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Results 251 - 300 of 4842
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Dimitra Sali - - 2013
Mild cognitive impairment (MCI) is recognized as a precursor to dementia. The amnestic MCI progresses usually to Alzheimer disease. Amnestic MCI multiple domain (md-MCI) seems to progress more rapidly than amnestic MCI single domain (a-MCI). In an attempt to identify patients at risk, we examined white matter changes in MCI ...
Martinez de Albornoz Pilar - - 2013
PURPOSE: To ascertain whether changing position and size of the spacer may modify the load and displacement of the tibial plateau when performing an opening wedge high tibial osteotomy. METHODS: Fifteen sawbones tibia models were used. In the axial plane, the anterior, medial, and posterior thirds of the tibial plateau ...
Min Kyoungseon - - 2013
In this study, a novel system for synthesis of 2-butanone from levulinic acid (γ-keto-acid) via an enzymatic reaction was developed. Acetoacetate decarboxylase (AADC; E.C. 4.1.1.4) from Clostridium acetobutylicum was selected as a biocatalyst for decarboxylation of levulinic acid. The purified recombinant AADC from Escherichia coli successfully converted levulinic acid to ...
Maxwell Christina R - - 2013
Abnormal brain oscillatory activity has been found in autism spectrum disorders (ASD) and proposed as a potential biomarker. While several studies have investigated gamma oscillations in ASD, none have examined resting gamma power across multiple brain regions. This study investigated resting gamma power using EEG in 15 boys with ASD ...
Yin Lanning - - 2013
Glycolytic pyruvate kinase isoenzyme type M2 (M2-PK) plays a key role in tumor metabolism and energy production. Vascular endothelial growth factor (VEGF) is critical in regulating angiogenesis which is an essential process required for tumor growth and metastasis. These two genes may function in accordance with tumor development. The purpose ...
King Adam C AC Department of Kinesiology, The Pennsylvania State University, 23 Rec Building, University Park, PA 16802, USA. - - 2013
This experiment was set up to investigate the influence of constant and variable practice on performance accuracy and the time- and frequency-dependent structure of the force output dynamics in the learning of an irregular isometric force pattern. Traditional approaches to the variability of practice hypothesis have demonstrated benefits of task-induced ...
Ghang Yoo-Jin YJ Department of Chemistry, School of Medicine, University of California, Riverside, California 92521, - - 2013
A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells.
Kaklamani Virginia G VG Division Hematology/Oncology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA. - - 2013
Adiponectin, a protein secreted by the adipose tissue, is an endogenous insulin sensitizer with circulating levels that are decreased in obese and diabetic subjects. Recently, circulating levels of adiponectin have been correlated with breast cancer risk. Our previous work showed that polymorphisms of the adiponectin pathway are associated with breast ...
Hong Chi-Chen CC Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. - - 2013
Immune signatures in breast tumors differ by estrogen receptor (ER) status. The purpose of this study was to assess associations between ER phenotypes and circulating levels of cytokines that co-ordinate cell-mediated [T-helper type 1 (Th1)] and humoral [T-helper type 2 (Th2)] immunity. We conducted a case-case comparison of 523 women ...
Ginige Maneesha P - - 2013
Managed aquifer recharge offers the opportunity to manage groundwater resources by storing water in aquifers when in surplus and thus increase the amount of groundwater available for abstraction during high demand. The Water Corporation of Western Australia (WA) is undertaking a Groundwater Replenishment Trial to evaluate the effects of recharging ...
Aldo Paulomi B - - 2013
PROBLEM: Macrophage function has many implications in a variety of diseases. Understanding their biology becomes imperative when trying to elucidate immune cell interactions with their environment, and in vitro cell lines allow researchers to manipulate these interactions. A common cell line used is THP-1, a promyeloid cell line suggestive to ...
Zhao Wei-Hua - - 2013
microRNA-124 (miR-124) plays an important role in regulating growth, invasiveness, stem-like traits, differentiation and apoptosis of glioblastoma cells. PPP1R3L, an inhibitory member of the apoptosis-stimulating protein of p53 family (IASPP), is also able to affect growth, cell cycle progression, metastasis and apoptosis of various types of cancer. To investigate the ...
