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Results 451 - 500 of 4842
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Yuan Lei - - 2013
BACKGROUND: With a well-developed strategy of acute graft-versus-host disease (aGVHD) prophylaxis, the prognosis of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who develop aGVHD has improved considerably. Meanwhile, transfusion-associated GVHD (TA-GVHD) can be fatal. Recent advancements in immune cellular therapy are being adopted in clinical practice, although many concerns including ...
De Ryck A - - 2013
OBJECTIVE: With a prevalence that varies between 20% and 65%, poststroke depression (PSD) is a frequent sequel of stroke. The aim of this study was to determine incidence and risk factors for PSD 18 months after stroke. METHODS: As part of the Middelheim Interdisciplinary Stroke Study, patients were followed up for ...
Smith Cameron B - - 2013
INTRODUCTION: Both voluntary and evoked conditioning contractions will potentiate muscle twitch contractile properties. The response of a voluntary contraction to each condition type is not well understood and may be a more functional model than evoked twitch potentiation. METHODS: Baseline measurements from tibialis anterior were: maximal isometric twitch torque and ...
Appoloni Aline Helena - - 2013
OBJECTIVE: To analyze the human response of delayed surgical recovery, approved by NANDA-I, and to validate its defining characteristics (DCs) and related factors (RFs). METHOD: This was a two-part study using a concept analysis based on the method of Walker and Avant, and diagnostic content validation based on Fehring's model. ...
Meghwal Murlidhar - - 2013
Black pepper (Piper nigrum L.) is a very widely used spice, known for its pungent constituent piperine. However, in addition to its culinary uses, pepper has important medicinal and preservative properties, and, more recently, piperine has been shown to have fundamental effects on p-glycoprotein and many enzyme systems, leading to ...
Hesselbjerg Louise Justesen - - 2013
Abstract Objective Dabigatran was the first of a new generation of anticoagulation drugs for the indication non-valvular atrial fibrillation (AF) to be approved. Evidence show that dabigatran 150mg twice daily significantly reduces risk of stroke and systemic embolism (RR 0.65; p<0.001) and shows a comparable rate of major bleedings (RR ...
Watkins Rochelle E - - 2013
BACKGROUND: National notification data for sexually transmitted infections (STIs) and blood borne viruses (BBVs) continue to have a high proportion of missing data on Indigenous status, potentially biasing estimates of notification rates by Aboriginality. We evaluated the use of data linkage to improve the accuracy of estimated notification rates for ...
Shingler Sl - - 2013
Abstract Objective Most incidences of basal cell carcinoma are cured by a number of surgical or non-surgical treatments. However, a few patients have lesions which have metastasised or progressed to an extent that surgery or other treatment options are not possible. The lesions associated with advanced basal cell carcinoma (aBCC) ...
Ohbayashi Ryudo - - 2013
The freshwater cyanobacterium Synechococcus elongatus PCC 7942 exhibits light-dependent growth. Although it has been reported that DNA replication also depends on light irradiation in S. elongatus 7942, the involvement of the light in the regulation of DNA replication remains unclear. To elucidate the regulatory pathway of DNA replication by light, ...
Martínez-Íñigo David - - 2013
Background: This investigation focuses on what occurs to individuals' self-regulatory resource during controlled Interpersonal Affect Regulation (IAR) which is the process of deliberately influencing the internal feeling states of others. Combining the strength model of self-regulation and the resources conservation model, the investigation tested whether: (1) IAR behaviors are positively ...
Wang Xiaofang - - 2013
Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit in the Three Gorge Reservoir (TGR). In the present study, we investigated the endocrine disrupting effects of di-(2-ethylhexyl)-phthalate (DEHP), on the Chinese rare minnow (Gobiocypris rarus), an endemic fish distributing upstream waters in ...
Stowell Sean R - - 2013
BACKGROUND: Red blood cell (RBC) alloantibodies to nonself antigens may develop after transfusion or pregnancy, leading to morbidity and mortality in the form of hemolytic transfusion reactions or hemolytic disease of the newborn. A better understanding of the mechanisms of RBC alloantibody induction, or strategies to mitigate the consequences of ...
Ito K - - 2013
Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (Cdk6) blocks chondrocyte differentiation without affecting cell-cycle progression in vitro. To investigate whether Cdk6 inhibits chondrocyte differentiation in vivo, we generated chondrocyte-specific Cdk6 transgenic mice using Col2a1 promoter. Unexpectedly, differentiation and cell-cycle progression of ...
