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Shifrin David A DA Jr Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, - - 2013
Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has revealed that specific ligands, enzymes, and macromolecules are distributed into the extracellular ...
Lewis Kim K Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115, USA. - - 2013
The spread of resistant bacteria, leading to untreatable infections, is a major public health threat but the pace of antibiotic discovery to combat these pathogens has slowed down. Most antibiotics were originally isolated by screening soil-derived actinomycetes during the golden era of antibiotic discovery in the 1940s to 1960s. However, ...
Bowes Lucy L King's College London, - - 2013
We investigated the antecedents and consequences of chronic victimization by bullies across a school transition using a genetically sensitive longitudinal design. Data were from the Environmental Risk Longitudinal Twin Study (E-Risk), an epidemiological cohort of 2,232 children. We used mothers' and children's reports of bullying victimization during primary school and ...
Podzielinski Iwona I Fort Wayne Gynecologic Oncology Center, Fort Wayne, Indiana, - - 2013
SELDI-TOF MS analysis of ovarian cyst fluids revealed that peaks m/z 8696 and 8825 discriminate malignant, borderline, and benign tumors. These peaks correspond to isoforms of apoA2. ELISA demonstrates that apoA1, A2, B, C2, C3, and E cyst fluid concentrations are uncorrelated and higher in malignant ovarian tumors, but only ...
Dickson Eamonn J EJ Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, - - 2013
Gq-coupled plasma membrane receptors activate phospholipase C (PLC), which hydrolyzes membrane phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). This leads to calcium release, protein kinase C (PKC) activation, and sometimes PIP2 depletion. To understand mechanisms governing these diverging signals and to determine which of ...
Falkenburger Björn H BH Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, - - 2013
Gq protein-coupled receptors (GqPCRs) of the plasma membrane activate the phospholipase C (PLC) signaling cascade. PLC cleaves the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylgycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), leading to calcium release, protein kinase C (PKC) activation, and in some cases, PIP2 depletion. We determine ...
Hyde Luke W LW University of Michigan, Ann Arbor, MI 48109, USA. - - 2013
This study examined dimensions of callous behaviors in early childhood and the role of these behaviors in the development of conduct problems, as well as responsiveness to a family-centered preventative intervention. Caregiver reports of callous behaviors were examined using exploratory and confirmatory factor analysis. Problem behavior was examined using within- ...
Zhang Delin - - 2013
We investigate the structural stability and magnetic properties of the cubic, tetragonal and hexagonal phases of Mn3Z (Z=Ga, Sn and Ge) Heusler compounds using first-principles density-functional theory. We propose that the cubic phase plays an important role as an intermediate state in the phase transition from the hexagonal to the ...
Grimblat Nicolás - - 2013
The Diels-Alder reactions of simple unsaturated boronates have been investigated using computational methods and the results were compared with those for the analogue dihalo- and dialkylboranes. Our results indicate that the activating effect of the boronate moiety is small. All the studied reactions are concerted normal electron-demand Diels-Alder reactions with ...
Lynnhtun Kyaw - - 2013
A 58-year-old lady presented with mediastinal lymphadenopathy. A thoracoscopic ultrasound-guided fine-needle aspiration showed large atypical epithelioid cells arranged in cohesive sheets and dispersed as single cells with intact cytoplasm amid a background of lymphocytes and histiocytes. A cytological diagnosis of "a malignant neoplasm" was made, raising a broad list of ...
Shi Yun - - 2013
Dose finding for combined drugs has grown rapidly in oncology drug development. The escalation with overdose control (EWOC) method is a popular model-based dose-finding approach to single-agent phase I clinical trials. When two drugs are combined as a treatment, we propose a two-dimensional EWOC design for dose finding on the ...
Zhang Y-H - - 2013
Alzheimer's disease (AD), the most common human neurodegenerative disease, is characterized pathologically by numerous deposits of amyloid plaques in the brain. Systemic administration of clioquinol (CQ) and inoculation with amyloid-beta42 (Aβ42) vaccines have been demonstrated to significantly inhibit deposits of amyloid in AD brains. However, each of these treatments has ...
Zhou Qingxiang - - 2013
Benzoylurea insecticides are a kind of important pesticides and have contributed great to the output of crops. Their residue in environment put serious threats on the human health and environmental safety. Present study established a new, rapid and reliable method for the monitoring of typical benzoylurea insecticides such as diflubenzuron, ...
