Search Results
Results 1 - 50 of 2959
1 2 3 4 5 6 7 8 9 10 >
Otten H G HG Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. - - 2013
Antibodies recognizing denatured human leucocyte antigen (HLA) can co-react with epitopes on intact HLA or recognize cryptic epitopes which are normally unaccessible to HLA antibodies. Their specificity cannot be distinguished by single antigen beads (SAB) alone, as they carry a mixture of intact and denatured HLA. In this study, we ...
Barr Laura C LC University of Edinburgh/Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United - - 2013
Depletion of monocytes reduces LPS-induced lung inflammation in mice, suggesting monocytes as potential therapeutic targets in acute lung injury. To investigate whether depletion of circulating blood monocytes has beneficial effects on markers of systemic and pulmonary inflammation in a human model of acute lung inflammation. A total of 30 healthy ...
Anthony Desiree D Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, - - 2013
Neutrophilic inflammation is an important pathologic feature of chronic obstructive pulmonary disease (COPD) and infectious exacerbations of COPD. Serum amyloid A (SAA) promotes neutrophilic inflammation by its interaction with lung mucosal ALX/FPR2 receptors. However, little is known about how this endogenous mediator regulates IL-17A immunity. To determine whether SAA causes ...
Malek-Ahmadi Michael M The Cleo Robert Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ 85351, - - 2013
Past studies investigating the association between Alzheimer's disease (AD) pathology and diabetes mellitus type 2 (DM2) have provided conflicting results. While several studies indicate that subjects with comorbid AD and DM2 have less AD pathology, others have found no significant differences in AD pathology between the two groups. Other studies ...
Zhao Guanjia G Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, - - 2013
In this work, we will show that ferromagnetic microjets can pick-up paramagnetic beads while not showing any interaction with diamagnetic silica microparticles for the active separation of microparticles in solution.
Hsieh Christine L CL San Francisco VA Medical Center, San Francisco, CA, USA. - - 2013
Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after injury and >77-fold 4 ...
Kohut Thomas R - - 2013
Operation of the NIF requires a large and varied number of routine and infrequent activities involving contaminated and radioactive systems, both in servicing online equipment and offline refurbishment of components. Routine radiological operations include up to several dozen entries into contaminated systems per day, multiple laboratories refurbishing radiologically impacted parts, ...
Kohut Thomas R - - 2013
The National Ignition Facility (NIF) has been designed to accommodate some challenging radiological conditions. The high prompt neutron source (up to 1.6 × 10 neutrons per shot) results in the need for significant fixed shielding. Concrete shielding approximately 2 m thick is used for the primary (target bay) shield. Penetrations ...
Draggoo Vaughn - - 2013
Isotopic mixtures of hydrogen constitute the basic fuel for fusion targets of the National Ignition Facility (NIF). A typical NIF fusion target shot requires approximately 0.5 mmoles of hydrogen gas and as much as 750 GBq (20 Ci) of H. Isotopic mix ratios are specified according to the experimental shot/test ...
Colombo Massimo - - 2013
Hepatocellular carcinoma (HCC) is a complex disease with a poor prognosis. Incidence and mortality rates are increasing in many geographical regions, indicating a need for better management strategies. Among several risk factors for HCC, the most common are cirrhosis because of chronic hepatitis B virus or hepatitis C virus infection ...
Datte Philip - - 2013
The National Ignition Facility (NIF) is a 192 laser beam facility that supports the Inertial Confinement Fusion program. During the ignition experimental campaign, the NIF is expected to perform shots with varying fusion yield producing 14 MeV neutrons up to 20 MJ or 7.1 × 10 neutrons per shot and ...
Khater Hesham - - 2013
A detailed model of the Target Bay (TB) at the National Ignition Facility (NIF) has been developed to estimate the post-shot radiation environment inside the facility. The model includes the large number of structures and diagnostic instruments present inside the TB. These structures and instruments are activated by neutrons generated ...
Reed Robert K - - 2013
The National Ignition Facility (NIF) is the world's largest and most energetic laser system. The facility has the potential to generate ionizing radiation due to the interaction between the laser beams and target material, with neutrons and gamma rays being produced during deuterium-tritium fusion reactions. To perform these experiments, several ...
Thacker Rick L - - 2013
The National Ignition Facility at Lawrence Livermore National Laboratory is the world's largest and most energetic laser system for inertial confinement fusion and experiments studying high energy density science. Many experiments performed at the National Ignition Facility involve radioactive materials; these may take the form of tritium and small quantities ...
