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Floras John S JS University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada. - - 2013
Blood pressure is a continuous, not a static, variable. Individuals exhibiting similar clinic or home blood pressure can differ considerably with respect to their average day and nighttime values, beat-by-beat blood pressure variation during wakefulness and sleep, responses to mental and physical stimuli, and intersession and seasonal variation. There now ...
Saindane Amit M AM Department of Radiology and Imaging Sciences, Emory University Hospital, Atlanta, GA 30322, USA. - - 2013
Although often incidental, the "empty" sella turcica can reflect chronically elevated intracranial pressure (ICP). It is particularly common in the setting of idiopathic intracranial hypertension (IIH). This study evaluated which clinical and MRI findings could be used to differentiate patients with chronically elevated ICP from those with incidental empty sella ...
Chakravorty Subhajit S MIRECC VISN-4, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA. - - 2013
Patients with alcohol dependence presenting for treatment may have multiple associated co-morbid conditions and limited social supports, which complicate treatment. Each of these factors has been independently associated with complaints of insomnia. In this preliminary study, we investigated the relations between insomnia complaints and socio-demographic factors and psychiatric co-morbidity in ...
Mohan Kabhilan K Iowa City Veterans Administration Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA. - - 2013
To evaluate retina and optic nerve damage following experimental blast injury. Healthy adult mice were exposed to an overpressure blast wave using a custom-built blast chamber. The effects of blast exposure on retina and optic nerve function and structure were evaluated using the pattern electroretinogram (pERG), spectral domain optical coherence ...
Kamada Nobuhiko N Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109, Michigan, - - 2013
The mammalian intestine is colonized by trillions of microorganisms, most of which are bacteria that have co-evolved with the host in a symbiotic relationship. The collection of microbial populations that reside on and in the host is commonly referred to as the microbiota. A principal function of the microbiota is ...
Keedy Alexander W AW Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143-0628, - - 2013
The purpose of this article is to investigate the determinants of second-order bile duct visualization at CT cholangiography in living potential liver donors. We retrospectively identified 143 potential living liver donors (83 men and 60 women; mean age, 37 years) evaluated with CT cholangiography, which included a slow infusion of ...
Urger Efsun E Department of Radiology, Duke University Medical Center, Durham, NC 27710, - - 2013
We compared results from various methods of analysis of diffusion tensor imaging (DTI) data from a single dataset consisting of 10 healthy adolescents. All subjects were imaged on a single 3-T MRI system (single-shot echo-planar imaging pulse sequence; b value, 1000 s/mm(2)). We measured fractional anisotropy (FA), apparent diffusion coefficient ...
Lo Celia C CC School of Social Work, University of Alabama, Tuscaloosa, AL 35487, USA. - - 2013
This study of Alabama public school students sought urban-rural differences in social and spatial mechanisms connecting structural factors to recent use of alcohol and marijuana. Its dataset comprised a state-sponsored 2002 need-assessment survey of Alabama students; Alabama education department data; U. S. Census data; and alcohol-outlet locations listed by Alabama's ...
Barry Declan T DT Yale University School of Medicine, New Haven, CT 06519, USA. - - 2013
A paucity of studies has examined the pain experiences of opioid dependent individuals seeking office-based buprenorphine-naloxone treatment (BNT). We set out to examine, among those seeking BNT: (a) the prevalence of pain types (i.e., recent pain, chronic pain), (b) the characteristics of pain (intensity, frequency, duration, interference, location, and genesis), ...
Hartman Christie C University of Colorado Anschutz Medical Campus, Aurora, CO, - - 2013
We tested one of Cloninger's temperament theories - that high novelty seeking (NS), along with low harm avoidance (HA), reward dependence (RD), and persistence (PE), predicts early-onset substance problems. In a community-based sample of 777 adolescents examined at two time points (mean age 13 and 18, respectively), we examined whether ...
Birdee Gurjeet S GS Division of General Internal Medicine and Pediatrics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. - - 2013
To characterize factors associated with physical inactivity among employees with access to workplace wellness program. We examined data on physical inactivity, defined as exercise less than once a week, from the 2010 health risk assessment completed by employees at a major academic institution (N = 16,976). Among employees, 18% of ...
Tramontano Angela C AC Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, - - 2013
A subset of patients with stage IA and IB non-small cell lung cancer (NSCLC) is ineligible for surgical resection and undergoes radiation therapy. Radiofrequency ablation (RFA) and stereotactic body radiotherapy are newer potentially attractive alternative therapies. We added RFA and stereotactic body radiotherapy treatment modules to a microsimulation model that ...