Burnham S C - - 2013
Dementia is a global epidemic with Alzheimer's disease (AD) being the leading cause. Early identification of patients at risk of developing AD is now becoming an international priority. Neocortical Aβ (extracellular β-amyloid) burden (NAB), as assessed by positron emission tomography (PET), represents one such marker for early identification. These scans ...
Arevalo Ryan Lacdao - - 2013
We show through first-principles calculations that the electronic properties of Pt4 clusters can be tuned by adsorption on substrates with different electronic valence characters. Pt clusters exhibit a metallic character on γ-Al2O3(111) and insulator properties on CaZrO3(001). The noted difference indicates the role of the electronic valence states of the ...
Danescu Adrian - - 2013
Endometrioid or type-I endometrial carcinoma (EC) develops from hyperproliferative glandular pathologies. Inactivation of the tumor suppressor gene PTEN is frequently associated with type-I EC. Using a previously characterized Pten heterozygous (Pten+/-) mouse model, this study investigates the three-dimensional (3D) telomere profiles during progression from hyperplastic lesions to EC to test ...
Zhao Yaguang - - 2013
This article describes the photo-induced living radical polymerization of acrylamides mediated by organo-cobalt porphyrins through photo-cleavage of the Co-C bond to give organic radicals, which propagate polymerization, and cobalt(ii), which is a persistent metal-centered radical. Photo stimulus controls the initiation steps and regulates chain growth by activating the Co-C bond.
Cheng Quan - - 2013
Abstract Aim: To investigate the relation between brain ischemia and persistent vegetative state after severe traumatic brain injury. Methods:The 66 patients with severe brain injury were divided into two groups: The persistent coma group (coma duration >10 days) included 51 patients who had an admission coma score of 5 to 7 ...
Xue Jiangli - - 2013
The pure natural cotton provides a low-cost material platform for the facile assembly of all-cotton-derived electrochemical supercapacitors (allC-ECs) with a remarkable character of arbitrary foldability and high response rate, which can be bent, rolled-up, and fully folded without loss of high-rate (<50 ms) capacitive performance.
Ichibangase T - - 2013
8-Amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione (L-012) was recently synthesized as a new chemiluminescence (CL) probe; the light intensity and the sensitivity of L-012 are higher than those of other CL probes such as luminol. Previously, our group developed four lophine-based CL enhancers of the horseradish peroxidase (HRP)-catalyzed CL oxidation of luminol, namely 2-(4-hydroxyphenyl)-4,5-diphenylimidazole (HDI), ...
Ashford Stephen - - 2013
BACKGROUND AND PURPOSE: This paper aimed to select studies evaluating botulinum toxin (BoNT) intervention applied for upper-limb spasticity and from these identify outcome measures that are a) applicable in the hemiparetic upper limb and b) include evaluation of functional outcome in the context of everyday real-life activities. METHODS: A systematic ...
Haponiuk Ireneusz - - 2013
Since 2008 we have performed 10 hybrid procedures for perventricular muscular ventricular septal defects (mVSD) closure. The mean age was 8.5 months (range 2.7 to 17.8), the mean diameter of mVSD was 6.3 mm (range 4 to 10 mm). The postoperative course was uncomplicated and complete closure of the mVSD was accomplished ...
Beasley Spencer W - - 2013
Introduction of an increasingly competence-based Royal Australasian College of Surgeons (RACS) Surgical Education and Training (SET) programme has influenced the nature and conduct of the Fellowship Examination (FEX). The FEX is the final summative assessment taken near the completion of SET training, and is aligned to the other SET assessment ...
Kyriakides T - - 2013
BACKGROUND: Myalgia, defined as any pain perceived in muscle, is very common in the general population and a frequent cause for referral to neurologists, rheumatologists and internists in general. It is however only rarely due to primary muscle disease and often referred from ligaments, joints, bones, the peripheral and central ...
Li Meifang - - 2013
Glycine betaine (GB) can enhance heat tolerance and the accumulation of heat shock protein (HSP) in plants, but the effects of GB on HSP accumulation during salt stress were not previously known. To investigate the mechanism of how GB influences the expression of HSP, wild-type tobacco (Nicotiana tabacum) seedlings pretreated ...
