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Gangjee Aleem A Division of Medicinal Chemistry, Graduate School Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA. - - 2013
Opportunistic infections caused by Pneumocystis jirovecii (P. jirovecii, pj), Toxoplasma gondii (T. gondii, tg), and Mycobacterium avium (M. avium, ma) are the principal causes of morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS). The absence of any animal models for human Pneumocystis jirovecii pneumonia and the lack of ...
Zheng Tianqing T Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Ave, Bronx, New York 10461, United - - 2013
In this communication, we report a new class of cleavable linker based on automatically synthesized, single-stranded DNAs. We incorporated a DNA oligo into an azide-functionalized biotin (biotin-DNA-N3) and used the probe to enrich for alkyne-tagged glycoproteins from mammalian cell lysates. Highly efficient and selective release of the captured proteins from ...
Cummins Brian M BM Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA. - - 2013
To date, the dependent nature of the recognition and transduction mechanisms in optical glucose sensors based upon Concanavalin A (ConA) has tended to prevent the sensors' full potential from being realized. In this paper, these mechanisms are independently optimized for a given assay configuration in order to decrease the predictive ...
Feriancikova Lucia L Department of Geosciences, University of Wisconsin-Milwaukee, 3209 N Maryland Ave, Milwaukee, Wisconsin 53211, United - - 2013
The outer membrane protein (OMP) TolC is the cell surface component of several drug efflux pumps that are responsible for bacterial resistance against a variety of antibiotics. In this research, we investigated the effects of OMP TolC on E. coli transport within saturated sands through column experiments using a wild-type ...
Mallajosyula Sairam S SS Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland 21201, United - - 2013
The antiproliferative factor (APF) involved in interstitial cystitis is a glycosylated nonapeptide (TVPAAVVVA) containing a sialylated core 1 α-O-disaccharide linked to the N-terminal threonine. The chemical structure of APF was deduced using spectroscopic techniques and confirmed using total synthesis. The synthetic APF provided a platform to study amino acid modifications ...
Yan Xiaoyu X Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK. - - 2013
Bioethanol is the world's largest-produced alternative to petroleum-derived transportation fuels due to its compatibility within existing spark-ignition engines and its relatively mature production technology. Despite its success, questions remain over the greenhouse gas (GHG) implications of fuel ethanol use with many studies showing significant impacts of differences in land use, ...
Wolfe Amanda L AL Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, - - 2013
Two novel cyclic N-acyl O-amino phenol prodrugs are reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family of natural products. These prodrugs were explored with the expectation that they may be cleaved selectively within hypoxic tumor environments that have intrinsically higher concentrations of ...
Jahn Stephan C SC Department of Pharmacology and Therapeutics and the ‡Shands Cancer Center, University of Florida , Gainesville, Florida 32610, United - - 2013
Previous studies have shown conflicting data regarding cyclin D1/cyclin-dependent kinase 2 (Cdk2) complexes, and considering the widespread overexpression of cyclin D1 in cancer, it is important to fully understand their relevance. While many have shown that cyclin D1 and Cdk2 form active complexes, others have failed to show activity or ...
Péter Arpád A Iatrika Eü. Bt. FelsĹ‘szentiván Jókai u. 33. 6447. - - 2013
The author, who is a sole general practitioner in a Hungarian village, has continuously followed mortality in his practice for a long period of time. He found connections between cancer- and alcohol-related mortality in the first observational period between 1987 and 1999. Among men, cancer mortality related to alcoholism reached ...
Radtke Catherine L - - 2013
Objective-To characterize equine muscle tissue- and periosteal tissue-derived cells as mesenchymal stem cells (MSCs) and assess their proliferation capacity and osteogenic potential in comparison with bone marrow- and adipose tissue-derived MSCs. Sample-Tissues from 10 equine cadavers. Procedures-Cells were isolated from left semitendinosus muscle tissue, periosteal tissue from the distomedial aspect ...
Ye Ken - - 2013
The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used ...
Miyakoshi Naohisa - - 2013
Vitamin D affects both bone and muscle. Recent meta-analyses of high-quality trials showed that both native vitamin D and active forms of vitamin D3 significantly reduced the risk of vertebral and non-vertebral fractures. These anti-fracture efficacies of vitamin D are considered to be mainly exerted through direct effects on mineral ...
