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Results 601 - 650 of 2977
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Anta Lourdes - - 2013
OBJECTIVES: Limited data are available on resistance to etravirine, rilpivirine, darunavir and tipranavir in patients infected with HIV-1 non-B subtypes, in which natural polymorphisms at certain positions could influence the barrier and/or pathways to drug resistance. METHODS: FASTA format sequences from the reverse transcriptase and protease genes recorded within the ...
Dai Chuanfu - - 2013
Abstract Conclusions: The first presentation of intratemporal facial neurofibromas was variable, with facial palsy most common. The tumors often involve two or more segments of facial nerve. Outcomes of the tumors were closely related to nerve integrity, preoperative facial nerve function level, and follow-up period. Objective: The aim of this ...
Motohashi Hideyuki - - 2013
Organic anion transporters (OATs) and organic cation transporters (OCT) play pivotal roles in the uptake of drugs into epithelial cells at the basolateral membranes, and multidrug and toxin extrusion (MATE) mediates drug secretion into urine at the brush-border membranes. In this study, the expression and distribution of apical MATE1 and ...
Kedishvili Natalia Y NY Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. - - 2013
All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous physiological processes. The concentration of retinoic acid in the cells is tightly regulated, but the exact mechanisms responsible for this regulation are not completely understood, largely because the enzymes involved in the biosynthesis of retinoic acid have ...
Fischer Andrej - - 2013
The spectrum of mutations discovered in cancer genomes can be explained by the activity of a few elementary mutational processes. We present a novel probabilistic method, EMu, to infer the mutational signatures of these processes from a collection of sequenced tumors. EMu naturally incorporates the tumor-specific opportunity for different mutation ...
Shit Anindita - - 2013
Escape from a metastable state in presence of high-frequency field (where the driving becomes nonadiabatic) underlies a broad range of phenomena of physics and chemistry and thus its understanding is of paramount importance. We study the problem of intermediate-to-high-damping escape from a metastable state of a dissipative system driven by ...
Ybarra Michele L - - 2013
Data from high-income countries suggest that cell phone-based smoking cessation programs have the potential to affect cessation rates. There is a paucity of research, however, about the feasibility of cell phone-based smoking cessation programs in lower income countries that have higher smoking prevalence rates. A one-arm feasibility and acceptability pilot ...
Richards Derek - - 2013
OBJECTIVE: This article aimed to critically review the literature on online counseling. METHOD: Database and hand-searches were made using search terms and eligibility criteria, yielding a total of 123 studies. RESULTS: The review begins with what characterizes online counseling. Outcome and process research in online counseling is reviewed. Features and ...
Woodhead Erin L - - 2013
OBJECTIVES: To examine associations between coping strategies at baseline and adverse outcomes 13 years later, and whether gender and age moderated these associations. METHOD: Participants (N = 651) completed a survey on demographic characteristics, coping strategies, and psychosocial outcomes (negative life events, alcohol consumption, drinking problems, and suicidal ideation). RESULTS: ...
Wessel Sarah R SR Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, - - 2013
Frequent collisions between cellular DNA replication complexes (replisomes) and obstacles such as damaged DNA or frozen protein complexes make DNA replication fork progression surprisingly sporadic. These collisions can lead to the ejection of replisomes prior to completion of replication, which, if left unrepaired, results in bacterial cell death. As such, ...
Bradshaw Ben - - 2013
A general effective organocatalyzed synthesis of enantioenriched morphans with up to 92% ee was developed. The morphan scaffold was constructed in a one-pot tandem asymmetric organocatalyzed Michael addition followed by a domino Robinson annulation/aza-Michael intramolecular reaction sequence from easily available starting materials.
Krahé Barbara - - 2013
This study examined the prevalence of sexual aggression and victimization in a large convenience sample of N = 2,149 first-year college students from different universities in Germany. Participants were asked about both victimization by, and perpetration of, sexual aggression since the age of 14. Both same-sex and heterosexual victim-perpetrator constellations were examined. ...