Liu Jie - - 2013
Aspergillus terreus is widely used for industrial production of important chemical compounds such as itaconate and lovastatin. To improve understanding of its physiology, we reconstructed a genome-scale metabolic model, iJL1454, consisting of 1454 genes, 1451 reactions and 1155 metabolites, based on genome annotation and literature mining. The model accurately predicted ...
Ford Michael T - - 2013
By drawing from theoretical perspectives suggesting that unfair conditions threaten fundamental psychological needs, perceived unfairness at work was proposed and tested as a predictor of resting blood pressure. As part of the Midlife Development in the United States Biomarkers project, participants completed questionnaires measuring perceived unfairness, self-esteem and coworker support. ...
Louis Deepak - - 2013
Abstract Objective: To study SMA doppler for predicting feed intolerance and necrotizing enterocolitis (NEC) in preterm SGA neonates with umbilical artery absent/reversed end diastolic flow (A/REDF) Study design: Prospective study. Patients: SGA neonates < 36 weeks born with antenatally diagnosed A/REDF formed cases. Those with normal Doppler formed controls. Primary ...
Gunawan Cindy - - 2013
The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver-stimulated cellular oxidative stress, ranging from only minimal cellular redox imbalance to the lethal ...
Plotnikova Alexandra - - 2013
The HEN1 methyltransferase from Arabidopsis thaliana modifies the 3'-terminal nucleotides of small regulatory RNAs. Although it is one of the best characterized members of the 2'-O-methyltransferase family, many aspects of its interactions with the cofactor and substrate RNA remained unresolved. To better understand substrate interactions and contributions of individual steps ...
Wojdyla Michal - - 2013
We study the thermal and out-of-equilibrium mechanical dynamics of single, living human red blood cells (RBCs) by combining two-probe passive and active microrheology techniques. Both experiments were performed quasisimultaneously on the same cell using two identical polystyrene probes, biochemically attached to the cell membrane. We obtained compelling evidence of nonequilibrium ...
Kudlicka Aleksandra - - 2013
OBJECTIVE: High-quality person-centred care for people with Parkinson's disease (PwPD) and their families relies on identifying and addressing factors that specifically impact on quality of life (QoL). Deficits in executive functions (EF) are common in Parkinson's disease, but their impact on PwPD and their caregivers is not well understood. The ...
Nagasawa Nobuhiro - - 2013
The embryo/endosperm size in mature seed differs among angiosperms to a high degree. However, little is known about the molecular mechanism underlying the size control between these neighboring tissues. Here we report the rice GIANT EMBRYO (GE) gene that is essential for controlling the size balance. GE function in each ...
Wang Yong - - 2013
In the Red Sea, two neighboring deep-sea brine pools, Atlantis II and Discovery, have been studied extensively, and the results have shown that the temperature and concentrations of metal and methane in Atlantis II have increased over the past decades. Therefore, we investigated changes in the microbial community and metabolic ...
Sun Peter - - 2013
Abstract Objective: To assess the time from the first observed diagnosis of type 2 diabetes (T2DM) to initiation of an oral antihyperglycemic agent (OAHA) and statin. Methods: In a retrospective US cohort study using the GE electronic medical record database, patients ≥18 years were included if they had a T2DM ...
Chakraborty Angana - - 2013
In this article we propose a Fast Optimal Global Sequence Alignment Algorithm, FOGSAA, which aligns a pair of nucleotide/protein sequences faster than any optimal global alignment method including the widely used Needleman-Wunsch (NW) algorithm. FOGSAA is applicable for all types of sequences, with any scoring scheme, and with or without ...
Diao Jiajie - - 2013
In vitro reconstitution assays are commonly used to study biological membrane fusion. However, to date, most ensemble and single-vesicle experiments involving SNARE proteins have been performed only with lipid-mixing, but not content-mixing indicators. Through simultaneous detection of lipid and small content-mixing indicators, we found that lipid mixing often occurs seconds ...
Jensen Rodrigo - - 2013
PURPOSE: To test the viability of to use specialists' opinions to establish degrees of membership between nursing diagnoses and its elements (defining characteristics or risk factors), based on the concepts of fuzzy sets theory. This strategy may feasibly mapping the specialist's knowledge on the diagnostic task. METHODS: Specialists were invited ...
Xu Wen-Liang - - 2013
Proline-rich proteins contribute to cell wall structure of specific cell types and are involved in plant growth and development. In this study, a fiber-specific gene, GhPRP5, encoding a proline-rich protein was functionally characterized in cotton. GhPRP5 promoter directed GUS expression only in trichomes of both transgenic Arabidopsis and tobacco plants. ...
