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Yeatman Sara S Department of Health and Behavioral Sciences, University of Colorado Denver, Campus Box 188, P.O. Box 173364, Denver, CO, 80217, USA, - - 2013
Dynamic theories of family size preferences posit that they are not a fixed and stable goal but rather are akin to a moving target that changes within individuals over time. Nonetheless, in high-fertility contexts, changes in family size preferences tend to be attributed to low construct validity and measurement error ...
Zhang H H Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2013
B cells perform various immunological functions that include production of antibody, presentation of antigens, secretion of multiple cytokines and regulation of immune responses mainly via their secretion of interleukin (IL)-10. While the liver is regarded both as an important immune organ and a tolerogenic environment, little is known about the ...
Pietroni Paola - - 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the ER (endoplasmic reticulum) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and inactivate ribosomes. The currently accepted model is that the bulk of ER-dislocated RTA is degraded ...
Seubert Christoph N CN Department of Anesthesiology, University of Florida, Gainesville, Florida 32610-0254, - - 2013
The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, isoflurane and sevoflurane exhibit substantial differences in their actions. The authors sought to determine whether these differences can also be detected at the level of neurodevelopmental effects. Postnatal ...
Whitson Heather E - - 2013
We are unaware of any standardized protocols within low-vision rehabilitation (LVR) to address cognitive impairment. To design and pilot-test an LVR program for patients with macular disease and cognitive deficits. The Memory or Reasoning Enhanced Low Vision Rehabilitation (MORE-LVR) program was created by a team representing optometry, occupational therapy, ophthalmology, ...
Danis Ronald P RP Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53717, USA. - - 2013
To establish continuity with the grading procedures and outcomes from the historical data of the Age-Related Eye Disease Study (AREDS), color photographic imaging and evaluation procedures for the assessment of age-related macular degeneration (AMD) were modified for digital imaging in the AREDS2. The reproducibility of the grading of index AMD ...
Gerlach Undine A - - 2013
It is now well known that the outcome after allogeneic transplantation, such as incidence of acute rejections, very much depends on the individual's immune reactivity status. There is also increasing evidence that the presence of preexisting memory T cells can affect antigraft immune responses. In a prospective study, we monitored ...
Murphy Greer M GM - - 2013
Brain-derived neurotrophic factor (BDNF) is associated with antidepressant response on the cellular level, in animal models, and in clinical studies. A common variant in the BDNF gene results in a substitution of a methionine (Met) for a valine at the amino acid position 66. Previous studies reported that the Met ...
Kaida Hayato - - 2013
This study was conducted to evaluate the relationship between fluorine-18 fluorodeoxyglucose metabolic parameters [maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] and clinicopathological factors of breast cancer. The study comprised 93 patients. A volumetric region of interest was drawn over the abnormal focal uptake ...
Hanly Ruth - - 2013
The intestinal absorption of vitamin D is linked to bile acid absorption. This link may be abnormal in patients with osteoporosis. The aim of this study was to investigate a possible relation between osteoporosis and bile acid turnover, measured as whole-body Se-75-HCAT retention (WBR), in postmenopausal women. Whole-body counts were ...
Jansen Rick J - - 2013
Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design. Our study included 384 rapidly ascertained cases and 983 ...
Arbuckle Melissa R - - 2013
In the setting of traditional residency training programs, physician-scientists are often limited in their ability to pursue research training goals while meeting clinical training requirements. This creates a gap in research training at a critical developmental stage. In response, Columbia University Medical Center's Department of Psychiatry, in partnership with the ...
Binley Katie K Oxford BioMedica-UK Ltd., Oxford Science Park, Oxford, United Kingdom. - - 2013
StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transduce rod and cone photoreceptors in addition to retinal pigment epithelium in ...
Tierney Michael J MJ Compensation and Pension and Ambulatory Care, VA Palo Alto Healthcare System, Palo Alto, California 94304, USA. - - 2013
In the last decade, electronic medical record (EMR) use in academic medical centers has increased. Although many have lauded the clinical and operational benefits of EMRs, few have considered the effect these systems have on medical education. The authors review what has been documented about the effect of EMR use ...