Haino Takeharu - - 2013
Photochromic tris(phenylisoxazolyl)benzene and bispyridine derivatives were mixed in a certain ratio to generate stable gels in benzyl alcohol, 4-methoxybenzyl alcohol, and aniline. Supramolecular assembly of in solution was confirmed by (1)H NMR study. The Tgel value was saturated in a 2 : 3 ratio of and . The intermolecular hydrogen bonds OHN ...
Jiang De-En - - 2013
Thiolated gold nanoclusters form a universe of their own. Researchers in this field are constantly pushing the boundary of this universe by identifying new compositions and in a few "lucky" cases, solving their structures. Such solved structures, even if there are only few, provide important hints for predicting the many ...
Schmidt-Edelkraut Udo - - 2013
Cell-fate decisions and differentiation of embryonic and adult neural stem cells (NSC) are tightly controlled by lineage-restricted and temporal factors that interact with cell-intrinsic programs and extracellular signals through multiple regulatory loops. Imprinted genes are important players in neurodevelopment and mental health although their molecular and cellular functions remain poorly ...
Riolobos Laura - - 2013
The clinical use of human pluripotent stem cells and their derivatives is limited by the rejection of transplanted cells due to differences in their human leukocyte antigen (HLA) genes. This has led to the proposed use of histocompatible, patient-specific stem cells; however, the preparation of many different stem cell lines ...
Nagel Stefan - - 2013
Chromosomal rearrangements are common features of most cancers, where they contribute to deregulated gene expression. Chromothripsis is a recently described oncogenic mechanism whereby small genomic pieces originating from one chromosomal region undergo massive rearrangements in a single step. Here, we document chromothripsis in Hodgkin lymphoma (HL) cell lines by genomic ...
Holanda L M - - 2013
This work reports on electron spin resonance experiments in oriented single crystals of the hexagonal AlB2 diboride compound (P6/mmm, D16h structure) which display conduction electron spin resonance. The X-band electron spin resonance spectra showed a metallic Dysonian resonance with g-value and intensity independent of temperature. The thermal broadening of the ...
Lee Ki-Ryong - - 2013
We demonstrate a facile controlling of the optical and colorimetric properties of a donor-acceptor conjugated polymer simply by varying the mix ratio of two precursors in a precursor blend. The conversion of a precursor blend results in an entirely new donor-acceptor polymer, distinct from the conjugated polymer of each precursor. ...
Yao Li - - 2013
We report a technique that is based on exchange-induced remnant magnetization for microRNA (miRNA) detection. In sequence-specific exchange reactions between label-free miRNA and magnetically labelled RNA with one mismatched base, the decrease in magnetization quantitatively represents the target miRNA. The detection limit reaches the zeptomole regime, with no amplification or ...
Jaeger Sara R - - 2013
BACKGROUND: A case study with wine where two statistical methods for the analysis of rating-based conjoint analysis data were applied. Traditionally, Ordinary Least Squares (OLS) regression is used to estimate relative importance of the experimental factors and part-worth utilities of factor levels. Partial Least Squares (PLS) regression, which is a ...
Wang Hanqing - - 2013
Amino acids are naturally occurring compounds in many edible or medicinal plants, which possess a variety of pharmacological effects on humans. The aim of this study is to develop and validate a hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method for absolute and relative quantification of amino acids ...
Biver Galadrielle - - 2013
Accumulating evidence indicates that extracellular nucleotides, signaling through purinergic receptors, play a significant role in bone remodeling. Mesenchymal stem cells (MSC) express functional P2Y receptors whose expression level is regulated during osteoblast or adipocyte differentiation. P2Y13- deficient mice were previously shown to exhibit a decreased bone turnover associated with a ...
Boden Matthew Tyler - - 2013
AIMS: To prospectively investigate the relation between cannabis use expectancies and cannabis use prior to and during a self-initiated cannabis cessation attempt. DESIGN: Cohort design that followed participants for four weeks following a self-initiated cessation attempt. SETTING: United States Department of Veterans Affairs medical center. PARTICIPANTS: 100 cannabis dependent military ...
de Winter C F - - 2013
BACKGROUND: Depression, anxiety, diabetes and cardiovascular risk factors are frequent health problems among older people with intellectual disability (ID). These conditions may be bidirectionally related. Depression and anxiety may have biological effects causing glucose intolerance, fat accumulation and also lifestyle changes causing metabolic syndrome. But also the effects of diabetes, ...
