Search Results
Results 251 - 300 of 2977
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Malihi Z - - 2013
BACKGROUND: The primary objective of the present study was to assess changes in the nutritional status and quality of life in acute leukaemia patients, aged ≥15 years, who had undergone induction chemotherapy. METHODS: A preliminary and post-induction chemotherapy assessment of patients' nutritional status, quality of life, sociodemographic status and medical characteristics ...
Berhan Yifru - - 2013
BACKGROUND: Literature review has shown that some years back the fertility desires of people living with HIV was low but in the recent years, it was reported as increasing. However, little is known about the strength of association of fertility desire of HIV positive people with antiretroviral therapy (ART) experience, ...
Radzisheuskaya Aliaksandra A Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Biochemistry, University of Cambridge, Cambridge, - - 2013
Oct4 is considered a master transcription factor for pluripotent cell self-renewal, but its biology remains poorly understood. Here, we investigated the role of Oct4 using the process of induced pluripotency. We found that a defined embryonic stem cell (ESC) level of Oct4 is required for pluripotency entry. However, once pluripotency ...
Pallagi Attila - - 2013
The equilibria and structure of complexes formed between the Ca(2+) ion and the heptagluconate (Hglu(-)) ion in both neutral and alkaline solutions have been studied. In alkaline solutions an uncharged, multinuclear complex is formed with the composition of Ca3Hglu2(OH)4 (or [Ca3Hglu2H-4](0)) with an unexpectedly high stability constant (lg β32-4 = ...
Zhang Xinguo - - 2013
An orange-emitting phosphor, Eu(2+) -activated LiSr4 (BO3 )3 , was synthesized using the conventional solid-state reaction. The photoluminescence excitation and emission spectra, and temperature dependence of the luminescence intensity of the phosphor were investigated. The results showed that LiSr4 (BO3 )3 :Eu(2+) could be efficiently excited by incident light of ...
Trevillion K - - 2013
Aims. High numbers of psychiatric service users experience domestic violence, yet limited interventions exist for these victims. We piloted a domestic violence intervention for community mental health services to explore the feasibility of a future cluster randomized controlled trial. Methods. Quasi-experimental controlled design within five Community Mental Health Teams (three ...
Baran David A - - 2013
Heart transplantation has evolved into the treatment of choice for eligible patients with end-stage heart failure. Effective immunosuppression is critical to the success of this treatment, with the modern era beginning with the advent of cyclosporin A in the 1980s. In this Perspectives article, the major prospective, randomized trials of ...
Noguchi Shunsuke S United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan. - - 2013
microRNA (miR)-205 is downregulated and acts as a tumor suppressor in human melanoma cells. Previously, for clinical application, we added aromatic benzene-pyridine (BP-type) analogs to the 3'-overhang region of the RNA-strand and changed the sequences of the passenger strand in the miR-143 duplex. Here, we demonstrated the antitumor effect in ...
Meyer C - - 2013
Chromosomal rearrangements of the human MLL gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long distance inverse PCR (LDI-PCR) to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute ...
Melamed Yerushalmi Sarit - - 2013
Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, ...
Rai Gitanjali - - 2013
The present communication divulges interesting thermal behavior of different protic ionic liquids arising due to the hydrophobicity modifications in their parent cationic ring structures. This work assists us in differentiating between protic ionic liquids, their aprotic counterparts and common electrolytes in water. The thermal signatures produced by protic ionic liquids, ...
Awa Wendy L - - 2013
AIM: To characterize the clinical and immunological features of HLA-typed youth with pediatric onset of type 2 diabetes mellitus (T2DM). METHOD: One hundred and seven patients with clinically diagnosed T2DM (aged ≤20 yr at diagnosis) were examined. DNA and serum, obtained after a median diabetes duration of 2.2 (Q1-Q3: 0.8-4.6) yr, ...
Sadeghi Afshin - - 2013
BACKGROUND: Analysis and interpretation of biological networks is one of the primary goals of systems biology. In this context identification of sub-networks connecting sets of seed proteins or seed genes plays a crucial role. Given that no natural node and edge weighting scheme is available retrieval of a minimum size ...
Guay Claudiane - - 2013
Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, ...
