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Results 301 - 350 of 4842
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Chiang Emily C - - 2013
The anti-cancer activity of organic selenium has been most consistently documented at supra-nutritional levels at which selenium-dependent, antioxidant enzymes are maximized in both expression and activity. Thus, there is a strong imperative to identify mechanisms other than antioxidant protection to account for selenium's anti-cancer activity. In vivo work in dogs ...
Yendrek Craig R - - 2013
Elevated ozone (O3 ) and limiting soil nitrogen (N) availability both negatively affect crop performance. However, less is known about how the combination of elevated O3 and limiting N affect crop growth and metabolism. In this study, we grew tobacco (Nicotiana sylvestris) in ambient and elevated O3 at two N ...
Emsell Louise - - 2013
OBJECTIVES: A broad range of subtle and markedly heterogenous neuroanatomical abnormalities of grey matter and white matter have been reported in bipolar disorder. Euthymic bipolar disorder patients represent a clinically homogenous group in which to identify trait-based biomarkers of bipolar disorder. In this study, we sought to clarify the nature ...
Vultur A - - 2013
Elevated activity of the mitogen-activated protein kinase (MAPK) signaling cascade is found in the majority of human melanomas and is known to regulate proliferation, survival and invasion. Current targeted therapies focus on decreasing the activity of this pathway; however, we do not fully understand how these therapies impact tumor biology, ...
Proietti Silvia - - 2013
Resistance conferred by biotrophic pathogens often requires salicylic acid (SA) signaling, whereas necrotrophic pathogens or wounding mainly activate the jasmonate/ethylene (JA/ET)-dependent pathway. Crosstalk connections between these two independent signaling pathways may lead to synergistic or antagonistic behavior. In order to shed some light on the crosstalk between these two hormones ...
Gibney Geoffrey T - - 2013
Introduction: The development of selective BRAF inhibitors in patients with metastatic BRAF V600 mutant melanoma has proven to be an effective therapeutic strategy. While vemurafenib was the first approved BRAF inhibitor for this indication, another selective BRAF inhibitor, dabrafenib , has demonstrated efficacy in patients with BRAF mutant melanoma, including ...
Menter T - - 2013
Some chemotherapeutic agents can cause iatrogenic lymphoproliferative disorders. In analogy to what has been observed with other nucleoside analogues such as cladribine and fludarabine, we document the first case of an Epstein-Barr virus-positive, iatrogenic immunodeficiency-associated, lymphoproliferative disease, formally resembling polymorphic post-transplant lymphoproliferative disease in a patient treated with azacitidine (Vidaza) ...
Mahrhold Stefan - - 2013
The highly specific binding and uptake of botulinum neurotoxins (BoNT/A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle membrane protein leads to neurotoxin endocytosis. The synaptic vesicle (glyco-)protein 2 (SV2) ...
Krasnow Max M - - 2013
Humans are often generous, even towards strangers encountered by chance and even in the absence of any explicit information suggesting they will meet again. Because game theoretic analyses typically conclude that a psychology designed for direct reciprocity should defect in such situations, many have concluded that alternative explanations for human ...
Turner Jill R - - 2013
Smoking is the largest preventable cause of death in the United States ADDIN EN.CITE <EndNote><Cite><Author>CDC</Author><Year>2007</Year><RecNum>286</RecNum><record><rec-number>286</rec-number><foreign-keys><key app="EN" db-id="epdr95affz2wsqeezr5pzrzofevvxxesexer">286</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>CDC</author></authors></contributors><titles><title>Cigarette smoking among adults--United States, 2006.</title><secondary-title>Morbid. Mortal. Wkly. Rep.</secondary-title></titles><periodical><full-title>Morbid. Mortal. Wkly. Rep.</full-title></periodical><pages>1157-61</pages><volume>56</volume><number>44</number><dates><year>2007</year></dates><urls></urls></record></Cite></EndNote>(CDC, 2007). Furthermore, a recent study found that less than 10% of quit attempts resulted in continuous abstinence for one yearADDIN ...
Bartfai Tamas - - 2013
The task of finding selective and stable peptide receptor agonists with low molecular weight, desirable pharmacokinetic properties and penetrable to the blood-brain barrier has proven too difficult for many highly coveted drug targets, including receptors for endothelin, vasoactive intestinal peptide and galanin. These receptors and ligand-gated ion channels activated by ...