Sears Jeanne M JM Department of Health Services, School of Public Health, University of Washington, Seattle 98195, USA. - - 2013
Traumatic brain injury (TBI) is one of the most common, costly, and disabling occupational injuries. Objectives included determining whether work-related TBI could be reliably identified using the Occupational Injury and Illness Classification System (OIICS) and describing challenges in developing an OIICS-based TBI case definition. Washington State trauma registry reports and ...
Madnani Nina N Department of Dermatology, P D Hinduja National Hospital, Mahim, Mumbai, - - 2013
Polycystic ovarian syndrome (PCOS) is a "multispeciality" disorder suspected in patients with irregular menses and clinical signs of hyperandrogenism such as acne, seborrhoea, hirsutism, irregular menses, infertility, and alopecia. Recently, PCOS has been associated with the metabolic syndrome. Patients may develop obesity, insulin resistance, acanthosis nigricans, Type 2 diabetes, dyslipidemias, ...
Branch Kelley R KR Division of Cardiology, University of Washington, Seattle, WA 98195, USA. - - 2013
Coronary CT angiography has high sensitivity, but modest specificity, to detect acute coronary syndrome. We studied whether adding resting CT myocardial perfusion imaging improved the detection of acute coronary syndrome. Patients with low-to-intermediate cardiac risk presenting with possible acute coronary syndrome received both the standard of care evaluation and a ...
Chang Sandy S Department of Laboratory Medicine and Pathology at Yale University School of Medicine, New Haven, Connecticut, USA. - - 2013
Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.
Makowski Kamil K Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, - - 2013
C75 is a synthetic compound described as having antitumoral properties. It produces hypophagia and weight loss in rodents, limiting its use in cancer therapy but identifying it as a potential anti-obesity drug. C75 is a fatty acid synthase (FAS) inhibitor and, through its coenzyme A (CoA) derivative, it acts as ...
Besra Laxman L Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, - - 2013
Periorbital dermatoses are very common dermatological disorders which pose a diagnostic and therapeutic challenge for the treating dermatologist due to the similarity of symptoms in this area. To study the spectrum of periorbital dermatoses and to assess the association of systemic diseases with periorbital dermatoses. This was a hospital based ...
Ocampo-García Blanca E BE Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Estado de México, - - 2013
The α(ν)β(3) integrin is over-expressed in the tumor neovasculature and the tumor cells of glioblastomas. The HIV Tat-derived peptide has been used to deliver various cargos into cells. The aim of this research was to synthesize and assess the in vitro and in vivo uptake of (99m)Tc-N₂S₂-Tat(49-57)-c(RGDyK) ((99m)Tc-Tat-RGD) in α(ν)β(3) ...
Hill Kevin P KP Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts, USA. - - 2013
We assessed the feasibility of a new cognitive behavioral therapy (CBT) manual, plus transdermal patch nicotine replacement therapy (NRT), to treat co-occurring nicotine and cannabis dependence. Seven of 12 (58.3%) adults with DSM-IV diagnoses of both nicotine and cannabis dependence completed 10 weeks of individual CBT and NRT. Participants smoked ...
Clements Wilson K WK Department of Hematology, Division of Experimental Hematology, St Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, Tennessee 38105, - - 2013
Haematopoietic stem cells (HSCs) are tissue-specific stem cells that replenish all mature blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of transplantation-based therapies for leukaemias and congenital blood disorders. Researchers have long been interested in understanding the normal signalling mechanisms that specify HSCs in the ...
Gryczynski Jan J Friends Research Institute, 1040 Park Avenue, Baltimore, MD 21201, USA. - - 2013
Recent policy initiatives in Baltimore City, MD significantly reduced access disparities between methadone and buprenorphine in the publicly funded treatment sector. This study examines reasons for choosing buprenorphine over methadone among patients with access to both medications. This study was embedded within a larger clinical trial conducted at two outpatient ...
Shah Rashmi R RR Rashmi Shah Consultancy Ltd., 8 Birchdale, Gerrards Cross, Buckinghamshire SL9 7JA, UK. - - 2013
The development of tyrosine kinase inhibitors (TKI) represents a major milestone in oncology. However, their use has been found to be associated with serious toxicities that impinge on various vital organs including the heart. Sixteen TKIs have been approved for use in oncology as of 30 September 2012, and a ...