Deep Gagan G Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, CO, - - 2013
Tumor microenvironment (TME) refers to the dynamic cellular and extra-cellular components surrounding tumor cells at each stage of the carcinogenesis. TME has now emerged as an integral and inseparable part of the carcinogenesis that plays a critical role in tumor growth, angiogenesis, epithelial to mesenchymal transition (EMT), invasion, migration and ...
Dickens David D Department of Molecular and Clinical Pharmacology, The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, - - 2013
P-glycoprotein (P-gp) is a multidrug efflux transporter that has a defined role in the absorption and disposition of drugs. Many studies have investigated the potential influence of ABCB1 polymorphisms on the disposition of its substrates. However, there remains significant controversy regarding the role of these polymorphisms. Our aim was to ...
Bow Hansen C HC Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2013
During their preclinical course work, medical students must memorize and recall substantial amounts of information. Recent trends in medical education emphasize collaboration through team-based learning. In the technology world, the trend toward collaboration has been characterized by the crowdsourcing movement. In 2011, the authors developed an innovative approach to team-based ...
Hookham Michelle B MB Centre for Vision and Vascular Science, Queen's University Belfast, - - 2013
Diabetic nephropathy (DN) is a progressive fibrotic condition that may lead to end-stage renal disease and kidney failure. Transforming growth factor-β1 and bone morphogenetic protein-7 (BMP7) have been shown to induce DN-like changes in the kidney and protect the kidney from such changes, respectively. Recent data identified insulin action at ...
Nyamache Anthony Kebira AK Department of Plant and Microbial Sciences, Kenyatta University, Nairobi, - - 2013
A switch of HIV coreceptor usage from CCR5 to CXCR4 occurs in AIDS pathogenesis and may play a critical role in the use of entry inhibitors. To determine the potential usefulness of maraviroc and other CCR5 antagonists among drug-naive and experienced patients in Kenya, the env-C2-V3 gene was successfully sequenced ...
Tworkoski Kathryn A KA Department of Pathology, Yale University School of Medicine, New Haven, CT, - - 2013
The receptor tyrosine kinase AXL regulates melanoma cell proliferation and migration. We now demonstrate that AXL and the related kinase MERTK are alternately expressed in melanoma and are associated with different transcriptional signatures. MERTK-positive melanoma cells are more proliferative and less migratory than AXL-positive melanoma cells and overexpression of AXL ...
Chatterjee Prithwish P School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, Arizona 85287, - - 2013
Environmentally responsive hydrogels hold multiple important applications. However, the functionality of these materials alone is often limited in comparison to other materials like silicon; thus, there is a need to integrate soft and hard materials for the advancement of environmentally sensitive materials. Here we demonstrate the capability of integrating a ...
Barazza Alessandra A Leon H. Charney Division of Cardiology and Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, New York University School of Medicine, Smilow 7, 522 First Avenue, New York, New York 10016, United - - 2013
We have previously reported enhancing the imaging of atherosclerotic plaques in mice using reconstituted high density lipoproteins (HDL) as nanocarriers for the MRI contrast agent gadolinium (Gd). This study focuses on the underlying mechanisms of Gd delivery to atherosclerotic plaques. HDL, LDL, and VLDL particles containing Gd chelated to phosphatidyl ...
Zubris Kimberly Ann V KA Departments of Biomedical Engineering and Chemistry, Boston University , Boston, Massachusetts 02215, United - - 2013
Through a series of in vitro studies, the essential steps for intracellular drug delivery of paclitaxel using a pH-responsive nanoparticle system have been investigated in breast cancer cells. We successfully encapsulated paclitaxel within polymeric expansile nanoparticles (Pax-eNPs) at 5% loading via a miniemulsion polymerization procedure. Fluorescently tagged eNPs were readily ...
Morrow Marie E ME Department of Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United - - 2013
Ubiquitination is countered by a group of enzymes collectively called deubiquitinases (DUBs); ∼100 of them can be found in the human genome. One of the most interesting aspects of these enzymes is the ability of some members to selectively recognize specific linkage types between ubiquitin in polyubiquitin chains and their ...
Fox Michael G - - 2013
OBJECTIVE. The purpose of this study was to evaluate the lateral mortise approach for performing therapeutic ankle injections. MATERIALS AND METHODS. Fluoroscopically guided ankle joint injections performed from November 2009 through June 2011 using the lateral ankle mortise approach were retrospectively reviewed. Data recorded included age, sex, fluoroscopic time, person ...
