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Kang Kai B KB *Department of Ophthalmology, Weill Cornell Medical College, New York, New York; †Division of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, California; and Departments of ‡Ophthalmology and §Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, - - 2013
To describe the utility of using wide-angle digital imaging in the training for retinopathy of prematurity with laser and in identifying common locations of skip areas that were present after initial panretinal photocoagulation with indirect ophthalmoscopy by ophthalmologists-in-training. Retrospective review of digital retinal images of 22 eyes of 12 infants ...
Manunta Maria D I MD Wolfson Centre for Gene Therapy of Childhood Disease, UCL-Institute of Child Health, University College London, 30 Guilford St., London, United - - 2013
Receptor-targeted nanocomplexes are nonviral vectors developed for gene delivery to the airway epithelium for the treatment of pulmonary disease associated with cystic fibrosis. The present study aimed to optimize the delivery of the nanocomplex by nebulization, and to monitor the in vivo deposition of radiolabeled vector in the airways of ...
Hansen Sean O SO Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, - - 2013
To evaluate retinal structural and functional abnormalities in a patient with acute macular neuroretinopathy. An adaptive optics scanning light ophthalmoscope was used to image the photoreceptor mosaic and assess rod and cone structure. Spectral-domain optical coherence tomography was used to examine retinal lamination. Microperimetry was used to assess function across ...
Goldenberg Shira M SM *Division of Global Public Health, Department of Medicine University of California, San Diego, CA; †Departamento de Estudios de Poblacion, El Colegio de la Frontera Norte, Tijuana, Mexico; ‡Faculty of Medicine, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez, Mexico; and §Pro-COMUSIDA, Tijuana, - - 2013
To investigate individual, interpersonal, and social-structural factors associated with involuntary sex exchange among female sex workers (FSWs) along the Mexico-U.S. border. In 2010 to 2011, 214 FSWs from Tijuana (n = 106) and Ciudad Juarez (n = 108) aged ≥ 18 years who reported lifetime use of heroin, cocaine, crack, ...
Kigozi Godfrey G *Rakai Health Sciences Program, Entebbe, Uganda; †Department of Urology, Mulago Hospital, Kampala, Uganda; ‡School of Public Health, Makerere University, Kampala, Uganda; §Department of Urology, Weill Cornell Medical College, Cornell University, New York, NY; ‖Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; and ¶College of Health Sciences, Makerere University, Kampala, - - 2013
Medical male circumcision (MMC) is recommended for HIV prevention in men. We assessed the acceptability and safety of the Shang Ring device compared with those of the dorsal slit method. HIV-negative, uncircumcised men aged 18 years or older who requested free MMC services in rural Rakai, Uganda, were informed about ...
Karim Saadia A SA Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, - - 2013
Src family kinase activity is elevated in a number of human cancers including breast cancer. This increased activity has been associated with aggressive disease and poor prognosis. Src inhibitors are currently in clinical development with a number of trials currently assessing their activity in breast cancer. However, the results to ...
Stoilova-McPhie Svetla - - 2013
Factor VIII (FVIII) is the blood coagulation protein which when defective or deficient causes for hemophilia A, a severe hereditary bleeding disorder. Activated FVIII (FVIIIa) is the cofactor to the serine protease factor IXa (FIXa) within the membrane-bound Tenase complex, responsible for amplifying its proteolytic activity more than 100,000 times, ...
Hakem Ilhem F - - 2013
The compositional heterogeneity associated with polymer conjugation reactions of biomolecules is analyzed for the particular case of nonspecific PEGylation reactions. It is shown that the distribution of the number of PEG moieties grafted to biomolecules such as proteins is a binomial-type function of two parameters-the reaction efficiency as well as ...
Nguyen Hieu N - - 2013
The gene 5 protein (g5p) encoded by the Ff strains of Escherichia coli bacteriophages is a dimeric single-stranded DNA-binding protein (SSB) that consists of two identical OB-fold (oligonucleotide/oligosaccharide-binding) motifs. Ultrafast time-resolved fluorescence measurements were carried out to investigate the effect of g5p binding on the conformation of 2-aminopurine (2AP) labels ...
Kulkarni Ashok K - - 2013
The NMR and molecular dynamics methods are used to study the conformations of a hexapeptide, GRGDTP, which has been shown to be accessible to various types of cell-adhesion based cellular behaviors such as cell-to-matrix interactions, cell differentiation, immunogenicity development, gene expression, angiogenesis, metastasis, sex determination and gamete fusion. (1) H-NMR ...
Suzuki Nanao - - 2013
Calmodulin (CaM) is a Ca(2+) -binding protein that regulates a number of fundamental cellular activities. Nicotiana tabacum CaM (NtCaM) comprises 13 genes classified into three types, among which gene expression and target enzyme activation differ. We performed Fourier-transform infrared spectroscopy to compare the secondary and coordination structures of Mg(2+) and ...
Okuyama Kenji - - 2013
The single-crystal structure of the collagen-like peptide (Pro-Pro-Gly)4 -Hyp-Asp-Gly-(Pro-Pro-Gly)4 , was analyzed at 1.02 Å resolution. The overall average helical twist (θ = 49.6°) suggests that this peptide adopts a 7/2 triple-helical structure and that its conformation is very similar to that of (Gly-Pro-Hyp)9 , which has the typical repeating ...