Andersson Susanne - - 2013
Objective. To investigate gender differences in the association between self-rated health (SRH) and impaired glucose tolerance (IGT) in subjects unaware of their glucose tolerance. Design. A cross-sectional population-based study. Setting. The two municipalities of Vara and Skövde in south-western Sweden. Subjects. A total of 2502 participants (1301 women and 1201 ...
Immonen Sirpa - - 2013
Objectives. The aim of this study was to assess the possibility of clinically significant drug-alcohol interactions among home-dwelling older adults aged ≥ 65 years. Design. This study was a cross-sectional assessment of a stratified random sample of 2100 elderly people (≥ 65 years) in Espoo, Finland. The response rate was ...
Meier-Abt Fabienne - - 2013
INTRODUCTION: Early pregnancy has a strong protective effect against breast cancer in humans and rodents, but the underlying mechanism is unknown. Because breast cancers are thought to arise from specific cell subpopulations of mammary epithelia, we studied the effect of parity on the transcriptome and the differentiation/proliferation potential of specific ...
Li Haoran - - 2013
Chemotherapy has been widely used in treating cancer patients. Despite the tremendous progress in cancer treatment achieved during the last decades, drug resistance still accounts for most of the tumor relapses in chemotherapy-treated patients. Emerging evidence shows that microRNAs play an important role in regulating the drug sensitivity of tumor ...
Lee Yu Sun - - 2013
BACKGROUND: To evaluate the utility of the preoperative PET-CT using deformable image registration (DIR) in the treatment of patients with locally advanced breast cancer and to find appropriate radiotherapy technique for further adequate treatment of axillary nodal area. METHODS: Sixty-five breast cancer patients who had level II, III axillary or ...
Yoneda Tomoko - - 2013
The incidence of endometrial cancer, a common gynecological malignancy, is increasing in Japan. We have previously shown that the ER/MDM2/p53/p21 pathway plays an important role in endometrial carcinogenesis. In the present study, we investigated the effects of germline single nucleotide polymorphisms in murine double minute 2 (MDM2) SNP309, TP53 Arg72Pro, ...
Maldonado Igor Lima - - 2013
A rostrocaudal pathway connecting the temporal and parietal lobes was described in monkeys using autoradiography and was named the middle longitudinal fasciculus (MdLF). Recently, the use of diffusion tensor tractography has allowed it to be depicted in human volunteers. In the present study, a technique of fiber dissection was used ...
Boon Andrea J AJ Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota 55905, USA. - - 2013
Real time ultrasound imaging of the diaphragm is an under-used tool in the evaluation of patients with unexplained dyspnea or respiratory failure. We measured diaphragm thickness and the change in thickness that occurs with maximal inspiration in 150 normal subjects, with results stratified for age, gender, body mass index, and ...
Van Den Berg Petronella J PJ Department of Neurology, St. Elisabeth Hospital, PO Box 90151, 5000 LC Tilburg, The - - 2013
The aim of this study was to assess the presence of (sub)luxation of the ulnar nerve in patients with ulnar neuropathy at the elbow (UNE) compared with healthy controls (HC). We assessed its clinical patterns, electrodiagnostic, and sonographic characteristics. Using high-resolution sonography, we studied the incidence of (sub)luxation in a ...
Cai Huawei H Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8542, - - 2013
Copper is required for cell proliferation and tumor angiogenesis. Cellular copper metabolism is regulated by a network of copper transporters and chaperones. Antioxidant-1 (ATOX1) is a cytosolic copper chaperone important for intracellular copper transport, which plays a role in the regulation of cell proliferation by functioning as a transcription factor ...
Everett Roger D RD MRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, UK. - - 2013
Post-translational modification by members of the small ubiquitin-like modifier (SUMO) family of proteins is important for the regulation of many cellular proteins and pathways. As obligate parasites, viruses must engage with the host cell throughout their replication cycles, and it is therefore unsurprising that there are many examples of interplay ...
Lazic N N Microsoft Research Cambridge, Cambridge, - - 2013
Although atopic sensitization is one of the strongest risk factors for asthma, its relationship with asthma is poorly understood. We hypothesize that 'atopy' encompasses multiple sub-phenotypes that relate to asthma in different ways. In two population-based birth cohorts (Manchester and Isle of Wight - IoW), we used a machine learning ...