Melzer Christian - - 2013
The temporal evolution of the surface-potential distribution in the channel of pentacene based field-effect transistors is investigated during the charge reversal from the electron to the hole dominated operation. This measurement allows for the determination of the carrier density and electric field dependent hole mobility in the sub-threshold regime of ...
Kawasaki Yohei - - 2013
In drug development, non-inferiority tests are often employed to determine the difference between two independent binomial proportions. Many test statistics for non-inferiority are based on the frequentist framework. However, research on non-inferiority in the Bayesian framework is limited. In this paper, we suggest a new Bayesian index τ = P(π1  > π2  - Δ0 ...
Kapur R P - - 2013
An accurate determination of the number of neurons in a segment of bowel is fundamental to establish population norms and identify neurodegenerative conditions, including age-related loss of myenteric ganglion cells. Although the latter phenomenon has been observed by several laboratories in various mammals, in this issue of Neurogastroenterology and Motility, ...
Ruiz-Rodríguez M - - 2013
The use of compounds produced by symbiotic bacteria against pathogens in animals is one of the most exciting discoveries in ecological immunology. The study of those antibiotic metabolites will enable an understanding of the defensive strategies against pathogenic infections. Here, we explore the role of bacteriocins explaining the antimicrobial properties ...
Riederer Beat M - - 2013
Most medical curricula rely on human bodies for teaching macroscopic anatomy. Over the past 20 years, plastination has become an important means of preservation of organs, for well dissected specimens or for body slices. Here, several critical points regarding body donation with legal and ethical considerations for long-term preservation, the use ...
Vermeulen Marion - - 2013
BACKGROUND: Several comparison studies showed that the Ultrio assay (Novartis Diagnostics) used in individual-donation nucleic acid amplification testing (ID-NAT) format was as sensitive as the TaqScreen assay (Roche) on minipools of six donations (MP6), but the sensitivity of HBV DNA detection has been improved in the new Ultrio Plus version ...
Mallajosyula V Vamsee Aditya - - 2013
The conserved 'stem' domain of influenza virus hemagglutinin (HA) is a target for broadly neutralizing antibodies (bnAbs) and a potential vaccine antigen for induction of hetero-subtypic protection. The epitope of 12D1, a previously reported bnAb neutralizing several H3 subtype influenza strains, was putatively mapped to residues 76-106 of the CD-helix, ...
Bednarska Agnieszka J - - 2013
We discuss herein the importance of selected natural abiotic and biotic factors in ecological risk assessment based on simplistic laboratory bioassays. Although it is impossible to include all possible natural factors in standard lower-tier ecotoxicological testing, neglecting them is not an option. Therefore, we try to identify the most important ...
Ni Yusu - - 2013
Objective: To explore the feasibility of constructing a functional biomaterial complex with regenerated silk fibroin membrane and immortalized chondrocytes in vivo. Methods: RACs (rat auricular chondrocytes) were transfected with the lentivirus vector pGC-FU-hTERT-3FLAG or pGC-FU-GFP-3FLAG, encoding the human telomerase reverse transcriptase (hTERT) or GFP gene. The effects of regenerated silk ...
Amato A - - 2013
Fetal hemoglobin may be slightly or significantly elevated in post-natal life due to a number of causes. We report two novel mutations found on the promoter of the Aγ gene and summarize all common and rare determinants associated with hereditary persistence of fetal hemoglobin (HPFH) described thus far. Hematological and ...
Visegrády András - - 2013
Introduction: G-protein-coupled receptors (GPCRs) form one of the largest groups of potential targets for novel medications. Low druggability of many GPCR targets and inefficient sampling of chemical space in high-throughput screening expertise however often hinder discovery of drug discovery leads for GPCRs. Fragment-based drug discovery is an alternative approach to ...
Kyula J N - - 2013
Melanoma is an aggressive skin cancer that carries an extremely poor prognosis when local invasion, nodal spread or systemic metastasis has occurred. Recent advances in melanoma biology have revealed that RAS-RAF-MEK-ERK signaling has a pivotal role in governing disease progression and treatment resistance. Proof-of-concept clinical studies have shown that direct ...