Dillon Jon T - - 2013
The National Ignition Facility at the Lawrence Livermore National Laboratory has implemented a protocol for evaluating and releasing material and equipment that is potentially "volumetrically contaminated" as a result of neutron activation and shown not to be "distinguishable from background." This protocol is an important element of the National Ignition ...
Reyes Susana - - 2013
The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL) in California is currently in operation with the goal to demonstrate fusion energy gain for the first time in the laboratory-also referred to as "ignition." Based on these demonstration experiments, the Laser Inertial Fusion Energy (LIFE) power plant ...
Packard Eric D - - 2013
Lawrence Livermore National Laboratory must control potentially activated materials and equipment in accordance with U.S. Department of Energy (DOE) Order 458.1, Radiation Protection of the Public and the Environment, which requires DOE approval of the process used to release volumetrically contaminated personal property and establishes a dose constraint of 10 ...
Brereton Sandra - - 2013
The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory is the world's largest and most energetic laser system for inertial confinement fusion (ICF) and experiments studying high energy density (HED) science. The NIF is a 192-beam, Nd-glass laser facility that is capable of producing 1.8 MJ, 500 TW of ...
Brereton Sandra J - - 2013
National Ignition Facility experiments involve the use of a variety of materials that generate a number of radiological issues. Along with the use of tritium and depleted uranium, shots generating neutrons create prompt radiation fields as well as fission and activation products. In order to assure readiness for these hazards, ...
Morita Shigeki S Department of Pathology and Clinical Laboratories, Thoracic Surgery Division, National Cancer Center Hospital, - - 2013
Low-grade lung adenocarcinoma of fetal lung type, which is well characterized by its unique clinicopathologic and molecular features, is recognized as a distinct variant of lung cancer. In contrast, high-grade lung adenocarcinoma with fetal lung-like morphology (HG-LAFM) has not been studied widely. To characterize this subset better, we analyzed 17 ...
Potts Jonathan R JR Department of Medicine, Brighton and Sussex Medical School, Brighton, - - 2013
Despite high recidivism rates in those treated for alcoholism, recurrent episodes of severe alcoholic hepatitis (SAH) have not been described. Our aim was to assess the clinical characteristics and outcomes in recurrent SAH. A retrospective review of patient records was carried out. Recurrent SAH was defined as two or more ...
Cuschieri Kate K Scottish HPV Reference Laboratory, Royal Infirmary of Edinburgh, UK. - - 2013
Human papillomavirus (HPV) immunization programs clearly have considerable potential to reduce HPV-associated disease; they are also resource-intense; so, it is essential that their effectiveness is determined accurately and in a timely way. Measuring circulating HPV types in a population can provide an early measure of vaccine impact. We assessed the ...
Rossi Giulio G Unità di Anatomia Patologica, Azienda Ospedaliera Arcispedale Santa Maria Nuova/Istituto di Ricerca e Cura a Carattere Scientifico, Reggio Emilia, Italy. - - 2013
Crystal-storing histiocytosis (CSH) localized to the thoracic region is a rare occurrence, often secondary to lymphoproliferative or plasma cell diseases. About 10 case reports have been previously published, and 3 of these have no relationship with clonal hematologic disorders. We collected here the first series of 5 consecutive cases of ...
Perry Sarah A SA Department of Anesthesiology and Critical Care Medicine, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, - - 2013
We investigated the in vitro inspired dose and particle size distribution of albuterol delivered by a vibrating mesh nebulizer through the Vapotherm (Stevensville, MD) humidified high-flow nasal cannula system. Albuterol (2.5 mg/3 mL) was delivered by an Aeroneb Solo (Aerogen, Galway, Ireland) nebulizer that was connected via adaptor proximal to ...
Badolato Raffaele R Department of Pediatrics, Institute of Molecular Medicine Angelo Nocivelli, University of Brescia, Brescia, Italy. - - 2013
This Viewpoint gives an overview of the inherited disorders that are characterized by defects of leukocyte trafficking. Three paradigmatic diseases have been selected: warts, hypogammaglobulinemia, infections, and myelokathexis; Wiskott-Aldrich; and leukocyte adhesion deficiency syndromes. These conditions encompass defects in the steps that are required for leukocyte motility: from the response ...
Tang Weihua W Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, - - 2013
Epstein-Barr virus (EBV) DNA is found within the malignant cells of some subtypes of lymphoma, and viral presence is being exploited for improved diagnosis, monitoring, and management of affected patients. Recent work suggests that viral genomic polymorphism, such as partial deletion of the viral genome, could interfere with virus detection ...
