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Results 501 - 550 of 2977
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Paillère Martinot M-L - - 2013
Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those alterations would be associated ...
Bauer J D - - 2013
BACKGROUND: Nutrition supplements enriched with immune function enhancing nutrients have been developed to aid wound-healing, although evidence regarding their effectiveness is limited and systematic reviews have lead to inconsistent recommendations. The present pragmatic, randomised, prospective open trial evaluated a wound-specific oral nutrition supplement enriched with arginine, vitamin C and zinc ...
Hulbert-Williams L - - 2013
BACKGROUND: Several cross-sectional studies have shown an association between exposure to life events and psychological problems in adults with intellectual disability (ID). To establish life events as a risk factor, prospective designs are needed. METHODS: Support staff informants provided data on the psychological problems of 68 adults with ID and ...
Choi Eun Jin - - 2013
The high genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) has been an obstacle to developing an effective vaccine for porcine reproductive and respiratory syndrome. This study was performed to assess the degree of genetic diversity in PRRSV collected from Korean pig farms where wasting and respiratory syndrome ...
Runsten Silja - - 2013
Objective: Childhood adversities have been linked to elevated high-sensitivity C-reactive protein (hsCRP), which has been associated with increased morbidity. Low social support has been reported to worsen the prognosis in heart disease and cancer, and high social support has been linked to lower hsCRP. We hypothesized that social support could ...
Shaki Fatemeh - - 2013
Depleted uranium (DU) is emerging as an environmental pollutant primarily due to its military applications. Gulf War veterans with embedded DU showed cognitive disorders that suggest that the central nervous system is a target of DU. Recent evidence has suggested that DU could induce oxidative stress and mitochondrial dysfunction in ...
Lalmohamed Arief - - 2013
OBJECTIVES:Gastrointestinal (GI) bleeding may impose a serious threat in patients undergoing total hip or knee replacement (THR/TKR). The objectives of this study are to evaluate the timing of GI bleeding following THR/TKR and to determine the effect modification by proton pump inhibitor (PPI) use.METHODS:In a nationwide Danish cohort study, we ...
Bartasyte Ausrine - - 2013
Phase composition of epitaxial/textured LiNbO3 films on sapphire substrates, grown by pulsed laser deposition, atmospheric pressure metal organic chemical vapor deposition and pulsed injection metal organic chemical vapor deposition was studied by conventional x-ray diffraction techniques. Raman spectroscopy, being highly sensitive to the symmetry of materials, was used as a ...
Yan Yigang - - 2013
Dodecaborates, i.e. the [B12H12](2-) containing species, are often observed as main intermediates in the hydrogen sorption cycle of metal borohydrides, hindering rehydrogenation. In the decomposition process of Y(BH4)3, yttrium octahydrotriborate, i.e. Y(B3H8)3, rather than the stable Y2(B12H12)3, is formed as the main intermediate.
Michaud V - - 2013
Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were administered a single 20 mg oral dose of omeprazole on two occasions: with a single 600 mg efavirenz dose; and after a 17-day ...
Bhanuchandra M - - 2013
Ru(ii)-catalyzed intermolecular ortho-C-H amidation of weakly coordinating aromatic ketones with sulfonyl azides is reported. The developed reaction protocol can be extended to various substituted aromatic ketones to afford a wide range of desired C-N bond formation products in good yields.
Moelants Eva Av - - 2013
Cytokines and chemokines represent two important groups of proteins that control the human immune system. Dysregulation of the network in which these immunomodulators function can result in uncontrolled inflammation, leading to various diseases including rheumatoid arthritis (RA), characterized by chronic inflammation and bone erosion. Potential triggers of RA include autoantibodies, ...
Brehmer-Rinderer B - - 2013
BACKGROUND: Based on the idea of the Common Sense Model of Illness Representations by Leventhal as well as Lohaus's concepts of health and illness, a health behaviour model was designed to explain health behaviours applied by persons with intellectual disabilities (ID). The key proposal of this model is that the ...
Gassenmaier Maximilian - - 2013
In many solid tumors, cancer stem cells (CSC) represent a small cell population with tumor-initiating, self-renewal and differentiation potential, which can be identified by surface protein markers. No generally applicable markers are yet known for renal cell carcinoma (RCC). Two RCC cell lines (RCC-26, RCC-53) were found to differ widely ...