Halligan Sarah L - - 2013
The development of emotional regulation capacities in children at high versus low risk for externalizing disorder was examined in a longitudinal study investigating: (a) whether disturbances in emotion regulation precede and predict the emergence of externalizing symptoms and (b) whether sensitive maternal behavior is a significant influence on the development ...
Delgado Ana R - - 2013
Background: Guidelines for Spanish university curricula include the descriptor Quantitative and Qualitative Methods, but the latter are still poorly represented. Method: To inform the argument for phenomenological methods, the last 20-year interval of ISI databases has been content-analyzed with the following codes: discourse analysis, grounded theory, narrative analysis, phenomenological analysis ...
Cortinhas Cristina S - - 2013
Objective-To compare the minimum inhibitory concentration (MIC) of cephapirin and ceftiofur with MICs of their active metabolites (desacetylcephapirin and desfuroylceftiofur) for selected mastitis pathogens. Sample-488 mastitis pathogen isolates from clinically and subclinically affected cows in commercial dairy herds in Wisconsin. Procedures-Agar dilution was used to determine MICs for Staphylococcus aureus ...
van Oldenrijk Jakob - - 2013
STUDY DESIGN.: A systematic review of published trials in orthopedic spine literature. OBJECTIVE.: To determine the quality of reporting in open spine surgery randomized controlled trials (RCTs) between 2005 and 2010 with special focus on the reporting of surgical skill or expertise. SUMMARY OF BACKGROUND DATA.: In technically demanding procedures ...
Martini Maurizio - - 2013
The inflammatory fibroid polyp (IFP) is a benign lesion occurring in the digestive tract, mostly in the stomach and small bowel, composed of fibrovascular tissue infiltrated by inflammatory cells including eosinophils and mastocytes. Its pathogenesis has been controversial (reactive versus neoplastic). The recent finding of mutations in platelet-derived growth factor ...
Diaz-Orea M A - - 2013
INTRODUCTION. Neurocysticercosis (NCC) is a parasitic infection caused by the establishment of Taenia solium cysticerci in the central nervous system. The larval stage of the parasite also affects the pig, which is the essential intermediate host for transmission. For this reason, many researchers have focused on identifying protective antigens to ...
Sun Zheng - - 2013
Nox1 mRNA, protein, and activities were compared in the paired primary and metastatic colon adenocarcinoma cell lines SW480 and SW620, and in normal colon tissues and colon cancer tissues. Our results demonstrated that Nox1 levels were higher in the primary SW480 cells than that in metastatic SW620 cells and were ...
Scharf Valery F - - 2013
Objective-To investigate the effects of bevacizumab, a human monoclonal antibody against vascular endothelial growth factor, on the angiogenesis and growth of canine osteosarcoma cells xenografted in mice. Animals-27 athymic nude mice. Procedures-To each mouse, highly metastasizing parent osteosarcoma cells of canine origin were injected into the left gastrocnemius muscle. Each ...
Sheyn Dmitriy - - 2013
Background: Brown adipose tissue plays a pivotal role in mammal metabolism and thermogenesis. It has a great therapeutic potential in several metabolic disorders such as obesity and diabetes. Mesenchymal stem cells (MSCs) are suitable candidates for brown adipose tissue formation de novo. Pparγ2 and C/ebpα are nucleic receptors known to ...
Ohtani Michiteru - - 2013
The relationship between the fall and types of hypnotics was studied. The incidence of falls on hypnotics was lower in subjects on ultra-short-acting type, such as Myslee tablet (1.6%) than in those on short-acting type (5.0 to 6.8%) drugs. For Myslee tablet, the incidences were similar in the daytime and ...
Crockett Lisa J - - 2013
This longitudinal study examined the joint role of pubertal timing and temperament variables (emotional reactivity and self-regulation) in predicting adolescents' internalizing symptoms. The multiethnic sample included 1,025 adolescent girls and boys followed from age 11 to age 15 (M age = 11.03 years at Time 1). In structural equation models, ...
Olivera La Rosa Antonio - - 2013
Background: Disgust is, at its core, an emotion that responds to cues of parasites and infection, likely to be evolved to protect human organism from the risk of disease. Interestingly, a growing body of research implicates disgust as an emotion central to human morality. The fact that disgust is associated ...