Ribeiro Tatiane C - - 2013
Autism spectrum disorders (ASDs) are characterized by impaired communication, particularly pragmatic and semantic language, resulting in verbal comprehension deficits. Semantic processing in these conditions has been studied extensively, but mostly limited only to linguistic material. Emerging evidence, however, suggests that semantic integration deficits may extend beyond the verbal domain. Here, ...
Choi In-Sun - - 2013
We examined 5-hydroxytryptamine 1A (5-HT1A) receptor-mediated modulation of glutamatergic transmission in rat medullary dorsal horn neurons using a conventional whole-cell patch clamp technique. 5-HT reversibly and concentration dependently decreased the amplitude of glutamatergic excitatory postsynaptic currents and increased the paired-pulse ratio, indicating that 5-HT acts presynaptically to reduce glutamate release ...
Paaijmans Krijn P KP Department of Entomology, The Pennsylvania State University, University Park, PA 16802, USA. - - 2013
Ectotherms are considered to be particularly vulnerable to climate warming. Descriptions of habitat temperatures and predicted changes in climate usually consider mean monthly, seasonal or annual conditions. Ectotherms, however, do not simply experience mean conditions, but are exposed to daily fluctuations in habitat temperatures. Here, we highlight how temperature fluctuation ...
Small Donna M DM School of Pharmacy, Queen's University Belfast, Lisburn Road, Belfast, BT9 7BL, United - - 2013
Recent murine studies have demonstrated that tumor-associated macrophages in the tumor microenvironment are a key source of the pro-tumorigenic cysteine protease, cathepsin S. We now show in a syngeneic colorectal carcinoma murine model that both tumor and tumor-associated cells contribute cathepsin S to promote neovascularization and tumor growth. Cathepsin S ...
Fleming Jennifer R - - 2013
Tubulin-binding cofactor (TBC)-B is implicated in the presentation of α-tubulin ready to polymerize, and at the correct levels to form microtubules. Bioinformatics analyses, including secondary structure prediction, CD, and crystallography, were combined to characterize the molecular architecture of Trypanosoma brucei TBC-B. An efficient recombinant expression system was prepared, material-purified, and ...
Gangjee Aleem A Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA. - - 2013
Opportunistic infections caused by Pneumocystis jirovecii (P. jirovecii, pj), Toxoplasma gondii (T. gondii, tg), and Mycobacterium avium (M. avium, ma) are the principal causes of morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS). The absence of any animal models for human Pneumocystis jirovecii pneumonia and the lack of ...
Zheng Tianqing T Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, New York 10461, United - - 2013
In this communication, we report a new class of cleavable linker based on automatically synthesized, single-stranded DNAs. We incorporated a DNA oligo into an azide-functionalized biotin (biotin-DNA-N3) and used the probe to enrich for alkyne-tagged glycoproteins from mammalian cell lysates. Highly efficient and selective release of the captured proteins from ...
Radtke Catherine L - - 2013
Objective-To characterize equine muscle tissue- and periosteal tissue-derived cells as mesenchymal stem cells (MSCs) and assess their proliferation capacity and osteogenic potential in comparison with bone marrow- and adipose tissue-derived MSCs. Sample-Tissues from 10 equine cadavers. Procedures-Cells were isolated from left semitendinosus muscle tissue, periosteal tissue from the distomedial aspect ...
Ye Ken - - 2013
The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used ...
Miyakoshi Naohisa - - 2013
Vitamin D affects both bone and muscle. Recent meta-analyses of high-quality trials showed that both native vitamin D and active forms of vitamin D3 significantly reduced the risk of vertebral and non-vertebral fractures. These anti-fracture efficacies of vitamin D are considered to be mainly exerted through direct effects on mineral ...
Halligan Sarah L - - 2013
The development of emotional regulation capacities in children at high versus low risk for externalizing disorder was examined in a longitudinal study investigating: (a) whether disturbances in emotion regulation precede and predict the emergence of externalizing symptoms and (b) whether sensitive maternal behavior is a significant influence on the development ...
Unadkat Jignesh V - - 2013
: Vascularized composite allotransplantation has become a clinical reality. Patients undergoing vascularized composite allotransplantation have modest functional return. Most patients have had multiple acute rejections. The effect of multiple acute rejections influencing functional outcomes is unknown. This study systematically analyzes the effects of multiple acute rejections on functional outcome. : ...
