reference standard for evidence to inform clinical practice. In this article, the authors set out guidance on appraising the quality and ...
Kumar Anand T N - - 2013
It is demonstrated that high spatial frequency filtering of time domain fluorescence signals can allow efficient detection of intrinsic fluorescence lifetimes from turbid media and the rejection of diffuse excitation leakage. The basis of this approach is the separation of diffuse fluorescence signals into diffuse and fluorescent components with distinct ...
Melgaard Seth D - - 2013
We report on bulk optical refrigeration of Yb:YLF crystal to a temperature of ∼124  K, starting from the ambient. This is achieved by pumping the E4-E5 Stark multiplet transition at ∼1020  nm. A lower temperature of 119±1  K (∼-154C) with available cooling power of 18 mW is attained when the temperature of the surrounding ...
Roline Chad E - - 2013
Bedside thoracic ultrasound has been shown to be a valuable diagnostic tool in the emergency department. The purpose of this study was to evaluate the feasibility of bedside thoracic ultrasound in the prehospital HEMS setting. Air ambulance helicopters during patient transportation. This was a prospective pilot study. 71 consecutive, nonpregnant ...
Yates P - - 2013
In May 2012, in airports across the globe, seven orthopaedic surgeons bravely said goodbye to their loved ones, and slowly turned towards their respective aircraft. Filled with expectation and mild trepidation they stepped into the unknown… the ABC fellowship of 2012.
Huang Lei - - 2013
The calibration of camera with intrinsic and extrinsic parameters is a procedure of significance in current imaging-based optical metrology. Improvement at two aspects, feature detection and overall optimization, are investigated here by using an active phase target and statistically constrained bundle adjustment (SCBA). From the observations in experiment and simulation, ...
Ord Emily N J EN Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, - - 2013
We hypothesized that targeting key points in the ischemic cascade with combined neuroglobin (Ngb) overexpression and c-jun N-terminal kinase (JNK) inhibition (SP600125) would offer greater neuroprotection than single treatment after in vitro hypoxia/reoxygenation and in a randomized, blinded in vivo experimental stroke study using a clinically relevant rat strain. Male ...
Kim Y W - - 2013
Objective: We report two extremely rare cases of symptomatic nasopharyngeal branchial cleft cyst treated by powered instrument assisted marsupialisation. Methods: Case report and literature review concerning nasopharyngeal branchial cleft cyst and surgical treatment methods. Results: The first case was a two-year-old boy with a 1 × 2 cm, cystic, oropharyngeal mass, who also ...
Lorbach O - - 2013
The present article summarizes the different osteotomy techniques for an extension of standard surgical approaches to the knee joint in selected patients. The aim is to achieve satisfactory exposure and reduce potential postoperative complications compared to alternative techniques, such as the V-Y plasty or the quadriceps snip procedures. Osteotomy of ...
Lima Karina Jerônimo Rodrigues Santiago de - - 2013
The aim of this study was to compare the dentoskeletal changes of patients with Class II Division 1 malocclusion treated with either the Jasper jumper appliance or the activator-headgear combination, both associated with fixed appliances. The sample comprised 72 subjects with Class II Division 1 malocclusion divided into 3 groups: group 1 ...
Cheng Shuna S Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, - - 2013
Fluorescence lifetime imaging (FLIM) offers a noninvasive approach for characterizing the biochemical composition of biological tissue. There has been an increasing interest in the application of multispectral FLIM for medical diagnosis. Central to the clinical translation of FLIM technology is the development of compact and high-speed endoscopy systems. Unfortunately, the ...
Herrin Jeph J Health Research and Educational Trust, Chicago, IL 60606, USA. - - 2013
The Centers for Disease Control and Prevention recommends HIV screening in U.S. health-care settings unless providers document a yield of undiagnosed HIV infections of <1 per 1,000 population. However, implementation of this guidance has not been widespread and little is known of the characteristics of hospitals with screening practices in ...
Cusack Karen J - - 2013
OBJECTIVE Many of the individuals with serious mental illness involved in the criminal justice system have experienced interpersonal victimization, such as sexual abuse, and have high rates of alcohol and drug use disorders. Little attention has been paid to the prevalence of posttraumatic stress disorder (PTSD) and its potential role ...
Mullegama Sureni V - - 2013
Copy number variations associated with abnormal gene dosage have an important role in the genetic etiology of many neurodevelopmental disorders, including intellectual disability (ID) and autism. We hypothesize that the chromosome 2q23.1 region encompassing MBD5 is a dosage-dependent region, wherein deletion or duplication results in altered gene dosage. We previously ...
Smith Thomas E - - 2013
OBJECTIVE This study sought to describe reasons for disengagement from services and practical guidelines to enhance engagement among individuals with serious mental illness and high need for treatment. METHODS Qualitative interviews were conducted with 56 individuals with serious mental illness and 25 providers recruited from a larger project that used ...