Ishibashi Hideaki - - 2013
Locomotive syndrome means a condition at a risk for requiring nursing care due to deteriorated musculoskeletal organs in the middle-aged and older people. Considering that this concept aims to care prevention and that fracture for fall consists of one-tenth of causes for requiring using care, fall prevention should be an ...
Luyt Charles-Edouard - - 2013
Ventilator-associated pneumonia is a serious hospital-acquired infection, with 20-70% crude mortality and 10-40% estimated attributable mortality. Insufficient antibiotic concentrations at the infection site when these drugs are given intravenously may lead to poor outcomes, particularly when difficult-to-treat pathogens are responsible; for example, Pseudomonas aeruginosa, extended spectrum beta lactamase-producing Gram-negative bacilli, ...
Díaz-Aguado Jalón María J - - 2013
Background: Although there have been many studies of bullying, few have linked it with the escalation of disruption-coercion that sometimes occur in the classroom. Understanding this relationship is the aim of this research. Method: The study included 22114 Spanish adolescents, aged 12 to 18 years (mean age = 14.22, SD ...
Brodeur Darlene A - - 2013
We investigated differences in multiple-object tracking among individuals with Down syndrome (DS) as compared to typically developing children matched on a visual-spatial mental age of approximately 5.5 years. In order to ensure that these effects did not originate in differences in encoding or reporting the positions of targets in distracters ...
Simon Richard - - 2013
The recent surge in high-throughput sequencing of cancer genomes has supported an expanding molecular classification of cancer. These studies have identified putative predictive biomarkers signifying aberrant oncogene pathway activation and may provide a rationale for matching patients with molecularly targeted therapies in clinical trials. Here, we discuss some of the ...
Suzuki Takao - - 2013
For the prevention of fall and its associated injuries including various fractures among the elderly, some simple and clinical screening tools for prediction of falls for the community-dwelling elderly have been developed. In Japan, Toba et al. (2005) explored a portable Fall Risk Index (FRI) consisting of 22items for the ...
Giuffrè Mario - - 2013
Methicillin-resistant Staphylococcus aureus (MRSA) is well known as one of the most frequent etiological agents of healthcare-associated infections. The epidemiology of MRSA is evolving with emergence of community-associated MRSA, the clonal spread of some successful clones, their spillover into healthcare settings and acquisition of antibacterial drug resistances. Neonatal intensive care ...
López-Escribano Carmen - - 2013
Background: The study of the contribution of language and cognitive skills to reading comprehension is an important goal of current reading research. However, reading comprehension is not easily assessed by a single instrument, as different comprehension tests vary in the type of tasks used and in the cognitive demands required. ...
Basler Christopher F - - 2013
Evaluation of: Mohan GS, Li W, Ye L, Compans RW, Yang C. Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus. PLoS Pathog. 8(12), e1003065 (2012). Ebola viruses encode two glycoproteins (GPs): a membrane-associated GP that is present in the viral membrane and mediates viral attachment and ...
Martínez Sánchez Francisco - - 2013
Background: Emotional events are followed by recurrent talking about the event (Social Sharing of Emotion, SSE). Several factors that can account for variations in beliefs about SSE were examined: alexithymia, age and sex among two sample groups, Spanish (n= 388) and Uruguayan (n= 537). Method: Both samples completed the 20-item ...
Alvarez Irene - - 2013
Objective-To determine the reference interval for WBC counts in Holstein dairy cows from herds with high seroprevalence for anti-bovine leukemia virus (BLV) antibodies, analyze the correlation of total WBC counts and blood proviral load (bPVL) in BLV-infected animals, and determine whether total WBC count can be used a hematologic marker ...
Muñiz José - - 2013
International Test Commission Guidelines for test translation and adaptation: Second edition. Background: Adapting tests across cultures is a common practice that has increased in all evaluation areas in recent years. We live in an increasingly multicultural and multilingual world in which the tests are used to support decision-making in the ...
Fiel M Isabel - - 2013
Context.-The incidence of obesity is increasing and contributes to the rising incidence of fatty liver. Body mass index (BMI) is used to assess the degree of obesity but does not take into account the pattern of body fat distribution. Objectives.-To confirm the increasing incidence of fatty liver in an autopsy ...