Delgado Ana R - - 2013
Background: Guidelines for Spanish university curricula include the descriptor Quantitative and Qualitative Methods, but the latter are still poorly represented. Method: To inform the argument for phenomenological methods, the last 20-year interval of ISI databases has been content-analyzed with the following codes: discourse analysis, grounded theory, narrative analysis, phenomenological analysis ...
Cortinhas Cristina S - - 2013
Objective-To compare the minimum inhibitory concentration (MIC) of cephapirin and ceftiofur with MICs of their active metabolites (desacetylcephapirin and desfuroylceftiofur) for selected mastitis pathogens. Sample-488 mastitis pathogen isolates from clinically and subclinically affected cows in commercial dairy herds in Wisconsin. Procedures-Agar dilution was used to determine MICs for Staphylococcus aureus ...
van Oldenrijk Jakob - - 2013
STUDY DESIGN.: A systematic review of published trials in orthopedic spine literature. OBJECTIVE.: To determine the quality of reporting in open spine surgery randomized controlled trials (RCTs) between 2005 and 2010 with special focus on the reporting of surgical skill or expertise. SUMMARY OF BACKGROUND DATA.: In technically demanding procedures ...
Martini Maurizio - - 2013
The inflammatory fibroid polyp (IFP) is a benign lesion occurring in the digestive tract, mostly in the stomach and small bowel, composed of fibrovascular tissue infiltrated by inflammatory cells including eosinophils and mastocytes. Its pathogenesis has been controversial (reactive versus neoplastic). The recent finding of mutations in platelet-derived growth factor ...
Diaz-Orea M A - - 2013
INTRODUCTION. Neurocysticercosis (NCC) is a parasitic infection caused by the establishment of Taenia solium cysticerci in the central nervous system. The larval stage of the parasite also affects the pig, which is the essential intermediate host for transmission. For this reason, many researchers have focused on identifying protective antigens to ...
Sun Zheng - - 2013
Nox1 mRNA, protein, and activities were compared in the paired primary and metastatic colon adenocarcinoma cell lines SW480 and SW620, and in normal colon tissues and colon cancer tissues. Our results demonstrated that Nox1 levels were higher in the primary SW480 cells than that in metastatic SW620 cells and were ...
Scharf Valery F - - 2013
Objective-To investigate the effects of bevacizumab, a human monoclonal antibody against vascular endothelial growth factor, on the angiogenesis and growth of canine osteosarcoma cells xenografted in mice. Animals-27 athymic nude mice. Procedures-To each mouse, highly metastasizing parent osteosarcoma cells of canine origin were injected into the left gastrocnemius muscle. Each ...
Foley Theodore T - - 2013
: The prominent inflammatory cell identified in excessive scarring is the mast cell. Hypertrophic scar exhibits myofibroblasts derived from the transformation of fibroblasts, increased collagen synthesis, and stationary nonmigratory resident cells. The co-culture of fibroblasts with an established rat mast cell line (RMC-1) was used to explore the hypothesis of ...
Sheyn Dmitriy - - 2013
Background: Brown adipose tissue plays a pivotal role in mammal metabolism and thermogenesis. It has a great therapeutic potential in several metabolic disorders such as obesity and diabetes. Mesenchymal stem cells (MSCs) are suitable candidates for brown adipose tissue formation de novo. Pparγ2 and C/ebpα are nucleic receptors known to ...
Ohtani Michiteru - - 2013
The relationship between the fall and types of hypnotics was studied. The incidence of falls on hypnotics was lower in subjects on ultra-short-acting type, such as Myslee tablet (1.6%) than in those on short-acting type (5.0 to 6.8%) drugs. For Myslee tablet, the incidences were similar in the daytime and ...
Crockett Lisa J - - 2013
This longitudinal study examined the joint role of pubertal timing and temperament variables (emotional reactivity and self-regulation) in predicting adolescents' internalizing symptoms. The multiethnic sample included 1,025 adolescent girls and boys followed from age 11 to age 15 (M age = 11.03 years at Time 1). In structural equation models, ...
Olivera La Rosa Antonio - - 2013
Background: Disgust is, at its core, an emotion that responds to cues of parasites and infection, likely to be evolved to protect human organism from the risk of disease. Interestingly, a growing body of research implicates disgust as an emotion central to human morality. The fact that disgust is associated ...
1 2 3 4 5 6 7 8 9 10 >