Zaslavsky Boris G - - 2013
The author considers studies with multiple dependent primary endpoints. Testing hypotheses with multiple primary endpoints may require unmanageably large populations. Composite endpoints consisting of several binary events may be used to reduce a trial to a manageable size. The primary difficulties with composite endpoints are that different endpoints may have ...
Abe Takaya - - 2013
The use of live imaging approaches to examine and understand the dynamic processes that take place during mouse development has become widespread. Several groups have reported their success in generating different reporter mouse lines that express a variety of fluorescent markers for imaging. However, there is currently no established database ...
Hamada Tsuyoshi - - 2013
BACKGROUND: Feasibility of antireflux metal stent (ARMS), designed to prevent duodenobiliary reflux, was reported in patients with distal malignant biliary obstruction. In this prospective pilot study, we aimed to evaluate a newly designed ARMS as a reintervention for self-expandable metallic stent (SEMS) occlusion believed to be caused by duodenobiliary reflux. ...
Waters Karen - - 2013
AIM: To evaluate the ability of lateral airway radiography (LAR) to assess adenoidal hypertrophy in children and correlate with the severity of obstructive sleep apnoea (OSA). METHODS: This cohort study was undertaken in 72 children who presented consecutively for evaluation of OSA to the outpatients of the Children's Hospital at ...
Cheng Lei - - 2013
A methanogenic hexadecane-degrading consortium designated SK originating from the Shengli oilfield was cultured at 55°C. The structure and dynamics of the microbial community during successive transfers were examined using terminal restriction fragment length polymorphism (T-RFLP) fingerprinting and sequencing of 16S rRNA gene fragments. The archaeal community was mainly composed of ...
Laval S - - 2013
Given the failure of chemo- and biotherapies to fight advanced pancreatic cancer, one major challenge is to identify critical events that initiate invasion. One priming step in epithelia carcinogenesis is the disruption of epithelial cell anchorage to the basement membrane which can be provided by hemidesmosomes (HDs). However, the existence ...
Li Zhong-Hua - - 2013
Histone deacetylases (HDACs) are overexpressed in various types of primary human cancer and have become attractive targets for cancer therapy. We designed and synthesized a series of new class of HDAC inhibitors (HDACi). Among these, S-(E)-3-(1-(1-(benzo[d]oxazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide (NK-HDAC-1) showed potent antitumor activity. In the present study, we examined the antitumor effects ...
Casamayor Emilio O - - 2013
The Monegros desert contains one of the largest sets of inland saline lakes in Europe constituting a threatened landscape of great scientific and ecological value with large number of reported endemisms. We analyzed bacteria, archaea and microbial eukaryotes from 11 saline lakes in winter and spring by rRNA gene fingerprinting ...
Buatois L A - - 2013
The extensive matgrounds in Carboniferous-Permian open-marine deposits of western Argentina constitute an anachronistic facies, because with the onset of penetrative bioturbation during the early Paleozoic microbial mats essentially disappeared from these settings. Abundant microbially induced sedimentary structures in the Argentinean deposits are coincident with the disappearance of trace and body ...
Capalbo Gianni - - 2013
The gene product of the zinc finger CCCH-type containing 15 (ZC3H15) gene, an immediate early erythropoietin response gene (synonymous: LEREPO4), was further characterized. ZC3H15 was expressed ubiquitously in all human tissues tested by northern blotting and showed mainly a diffuse cytoplasmic distribution by immune fluorescence microscopy and western blotting of ...
Ni Shao-Qing - - 2013
Aim:To develop a population pharmacokinetic model for the immunosuppressant ciclosporin in Chinese children with aplastic anemia and to identify covariates influencing ciclosporin pharmacokinetics.Methods:A total of 102 children with either acquired or congenital aplastic anemia aged 8.8±3.6 years (range 0.9-17.6 years) were included. Therapeutic drug monitoring (TDM) data for ciclosporin were ...
Mizuno Toshiaki - - 2013
This paper focuses on an overview of radioactive cesium 137 (quasi-Cs137 included Cs134) contamination of freshwater fish in Fukushima and eastern Japan based on the data published by the Fisheries Agency of the Japanese Government in 2011. In the area north and west of the Fukushima Nuclear plant, freshwater fish ...
Abdel-Raheem Ihab T - - 2013
Doxorubicin is a chemotherapeutic drug used to treat solid and haematopoietic tumours. Its use is limited by a major side effect of cardiotoxicity. It was reported that doxorubicin-induced cardiotoxicity is mediated through oxidative stress coupled with impaired NO bioavailability and NF-κB activation. Nicorandil, a mitochondrial ATP-dependent potassium (KATP ) channel ...