Kandimalla Raju - - 2013
Urinary bladder cancer is the fifth most common cancer in the Western world. Increasing evidence has shown that DNA methylation in bladder cancer is expansive and is implicated in pathogenesis. Furthermore, distinct methylation patterns have been identified between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), as well as ...
Chmara Magdalena - - 2013
Constitutional mismatch repair deficiency (CMMR-D) due to biallelic germline mutations in one of four mismatch repair genes causes a childhood cancer syndrome characterized by a broad tumor spectrum including hematological malignancies, and brain and Lynch syndrome-associated tumors. Herein, we report three children who had in addition to CMMR-D-associated malignancies multiple ...
da Costa Dias F L - - 2013
Cholinesterase inhibitors (ChEIs), the mainstay treatment for dementia, have systemic actions that can affect cardiovascular and autonomic nervous system (ANS). Thirty-nine patients with Alzheimer's disease or mixed dementia underwent a comprehensive clinical evaluation, prior to and during ChEIs therapy, including orthostatic challenge, electrocardiogram (EKG) and heart rate variability (HRV) spectral ...
Khan M Awais - - 2013
Fire blight, incited by the enterobacterium Erwinia amylovora, is a destructive disease of Rosaceae, particularly of apples and pears. There are reports on the molecular mechanisms underlying E. amylovora pathogenesis and how the host activates its resistance mechanism. The host's resistance mechanism is quantitatively controlled, although some major genes might ...
McKay K M - - 2013
BACKGROUND: Basal cell carcinoma (BCC) is the most common malignancy in Caucasians. It is an important driver of health care costs and causes significant morbidity. Topical imiquimod is a good non-invasive treatment alternative for surgical excision in superficial BCC (sBCC). However, there are currently no uniform histological definitions of sBCC. ...
Groth Martin - - 2013
Arbuscular mycorrhiza (AM) fungi form nutrient-acquiring symbioses with the majority of higher plants. Nutrient exchange occurs via arbuscules, highly branched hyphal structures that are formed within root cortical cells. With a view to identify host genes involved in AM development, we isolated Lotus japonicus AM-defective mutants via a microscopic screen ...
Roy A - - 2013
We study the zero temperature non-equilibrium dynamics of a fermionic superfluid in the BCS limit and in the presence of a drive leading to a time-dependent chemical potential μ(t). We choose a periodic driving protocol characterized by a frequency ω and compute the fermion density, the wavefunction overlap, and the ...
Käkilehto Taina - - 2013
Abstract Objective. Paediatric restorative dentistry continues being a challenge in everyday clinical practice. Practise-based survival analysis covering entire age cohorts offer an epidemiological approach to this issue in studying survival of restorations in primary teeth. The aim of this study was to compare survival of restorations in primary molars in ...
Park Jeesook - - 2013
A colorimetric and ratiometric fluorescent probe consisting of a boron-dipyrromethene (BODIPY) dye conjugated with a 2-dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) group has been designed for the selective and sensitive detection of HOCl/OCl(-)via oxidative cleavage of an alkene linker between BODIPY and DCDHF.
Bujkiewicz Sylwia - - 2013
Multivariate random effects meta-analysis (MRMA) is an appropriate way for synthesizing data from studies reporting multiple correlated outcomes. In a Bayesian framework, it has great potential for integrating evidence from a variety of sources. In this paper, we propose a Bayesian model for MRMA of mixed outcomes, which extends previously ...
Wang Huiyong - - 2013
It was found for the first time that single tail ionic liquid (IL) surfactants, 1-alkyl-3-methylimidazolium bromides [Cnmim]Br (n = 10, 12, 14), form unilamellar vesicles in aqueous solutions without any additives. With the increase in IL concentrations, the self-assembly of these ILs can transfer from spherical micelles to rodlike micelles ...
Arseneau Kristen O - - 2013
Introduction: CCR9 antagonism is a promising new therapeutic approach for the treatment of Crohn's disease. CCR9 is expressed on the cell surface of memory/effector CD4(+) T cells and selectively binds to the small intestinal lymphocyte chemoattractant CCL25 (TECK). Blockade of the CCR9/CCL25 interaction inhibits lymphocyte homing to the intestinal mucosa, ...
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