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Kloosterhof Nanne K - - 2013
Recent studies have indicated a prognostic role for genome-wide methylation in gliomas: Tumors that show an overall increase in DNA methylation at CpG sites (CIMP+; CpG island methylator phenotype) have a more favorable prognosis than CIMP- gliomas. Here, we have determined whether methylation profiling can identify more and clinically relevant ...
Kadib Abdelkrim El - - 2013
The self-assembly and sol-gel polymerisation of novel alkoxysilane-functionalized polymethylsiloxanes provide versatile access to nano-assembled containers, silica-based micro- and nano-architectures and dispersed mixed metal oxide hybrid materials.
Jalani Krishnendu - - 2013
A non-covalent, amphiphilic foldamer design leads to an efficient charge-transfer complex between dipyrene (donor) and naphthalene diimide (acceptor) derivatives, which further self-assembles into one-dimensional nanofibers with an alternate (mixed) donor-acceptor arrangement.
Shah Naman K - - 2013
OBJECTIVE: To characterise the epidemiology of Plasmodium falciparum gametocytemia and determine the prevalence, age structure and the viability of a predictive model for detection. METHODS: We collected data from 21 therapeutic efficacy trials conducted in India during 2009-2010 and estimated the contribution of each age group to the reservoir of ...
Medina Reinhold J - - 2013
Harnessing outgrowth endothelial cells (OECs) for vasoreparative therapy and tissue-engineering requires efficient ex-vivo expansion. How such expansion impacts on OEC function is largely unknown. In this study, we show that OECs become permanently cell-cycle arrested after ex-vivo expansion, which is associated with enlarged cell size, β-galactosidase activity, DNA damage, tumour ...
Mao Wuxiang - - 2013
Treatment of DNA containing 5-formylcytosine with hot piperidine produced a cleaved band at the position of 5-formylcytosine in DNA sequences. After oxidation with KRuO4, 5-hydroxymethylcytosine could also be detected using the same method. Using our strategy, we could detect 5-hydroxymethylcytosine and 5-formylcytosine respectively.
Hwang Tsong-Long - - 2013
Our previous studies identified an Fmoc-(S,R)-tryptophan-containing dipeptide derivative, , which selectively inhibited neutrophil elastase release induced by formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) in human neutrophils. In an attempt to improve pharmacological activity, a series of tryptophan-containing dipeptides were synthesized and their pharmacological activities were investigated in human neutrophils. Of these, five compounds , ...
Yunoki Kei - - 2013
Inflammation and oxidative stress play key roles in atherosclerotic plaque instability, and plaque rupture/erosion and subsequent thrombus formation constitute the principal mechanisms of total vessel occlusion and acute ST-elevation myocardial infarction (STEMI). Plaque disruption triggers the formation of initial platelet aggregates that grow in association with an increase in fibrin ...
Márquez Joana - - 2013
Random homozygous gene perturbation (RHGP), in combination with liver sinusoidal endothelial cell (LSEC) adhesion screening of clonal colon cancer cells with perturbed genes, was used to identify genes contributing to the hepatic microvascular adhesion of colon cancer cells. Plasmid vector encoding transactivator and GSV vector were transfected into HT-29 human ...
Ramos I P - - 2013
The development of cage fish farms has been associated with an increase in parasitic diseases. Organic matter resulting from feed waste and faeces attracts animals such as birds and invertebrates that can act as hosts for parasites. The aim of this study was to evaluate the influence of cage farming ...
Meggendorfer M - - 2013
Chronic myeloid malignancies are categorized to the three main categories myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and MDS/MPN overlap. So far, no specific genetic alteration profiles have been identified in the MDS/MPN overlap category. Recent studies identified mutations in SETBP1 as novel marker in myeloid malignancies, especially in atypical CML ...
Wu Hui - - 2013
In hepatocellular carcinomas (HCCs), the levels of histone H3 dimethylation at lysine 9 (H3K9me2) and its corresponding histone methyltransferase G9a are significantly elevated. Recently, G9a was reported to form a complex with the H3K9 methylation effector protein CDYL, but little is known about the expression of CDYL in HCC patients. ...
Tsamis K I - - 2013
Neostriatum is one of the brain areas that are not primarily affected in Alzheimer's disease, according to classic regard of the disease. However, recent data emphasize the involvement of neostriatum, especially the head of the caudate nucleus, in the emergence of characteristic symptoms of the disease. Glutamatergic neurotransmission is a ...