Van Laer Liesbeth - - 2013
In the Noorderkempen (NW Belgium), a large area (about 280 km(2)) is contaminated with cadmium (Cd) and zinc (Zn) due to historical pollution by the Zn smelters. Direct aquatic emissions of metals have diminished over time, however the surface water metal concentration largely exceeds quality standards, mainly during winter periods. ...
Reich K - - 2013
BACKGROUND: Continuous maintenance therapy with infliximab 5 mg/kg every 8 weeks is effective for moderate-to-severe plaque-type psoriasis. OBJECTIVE: This study evaluated efficacy and safety of continuous versus intermittent infliximab maintenance therapy. METHODS: RESTORE2 was a long-term extension of RESTORE1. At baseline of RESTORE2, eligible patients who had received infliximab for ...
Palmer Biff F - - 2013
Objective: Given the epidemic of obesity worldwide there is a need for more novel and effective weight loss methods. Altitude is well known to be associated with weight loss and has actually been used as a method of weight reduction in obese subjects. This review demonstrates the critical role of ...
Kamal Md Zahid - - 2013
Studying alterations in biophysical and biochemical behavior of enzymes in the presence of organic solvents and the underlying cause(s) has important implications in biotechnology. We investigated the effects of aqueous solutions of polar organic solvents on ester hydrolytic activity, structure and stability of a lipase. Relative activity of the lipase ...
Van den Brink Paul J - - 2013
This paper presents a framework to diagnose and predict the effects of chemicals, integrating two promising tools to incorporate more ecology into ecological risk assessment, viz. traits-based approaches and ecological modelling. Traits-based approaches are increasingly used to derive correlations between the occurrence of species traits and chemical exposure from biological ...
Sharma Vinay - - 2013
Ion radius and charge density are important parameters that determine the solvation behavior in aqueous electrolyte solutions. Here, we report on high precision THz absorption measurements of solvated LaCl3 and LaBr3 using narrow-band (75-90 cm(-1)) p-Ge laser and wideband (30-350 cm(-1)) Fourier transform spectroscopy. The concentration dependent absorption up to ...
Sawada Toshiki - - 2013
Peptides that specifically bind to the simplest polycyclic aromatic hydrocarbon, naphthalene, were obtained by affinity-based screening using a phage-displayed peptide library. The identified peptide with a β-turn structure showed specific binding to naphthalene present not only on substrates but also in aqueous solutions.
Kim Steve S - - 2013
Achieving highly enriched single wall carbon nanotubes (SWNTs) is one of the major hurdles today because their chirality-dependent properties must be uniform and predictable for use in nanoscale electronics. Due to the unique wrapping and groove-binding mechanism, DNA has been demonstrated as a highly specific SWNT dispersion and fractionation agent, ...
Ward Jennifer - - 2013
BACKGROUND: Reducing dietary salt intake lowers blood pressure and proteinuria, both of which are beneficial in preventing renal disease progression. Hospital meals are often accompanied by salt sachets, providing patients with additional salt. OBJECTIVES: The aim of this study was to determine the effects of salt sachet provision by request ...
Setyawan Juliana - - 2013
Abstract Objective: To assess treatment adherence in attention deficit/hyperactivity disorder (ADHD) patients initiated on Lisdexamfetamine (LDX) versus other FDA-approved stimulants and non-stimulant medications. Methods: ADHD patients initiated on an ADHD medication (index medication) were selected from a large US administrative claims database. Based on age and previous treatment status, patients ...
Mehal Jason M - - 2013
Our objective was to examine trends and epidemiology of amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) associated deaths in the United States. ALS/MND associated death rates and trends in the United States for 1999-2009 were examined using the multiple cause-of-death mortality data. Age-specific and age-adjusted death rates were calculated. For ...
Ilhan-Mutlu Ayseguel - - 2013
Myxopapillary ependymoma (MPE) is a rare tumor of the distal spinal cord. Despite benign histopathology, local recurrences occur in ~30 % of patients and distant metastases have been described in few cases. MPE tumor cells typically express glial fibrillary acidic protein (GFAP), which could be released to the circulation. In this ...