Rocco Mariapina - - 2013
Plants, as sessile organisms, are continuously exposed to temperature changes in the environment. Low and high temperature stresses have a great impact on agricultural productivity, since they significantly alter plant metabolism and physiology. Plant response to temperature stress is a quantitative character, being influenced by the degree of stress, time ...
Aalberse J A - - 2013
BACKGROUND: Replacement of peanut extracts by recombinant peanut components is an important step in allergy serologic testing. Criteria are needed for the unbiased inclusion of patients into a study to validate such a replacement. METHODS: Plasma samples from 64 peanut-positive children (42 reactors, 22 nonreactors in a double-blind, placebo-controlled food ...
Clayton S B - - 2013
BACKGROUND: Non-obstructive Dysphagia (NOD) is one of the most common symptoms evaluated using esophageal manometry. Although manometry is considered the gold standard, many NOD patients have normal evaluations. Esophageal function testing with combined multichannel intraluminal impedance and esophageal manometry (MII-EM) is performed using ten 5-mL swallows of a liquid and ...
Otto Jens - - 2013
Purpose: Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices, have to include the impact of strain on stretchability and effective porosity. ...
Inoue Takuya - - 2013
BACKGROUND: Perforation is a major complication of endoscopic resection for gastrointestinal neoplasms. However, little is known about delayed perforation after endoscopic resection for non-ampullary duodenal neoplasm. The aim of the present study was to investigate the clinical features of delayed perforation after endoscopic resection for non-ampullary duodenal neoplasm. PATIENTS AND ...
Watanabe Gen - - 2013
The first regiocontrolled synthesis of procyanidin B6, a dimer with a rare 4,6-interflavan linkage, is described. Regioselective linking was achieved by the halo-capping strategy followed by removal of all the benzyl protecting groups and the halo-caps by one-pot hydrogenolysis.
Zhang Wen Wen - - 2013
BACKGROUND: Stroke rehabilitation is regarded as an essential component of organized care, therefore withholding treatment is considered unethical in Western trials. Poststroke rehabilitation is not standard in China, and trials with no treatment controls have been possible. We believed aggregation of these data represented a unique opportunity to examine the ...
Gamys Cé Guinto - - 2013
This review deals with nanoporous materials made from the self-assembly of block copolymers with a special interest in the chemical functions covering the surface of their nanopores. A detailed overview of the existing methods and strategies to generate well-defined organic functional groups covering the surface of the pore walls is ...
Johannesdottir Sa - - 2013
Abstract Objective: Health resource utilization (HRU) and outcomes associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are not well described. We therefore conducted a population-based cohort study to characterize patients hospitalized with AECOPD with regard to HRU, mortality, recurrence, and predictors of readmission with AECOPD. Methods: Using Danish ...
Mains Jenifer - - 2013
Beta-adrenocepetor antagonists (beta-blockers) alter the nanostructure of lysozyme amyloids, resulting in different drug release profiles.
Zhang J Y - - 2013
BACKGROUND: Dyschromatosis symmetrica hereditaria (DSH) is characterized by the presence of hyperpigmented and hypopigmented macules mostly on the dorsal aspects of the extremities. Mutations in adenosine deaminase acting on RNA 1 (ADAR1) gene have been revealed to be the causation of DSH. ADAR1gene is known to give rise to two ...
Jin Zuolin - - 2013
BACKGROUND: Maxillofacial-oral injuries is a serious health problem in China. The main aetiologic factors and types of maxillofacial-oral injuries differ according to different geographical areas and socio-economic statuses of populations in different countries or within the same country. AIM: The aim of this study was to analyze the types and ...
Eichel Andrea - - 2013
Abstract Objectives: In this observational study, data on the efficacy, effects on quality of life and the tolerability of the topical formulation SNS01 (Ectoin Rhinitis nasal spray 1 ) were compared to those of BNO-101 (Sinupret forte dragées 2 ) in patients with acute rhinosinusitis in the ear, nose, and ...
Xing Huaiyong - - 2013
The clinical potentials of radiotherapy could not be achieved completely because of the inaccurate positioning and inherent radioresistance of tumours. In this study, a novel active-targeting upconversion theranostic agent (arginine-glycine-aspartic acid-labelled BaYbF5: 2% Er(3+) nanocube) was developed for the first time to address these clinical demands. Heavy metal-based nanocubes (~10 nm) ...