Nakayama Yosuke - - 2013
New and unknown electrocatalytic oxidation of water was found to occur on a nano-gold attached palladium electrode. Since the oxidation potential was negative enough to that of well-known normal oxidation of water to form O2, the direct use of water as a fuel, instead of alcohols, might be possible using ...
Kim Min-Jung - - 2013
  The tyrosine kinase inhibitor, nilotinib was examined for its inhibition of cytochrome P450s (CYPs) in human liver microsomes and in human CYPs expressed in a baculovirus-insect cell system. Nilotinib demonstrated preferential inhibition of CYP2C8-mediated paclitaxel 6α-hydroxylation, rosiglitazone hydroxylation and amodiaquine N-deethylation in human liver microsomes, with IC50 values of 0.4, ...
Yunoki Kei - - 2013
Inflammation and oxidative stress play key roles in atherosclerotic plaque instability, and plaque rupture/erosion and subsequent thrombus formation constitute the principal mechanisms of total vessel occlusion and acute ST-elevation myocardial infarction (STEMI). Plaque disruption triggers the formation of initial platelet aggregates that grow in association with an increase in fibrin ...
Márquez Joana - - 2013
Random homozygous gene perturbation (RHGP), in combination with liver sinusoidal endothelial cell (LSEC) adhesion screening of clonal colon cancer cells with perturbed genes, was used to identify genes contributing to the hepatic microvascular adhesion of colon cancer cells. Plasmid vector encoding transactivator and GSV vector were transfected into HT-29 human ...
Ramos I P - - 2013
The development of cage fish farms has been associated with an increase in parasitic diseases. Organic matter resulting from feed waste and faeces attracts animals such as birds and invertebrates that can act as hosts for parasites. The aim of this study was to evaluate the influence of cage farming ...
Chow Hsueh-Wen - - 2013
BACKGROUND: Participation in leisure activities strongly associates with health and well-being. Little research has explored the relationship between participation in leisure activities and constraints on breastfeeding mothers during leisure activities. The purposes of this study are: 1) to investigate constraints on breastfeeding mothers during leisure activities and participation in leisure ...
Barry G - - 2013
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of the early transcriptomic responses to neuronal activation. Here, we profile these transcriptomic responses and show that long non-coding ...
Zhang Qian - - 2013
A rapid and sensitive UPLC-ESI/MS method was established and validated to determine 17 active constituents (aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylhypaconine, benzoylmesaconine, berberine, palmatine, jatrorrhizine, coptisine, baicalein, wogonin, baicalin, wogonoside, emodin, aloe-emodin and rhein) in Sanhuang Xiexin Tang (SXT) and Fuzi Xiexin Tang (FXT), which are two classic compound recipes from ...
Gazzerro Patrizia - - 2013
HMG-CoA reductase inhibitors, statins and pleiotropic effects have been associated with both increased and decreased cancer risk. This letter intends to contribute to ascertaining the real role of statins in cancer since there are conflicting results in the literature(1) . In the last volume of The Lancet Oncology, Cagney(2) outlined ...
Marchand Peter - - 2013
The production of thin films of materials has become the attention of a great deal of research throughout academia and industry worldwide owing to the array of applications which utilise them, including electronic devices, gas sensors, solar cells, window coatings and catalytic systems. Whilst a number of deposition techniques are ...
Ryan Cristín - - 2013
AIMS: Explore and compare junior doctors' perceptions of their self-efficacy in prescribing, their prescribing errors and the possible causes of those errors. METHODS: A cross-sectional questionnaire study was distributed to foundation doctors throughout Scotland, based on Bandura's Social Cognitive Theory and Human Error Theory (HET). RESULTS: 548 questionnaires were completed ...
Yumani Dana Fj - - 2013
AIM: To determine the incidence and potential novel risk factors for catheter-associated bloodstream infections (CABSI) in neonates. METHODS: A retrospective study was conducted for infants admitted to the VU University Medical Center neonatal intensive care unit in 2007. RESULTS: One hundred and ninety six infants with a total of 369 ...