Ferreira Victor H - - 2013
PROBLEM: It is unknown whether viral replication or viral components that subvert innate responses in other cells, specifically the virion host shutoff (VHS) protein, play a role in determining primary genital epithelial cell (GEC) innate antiviral responses. METHOD OF STUDY: Cultures of primary female GECs were exposed to wildtype (WT), ...
Bezinelli Letícia Mello - - 2013
Oral mucositis (OM) is one of the side effects of hematopoietic stem cell transplantation (HSCT), resulting in major morbidity. The aim of this study was to determine the cost-effectiveness of the introduction of a specialized oral care program including laser therapy in the care of patients receiving HSCT with regard ...
Fallouh Nabil - - 2013
Perioperative statin therapy has come to represent a cornerstone of risk reduction for millions of patients who undergo cardiac and noncardiac surgeries. While large-scale, robust, randomized controlled studies support the use of statins in cardiac surgery, their role in noncardiac surgery has become ambiguous following concerns regarding scientific misconduct in ...
Park Jonghoo - - 2013
Time-of-flight (TOF) mass spectrometry has been considered as the method of choice for mass analysis of large intact biomolecules, which are ionized in low charge states by matrix-assisted-laser-desorption/ionization (MALDI). However, it remains predominantly restricted to the mass analysis of biomolecules with a mass below about 50,000 daltons. This limitation mainly ...
Amer Motassem S - - 2013
Objectives: Sleep complaints are common among elderly, especially institutionalized elderly, as they experience poorer sleep quality and higher use of sedative hypnotics, when compared to community-dwelling elderly. Recent findings suggest that there may be a relationship between poor quality of sleep and cognitive deficits. This study aimed at studying the ...
Bhargava Vipul - - 2013
We developed a novel Designed Primer-based RNA-sequencing strategy (DP-seq) that uses a defined set of heptamer primers to amplify the majority of expressed transcripts from limiting amounts of mRNA, while preserving their relative abundance. Our strategy reproducibly yielded high levels of amplification from as low as 50 picograms of mRNA ...
von Hanno Therese - - 2013
Purpose:  To describe the association between retinal vascular calibres and cardiovascular risk factors. Methods:  Population-based cross-sectional study including 6353 participants of the Tromsø Eye Study in Norway aged 38-87 years. Retinal arteriolar calibre (central retinal artery equivalent) and retinal venular calibre (central retinal vein equivalent) were measured computer-assisted on retinal photographs. ...
Liu Yajie - - 2013
Melatonin is an endogenous hormone with neuroprotective effects. Melatonin levels in elderly patients are reduced following surgeries that require anaesthesia. Whether reduced melatonin levels are important for postoperative cognitive dysfunction (POCD) remains unclear. Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these ...
Lü Xiao-Tao - - 2013
Human activities have significantly altered nitrogen (N) availability in most terrestrial ecosystems, with consequences for community composition and ecosystem functioning. While studies of how changes in N availability affect biodiversity and community composition are relatively common, much less is known about the effects of N inputs on the coupled biogeochemical ...
Tripathi P - - 2013
NFAT (the nuclear factor of activated T cells) upregulation has been linked to cellular transformation intrinsically, but it is unclear whether and how tissue cells with NFAT activation change the local environment for tumor initiation and progression. Direct evidence showing NFAT activation initiates primary tumor formation in vivo is also ...
Lu Qiaozhi - - 2013
Cellular metabolic activity, especially mitochondrial metabolism, plays a vital role in regulating cell proliferation and differentiation. Metabolism could therefore be an important factor to consider when using engineering technologies to stimulate tissue development and repair. The small metabolite carnitine and its derivative acetylcarnitine affect the activities of several pathways in ...
Maetani Iruru - - 2013
BACKGROUND: Usually, uncovered self-expandable metallic stents (SEMS) are used for palliation of malignant gastric outlet obstruction (GOO). A triple-layered covered SEMS is reported to be efficacious, but its performance has not been compared with uncovered SEMS. The present study is the first to compare the efficacy and safety of a ...
Sinha Nihal - - 2013
Impulse control disorders (ICDs) and apathy are recognized as two important neuropsychiatric syndromes associated with Parkinson's disease (PD), but as yet we understand very little about the cognitive mechanisms underlying them. Here, we review emerging findings, from both human and animal studies, that suggest that impulsivity and apathy are opposite ...
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