Wittenburg Henning - - 2013
A 40-year old woman presented with symptomatic intrahepatic gallstones in one liver segment only four years after cholecystectomy for cholelithiasis. Multiple small, yellow and round calculi were completely removed from the intrahepatic bile ducts via ERCP. The young age of the patient, recurrence of gallstones after cholecystectomy and intrahepatic gallstones ...
Karmazyn Boaz - - 2013
OBJECTIVE. The purpose of this study was to determine the effect of lowering tube voltage on dose and noise in cylindric water phantoms to optimize quality and decrease the radiation dose for body CT. MATERIALS AND METHODS. We performed CT on cylindric water phantoms with diameters of 10, 20, 25, ...
Makowski Kamil - - 2013
C75 is a synthetic compound described as having antitumoral properties. It produces hypophagia and weight loss in rodents, limiting its use in cancer therapy but identifying it as a potential anti-obesity drug. C75 is a fatty acid synthase (FAS) inhibitor and, through its coenzyme A (CoA) derivative, it acts as ...
Sepulveda Waldo - - 2013
We review the sonographic features, antenatal course, and perinatal outcomes in 7 cases of ectopia cordis diagnosed in the first trimester. Four cases were associated with a large omphalocele (pentalogy of Cantrell) and 2 with a body stalk anomaly. The remaining fetus had isolated thoracic ectopia cordis. Two pregnancies were ...
McGillicuddy Edward A - - 2013
Bleeding disorders pose a significant perioperative risk. Surgeons and surgical consultants should have a working knowledge of the cell-based coagulation model. Careful screening for bleeding diatheses begins with a careful history and physical examination. It is paramount to ascertain what medications and nonprescribed supplements and herbal preparations a patient is ...
Forabosco Flavio - - 2013
The diffusion of genetically modified (GM) animals has generated a demand for accurate and unique identification to assure compliance with relevant national and international legislation. Individual identification of GM animals is essential to improve safety and traceability, as well as to fulfill the present and future expectations of producers, consumers, ...
Krasznai Attila G - - 2013
Femoropopliteal bypass surgery is the most commonly performed type of peripheral bypass in vascular surgery. The great saphenous vein (GSV) is the preferred bypass conduit. Commonly used methods of GVS harvesting are related to morbidity, such as wound infection, skin necrosis, hematoma, and edema. In this feasibility study we present ...
Joshi Rajiv - - 2013
Interface dermatitis includes diseases in which the primary pathology involves the dermo-epidermal junction. The salient histological findings include basal cell vacuolization, apoptotic keratinocytes (colloid or Civatte bodies), and obscuring of the dermo-epidermal junction by inflammatory cells. Secondary changes of the epidermis and papillary dermis along with type, distribution and density ...
Buglyó Gergely - - 2013
The Wilms tumor 1 (WT1) gene is currently in focus by pediatric nephrologists as its mutations are associated with nephrotic syndrome, especially as part of complex clinical entities like Denys-Drash or Frasier syndrome. Renal failure may also develop in young WAGR patients, whose condition is attributed to a deletion at ...
Zacharias Claudia - - 2013
OBJECTIVE. The introduction of MDCT has increased the utilization of CT in pediatric radiology along with concerns for radiation sequelae. This article reviews general principles of lowering radiation dose, the basic physics that impact radiation dose, and specific CT integrated dose-reduction tools focused on the pediatric population. CONCLUSION. The goal ...
Malat Jan - - 2013
To examine characteristics of treatment-seeking outpatients from a clinic for co-occurring disorders within an urban psychiatric hospital. Patients (n = 131) completed six self-report scales including the Brief Symptom Inventory and Toronto Alexithymia Scale. The most common substance use disorders were: alcohol (62%), tobacco (50%), cannabis (22%), cocaine/stimulants (18%). The most common ...
Hannaford Karen - - 2013
Objectives- To determine whether umbilical cord cysts found by transvaginal sonography in the first trimester of pregnancy are associated with poor pregnancy outcomes. Methods- We conducted a matched cohort study between July 2006 and July 2008. Patients with umbilical cord cysts found on transvaginal sonography in the first trimester were ...