Gruber He - - 2013
IL-17 is expressed in a number of tissues including the intervertebral disc, where it exerts strong inflammatory properties. We evaluated IL-17 using immunolocalization in herniated and non-herniated human discs, IL-17 gene expression, and the production of IL-17 by annulus cells cultured in three dimensions in the presence of IL-1ß or ...
Jeon Kyeongman - - 2013
BACKGROUND AND OBJECTIVE: Previous studies have found evidence of an association between tuberculosis and vitamin D deficiency (VDD). However, the association between VDD and infection caused by nontuberculous mycobacteria (NTM) has never been studied. This study evaluated the prevalence and severity of VDD in NTM lung disease, and attempted to ...
Bauer J D - - 2013
BACKGROUND: Nutrition supplements enriched with immune function enhancing nutrients have been developed to aid wound-healing, although evidence regarding their effectiveness is limited and systematic reviews have lead to inconsistent recommendations. The present pragmatic, randomised, prospective open trial evaluated a wound-specific oral nutrition supplement enriched with arginine, vitamin C and zinc ...
Hulbert-Williams L - - 2013
BACKGROUND: Several cross-sectional studies have shown an association between exposure to life events and psychological problems in adults with intellectual disability (ID). To establish life events as a risk factor, prospective designs are needed. METHODS: Support staff informants provided data on the psychological problems of 68 adults with ID and ...
Runsten Silja - - 2013
Objective: Childhood adversities have been linked to elevated high-sensitivity C-reactive protein (hsCRP), which has been associated with increased morbidity. Low social support has been reported to worsen the prognosis in heart disease and cancer, and high social support has been linked to lower hsCRP. We hypothesized that social support could ...
Shaki Fatemeh - - 2013
Depleted uranium (DU) is emerging as an environmental pollutant primarily due to its military applications. Gulf War veterans with embedded DU showed cognitive disorders that suggest that the central nervous system is a target of DU. Recent evidence has suggested that DU could induce oxidative stress and mitochondrial dysfunction in ...
Lalmohamed Arief - - 2013
OBJECTIVES:Gastrointestinal (GI) bleeding may impose a serious threat in patients undergoing total hip or knee replacement (THR/TKR). The objectives of this study are to evaluate the timing of GI bleeding following THR/TKR and to determine the effect modification by proton pump inhibitor (PPI) use.METHODS:In a nationwide Danish cohort study, we ...
Yumani Dana Fj - - 2013
AIM: To determine the incidence and potential novel risk factors for catheter-associated bloodstream infections (CABSI) in neonates. METHODS: A retrospective study was conducted for infants admitted to the VU University Medical Center neonatal intensive care unit in 2007. RESULTS: One hundred and ninety six infants with a total of 369 ...
Huang Liying - - 2013
Novel WO3/g-C3N4 composite photocatalysts were prepared by a calcination process with different mass contents of WO3. The photocatalysts were characterized by thermogravimetric analysis (TG), powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS), high-resolution transmission electron microscopy (HRTEM), UV-vis diffuse reflection spectroscopy (DRS), X-ray photoelectron ...
Sana Dandara Emery Morais - - 2013
Herein, we evaluated cervical samples from normal tissue or HPV-infected tissue, to determine if the relative nuclear/cytoplasmic ratio (NA/CA) and the presence of nonclassical cytological criteria are a novel cytological criterion for the diagnosis of HPV. Significantly, larger NA/CA ratios were found for the HPV-ATYPIA+ and HPV+ATYPIA+ groups compared with ...
Li Xiao-Jian - - 2013
Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was readily achieved by conversion of them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air- and moisture-stable NiCl2(dppf) as a catalyst. Coupling ...
Wang Kui-Wu - - 2013
Complete and unambiguous (1) H and (13) C NMR chemical shift assignments for all-trans-retinal, 13-cis-retinal, 11-cis-retinal and 9-cis-retinal (1-4) have been established by means of two-dimensional COSY, HSQC, HMBC and NOESY spectroscopic experiments. Copyright © 2013 John Wiley & Sons, Ltd.
Zhao Jiong-Peng - - 2013
A new chiral 3D heterometallic coordination polymer [NaCo2()2(N3)·(MeOH)]∞ () ( = 2,6-pyridinedicarboxylate) was synthesized and characterized magnetically. Ferro- and antiferromagnetic interactions co-exist in , which results in a magnetic phase transition at the high temperature of 29 K.