Losada-Pérez María - - 2013
A number of transcription factors that are expressed within most, if not all, embryonic neuroblast (NB) lineages participate in neural subtype specification. Some have been extensively studied in several NB lineages (e.g. components of the temporal gene cascade) whereas others only within specific NB lineages. To what extent they function ...
Stützer Simon - - 2013
We investigate the interplay of Bloch oscillations and Anderson localization in optics. Gradual washing out of Bloch oscillations and the formation of nearly stationary averaged intensity distributions, which are symmetric for narrow and strongly asymmetric for broad input excitations, are observed experimentally in laser-written waveguide arrays. At large disorder levels ...
Ziegler A - - 2013
Biomarkers are of increasing importance for personalized medicine in many areas of application, such as diagnosis, prognosis, or the selection of targeted therapies. In many molecular biomarker studies, intensity values are obtained from large scale -omics experiments. These intensity values, such as protein concentrations, are often compared between at least ...
Addington Donald Emile - - 2013
OBJECTIVE Relapse is a frequently used outcome measure in schizophrenia research. However, difficulties in reliably measuring relapse diminish its usefulness. Hospitalization is a potential alternative, but its relationship to relapse has not been assessed. METHODS This study used data from a two-year, prospective study to examine associations between relapse and ...
Techalertpaisarn Paiboon - - 2013
The objective of this research was to investigate the mechanical properties at both sides of Opus closing loops by analyzing the effects of loop shape, loop position, coil position, and tipping of the vertical legs. Opus loops were compared with L-loops (with and without a coil) and a T-loop by ...
Wachman Elisha M EM Department of Pediatrics, The Floating Hospital for Children, Tufts Medical Center, 800 Washington St, Boston, MA 02111, - - 2013
Neonatal abstinence syndrome (NAS) caused by in utero opioid exposure is a growing problem; genetic factors influencing the incidence and severity have not been previously examined. Single-nucleotide polymorphisms (SNPs) in the μ-opioid receptor (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated with risk for opioid addiction in adults. ...
Abang Ada - - 2013
Fiber Bragg grating sensors recorded in poly(methyl methacrylate) fiber often exhibit hysteresis in the response of Bragg wavelength to strain, particularly when exposed to high levels of strain. We show that, when such a fiber grating sensor is bonded directly to a substrate, the hysteresis is reduced by more than ...
An Lin - - 2013
We report use of high-speed spectral domain optical coherence tomography to noninvasively image pulsatile axial movement of the optic nerve head (ONH) in normal human subjects. Time-lapse B-scan mode is used to image the ONH at 500 frames per second. Capture of phase differences between adjacent B-scans permits extraction of ...
Logan Jennifer L JL Oregon Health & Science University, Department of Public Health & Preventive Medicine, Portland, OR 97239, - - 2013
Homeless young adults are exposed to multiple risk factors for HIV infection. We identified HIV risk behaviors and their correlates among homeless young adults in Portland, Oregon. We conducted a community-based, cross-sectional survey of HIV risk behaviors among homeless young adults aged 18-25 years in 2010. Participants completed three study ...
Roszak Andrzej - - 2013
BACKGROUND AND OBJECTIVE: Data on the Val762Ala (rs1136410) polymorphism in the poly(adenosine diphosphate [ADP]-ribose) polymerase 1 (PARP-1) gene as a risk factor for various types of cancers in different ethnicities are inconsistent. We studied this association in a Caucasian population. METHODS: Using high-resolution melting curve analysis (HRM), we studied the ...
Sumithran P - - 2013
Background/Objectives:Diet-induced weight loss is accompanied by compensatory changes, which increase appetite and encourage weight regain. There is some evidence that ketogenic diets suppress appetite. The objective is to examine the effect of ketosis on a number of circulating factors involved in appetite regulation, following diet-induced weight loss.Subjects/Methods:Of 50 non-diabetic overweight ...
Liuk Ing Wei - - 2013
The purpose of this research was to investigate relationships among the location and orientation of palatally displaced canines and the dimension and orientation of the maxillary lateral incisor. An experimental group of 40 patients with 46 palatally displaced canines (20 from boys, 26 from girls; mean age of the subjects, ...
Gerety Sebastian S SS MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. - - 2013
We have generated an inducible system to control the timing of transgene expression in zebrafish and chick. An estrogen receptor variant (ERT2) fused to the GAL4 transcriptional activator rapidly and robustly activates transcription within 3 hours of treatment with the drug 4-hydroxy-tamoxifen (4-OHT) in tissue culture and transgenic zebrafish. We ...
Lowenthal Elizabeth D ED Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. - - 2013
Worldwide, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) efavirenz and nevirapine are commonly used in first-line antiretroviral regimens in both adults and children with human immunodeficiency virus (HIV) infection. Data on the comparative effectiveness of these medications in children are limited. To investigate whether virological failure is more likely among children ...