Allan Ian J - - 2013
The applicability of silicone rubber and low density polyethylene (LDPE) as passive sampling materials for target and non-target analyses of moderately polar and non-polar substances was assessed through a field deployment of samplers along a small polluted stream in Oslo (Norway). Silicone and LDPE samplers of identical surface area (but ...
Li Lin Z - - 2013
Conventional methods for the analysis of in vivo hyperpolarized (13) C NMR data from the lactate dehydrogenase (LDH) reaction usually make assumptions on the stability of rate constants and/or the validity of the two-site exchange model. In this study, we developed a framework to test the validity of the assumption ...
Suen J L - - 2013
BACKGROUND: Exposure to environmental hormones, such as alkylphenols, has been suggested to be associated with the development of asthma, but the mechanism of action remains unclear. OBJECTIVE: This study examined the effect of 4-nonylphenol (NP), one of the most important alkylphenols, on conventional dendritic cells (cDCs) and adaptive T-cell responses. ...
Ramdani Diky - - 2013
This study characterized the chemical composition of green and black teas as well as their spent tea leaves (STL) following boiling in water with different tea-to-water ratios. The green and black tea leaves had statistically similar (g/kg DM, unless stated otherwise) DM (937 vs 942 g/kg sample), crude protein (240 ...
Chung Ill-Min - - 2013
Accelerator mass spectrometry (AMS) is the ultimate technique for measuring rare isotopes in small samples. Biological and biomedical applications of (14)C-AMS (bio-(14)C-AMS) commenced in the early 1990s and are now widely used in many research fields including pharmacology, toxicology, food, and nutrition. For accurate, precise, and reproducible bio-(14)C-AMS analysis, the ...
Logsdail Andrew J - - 2013
The structural preferences of nanoparticles are important for understanding their chemical properties and potential applications, and remain widely debated. Based on recent experimental observations, we present calculations on the stability of high-symmetry AuN and PdN clusters of various structural motifs, performing a systematic search of faceting preferences using mathematical constructs, ...
Cho Hongsik - - 2013
The intervertebral disc is composed of load-bearing fibrocartilage that may be subjected to compressive forces up to 10 times the body weight. The multilaminated outer layer, the annulus fibrosus (AF), is vulnerable to damage and its regenerative potential is limited, sometimes leading to nuclear herniation. Scaffold-based tissue engineering of AF ...
Persson Elisabeth - - 2013
Abstract Background: Knowledge of the diversity of occupational problems perceived by people with chronic pain is insufficient. Aims: To describe everyday occupational problems among patients with musculoskeletal pain enrolled in a pain rehabilitation programme, and to compare subgroups based on participant characteristics. Methods: The sample consisted of 152 men and ...
Frank Steven M - - 2013
BACKGROUND: A necessary component of an effective blood management program is the accurate and comprehensive collection and analysis of blood utilization data. This study describes innovative methods for analyzing and presenting data for red blood cell (RBC) utilization that compare hemoglobin (Hb) transfusion triggers and targets to those representing the ...
Chen Y-H - - 2013
Pilocytic astrocytoma (PA) is the most common glial cell tumor arising in children. Sporadic cases are associated with KIAA1549:BRAF fusion rearrangements, while 15-20% of children develop PA in the context of the neurofibromatosis 1 (NF1) inherited tumor predisposition syndrome. The unique predilection of these tumors to form within the optic ...
Gholipour Behrad - - 2013
Non-volatile, bidirectional, all-optical switching in a phase-change metamaterial delivers high-contrast transmission and reflection modulation at near- to mid-infrared wavelengths in device structures down to ≈(1) /27 of a wavelength thick.
Mendoza-González Gabriela - - 2013
Climate change (CC) and sea level rise (SLR) are phenomena that could have severe impacts on the distribution of coastal dune vegetation. To explore this we modeled the climatic niches of six coastal dunes plant species that grow along the shoreline of the Gulf of Mexico and the Yucatan Peninsula, ...
Hermont Ana Paula - - 2013
OBJECTIVE: To compare the occurrence of tooth erosion (TE) and dental caries (DC) in adolescents with and without risk behavior for eating disorders (EDs). METHOD: A controlled cross-sectional study involving 1,203 randomly selected female students aged 15-18 years was conducted in Brazil. Risk behavior for EDs was evaluated through the ...
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