Huang Liying - - 2013
Novel WO3/g-C3N4 composite photocatalysts were prepared by a calcination process with different mass contents of WO3. The photocatalysts were characterized by thermogravimetric analysis (TG), powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS), high-resolution transmission electron microscopy (HRTEM), UV-vis diffuse reflection spectroscopy (DRS), X-ray photoelectron ...
Sana Dandara Emery Morais - - 2013
Herein, we evaluated cervical samples from normal tissue or HPV-infected tissue, to determine if the relative nuclear/cytoplasmic ratio (NA/CA) and the presence of nonclassical cytological criteria are a novel cytological criterion for the diagnosis of HPV. Significantly, larger NA/CA ratios were found for the HPV-ATYPIA+ and HPV+ATYPIA+ groups compared with ...
Tharp William G - - 2013
BACKGROUND: Amyloid-beta plaques are a defining characteristic of Alzheimer Disease. However, Amyloid-beta deposition is also found in other forms of dementia and in non-pathological contexts. Amyloid-beta deposition is variable among vertebrate species and the evolutionary emergence of the amyloidogenic property is currently unknown. Evolutionary persistence of a pathological peptide sequence ...
Li Xiao-Jian - - 2013
Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was readily achieved by conversion of them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air- and moisture-stable NiCl2(dppf) as a catalyst. Coupling ...
Wang Kui-Wu - - 2013
Complete and unambiguous (1) H and (13) C NMR chemical shift assignments for all-trans-retinal, 13-cis-retinal, 11-cis-retinal and 9-cis-retinal (1-4) have been established by means of two-dimensional COSY, HSQC, HMBC and NOESY spectroscopic experiments. Copyright © 2013 John Wiley & Sons, Ltd.
Zhao Jiong-Peng - - 2013
A new chiral 3D heterometallic coordination polymer [NaCo2()2(N3)·(MeOH)]∞ () ( = 2,6-pyridinedicarboxylate) was synthesized and characterized magnetically. Ferro- and antiferromagnetic interactions co-exist in , which results in a magnetic phase transition at the high temperature of 29 K.
Knobel Gaston - - 2013
We describe the first application of a Quick, Easy, Cheap, Effective, Rugged and Safe extraction technique to the capillary zone electrophoresis analysis of monohydroxylated metabolites of polycyclic aromatic hydrocarbons in milk. Complete resolution of 2-hydroxyfluorenene, 1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyphenanthrene and 9-hydroxyphenanthrene was accomplished in 4 minutes of electrophoretic run. Limits of ...
Gaboriaud-Kolar Nicolas - - 2013
Introduction: Glycogen phosphorylase (GP) is the enzyme responsible for the synthesis of glucose-1-phosphate, the source of energy for muscles and the rest of the body. The binding of different ligands in catalytic or allosteric sites assures activation and deactivation of the enzyme. A description of the regulation mechanism and the ...
Roerecke Michael - - 2013
AIMS: To conduct a systematic review and meta-analysis on all-cause mortality in people with alcohol use disorders. METHODS: Using the MOOSE guidelines, studies were identified through MEDLINE, EMBASE, and Web of Science up to August, 2012. Prospective and historical cohort studies including a comparison of alcohol use disorder with a ...
Kong Shanshan S State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, - - 2013
Cytoplasmic dynein 1 is fundamentally important for transporting a variety of essential cargoes along microtubules within eukaryotic cells. However, in mammals, few mutants are available for studying the effects of defects in dynein-controlled processes in the context of the whole organism. Here, we deleted mouse Dlic1 gene encoding DLIC1, a ...
Martinelli Erika - - 2013
The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of proliferation and survival in human cancer cells. Selective inhibitors of different transducer molecules in these pathways have been developed as molecular targeted anti-cancer therapies. The in vitro and in vivo anti-tumor activity of pimasertib, a selective MEK 1/2 inhibitor, alone ...
Sakamoto Yoshiaki - - 2013
Abstract The aetiology of scaphocephaly is often described as premature fusion of the sagittal suture. This study observed wave-like deformations in abnormally long and narrow skulls typical of scaphocephaly, and these deformations were divided into two types: type I deformations (one wave) and type II deformations (two waves). However, the ...