Sakurai Masashi - - 2013
Objective-To determine whether angiogenesis and microglial activation were related to seizure-induced neuronal death in the cerebral cortex of Shetland Sheepdogs with familial epilepsy. Animals-Cadavers of 10 Shetland Sheepdogs from the same family (6 dogs with seizures and 4 dogs without seizures) and 4 age-matched unrelated Shetland Sheepdogs. Procedures-Samples of brain ...
Lee Eun Ju - - 2013
Background: Human bone marrow-derived mesenchymal stem cells (hMSCs) are advantageous for cell-based therapy to treat ischemic diseases owing to their capacity to secrete various paracrine factors with potent angiogenic activity. Materials & methods: In this study, we describe a method to increase secreted levels of VEGF and HGF from hMSCs ...
Tochigi Naobumi - - 2013
Context.-The diagnosis of sarcomatoid neoplasms of the lung and pleura can be challenging. Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as the most common genetic alteration in malignant mesotheliomas that is of potential diagnostic and prognostic significance. Objectives.-To evaluate the frequency of 9p21 deletion ...
Naujokas Agne - - 2013
Context.-Providing basic medical care to patients in underserved communities around the world is a valuable service and should not be compromised. Limited publicly available information on the use of pathology services during short-term medical missions (STMMs) shows a dire need for the improved quality of care being provided. Objective.-To assess ...
Komatsu Taiki - - 2013
The fall risk has 3.6 fold in Dementia with Lewy Bodies (DLB) and 16 fold post faller syndrome among diseases to cause dementia, and it was reported that have a significant parkinsonism and a fall more. DLB has multiple symptoms such as that physical symptom, rather than worsening a symptom ...
Muñoz Centifanti Luna C - - 2013
Different patterns of emotional reactivity characterize proactive and reactive functions of aggressive behavior, and theory also suggests a link of both types with narcissism. How people with narcissistic traits respond emotionally to competitive scenarios could influence their aggressiveness. Participants were 85 adolescent boys from a detention center. Several indices of ...
Fontanil Yolanda - - 2013
Background: The most commonly used instruments for assessing adult attachment have shown differing combinations of items and divergences in the resulting sub-scales. Method: This study presents the Scale of Preferences and Expectations in Close Interpersonal Relationships ( Escala de Preferencias y Expectativas en las Relaciones Interpersonales Cercanas, EPERIC), made up ...
Cai Fan - - 2013
Fibroblast activation protein (FAP) is a specific serine protease expressed in tumor stroma proven to be a stimulatory factor in the progression of some cancers. The purpose of this study was to investigate the effects of FAP knockdown on tumor growth and the tumor microenvironment. Mice bearing 4T1 subcutaneous tumors ...
Kisiday John D - - 2013
Objective-To compare the mesenchymal stem cell (MSC) yield and chondrogenic and osteogenic differentiation from 5- and 50-mL bone marrow aspirates from horses. Animals-Six 2- to 5-year-old mixed-breed horses. Procedures-2 sequential 5-mL aspirates were drawn from 1 ilium or sternebra. A single 50-mL aspirate was drawn from the contralateral ilium, and ...
Packer Claire - - 2013
Regenerative medicine techniques to restore cardiac and vascular function are being increasingly investigated as management options for cardiovascular disease. The authors set out to identify emerging regenerative techniques in cardiovascular disease and investigate their stage of development. The relevant networks in the field in the UK were contacted and online ...
Kryvenko Oleksandr N - - 2013
Context.-Prostate cancer (PC) with lymph node metastases (LN(+)) is relatively rare, whereas it is relatively common in disease with a Gleason score (GS) 8 to 10 and virtually never seen in PC with GS 6 or less. It is most variable in GS 7 PC. Objective.-To determine clinicopathologic features associated ...
Hong Tingting - - 2013
Serum C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been reported to be associated with the risk of a number of cancers including breast cancer. However, the results are inconsistent. To investigate the association between serum CRP levels and early breast cancer, we conducted a hospital-based case-control study ...
Brendgen Mara - - 2013
The study examined whether reciprocal friendship quantity or quality can mitigate genetic vulnerability for depression symptoms in children. The sample comprised 168 monozygotic twin pairs and 126 same-sex dizygotic twin pairs assessed in Grade 4 (mean age = 10.04 years). Friendship participation was measured via reciprocal nominations of close friendships ...
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