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Results 401 - 450 of 3079
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Xue Li L Pharmacokinetics, Dynamics & Metabolism (PDM-NBE), Pfizer Inc., Andover, MA, USA. - - 2013
The immunogenicity profile of a biotherapeutic is determined by a multitude of product and patient-related risk factors that can influence the observed incidence and clinical consequences of immunogenicity. Pre-existing antibodies, i.e., biotherapeutic-reactive antibodies present in samples from treatment-naïve subjects, have been commonly observed during immunogenicity assessments; however their relevance in ...
Shaira A - - 2013
The kinetics of chloride substitution from a series of square-planar platinum(ii) complexes, viz. [Pt(terpyridine)Cl](+), (), [Pt{2-(2'-pyridyl)-1,10-phenanthroline}Cl]Cl, (), [Pt{4'-(2'''-CH3-phenyl)-2,2':6',2''-terpyridine}Cl]CF3SO3 () and [Pt{4'-(2'''-CH3-phenyl)-6-(3''-isoquinoyl)-2,2'bipyridine}Cl]SbF6 () were studied using a series of five-membered heterocyclic neutral nitrogen donor nucleophiles, viz. pyrazole (), triazole (), imidazole (), 1-methylimidazole () and 1,2-dimethylimidazole () under pseudo-first-order conditions in ...
Arnold M C - - 2013
Engineered cerium oxide nanoparticles (CeO2 NPs) are widely used in biomedical and engineering manufacturing industries. Previous research has shown the ability of CeO2 NPs to act as a redox catalyst, suggesting potential to both induce and alleviate oxidative stress in organisms. In this study, Caenorhabditis elegans and zebrafish (Danio rerio) ...
Francone Elisa - - 2013
Ectopic breast tissue comes in two forms: supernumerary and aberrant. Despite morphologic differences, ectopic breast tissue presents characteristics analogous to orthotopic breast tissue in terms of function and, most importantly, pathologic degeneration. Data in the literature concerning its precise incidence, the probability of malignant degeneration, and its standardized management are ...
Ranjini Mysore S - - 2013
Drosophila nasuta nasuta (2n = 8) and D. n. albomicans (2n = 6) are morphologically identical, cross fertile and karyotypically dissimilar pair of chromosomal races belonging to nasuta subgroup of immigrans group of Drosophila. Interracial hybridization between these two races yielded karyotypically stabilized newly evolved Cytoraces with new combinations of chromosomes and DNA content, ...
Saito Yoshimasa - - 2013
Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of hepatocellular carcinoma (HCC). Epigenetic silencing of tumor suppressor genes in HCC is generally mediated by DNA hypermethylation of CpG island promoters and histone modifications such as histone deacetylation, methylation of histone ...
Pariente G - - 2013
Abstract Objective: To evaluate the prevalence of first trimester vaginal bleeding among patients with abnormal second and third trimester uterine artery Doppler. Methods: A prospective study of patients with a uterine artery Doppler measurement between 27-42 weeks'gestation was undertaken. A comparison was made between two groups: patients with and without ...
Raval Zankhana Z Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, - - 2013
The age-adjusted prevalence of peripheral arterial disease in the US population was estimated to approach 12% in 1985, and as the population ages, the overall population having peripheral arterial disease is predicted to rise. The clinical consequences of occlusive peripheral arterial disease include intermittent claudication, that is, pain with walking, ...
Siddique Khurram - - 2013
The effect of the severity of appendiceal inflammation on post-operative stay in children following appendicectomy has shown conflicting results. This study was conducted to determine the association between the severity of appendiceal inflammation and post-operative stay amongst children undergoing open appendicectomy. A retrospective cohort study was conducted at a District ...
Mierzejewska-Krzyżowska B - - 2013
The sex differences in the number and morphometric parameters of motoneurons in motor nuclei are poorly known. The aim of this study was to determine the differences in the number and size of alpha and gamma motoneurons of the medial gastrocnemius (MG) muscle in male and female Wistar rats. Retrogradely ...
Fitzpatrick Sarah G - - 2013
Papillary squamous cell carcinoma (PSCCA) is a rarely occurring variant of squamous cell carcinoma (SCCA) with distinctive exophytic and papillary features and a more favorable prognosis than conventional SCCA. The larynx is the most commonly affected site in the head and neck. The oral cavity, oropharynx, sinonasal tract, and nasopharynx ...