McCabe Janet - - 2013
AIM: To explore the experiences of nurses providing sexual health care to adolescents with physical and/or developmental disabilities, with attention to the institutional and social discourses that shape these interactions. BACKGROUND: Previous research has shown that nurses demonstrate a lack of attention to the impact of illness or disability on ...
Oberg Kim - - 2013
Orthogonally functionalized PEGs displaying alkenes and azides have been prepared and their dual-purpose scaffolding potential was exploited via click chemistry for controlled insertion of biorelevant moieties as well as facile fabrication of soft, non-toxic and degradable hydrogels.
Mehta Sahil - - 2013
A 55-year-old man with carcinoma sigmoid colon (fluorouracil [5-FU]: cumulative dose of 6,600 mg/m(2); and oxaliplatinum: 245 mg/m(2)) presented with encephalopathy and pancerebellar involvement 2 weeks after receiving a third cycle of chemotherapy. Brain MRI showed diffusion restriction in bilateral deep white matter, cerebellar peduncles, and splenium of corpus callosum ...
Tanner Tarja - - 2013
Abstract Objective. Oral health of young people has improved in the industrialized countries during past decades. However, stagnation of this progress has been reported recently. The main aim of this epidemiological study was to investigate the level of cariological treatment history and need (DMFT, DT) and polarization of dental caries ...
Balamurali Subramanian - - 2013
Transparent conducting Mn-doped ZnO thin films have been prepared by successive ionic layer by adsorption reaction (SILAR) method. The deposition conditions have been optimized based on their structure and on the formation of smoothness, adherence, and stoichiometry. The results of the studies by X-ray diffraction, scanning electron microscope (SEM), reveal ...
Shiba Norio - - 2013
The cryptic t(5;11)(q35;p15.5) creates a fusion gene between the NUP98 and NSD1 genes. To ascertain the significance of this gene fusion, we explored its frequency, clinical impact, and gene expression pattern using DNA microarray in pediatric acute myeloid leukemia (AML) patients. NUP98-NSD1 fusion transcripts were detected in 6 (4.8%) of ...
Tsachaki M - - 2013
BRI2, a protein mutated in Familial British and Familial Danish Dementias, interacts with Amyloid Precursor Protein (APP) and reduces the levels of secreted APPβ (sAPPβ), which derives from APP cleavage by β-secretase (BACE1). Exploring the mechanisms of this effect, we obtained data that BRI2 decreases the cellular levels of BACE1 ...
Lee Shih-Chieh - - 2013
stract The anti-diabetic effect of cinnamon has generated broad interest during the past decade. We investigated the hypoglycemic activity and pancreas-protective effect of leaf essential oil from indigenous cinnamon (CO) in diabetic rats induced with streptozotocin (STZ, i.v., 65 mg/kg bw) and found linalool to be the major component representing ...
Cao Xiong - - 2013
Astrocytes are key components of the niche for neural stem cells (NSCs) in the adult hippocampus and play a vital role in regulating NSC proliferation and differentiation. However, the exact molecular mechanisms by which astrocytes modulate NSC proliferation have not been identified. Here, we identified adenosine 5'-triphosphate (ATP) as a ...
Zhu Tao - - 2013
Chill in the light is the major environmental stress that cyanobacteria encounter in winter. Cyanobacterial cells may acquire chill-light tolerance upon exposure to low temperature in autumn and early winter. We sought to establish the efficacy of the dual-fluorescence method in detecting the viability of overwintering cyanobacteria and to provide ...
Rasheed S - - 2013
BACKGROUND: Malnutrition is prevalent in acute hospitals and malnourished patients have an increased risk of morbidity and mortality. Studies of malnutrition and quality of life (QoL) are generally limited by both the nutritional and QoL assessment methods employed. The present study aimed to evaluate the relationship between malnutrition, as assessed ...
Gillemot Katalin - - 2013
A combined experimental and theoretical investigation is carried out into the electrical transport across a fullerene dumbbell one-molecule junction. The newly designed molecule comprises two C60 s connected to a fluorene backbone via cyclopropyl groups. It is wired between gold electrodes under ambient conditions by pressing the tip of a ...
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