Jiang Yue - - 2013
MicroRNAs (miRNA) are a class of small, noncoding RNA molecules involved in a diversity of cellular functions. Single nucleotide polymorphisms (SNPs) in miRNA biosynthesis genes may affect the biogenesis of miRNAs and consequently affect the miRNAs regulation. In this study, we systematically selected 24 functional SNPs located in 8 key ...
Meng Xiaomeng - - 2013
A simple and novel microRNA (miRNA) biosensor was developed using DNA-Au bio bar code (DNA-Au) and G-quadruplex-based DNAenzyme. DNA-Au increased the amount of miRNA-21 participating in hybridization. Hemin/G-quadruplex DNAenzyme significantly improved the catalysis of H2O2 by oxidation of hydroquinone, resulting in an obvious reduction current of benzoquinone for miRNA-21 indirect ...
Goh Yuhan A - - 2013
Aqueous based controlled decoration of platinum nanoparticles on plasma treated carbon nano-onions (CNOs) occurs within the shear flow generated by a vortex fluidic device (VFD), using ascorbic acid as the reducing agent, with the electrocatalytic potential of the resulting Pt-NPs@CNOs nano-composites demonstrated.
Robbins Thomas F - - 2013
A triazolopyridinium salt chemodosimeter has been developed that displays a 60-fold enhancement in fluorescence upon reaction with cyanide. The novel, fast, selective and sensitive reaction-based indicator relies on the pseudopericyclic ring opening of the bridgehead nitrogen-containing detector.
Qi Helena W - - 2013
This work presents a new fragment method, the electrostatically embedded many-body expansion of the nonlocal energy (EE-MB-NE) and shows that it, along with the previously proposed electrostatically embedded many-body expansion of the correlation energy (EE-MB-CE), produces accurate results for large systems at the level of CCSD(T) coupled cluster theory. We ...
Song Xue-Zhi - - 2013
The d(10)-metal-oxo clusters connected by the asymmetric tricarboxylate and linear neutral ligands give rise to two novel high-connected MOFs. They feature the highest (3,16)- and (3,8)-connected three-dimensional frameworks based on cube-like octanuclear [Zn8(μ2-OH)4(CO2)12] clusters and butterfly-like tetranuclear [Cd4(μ3-OH)2(CO2)6] clusters as the secondary building units, respectively.
Nyberg Fred - - 2013
Emerging data indicate that growth hormone (GH) therapy could have a role in improving cognitive function. GH replacement therapy in experimental animals and human patients counteracts the dysfunction of many behaviours related to the central nervous system (CNS). Various behaviours, such as cognitive behaviours related to learning and memory, are ...
Cox John A - - 2013
The benefits of adjuvant whole-breast irradiation (WBI) after breast-conserving surgery are well established and WBI is a standard of care. In selected patients with early stage breast cancer, accelerated partial breast irradiation (APBI) has emerged as an alternative treatment option to WBI. Early trials of APBI have demonstrated an excellent ...
Burnham S C - - 2013
Dementia is a global epidemic with Alzheimer's disease (AD) being the leading cause. Early identification of patients at risk of developing AD is now becoming an international priority. Neocortical Aβ (extracellular β-amyloid) burden (NAB), as assessed by positron emission tomography (PET), represents one such marker for early identification. These scans ...
Arevalo Ryan Lacdao - - 2013
We show through first-principles calculations that the electronic properties of Pt4 clusters can be tuned by adsorption on substrates with different electronic valence characters. Pt clusters exhibit a metallic character on γ-Al2O3(111) and insulator properties on CaZrO3(001). The noted difference indicates the role of the electronic valence states of the ...
Danescu Adrian - - 2013
Endometrioid or type-I endometrial carcinoma (EC) develops from hyperproliferative glandular pathologies. Inactivation of the tumor suppressor gene PTEN is frequently associated with type-I EC. Using a previously characterized Pten heterozygous (Pten+/-) mouse model, this study investigates the three-dimensional (3D) telomere profiles during progression from hyperplastic lesions to EC to test ...