Zidkova Anastassiya - - 2013
Sample containing 234 unrelated males and 197 unrelated females from Czech Republic was genotyped using an X-STR decaplex system in the following loci: DXS6789, DXS6809, DXS7132, DXS7133, DXS7423, DXS8378, DXS9898, DXS9902, GATA172D05, and GATA31E08. The linkage disequilibrium was observed between DXS6789 and DXS6809. The combined power of discrimination was 0.9999999998 ...
Krarup Peter-Martin - - 2013
PURPOSE: Submucosal collagen is paramount for colonic anastomotic integrity. Matrix metalloproteinases (MMPs) mediate collagen degradation that increases the risk of wound dehiscence. Although broad-spectrum MMP inhibitors are beneficial for anastomotic strength, they can cause adverse reactions. Knowledge of specific MMPs responsible for the weakening of anastomoses can be used to ...
Zalvan Craig H - - 2013
The objectives of this study are to compare the pathological results from office-based biopsy (OBB) and operative biopsy (ORB) of laryngopharyngeal lesions from 26 patients. Lesion location, specimen concordance, efficacy, cost savings, and patient management are discussed. OBB can provide a sample of laryngopharyngeal tissue that can be used to ...
Chen Wei - - 2013
Effects of cannabinoid receptor 1 (CB1R) blockade were observed by comparing 9-day and 6-week SR141716 treatments in monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity (HO) in rats for the first time and molecular mechanisms were investigated. Compared with normal rats, the MSG rats display typical symptoms of the metabolic syndrome, ...
Suhrheinrich Jessica - - 2013
Implementing evidence-based practices (EBPs) for children with autism is challenging for teachers because these practices are often complex, requiring significant training and resources that are not available in most school settings. This brief investigation was designed to identify areas of strength and difficulty for teachers implementing one such EBP, pivotal ...
Newsome William T WT Department of Neurobiology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, - - 2013
Leathers and Olson (Reports, 5 October 2012, p. 132) draw the strong conclusion that neurons in the monkey lateral intraparietal (LIP) cortical area encode only cue salience, and not action value, during value-based decision-making. Although their findings regarding cue salience are interesting, their broader conclusions are problematic because (i) their ...
Ficen Semra Zuhal - - 2013
BACKGROUND: Gene therapy is an important treatment for genetic and acquired diseases. The success of gene therapy is largely dependent on the development of suitable vectors for gene transfer. Vectors are desired to overcome cellular barriers and to achieve efficient DNA delivery with low cytotoxicity. To this aim we synthesized ...
Higginbotham Heather F - - 2013
A new core-substituted naphthalene diimide (cNDI) compound that is sensitive to both H(+) and solvent polarity has been synthesised and characterised. Optical absorption and emission change upon protonation while emission quantum yield and decay kinetics of the unprotonated form vary significantly with solvent polarity due to delayed fluorescence.
Grimaldi Luca - - 2013
Abstract The two-stage breast reconstruction with tissue expander and prosthesis is nowadays a common method for achieving a satisfactory appearance in selected patients who had a mastectomy, but its most common aesthetic drawback is represented by an excessive volumetric increment of the superior half of the reconstructed breast, with a ...
Kabalah-Amitai Lee - - 2013
Calcite, aragonite, and vaterite are the three anhydrous polymorphs of calcium carbonate, in order of decreasing thermodynamic stability. Although vaterite is not commonly found in geological settings, it is an important precursor in several carbonate-forming systems and can be found in biological settings. Because of difficulties in obtaining large, pure, ...
Martinez-Pasamar Sara - - 2013
BACKGROUND: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells governing the course of MS, therefore, has many implications for immunotherapy. Here, we used flow cytometry to analyze the time-dependent behavior ...
Schumann Burkard Gabriela - - 2013
Different life-cycle stages of Trypanosoma brucei are characterized by stage-specific glycoprotein coats. GPEET procyclin, the major surface protein of early procyclic (insect midgut) forms, is transcribed in the nucleolus by RNA polymerase I as part of a polycistronic precursor that is processed to monocistronic mRNAs. In culture, when differentiation to ...