Sharma Pragya P Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, - - 2013
Secretory phospholipase A2 group IIa (PLA2g2a) is associated with inflammation, hyperlipidemia, and atherogenesis. Transcription of the PLA2g2a gene is induced by multiple cytokines. Here, we report the surprising observation that thyroid hormone (T3) inhibited PLA2g2a gene expression in human and rat hepatocytes as well as in rat liver. Moreover, T3 ...
Hinton Devon E - - 2013
This article describes a culturally sensitive questionnaire for the assessment of the effects of trauma in the Cambodian refugee population, the Cambodian Somatic Symptom and Syndrome Inventory (CSSI), and gives the results of a survey with the instrument. The survey examined the relationship of the CSSI, the two CSSI subscales, ...
Zurek Jiří - - 2013
Abstract Intestinal ischemia and reperfusion is a common pathway for many diseases in children. The objective of our study was an analysis of Trefoil factor 1 levels dynamics in patients with SIRS or septic condition during a 5-day period. Analysis of TFF1 levels dynamics revealed that TFF1 levels kept steady ...
Zheng Peng - - 2013
Metal centers in metalloproteins involve multiple metal-ligand bonds. The release of metal ions from metalloproteins can have significant biological consequences so understanding of the mechanisms by which metal ion dissociates has broad implications. By definition, the release of metal ions from metalloproteins involves the disruption of multiple metal-ligand bonds, and ...
Malpass Gloria E GE Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC, - - 2013
Complete artificial saliva (CAS) is a saliva substitute often used as a vehicle for test articles, including smokeless tobacco products. In the course of a study employing normal adult human dermal fibroblasts (HDFa) as a model in vitro, we discovered that CAS as a vehicle introduced a significant change in ...
Wolbransky Melinda - - 2013
Researchers must provide participants with opportunities to make informed decisions about whether to participate in research studies. Investigators conducting research with youth in the juvenile justice system face unique ethical, legal, and practical challenges to obtaining informed consent. Juvenile justice researchers must navigate multiple legal and ethical standards for collecting ...
Hwang Inchan - - 2013
The photophysical properties in solution of three generations of carbazole-based dendrons and dendrimers with fluorenyl surface groups were studied using steady-state, time-resolved femtosecond transient absorption and anisotropy, and coherent two-dimensional ultraviolet spectroscopy. It was found that increasing the generation caused a switch in the nature of the emissive state between ...
Kuznetsov Alexey - - 2013
An efficient method for the synthesis of fused heteroaromatic dihydrosiloles via Ni-catalyzed hydrosilylation/intramolecular Ir-catalyzed dehydrogenative coupling of the Si-H bond with the heteroaromatic C-H bond has been developed. The method is efficient for both electron-deficient and -rich heterocycles. It exhibits high functional group tolerance and good regioselectivity. Fused heteroaromatic dihydrosiloles ...
Wagner Jenny - - 2013
Is it possible to maintain a positive perspective on the self into very old age? Empirical research so far is rather inconclusive, with some studies reporting substantial declines in self-esteem late in life, whereas others report relative stability into old age. In this article, we examine long-term change trajectories in ...
Paige Brock A - - 2013
A novel gammaherpesvirus was identified in a large flying fox (Pteropus vampyrus) with conjunctivitis, blepharitis, and meibomianitis by nested polymerase chain reaction and sequencing. Polymerase chain reaction amplification and sequencing of 472 base pairs of the DNA-dependent DNA polymerase gene were used to identify a novel herpesvirus. Bayesian and maximum ...
Anadón Ramón - - 2013
The glycinergic cell populations in the brain of the lesser spotted dogfish were studied by a glycine immunofluorescence method. Numerous glycine-immunoreactive (Gly-ir) neurons were observed in different brain nuclei. In the telencephalon, Gly-ir cells were observed in the olfactory bulb, telencephalic hemispheres and preoptic region. In the hypothalamus, cerebrospinal fluid-contacting ...
Fang Qichen Q Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai, - - 2013
Fibroblast growth factor 19 (FGF19), a hormone secreted from the small intestine, has recently been shown to stimulate glycogen synthesis and inhibit gluconeogenesis through insulin-independent pathways. This study investigated the change of FGF19 in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM) and explored the association of serum FGF19 ...