Maƛlanka Tomasz - - 2013
The aim of this study was to evaluate the effect of meloxicam (MEL) has on bovine CD25highCD4+, CD25lowCD4+ and CD25-CD4+ cells with respect to selected immune parameters. Peripheral blood mononuclear cells (PBMCs) collected from 12-month-old heifers were treated with MEL at a concentration which reflects the level of this medication ...
Zhao Yaguang - - 2013
This article describes the photo-induced living radical polymerization of acrylamides mediated by organo-cobalt porphyrins through photo-cleavage of the Co-C bond to give organic radicals, which propagate polymerization, and cobalt(ii), which is a persistent metal-centered radical. Photo stimulus controls the initiation steps and regulates chain growth by activating the Co-C bond.
Cheng Quan - - 2013
Abstract Aim: To investigate the relation between brain ischemia and persistent vegetative state after severe traumatic brain injury. Methods:The 66 patients with severe brain injury were divided into two groups: The persistent coma group (coma duration >10 days) included 51 patients who had an admission coma score of 5 to 7 ...
Schmidt-Edelkraut Udo - - 2013
Cell-fate decisions and differentiation of embryonic and adult neural stem cells (NSC) are tightly controlled by lineage-restricted and temporal factors that interact with cell-intrinsic programs and extracellular signals through multiple regulatory loops. Imprinted genes are important players in neurodevelopment and mental health although their molecular and cellular functions remain poorly ...
Koyama Yutaka - - 2013
BACKGROUND: Chemokines are involved in many pathological responses of the brain. Astrocytes produce various chemokines in brain disorders, but little is known about the factors that regulate astrocytic chemokine production. Endothelins (ETs) have been shown to regulate astrocytic functions through ETB receptors. In this study, the effects of ETs on ...
Riolobos Laura L Department of Medicine, University of Washington, Seattle, Washington 98195, - - 2013
The clinical use of human pluripotent stem cells and their derivatives is limited by the rejection of transplanted cells due to differences in their human leukocyte antigen (HLA) genes. This has led to the proposed use of histocompatible, patient-specific stem cells; however, the preparation of many different stem cell lines ...
Nagel Stefan - - 2013
Chromosomal rearrangements are common features of most cancers, where they contribute to deregulated gene expression. Chromothripsis is a recently described oncogenic mechanism whereby small genomic pieces originating from one chromosomal region undergo massive rearrangements in a single step. Here, we document chromothripsis in Hodgkin lymphoma (HL) cell lines by genomic ...
Holanda L M - - 2013
This work reports on electron spin resonance experiments in oriented single crystals of the hexagonal AlB2 diboride compound (P6/mmm, D16h structure) which display conduction electron spin resonance. The X-band electron spin resonance spectra showed a metallic Dysonian resonance with g-value and intensity independent of temperature. The thermal broadening of the ...
Lee Ki-Ryong - - 2013
We demonstrate a facile controlling of the optical and colorimetric properties of a donor-acceptor conjugated polymer simply by varying the mix ratio of two precursors in a precursor blend. The conversion of a precursor blend results in an entirely new donor-acceptor polymer, distinct from the conjugated polymer of each precursor. ...
Yao Li - - 2013
We report a technique that is based on exchange-induced remnant magnetization for microRNA (miRNA) detection. In sequence-specific exchange reactions between label-free miRNA and magnetically labelled RNA with one mismatched base, the decrease in magnetization quantitatively represents the target miRNA. The detection limit reaches the zeptomole regime, with no amplification or ...
Jaeger Sara R - - 2013
BACKGROUND: A case study with wine where two statistical methods for the analysis of rating-based conjoint analysis data were applied. Traditionally, Ordinary Least Squares (OLS) regression is used to estimate relative importance of the experimental factors and part-worth utilities of factor levels. Partial Least Squares (PLS) regression, which is a ...
Wang Hanqing - - 2013
Amino acids are naturally occurring compounds in many edible or medicinal plants, which possess a variety of pharmacological effects on humans. The aim of this study is to develop and validate a hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method for absolute and relative quantification of amino acids ...