Camacho-Sanchez Miguel - - 2013
Ecological and conservation genetics require sampling of organisms in the wild. Appropriate preservation of the collected samples, usually by cryostorage, is key to the quality of the genetic data obtained. Nevertheless, cryopreservation in the field to ensure RNA and DNA stability is not always possible. We compared several nucleic acid ...
Proffen Benedikt - - 2013
The last few years have witnessed significant advancements in arthroplasty. The procedure is mainly used to treat osteoarthritis of the hip and knee joint. Other joints such as the shoulder or ankle are also being successfully replaced by arthroplasty. The success of the operation depends on the implantation technique as ...
De Jong Anne Margreet - - 2013
Atrial fibrillation (AF) often occurs in the presence of an underlying disease. These underlying diseases cause atrial remodelling, which make the atria more susceptible to AF. Stretch is an important mediator in the remodelling process. The aim of this study was to develop an atrial cell culture model mimicking remodelling ...
Shen Wei-Wei - - 2013
Studies have shown that the expression of CD133, leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5), and ATP binding cassette (ABC)G2 proteins is associated with malignancy and poor prognosis in colon cancer. However, molecular regulation mechanism of the three proteins has not been elucidated. Here, we report that microRNA-142-3p (miR-142-3p) inhibits the expression ...
Wu Tao - - 2013
Copper metal nanoparticles were used as a reducing agent to reduce graphene oxide (GO). The reaction was complete in about 10 min and did not involve the use of any toxic reagents or acids that are typically used in the reduction of GO by Zn and Fe powders. The high reduction ...
Hansen Bjørge Herman - - 2013
OBJECTIVES: The aims of the study were to identify correlates of objectively measured physical activity and to determine whether the explanatory power of the correlates differed with sex, weight status or level of education. METHODS: Physical activity was assessed objectively in 3,867 participants, aged 20-85 years, for a consecutive 7 days using ...
Barone Mariarita - - 2013
The aim of this work was to evaluate the potential anti-inflammatory activity of eleven (5-15) new synthesized derivatives of benzo-thieno[3,2-d]pyrimidine on two cell models, namely human keratinocytes NCTC 2544 and mouse monocyte-macrophages J774. For the synthesis of test compounds an efficient approach was developed: the key isothiocyanate was prepared through ...
Ulm Christina - - 2013
Posttranslational modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is well studied in the nervous system and described as a dynamic modulator of plastic processes like precursor cell migration, axon fasciculation, and synaptic plasticity. Here, we describe a novel function of polysialylated NCAM (polySia-NCAM) in innate ...
Denkinger Benjamin - - 2013
Planning, predicting, reasoning, and acting often depend crucially on the correct encoding and application of knowledge concerning the temporal and causal ordering of events. Yet no pictorial stimulus set is optimized for investigating the processing of temporal and causal order information. We introduce a novel stimulus set of 265 black-and-white ...
Stoit Astrid M B - - 2013
Different views on the origin of deficits in action chaining in autism spectrum disorders (ASD) have been posited, ranging from functional impairments in action planning to internal models supporting motor control. Thirty-one children and adolescents with ASD and twenty-nine matched controls participated in a two-choice reach-to-grasp paradigm wherein participants received ...
Schulz Benjamin - - 2013
DNA methylation is an important, heritable epigenetic modification in most eukaryotic organisms that is connected with numerous biological processes. To study the impact of natural epigenetic variation in an ecological or evolutionary context, epigenetic studies are increasingly using methylation-sensitive amplification polymorphism (MSAP) for surveys at the population or species level. ...
Hui Christy L M - - 2013
PURPOSE: Delay in receiving treatment in psychosis may lead to adverse consequences. We examined the predictors for help-seeking duration in adult-onset psychosis Chinese patients in Hong Kong. We hypothesized that factors which are more related to the illness manifestation would be predictive of waiting time before any help-seeking initiation, and ...
Shuler C Osborne - - 2013
Atrial septal defects (ASDs) vary greatly depending on their size, age at closure, and clinical management. This report characterizes the prevalence, complexity, and clinical management of these lesions in a statewide pediatric cohort and examines predictors for receiving closures. A 15-year Medicaid data set (1996-2010) from one state was analyzed. ...
Niu Hongxing - - 2013
The purpose of this study was to investigate the most suitable polymer material for supporting stem cell growth as a myocardial patch. After cell isolation and expansion of mouse bone marrow mesenchymal stem cells (BMSC), the cells were induced to differentiate into cardiomyocytes with 5-azacytidine to determine their differentiation potential. ...