Park Jae-Hyung - - 2013
Green tea extract (GTE) is regarded to be effective against obesity and type 2 diabetes, but definitive evidences have not been proven. Based on the assumption that the gallated catechins (GCs) in GTE attenuate intestinal glucose and lipid absorption, while enhancing insulin resistance when GCs are present in the circulation ...
Gollnick I - - 2013
PROBLEM DEFINITION: Increasing specialization can be observed in the various medical fields and as a consequence there is little professional exchange between ear nose and throat (ENT) specialists and general practitioners. At the same time there has been significant technological development in telemedicine over the last 5 years; however, this potential ...
Wyen H - - 2013
BACKGROUND: The German National Surgical Trial Network (CHIR-Net) which has been funded since 2006 by the Federal Ministry of Education and Research (BMBF, funding code 01GH1001A-01GH1001F, 01GH0702) is made up of eight regional surgical centers. The aim of the CHIR-Net is the design, implementation and publication of prospective, randomized, multicenter ...
Rüßler H - - 2013
The social and political participation of elderly people is characterized by social inequality. Participation processes normally consolidate and intensify the exclusion of senior citizens having low incomes and low educational qualifications. In the research and development project "Quality of Life of Elderly People in Living Quarters" being conducted by Dortmund ...
Schülein S - - 2013
BACKGROUND: In order to develop and coordinate an integrated plan for treatment of hospitalized elderly patients in danger of future falls it is of utmost importance to ensure using the assessment that best targets people who are at risk for falling. For this purpose the performance-oriented mobility assessment (POMA) and ...
Haisch A - - 2013
BACKGROUND: There are very few studies analyzing the functional und audiological results of tympanoplasty type I using pure perichondrium. MATERIALS AND METHODS: Data of 80 randomly selected patients, who had tympanoplasty surgery between 1998 and 2008 with pure perichondrium were evaluated retrospectively. Average postoperative follow-up was 9 months. The preoperative- and ...
Becher K - - 2013
A multidisciplinary German expert group met in 2012 to discuss the current status and prospects of health care of geriatric patients with urinary incontinence in Germany. The purpose of this position paper is to raise awareness among health care providers for the challenges associated with adequate management of urinary incontinence ...
Schiel S - - 2013
The case of a 7-year-old boy suffering from progressive submental/submandibular swelling is reported. Following clinical and imaging diagnostics (MRI), the suspected diagnosis of a sublingual-plunging ranula was made. Surgery was performed with transoral excision of the sublingual gland in combination with excision of the ranula. Additional submandibular gland excision should ...
Schirren J - - 2013
Lung cancer is localized in the upper lobes in more than half of the cases. The risk of tumor infiltration of centrally located structures, such as bronchi and vessels are enhanced due to the anatomic topography. Pneumonectomy competes with sleeve resection for the surgical resection of centrally located tumors. The ...
Barg A - - 2013
Both arthroscopic and open surgical techniques may be used for treatment of osteochondral lesions of the ankle joint. Osteotomy around the ankle joint is a well established technique to extend the approach in cases where the osteochondral lesions are located more posteriorly. Medial, oblique, monoplanar malleolar osteotomy should be used ...
Möller A - - 2013
Social inequality in Germany is discussed primarily with regard to educational or social welfare issues. There is a political consensus that more action should be taken to ensure equality of chances and fulfillment of basic needs for everyone. In long-term care these considerations have not yet taken place and there ...
Ahmed Sofia S Department of Materials Science and Engineering, The Kroto Research Institute, University of Sheffield, North Campus, Broad Lane, Sheffield, S3 7HQ, - - 2013
Solid-state properties of tolfenamic acid (TA) and its complexes with chitosan (CT) have been studied. Effect of medium pH, molecular weight of polymer and its different concentrations on these TA-CT complexes were studied in detail. Low and medium molecular weight CT have been used in different ratios at pH ranging ...
McGonigle Barry - - 2013
Barry McGonigle was installed as the new President of the British Dental Association at the 2013 British Dental Conference and Exhibition held in ExCeL, London on 25-27th April 2013. The following is his presidential address.
Inomata Takeshi - - 2013
The spread of plaza-pyramid complexes across southern Mesoamerica during the early Middle Preclassic period (1000 to 700 BCE) provides critical information regarding the origins of lowland Maya civilization and the role of the Gulf Coast Olmec. Recent excavations at the Maya site of Ceibal, Guatemala, documented the growth of a ...