Supekar Kaustubh K Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA. - - 2013
Now, more than ever, the ability to acquire mathematical skills efficiently is critical for academic and professional success, yet little is known about the behavioral and neural mechanisms that drive some children to acquire these skills faster than others. Here we investigate the behavioral and neural predictors of individual differences ...
Sanders Ariëtte R J AR Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht. the Netherlands. - - 2013
In primary care, many consultations address symptom-based complaints. Recovery from these complaints seldom exceeds placebo effects. Patient participation, because of its supposed effects on trust and patient expectancies, is assumed to benefit patients' recovery. While the idea is theoretically promising, it is still unclear what the effects of increased patient ...
Attali Yigal - - 2013
Although "hot hands" in basketball are illusory, the belief in them is so robust that it not only has sparked many debates but may also affect the behavior of players and coaches. On the basis of an entire National Basketball Association season's worth of data, the research reported here shows ...
Leroy Sandrine - - 2013
BACKGROUND AND OBJECTIVE:Urinary tract infections (UTIs) are common childhood bacterial infections that may involve renal parenchymal infection (acute pyelonephritis [APN]) followed by late scarring. Prompt, high-quality diagnosis of APN and later identification of children with scarring are important for preventing future complications. Examination via dimercaptosuccinic acid scanning is the current ...
Zhang Jing-Jing - - 2013
A panel of [Au(III)(C⁁N)(R2NCS2)](+) (HC⁁N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.
Tagliaferri Gianpiero - - 2013
Complete samples are the basis of any population study. To this end, we selected a complete subsample of Swift long bright gamma ray bursts (GRBs). The sample, made up of 58 bursts, was selected by considering bursts with favourable observing conditions for ground-based follow-up observations and with the 15-150 keV 1 s ...
Silva-Gomes Sandro S Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal. - - 2013
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of HO-1 expression in macrophages (M) is strictly required for protection against mycobacterial infection ...
Slemmer Jennifer E - - 2013
 Beneficial health effects of cranberries (CBs) and wild blueberries (BBs), such as reduced levels of oxidative stress, have been demonstrated in feeding studies. These Vaccinium berries contain high levels of flavonoids; however, the bioavailability of flavonoids is generally low. We investigated the in vitro effects of these berries on intestinal ...
Attems J - - 2013
Age associated neurodegenerative diseases are characterized by intra- and extracellular aggregation and deposition of misfolded proteins. The neuropathological classification of neurodegenerative diseases is based on the semi-qunatitative assessment of these misfolded proteins, that constitute the neuropathological hallmark lesion for the respective disease: e.g. Alzheimer's disease (AD), amyloid-β (Aβ) hyperphosphorylated tau ...
Sharma Shruti - - 2013
Background:In our model of congenital heart disease (CHD) with increased pulmonary blood flow (Shunt), we have recently shown a disruption in carnitine homeostasis, associated with mitochondrial dysfunction and decreased eNOS/Hsp90 interactions that contribute to eNOS uncoupling, increased superoxide levels, and decreased bioavailable NO. Thus, we undertook this study to test ...
Lin Chuang-Yu - - 2013
Cellular adhesiveness to biomaterial is one of the important properties to the success of tissue engineering. The cell-biomaterial interactions involve close cooperation of adhesion proteins, the plasma membrane, and cytoskeletons in order to form focal adhesions during the process of anchoring. Dynamic development of the plasma membrane in the process ...
Voet Thierry T Department of Human Genetics, KU Leuven, Leuven, 3000, Belgium. - - 2013
The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per cell cycle mutation rates and mechanisms remain elusive. Although single-cell ...
Kaida Yusuke Y Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, - - 2013
Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We screened DNA aptamer directed against AGEs (AGEs-aptamer) in vitro and examined its effects on renal injury in KKAy/Ta mice, an animal model of type 2 diabetes. Eight-week-old male KKAy/Ta or C57BL/6J mice received continuous ...
Hendricks Michelle A - - 2013
Previous studies have suggested that both automatic and intentional processes contribute to the learning of grammar and fragment knowledge in artificial grammar learning (AGL) tasks. To explore the relative contribution of automatic and intentional processes to knowledge gained in AGL, we utilized dual-task methodology to dissociate automatic and intentional grammar- ...