Drescher Tilman - - 2013
Incidentally detected adrenal masses occur frequently especially in the elderly. This is due to technical advances as well as to widespread use of radiologic imaging performed for other reasons. After discovery of an adrenal mass two major questions arise: firstly, is the lesion malignant and, secondly, is it hormonally active? ...
Zhao Lianxin - - 2013
OBJECTIVE. The objective of our study was to show the feasibility and performance of diffusion-weighted MR neurography (MRN) of extremity nerves with unidirectional motion-probing gradients at 3 T. SUBJECTS AND METHODS. Forty-seven healthy volunteers and 10 patients underwent diffusion-weighted MRN of extremity nerves with unidirectional motion-probing gradients (anterior-posterior direction only) ...
Luyet Cédric - - 2013
Objectives- Sonographic guidance for peripheral nerve anesthesia has proven increasingly successful in clinical practice; however, fears that a change to sonographically guided regional anesthesia may impair the block quality and operating room work flow persist in certain units. In this retrospective cohort study, block quality and patient satisfaction during the ...
Silva Ivonete - - 2013
Introduction. Treatment of genotype 1 chronic hepatitis C in elderly patients has been associated with low rates of a sustained virological response (SVR), but the reasons are unclear. Objective. To determine the SVR rate in patients ≥ 60 years with genotype 1 chronic hepatitis C treated with Peg-IFN and ribavirin, ...
Beltran Luis S - - 2013
OBJECTIVE. The purpose of this article is to review the clinical and imaging features as well as the potential complications of hip dysplasia in the young adult. Hip dysplasia is an important cause of secondary osteoarthrosis, which accounts for a significant proportion of patients requiring total hip arthroplasty. The radiographic ...
Adrada Beatriz - - 2013
OBJECTIVE. Breast ultrasound is helpful in the characterization of masses to differentiate benign from malignant disease. The internal echotexture of a mass is an important ultra-sound feature in breast diagnostic workup. This article reviews the imaging and histopathology findings of benign and malignant hyperechoic masses to better recognize these conditions. ...
Chapman Stephen J - - 2013
Teaching in the operating room (OR) may add substantial value to undergraduate medical education but at present, the value of this as a core-learning environment is unclear. We assessed student attitudes to see how the experience may be improved. All medical students from University of Leeds, UK were invited to ...
Corell Hanna - - 2013
A particle-tracking model based on high-resolution ocean flow data was used to investigate particle residence times and spatial distribution of settling sediment for two geo-morphologically different Swedish coastal areas. The study was a part of a safety assessment for the location of a future nuclear-waste repository, and information about the ...
Papadatos-Pastos Dionysis - - 2013
The CNS is a common site of metastasis in patients with malignant melanoma. Locoregional control either with surgery or radiotherapy is first-line treatment for patients with brain metastasis should they be suitable candidates. For those patients who are not and those who progress after previous treatment, there is an unmet ...
Tazawa Ko-Ichi - - 2013
We report a 51-year-old female patient with adult-onset type II citrullinemia (CTLN2) who had a history of pancreatoduodenectomy for duodenal somatostatinoma with metastases to regional lymph nodes at age 49 years, paying special attention to indications for liver transplantation. At age 50 years, she developed hepatic encephalopathy with elevation of ...
Eriksson Christin - - 2013
The water turnover of two coastal areas, Forsmark and Laxemar-Simpevarp, has been modeled for 13 selected years between 6500 BC and 9000 AD by utilizing information about past, present, and future bathymetry. The Forsmark area can be described as an open-ended funnel, and is analyzed with a 3D-model (MIKE 3-FM); the ...
Yang Li - - 2013
Background. MUC2 and MUC5AC overproduction is considered to be associated with hepatolithiasis and related to inflammation. However, mechanisms underlying MUC upregulation under inflammatory stimulation in human intrahepatic biliary epithelial cells (HIBECs) are not completely understood. Material and Methods. Expression of MUC2 and MUC5AC mRNA in HIBECs was detected by real-time ...
Pang Shaofeng - - 2013
Several chiral ligands containing (R,R)-diaminocyclohexane moieties and pyrrole, furan, or benzene have been synthesized. These ligands were tested in enantioselective zinc-catalyzed hydrosilylation reactions; excellent enantioselectivities were obtained when the ligands containing (R,R)-diaminocyclohexane moieties and furan rings were used. For comparison, zinc chloride combined with different potassium carboxylate salts and ligands ...
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