Biver Galadrielle - - 2013
Accumulating evidence indicates that extracellular nucleotides, signaling through purinergic receptors, play a significant role in bone remodeling. Mesenchymal stem cells (MSC) express functional P2Y receptors whose expression level is regulated during osteoblast or adipocyte differentiation. P2Y13- deficient mice were previously shown to exhibit a decreased bone turnover associated with a ...
Hartig Gerrit - - 2013
One of the most disputed issues in primate evolution and thus of our own primate roots, is the phylogenetic position of the Southeast Asian tarsier. While much molecular data indicate a basal place in the primate tree shared with strepsirrhines (prosimian monophyly hypothesis), data also exist supporting either an earlier ...
Panagopoulos Ioannis - - 2013
Mesothelioma is a rare but very aggressive tumor derived from mesothelial cells. A number of often complex but nonrandom cytogenetic abnormalities have been found in these tumors, resulting in loss of chromosome bands 14q32 and 22q12 in more than 35% of the cases. In this study, we used RNA sequencing ...
Carlmark Anna - - 2013
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been suggested for dendritic polymers, including theranostics, biosensors, optics, adhesives and ...
Schlesinger William H - - 2013
A literature survey of studies reporting nitrous oxide uptake in the soils of natural ecosystems is used to suggest that the median uptake potential is 4 μg m(-2) hr(-1) . The highest values are nearly all associated with soils of wetland and peatland ecosystems. Globally, the consumption of nitrous oxide ...
Kozer Noga N Centre for Micro-Photonics, Faculty of Engineering and Industrial Sciences, Cell Biophysics Laboratory, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria 3122, - - 2013
The epidermal growth factor receptor (EGFR) kinase is generally considered to be activated by either ligand-induced dimerisation or a ligand-induced conformational change within pre-formed dimers. Ligand-induced higher-order EGFR oligomerisation or clustering has been reported but it is not clear how EGFR oligomers, as distinct from EGFR dimers, influence signaling outputs. ...
Karapinar Deniz Yilmaz - - 2013
Acquired severe aplastic anemia (SAA) is a life threatening bone marrow failure characterized by pancytopenia and hypocellular bone marrow. Matched sibling donor is not available for majority of the patients and many children receive immunosuppressive therapy (IST). Although horse antithymocyte globuline (ATG) is the preferred option, our patients received rabbit ...
Lee Kyung Hee - - 2013
OBJECTIVE: This study explored the relationship between observable emotional expression and wandering behaviors of people with dementia (PWD). METHODS: A secondary data analysis was conducted of a multi-site study that used a cross-sectional design with repeated measures nested within subjects. Participants included 142 PWD residing in 17 nursing homes and ...
Ibbotson S H - - 2013
There is good evidence to support the use of topical PDT for superficial nonmelanoma skin cancer and dysplasia; however, there is little information available on the structure, process and outcomes of PDT in clinical practice. We undertook a national survey to determine how PDT was being undertaken in dermatology centres ...
Retuerto M - - 2013
La1-xBixMn2O5 (x = 0, 0.2, 0.4, 0.6, 0.8 and 1) oxides are members of the RMn2O5 family. The entire series has been prepared in polycrystalline form by a citrate technique. The evolution of their magnetic and crystallographic structures has been investigated by neutron powder diffraction (NPD) and magnetization measurements. All the samples ...
Saraji Soheil - - 2013
ABSTRACT Injection of carbon dioxide in deep saline aquifers is considered as a method of carbon sequestration. The efficiency of this process is dependent on the fluid-fluid and rock-fluid interactions inside the porous media. For instance, the final storage capacity and total amount of capillary-trapped CO2 inside an aquifer are ...
Antonescu Cristina R CR Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. - - 2013
A subset of cutaneous and superficial soft tissue myoepithelial (ME) tumors displays a distinct ductal component and closely resembles mixed tumors/pleomorphic adenomas of salivary gland. As PLAG1 and HMGA2 rearrangements are the most common genetic events in pleomorphic adenomas, we sought to investigate if these abnormalities are also present in ...
Lin Peiyan - - 2013
A highly sensitive and specific LC-MS/MS method was developed to investigate the in vivo bio-transformation of oleuropein in rat. Rat feces and urine samples collected after oral administration were determined by liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the negative-ion mode. The assay procedure involves a ...
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