Wood R A RA Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. - - 2013
Immunotherapy for peanut allergy may be limited by the risk of adverse reactions. To investigate the safety and immunologic effects of a vaccine containing modified peanut proteins. This was a phase 1 trial of EMP-123, a rectally administered suspension of recombinant Ara h 1, Ara h 2, and Ara h ...
MacNeill S J SJ Department of Occupational and Environmental Medicine, National Heart and Lung Istitute, Imperial College London, London, UK. - - 2013
Evidence exists that a farming environment in childhood may provide protection against atopic respiratory disease. In the GABRIEL project based in Poland and Alpine regions of Germany, Austria and Switzerland, we aimed to assess whether a farming environment in childhood is protective against allergic diseases in Poland and whether specific ...
Huynh William W Neuroscience Research Australia and Prince of Wales Clinical School, University of New South Wales, Barker Street, Randwick, New South Wales 2031, - - 2013
Maladaptive plasticity involving the unaffected hemisphere (UH) in stroke patients may contribute to post-stroke deficits, including spasticity. We investigated the central and peripheral effects of botulinum toxin in post-stroke spasticity to determine whether there is modulation of cortical processes in the UH. Transcranial magnetic stimulation and peripheral nerve excitability studies ...
Aldo Paulomi B PB Department of Obstetrics Gynecology and Reproductive Science, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT 06520, - - 2013
Macrophage function has many implications in a variety of diseases. Understanding their biology becomes imperative when trying to elucidate immune cell interactions with their environment, and in vitro cell lines allow researchers to manipulate these interactions. A common cell line used is THP-1, a promyeloid cell line suggestive to outside ...
Dyer Christopher A CA University of Texas Health Science Center San Antonio, Medicine/Nephrology, South Texas Veterans Health Care System, 7703 Floyd Curl Dr, MC 7882, San Antonio 78229, USA. - - 2013
Secondary hyperparathyroidism (SHPT) is a complication of chronic kidney disease (CKD). Beyond skeletal complications, uncontrolled SHPT is associated with cardiovascular mortality. Vitamin D receptor activators (VDRAs) are a mainstay of therapy for SHPT; however, use is limited by hypercalcemia, though less so with calcitriol analogs such as paricalcitol and there ...
Sanghvi Kishore P KP Department of Pediatrics and Neonatology, Jaslok Hospital and Research Centre, Mumbai, India. - - 2013
To evaluate the feasibility of initiation of exclusive enteral feeds on first day of life in very low birthweight infants >1200 g. Haemodynamically stable infants with birthweights 1200-1500 g irrespective of gestational age were randomized into two groups. Enteral feeds 80 mL/kg/day started within 1 h of birth and increased ...
Zhang Rongchun R Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, - - 2013
Air cholangiogram has been used in patients with malignant hilar obstruction to reduce cholangitis after endoscopic retrograde cholangiopancreatography (ERCP). However, it still remains unclear whether CO2 could be used as an alternative for air cholangiography in such patients. To investigate the effect of CO2 cholangiogram on post-ERCP complications. Prospective, randomized ...
Kim Gilbert W GW Thomas Jefferson University, Department of Pharmacology and Experimental Therapeutics, Philadelphia, PA 19107, - - 2013
Obesity is a worldwide pandemic. Obesity-related health and economic costs are staggering. Existing strategies to combat obesity through lifestyle improvements and medical intervention have had limited success. Pharmacotherapy, in combination with lifestyle modification, may play a vital role in reversing the disease burden. However, past and current weight-loss medications have ...
Cannella Nazzareno N Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany. - - 2013
Medication development for cocaine-addicted patients is difficult, and many promising preclinical candidates have failed in clinical trials. One reason for the difficulty in translating preclinical findings to the human condition is that drug testing is typically conducted in behavioral procedures in which animals do not show addiction-like traits. Recently, a ...
Lock James J Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, - - 2013
There are limited data supporting specific treatments for adults with anorexia nervosa (AN). Randomized clinical trials (RCTs) for adults with AN are characterized by high attrition limiting the feasibility of conducting and interpreting existing studies. High dropout rates may be related to the inflexible and obsessional cognitive style of patients ...
Krikun Graciela G Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, - - 2013
Human endometrial endothelial cell (HEEC) innate immunity remains poorly characterized. Based on their direct contact with the circulation, HEECs are uniquely positioned to be exposed to viral infections. This study evaluated the innate immune response generated by HEECs after exposure to the TLR3 agonist, Poly(I:C) and the TLR8 agonist, viral ...
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