Pavier Julien - - 2013
The development and safety certification of less lethal projectiles require an understanding of the influence of projectile parameters on projectile-chest interaction and on the resulting terminal effect. Several energy-based criteria have been developed for chest injury assessment. Many studies consider kinetic energy (KE) or energy density as the only projectile ...
Leclercq Loic - - 2013
The surface tension equations of binary surfactant mixtures (di-n-decyldimethylammonium chloride and octaethylene glycol monododecyl ether) are established by combining the Szyszkowski equation of surfactant solutions, the ideal or nonideal mixing theory and the phase separation model. For surfactant mixtures, the surface tension at the air-water interface is calculated using nonideal ...
Flamholz Avi - - 2013
Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all domains of life, not all sugar-consuming organisms use the canonical Embden-Meyerhoff-Parnass (EMP) glycolytic pathway. Prokaryotic glucose metabolism is particularly diverse, including several alternative glycolytic pathways, the most common of which is the Entner-Doudoroff (ED) pathway. The ...
Papagiannitsis C C CC Department of Microbiology, National School of Public Health, Athens, Greece. - - 2013
The nucleotide sequence of pKP1433 (55,417 bp), a blaKPC-2-carrying plasmid from Klebsiella pneumoniae sequence type 340, was determined. pKP1433 displayed extensive sequence and structural similarities with the IncN plasmids possessing the KPC-2-encoding Tn4401b isoform. However, the replication, partitioning, and stability of pKP1433 were determined by sequences related to diverse non-IncN ...
Suman Kumari - - 2013
The metal-organic frameworks of amide based "flexible" ligands has been explored. The reaction of bis-(3-pyridyl)ethanediamide with Cu(PF6)2 resulted in a 1D looped chain, where the PF6(-) anions interact with the amide groups of the chains. This resulted in unavailability of space for guest inclusion in the loops. The exchange of ...
Abrams Steven A - - 2013
Bone health is a critical concern in managing preterm infants. Key nutrients of importance are calcium, vitamin D, and phosphorus. Although human milk is critical for the health of preterm infants, it is low in these nutrients relative to the needs of the infants during growth. Strategies should be in ...
Schaich Markus - - 2013
PURPOSETo assess the treatment outcome benefit of multiagent consolidation in young adults with acute myeloid leukemia (AML) in a prospective, randomized, multicenter trial. PATIENTS AND METHODSBetween December 2003 and November 2009, 1,179 patients (median age, 48 years; range, 16 to 60 years) with untreated AML were randomly assigned at diagnosis ...
Hsu Hui-Ling - - 2013
Rapid identification of single and multiple infectious agents is vital in clinical settings and during biothreat attack. This study assesses the assay of single-stranded multiplex PCR amplicons by suspension bead array (SSMP-SBA) for multiple pathogens identification in a single-tube reaction. A 15-plex assay for identification of eleven highly infectious pathogens ...
Kuo Kw - - 2013
Previous reports have described the use of extracorporeal membrane oxygenation (ECMO) for acute chest syndrome of sickle cell disease (SCD). However, there have been no reports of venoarterial (VA) ECMO for cardiac dysfunction in patients with SCD. We describe a patient with SCD and life-threatening cardiogenic shock who was successfully ...
Mao Haibin - - 2013
Amazing diazo: The title reaction leads to highly functionalized diazo compounds in good yields with excellent enantioselectivities (see scheme; Boc=tert-butoxycarbonyl). The utility of the products was demonstrated by the rapid synthesis of a number of optically pure nitrogen heterocycles. The key to this process was the use of 2,2,2-trifluoroethyl diazoacetate ...
Kuhlicke Alexander - - 2013
In this Letter we study the relations among shape, symmetry, and plasmon resonance shift in a single gold nanoparticle during laser melting. A beam of an argon ion laser is focused on a selected particle, while its optical and shape properties can be observed with the help of a combined ...
Sun Shaodong - - 2013
We have demonstrated an interesting approach for one-pot synthesis of CuO nanourchins with sub-100 nm through a sequential dissolution-precipitation process in a water/ethanol system. The first stage produces a precursory crystal (Cu7Cl4(OH)10H2O) that is transformed into monoclinic CuO nanourchins during the following stage. Water is a required reactant for the ...
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