Devlaminck Vincent - - 2013
In this Letter, we address the question of the physical validity of a depolarizing differential matrix. A parameterization of the diagonal terms of these depolarizing differential matrices is proposed. It ensures that the generators associated with diagonal depolarization terms lead to physical Mueller matrices. The validity of this parameterization is ...
Ozkaynak Halûk - - 2013
Epidemiological studies of the health effects of outdoor air pollution have traditionally relied upon surrogates of personal exposures, most commonly ambient concentration measurements from central-site monitors. However, this approach may introduce exposure prediction errors and misclassification of exposures for pollutants that are spatially heterogeneous, such as those associated with traffic ...
Chen Y - - 2013
There is currently no consensus about the mean volume of blood lost during spinal tumour surgery and surgery for metastatic spinal disease. We conducted a systematic review of papers published in the English language between 31 January 1992 and 31 January 2012. Only papers that clearly presented blood loss data ...
Edwards Stacey L SL Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, - - 2013
Neurons must cope with extreme membrane trafficking demands to produce axons with organelle compositions that differ dramatically from those of the cell soma and dendrites; however, the mechanism by which they accomplish this is not understood. Here we use electron microscopy and quantitative imaging of tagged organelles to show that ...
Veitz-Keenan Analia - - 2013
The Practitioners Engaged in Applied Research and Learning (PEARL) Network conducted a three-armed randomized clinical study to determine the comparative effectiveness of three treatments for hypersensitive noncarious cervical lesions (NCCLs): use of a potassium nitrate dentifrice for treatment of hypersensitivity, placement of a resin-based composite restoration and placement of a ...
Schurgers Leon J - - 2013
Vascular calcification has emerged as an independent risk factor for cardiovascular morbidity and mortality, especially in chronic kidney disease. Deficiencies in calcium-regulatory proteins directly relate to development of calcifications. McCabe and colleagues report that vitamin K is a key regulator of vascular calcification, via carboxylation of vitamin K-dependent proteins such ...
Sergeant Nicholas P - - 2013
Dielectric/metal/dielectric (DMD) electrodes have the potential to significantly increase the absorption efficiency and photocurrent in flexible organic solar cells. We demonstrate that this enhancement is attributed to a broadband cavity resonance. Silver-based semitransparent DMD electrodes with sheet resistances below 10  ohm/sq. are fabricated on flexible polyethylene terephthalate (PET) substrates in ...
Amaral Anderson M - - 2013
We show that by spatially arranging topological charges on a phase mask, it is possible to shape the spatial intensity profile of vortex beams in a controlled manner. As proof-of-principle experiments, we generated vortex beams with the spatial shape of straight lines, corners, and triangles. Potential applications for shaped beams ...
Pikor Larissa - - 2013
Genomic instability is a hallmark of cancer that leads to an increase in genetic alterations, thus enabling the acquisition of additional capabilities required for tumorigenesis and progression. Substantial heterogeneity in the amount and type of instability (nucleotide, microsatellite, or chromosomal) exists both within and between cancer types, with epithelial tumors ...
Fan Xuemei - - 2013
Abstract The high failure rate of traditional procedures of repairing pelvic organ prolapse by using sutures pushes multiple transvaginal mesh delivery systems into the marketplace; however, these are currently without optimal clinical results. We observed the short-term histological changes and the effects of Th1/Th2 cytokines after the implantation in rabbit ...
Estacio-Gómez Alicia - - 2013
Although the Hox genes are the main factors involved in the generation of diversity along the anterior/posterior body axis of segmented organisms, it is still largely unknown how these genes act in single cells to determine specific traits at precise developmental stages. The aim of this study was to understand ...
Gallo Sina S School of Dietetics and Human Nutrition, McGill University, Montréal, Québec, - - 2013
Vitamin D supplementation in infancy is required to support healthy bone mineral accretion. A supplement of 400 IU of vitamin D per day is thought to support plasma 25-hydroxyvitamin D (25[OH]D) concentrations between 40 and 50 nmol/L; some advocate 75 to 150 nmol/L for bone health. To investigate the efficacy ...
Borovoi Anatoli - - 2013
The backscattering reciprocity theorem is considered for large particles as compared with the incident wavelength particles of arbitrary shape. It is shown that, in the specific case of faceted particles, this theorem is provided by the appearance of pairs of conjugate backscattered beams. A parameter characterizing a deviation of any ...
Bruska Marta K - - 2013
Many but not all iron-sulphur clusters in metalloproteins are known to be sensitive to molecular oxygen with dramatic consequences for their biological function. We performed a systematic quantum chemical investigation that sheds light on the differences in oxygen sensitivity depending on charge and spin states of these clusters as well ...
Ichihara Kiyoshi - - 2013
Abstract Background: In a planned International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) worldwide study on reference intervals (RIs), a common panel of serum samples is to be measured by laboratories from different countries, and test results are to be compared through conversion using linear regression analysis. This report ...
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