Krol Marieke - - 2013
Productivity costs occur when the productivity of individuals is affected by illness, treatment, disability or premature death. The objective of this paper was to review past and current developments related to the inclusion, identification, measurement and valuation of productivity costs in economic evaluations. The main debates in the theory and ...
Ballantyne Anita - - 2013
Genentech and ImmunoGen are collaborating on the development of trastuzumab emtansine, a HER2 antibody-drug conjugate that comprises Genentech's trastuzumab antibody linked to ImmunoGen's anti-mitotic agent, mertansine (a maytansine derivative; also known as DM1). The conjugate combines two strategies: the anti-HER2 activity of trastuzumab, and the targeted intracellular delivery of mertansine, ...
Yogev Yariv - - 2013
Abstract OBJECTIVE: To compare the performance of the 50g-glucose challenge test (GCT) and the 100g-oral glucose tolerance test (OGTT) in twin versus singleton pregnancies. METHODS: A retrospective study of all women who underwent a GCT (24 to 28 weeks) and delivered in a single tertiary medical center (2001-2012). The performance ...
Chen Mei-Chun - - 2013
BACKGROUND: In Chinese physiognomy, lower-lid pretarsal fullness is considered a sign of beauty in women. However, there are no data regarding the normal measurements of pretarsal fullness. The purpose of this study was to evaluate the average appearance of lower-lid pretarsal fullness in oriental women of specific age groups with ...
Storr-Paulsen Allan - - 2013
Purpose:  The purpose of this study was to assess the incidence of intraoperative floppy iris syndrome (IFIS) and the morphology of the corneal endothelium after cataract extraction in Caucasian male patients exposed to the α-1a adrenergic receptor antagonist tamsulosin. Methods:  In a clinical prospective study, 23 male patients (23 eyes) ...
Ma Hong - - 2013
Analyses of a new male sterility gene from a well-known rice cytoplasmic sterile line reveal inhibition of a nucleus-encoded protein and counteractions by nuclear fertility restorer factors. The existence of these genes in wild rice populations suggests that they may confer selective advantages.
Liu Yuchen - - 2013
RNA-protein interaction plays a significant role in regulating eukaryotic translation. This phenomenon raises questions about the ability of artificial biological systems to take the advantage of protein-RNA interaction. Here, we designed an oncogenic signal-processing system expressing both a Renilla luciferase reporter gene controlled by RNA-protein interaction in its 5'-untranslated region ...
Fragouli Elpida - - 2013
Despite the clinical importance of aneuploidy, surprisingly little is known concerning its impact during the earliest stages of human development. This study aimed to shed light on the genesis, progression, and survival of different types of chromosome anomaly from the fertilized oocyte through the final stage of preimplantation development (blastocyst). ...
Parlamas George - - 2013
PURPOSE: The purpose of this study is to systematically review and meta-analyse the available literature on the treatment of chronic syndesmotic injuries of the ankle. METHODS: A systematic review of the PubMed/MEDLINE and EMBASE databases was conducted in August 2012 utilizing the keywords (treatment OR intervention) AND (injury OR sprain ...
Dixit Shreya - - 2013
This article presents findings from a survey of Australian dermatologists who were questioned about their preferred pain control methods when carrying out injectable procedures. We also present, what is to the best of our knowledge, the first proof-of-concept experiment exploring the relationship between ice-to-skin contact time and skin surface temperature, ...
Yang Jianghua - - 2013
Heat shock proteins (HSPs) are molecular chaperones and have an important role in the refolding and degradation of misfolded proteins, and these functions are related to aging. Rotifer is a useful model organism in aging research, owing to small body size (0.1-1 mm), short lifespan (6-14 days), and senescence phenotypes that can ...
Sun Xuanrong - - 2013
CaIPF19998, a functionally unknown gene in Candida albicans, was identified by its homology to Saccharomyces cerevisiae AIF1 gene, which is involved in cell apoptosis. In this study, ipf19998 null mutant was generated with the URA-blaster method and the construction of overexpression of CaIPF19998 was measured by quantitative RT-PCR. Minimal inhibitory ...
Raj G - - 2013
BACKGROUND: Guidelines for the management of genital Lichen sclerosus (LS) have recently been updated. OBJECTIVE: To look at the audit points suggested by the updated guidelines: performance of biopsies in active LS not responding to treatment; clear follow-up arrangements for patients with active disease; patient awareness of need to report ...
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