Heslehurst Nicola - - 2013
BACKGROUND: Increasing maternal obesity trends and accompanying risks have led to the development of guidelines internationally. However, the evidence-base is poor for effective intervention, and there is a lack of representation from the perspective of obese pregnant women in guidelines. Women's engagement with weight management support services is low. OBJECTIVE: ...
Goclon Jakub - - 2013
Using density functional theory with and without Hubbard-U correction we have calculated the geometric structure and the binding energy of H2S molecules adsorbed on the main cleavage plane of ZnO. We find that H2S molecules preferentially dissociate upon adsorption, with a negligible barrier for the first and an activation energy ...
Holden A - - 2013
This opinion-based article aims to highlight the worrying decline in support for dental public health as a specialty. Not only is this specialty important for its role in commissioning services, it is crucial for the identification of vulnerable groups in society and ensuring dental services are acceptable and assessable for ...
Macdonald J M JM Department of Neurobiology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, MA 01605, - - 2013
After neuronal injury or death glial cells become reactive, exhibiting dramatic changes in morphology and patterns of gene expression and ultimately engulfing neuronal debris. Rapid clearance of degenerating neuronal material is thought to be crucial for suppression of inflammation and promotion of functional recovery. Here we demonstrate that Drosophila c-Jun ...
Qian Bang-Ping - - 2013
BACKGROUND: Although human leukocyte antigen (HLA)-B27 gene is the major susceptible gene associated with ankylosing spondylitis (AS), it has been recognized that non-HLA-B27 genes also play key roles in the development of AS. The purpose of this study is to investigate whether a single nucleotide polymorphism (SNP) in the exon ...
Sun Cheng - - 2013
Shox2 is expressed in several developing organs in a tissue specific manner in both mice and humans, including the heart, palate, limb, and nervous system. To better understand the spatial and temporal expression patterns of Shox2 and to systematically dissect the genetic cascade regulated by Shox2, we created Shox2-LacZ and ...
Xie Jing-Ming - - 2013
PURPOSE: To determine the risk factors of neurologic deficits during PVCR correction, so as to help improve safety during and after surgery. METHODS: A consecutive series of 76 patients with severe and rigid spinal deformities who were treated with PVCR at a single institution between October 2004 and July 2011 ...
Tomasello Francesco - - 2013
BACKGROUND: The transcallosal approach provides a direct corridor to the lesions lying in the third ventricle with distinct advantages over alternative routes, such as the possibility to use multiple corridors for tumor resection. METHOD: Here we present a personal perspective of the surgery of tumors of the anterior portion of ...
Pinto E - - 2013
This study evaluates the composition, antifungal activity and mechanism of action of the essential oil of Ferulago capillaris (Link ex Spreng.) Cout. and its main components, limonene and α-pinene, against clinically relevant yeasts and moulds. Essential oil from the plant's aerial parts was obtained by hydrodistillation and analysed by gas ...
Wu Yiping - - 2013
This study reports a strategy that allows one to finely tune the distance between Ag nanoparticles decorated on thermoresponsive microgels to create vast 'hot spots' for electromagnetic enhancement. The dynamic gap (i.e. the interparticle distance) can be tuned easily because the microgel template undergoes a phase transition upon changing the ...
Faverani Leonardo Perez - - 2013
Procedures for the surgical correction of dentofacial deformities may produce important complications, whether due to the potential for vascular injury or to prolonged surgery, both of which may lead to severe blood loss. Fluid replacement with crystalloid, colloid, or even blood products may be required. The aim of this study ...
Zhao D H - - 2013
This study was carried out in 121 pigs to develop a population pharmacokinetic (PPK) model by oral (p.o.) administration of valnemulin at a single dose of 10 mg/kg. Serum biochemistry parameters of each pig were determined prior to drug administration. Three to five blood samples were collected at random time points, ...
Hasegawa Junichi - - 2013
Abstract Objectives: To clarify the capable of identifying risk factors for placental abruption (PA) during the antenatal and the peripartum period. Methods: Case-controlled study with matched pairs (1:5) was conducted. One hundred and twenty-three women with PA and 615 without that delivered singleton babies after 24 weeks of gestation were ...
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