Knobel Gaston - - 2013
We describe the first application of a Quick, Easy, Cheap, Effective, Rugged and Safe extraction technique to the capillary zone electrophoresis analysis of monohydroxylated metabolites of polycyclic aromatic hydrocarbons in milk. Complete resolution of 2-hydroxyfluorenene, 1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyphenanthrene and 9-hydroxyphenanthrene was accomplished in 4 minutes of electrophoretic run. Limits of ...
Michaud V - - 2013
Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were administered a single 20 mg oral dose of omeprazole on two occasions: with a single 600 mg efavirenz dose; and after a 17-day ...
Bhanuchandra M - - 2013
Ru(ii)-catalyzed intermolecular ortho-C-H amidation of weakly coordinating aromatic ketones with sulfonyl azides is reported. The developed reaction protocol can be extended to various substituted aromatic ketones to afford a wide range of desired C-N bond formation products in good yields.
Moelants Eva Av - - 2013
Cytokines and chemokines represent two important groups of proteins that control the human immune system. Dysregulation of the network in which these immunomodulators function can result in uncontrolled inflammation, leading to various diseases including rheumatoid arthritis (RA), characterized by chronic inflammation and bone erosion. Potential triggers of RA include autoantibodies, ...
Brehmer-Rinderer B - - 2013
BACKGROUND: Based on the idea of the Common Sense Model of Illness Representations by Leventhal as well as Lohaus's concepts of health and illness, a health behaviour model was designed to explain health behaviours applied by persons with intellectual disabilities (ID). The key proposal of this model is that the ...
Gassenmaier Maximilian - - 2013
In many solid tumors, cancer stem cells (CSC) represent a small cell population with tumor-initiating, self-renewal and differentiation potential, which can be identified by surface protein markers. No generally applicable markers are yet known for renal cell carcinoma (RCC). Two RCC cell lines (RCC-26, RCC-53) were found to differ widely ...
Nakayama Yosuke - - 2013
New and unknown electrocatalytic oxidation of water was found to occur on a nano-gold attached palladium electrode. Since the oxidation potential was negative enough to that of well-known normal oxidation of water to form O2, the direct use of water as a fuel, instead of alcohols, might be possible using ...
Kim Min-Jung - - 2013
  The tyrosine kinase inhibitor, nilotinib was examined for its inhibition of cytochrome P450s (CYPs) in human liver microsomes and in human CYPs expressed in a baculovirus-insect cell system. Nilotinib demonstrated preferential inhibition of CYP2C8-mediated paclitaxel 6α-hydroxylation, rosiglitazone hydroxylation and amodiaquine N-deethylation in human liver microsomes, with IC50 values of 0.4, ...
Yuwen Lei - - 2013
For biosynthesis of bacillamide C by Bacillus atrophaeus C89 associated with South China sea sponge Dysidea avara, it is hypothesized that decarboxylation from L-tryptophan to tryptamine could be performed before amidation by the downstream aromatic L-amino acid decarboxylase (AADC) to the non-ribosomal peptide synthetases (NRPS) gene cluster for biosynthesizing bacillamide ...
Wu Jianyang - - 2013
Helical carbon nanotubes with intentionally incorporated non-hexagonal defects have unexpectedly high toughness and plasticity, in addition to the well-recognized extreme elasticity. The obtained toughness approaches 5000 J g(-1) with decreasing spring radius. The high toughness originates from the plastic nanohinge formation as a result of distributed partial fractures. A strong ...
Rivera Gabriel - - 2013
A major focus of the field of organismal biology is to understand how morphology impacts performance. Although the functional implications of certain aspects of shape have been widely examined, the functional implications of a related parameter, symmetry, remain mostly unknown. We used finite-element models to examine the effects of turtle ...
Golnak Ronny - - 2013
Oxygen K-edge X-ray absorption, emission, and resonant inelastic X-ray scattering spectra were measured to site selectively gain insights into the electronic structure of aqueous zinc acetate solution. The character of the acetate ion and the influence of zinc and water on its local electronic structure are discussed.
Liu Jie - - 2013
A hairpin DNA probe mediated cascade signal amplification method was developed for visual and rapid DNA analysis with a detection limit of 100 aM. The implementation of tag/anti-tag DNA and gold nanoparticle reporters permits a universal platform for multiplex genotyping without instrumentation.
Malihi Z - - 2013
BACKGROUND: The primary objective of the present study was to assess changes in the nutritional status and quality of life in acute leukaemia patients, aged ≥15 years, who had undergone induction chemotherapy. METHODS: A preliminary and post-induction chemotherapy assessment of patients' nutritional status, quality of life, sociodemographic status and medical characteristics ...
Bartasyte Ausrine - - 2013
Phase composition of epitaxial/textured LiNbO3 films on sapphire substrates, grown by pulsed laser deposition, atmospheric pressure metal organic chemical vapor deposition and pulsed injection metal organic chemical vapor deposition was studied by conventional x-ray diffraction techniques. Raman spectroscopy, being highly sensitive to the symmetry of materials, was used as a ...
Yan Yigang - - 2013
Dodecaborates, i.e. the [B12H12](2-) containing species, are often observed as main intermediates in the hydrogen sorption cycle of metal borohydrides, hindering rehydrogenation. In the decomposition process of Y(BH4)3, yttrium octahydrotriborate, i.e. Y(B3H8)3, rather than the stable Y2(B12H12)3, is formed as the main intermediate.
van Houten E Leonie - - 2013
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is defined by two out of the following three criteria being met: oligo- or anovulation, hyperandrogenism, and polycystic ovaries. Affected women are often obese and insulin resistant. Although the etiology is still unknown, members of the Transforming Growth Factor beta (TGFbeta) family, including Bone Morphogenetic ...
van der Pol Peggy - - 2013
AIMS: To assess reliability and validity of self-reported cannabis dose and potency measures. DESIGN: Cross-sectional study comparing self-reports with objective measures of amount of cannabis and THC concentration. SETTING: Ecological study with assessments at participants' home or in a coffee shop. PARTICIPANTS: Young adult frequent cannabis users (n=106) from the ...
Koller Karin - - 2013
The transcription factor HOXB4 not only plays a role during nephrogenesis, but displays also oncogenic characteristics in different malignant neoplasms. An in-silico analysis revealed HOXB4 as a new target of microRNA-23a (miR-23a). Nephroblastomas are malignant embryonal renal neoplasms of childhood resembling developing kidney morphologically and genetically. In our study we ...
Martínez-Vázquez Francisco J - - 2013
In situ ring-opening polymerization of ε-caprolactone (ε-CL) was performed to coat β-tricalcium phosphate (β-TCP) scaffolds fabricated by robocasting in order to enhance their mechanical performance while preserving the predesigned macropore architecture. Concentrated colloidal inks prepared from β-TCP commercial powders were used to fabricate porous structures consisting of a three-dimensional mesh ...
Binks Bernard P - - 2013
We have studied the influence of adding propylene glycol to both aqueous dispersions of fumed silica nanoparticles and emulsions of paraffin liquid and water stabilized by the same particles. In the absence of oil, aerating mixtures of aqueous propylene glycol and particles yields either stable dispersions, aqueous foams, climbing particle ...
Jung Andrew K - - 2013
Developmental venous anomalies (DVA) are normally diminutive and incidental.(1,2) In this 33-year-old patient with epilepsy, the DVA is holohemispheric. Her epilepsy probably originates from the left side based on semiology; the EEG displayed left-sided slowing. Axial T1-weighted sequences show skull atrophy, ventricular widening, and satellite cavernous malformations with accumulation of ...
Gu Jinyu - - 2013
AIM: The aim of the study was to evaluate factors affecting postoperative outcomes after laparoscopic total abdominal colectomy (TAC) with end ileostomy (EI) for ulcerative colitis (UC). METHOD: Patients undergoing laparoscopic TAC/EI for severe UC/indeterminate colitis during 1998-2010 in our institution were retrospectively identified from a prospectively established database. Demographics, ...
Misra Rajneesh - - 2013
This article reports the design, and synthesis of D-pi1-A-pi2-D unsymmetrical, and D-pi1-A-pi2-A-pi1-D symmetrical type of ferrocenyl substituted benzothiadiazoles by the Pd-catalyzed Sonogashira, and Stille coupling reactions. The photophysical, and electrochemical behavior of the ferrocenyl substituted benzothiadiazoles show strong donor-acceptor interaction. The increase in the number of acceptor benzothiadiazole unit, results ...
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