Barton Matthias M Molecular Internal Medicine, University of Zurich, Zurich, Switzerland. - - 2013
In view of recent findings on the anatomic heterogeneity of rapid vasodilation via estrogen receptor (ER)-dependent mechanisms, it is obvious that with regard to human physiology and disease much of it is still unknown, and research in this area is urgently needed. This is also important because chronic drug therapy ...
Breivik Cathrine Nansdal CN Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway. - - 2013
There are few reports about the course of vestibular schwannoma (VS) patients following gamma knife radiosurgery (GKRS) compared with the course following conservative management (CM). In this study, we present prospectively collected data of 237 patients with unilateral VS extending outside the internal acoustic canal who received either GKRS (113) ...
Hauptman Jason S JS Department of Neurosurgery, Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles, California, - - 2013
It is unclear if socioeconomic factors like type of insurance influence time to referral and developmental outcomes for pediatric patients undergoing epilepsy surgery. This study determined whether private compared with state government insurance was associated with shorter intervals of seizure onset to surgery and better developmental quotients for pediatric patients ...
Hallstrand Teal S TS Department of Medicine, University ofWashington, Seattle, WA, USA. - - 2013
Indirect airway hyperresponsiveness (AHR) is a fundamental feature of asthma that is manifest as exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 group X (sPLA2-X) plays a key role in regulating eicosanoid formation and the development of inflammation and AHR in murine models. We sought to examine sPLA2-X in the airway epithelium ...
Ho Jennifer E JE Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, - - 2013
Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with existing cardiovascular disease. ST2 and its ligand, interleukin-33 (IL-33), are expressed in endothelial cells, and may play an important role in the development of early atherosclerosis and vascular biology. We sought to investigate the association of sST2 and progression ...
Geiger Hartmut H Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany. - - 2013
Hematopoietic stem cells (HSCs) continuously provide mature blood cells during the lifespan of a mammal. The functional decline in hematopoiesis in the elderly, which involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, is partly linked to HSC aging. Molecular mechanisms of HSC aging ...
Evans David T DT New England National Primate Research Center, Harvard Medical School, Southborough, Massachusetts, - - 2013
Over the past decades, AIDS research has made tremendous progress in all key areas, including pathogenesis, prevention, and treatment. In particular, the introduction of potent antiretroviral therapy (ART) has dramatically reduced the morbidity and mortality of HIV-infected individuals. However, several challenges remain, including the absence of a vaccine that can ...
Huang Yvonne J - - 2013
Study of the human lung microbiome in the context of pulmonary health and disease is an area of emerging research interest that is being driven by several contributing factors. These factors include increased recognition of the diversity of human-associated microbiota, their roles in health and in diseases associated with chronic ...
Smrž Daniel - - 2013
Following antigen/IgE-mediated aggregation of high affinity IgE-receptors (FcεRI), mast cells (MCs) degranulate and release inflammatory mediators leading to the induction of allergic reactions including anaphylaxis. Migration of MCs to resident tissues and sites of inflammation is regulated by tissue chemotactic factors such as stem cell factor (SCF (KIT ligand)). Despite ...
Schwartz Daniel P - - 2013
Nummular headache (NH) is a rare headache disorder characterized by focal and well-circumscribed pain fixed within a rounded or oval/elliptical-shaped area of the head, typically 2 to 6 cm in diameter (Grosberg et al. Curr Pain Headache Rep 11:310-2, 2007). The disorder most commonly affects the parietal region and is almost ...
Drapisz Sylwia - - 2013
Recently, it has been reported that nonstenotic bicuspid aortic valve (BAV) with dilated proximal aorta is linked with increased matrix metalloproteinase-2 (MMP-2) and endothelial dysfunction. We wondered whether asymmetric dimethylarginine (ADMA), a nitric oxide synthase inhibitor, might be altered and associated with MMP-2 in BAV patients. We assessed the relation ...
Kessler Thorsten - - 2013
Coronary artery disease is a complex disease influenced by modifiable risk factors as well as genetic susceptibility. The genetics of coronary artery disease and myocardial infarction have long been enigmatic. Recent advances in molecular genetics and biology, bioinformatics, and statistics have allowed us to study the interaction of exogenous and ...
Higgins H William HW Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, - - 2013
Reported physiologic nipple changes in pregnancy do not include hyperkeratosis and are expected to resolve or improve post partum. Hyperkeratosis of the nipple and/or areola can develop in the context of inflammatory diseases (such as atopic dermatitis), in acanthosis nigricans, as an extension of epidermal nevus, after estrogen treatment, and/or ...
Vivehanantha Sivanie S Department of Dermatology, Worcestershire Royal Hospital, Charles Hastings Way, Worcester WR5 1DD, England. - - 2013
Epidermolysis bullosa (EB) pruriginosa is a rare variant of dystrophic EB. It may manifest late in life and is characterized by intense pruritus, resulting in a phenotype resembling acquired inflammatory dermatoses. Dermatopathology textbooks include hereditary forms of EB among the "cell-poor" list of subepidermal blistering disorders. We report a case ...
Decety Jean J Department of Psychology, The University of Chicago, Chicago, Illinois 60637, USA. - - 2013
A marked lack of empathy is a hallmark characteristic of individuals with psychopathy. However, neural processes associated with empathic processing have not yet been directly examined in psychopathy, especially in response to the perception of other people in pain and distress. To identify potential differences in patterns of neural activity ...
Lei Fengyang F Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, - - 2013
Survivin, an inhibitor of apoptosis family molecule, has been proposed as a crucial intermediate in the signaling pathways leading to T-cell development, proliferation, and expansion. However, the importance of survivin to T-cell-driven inflammatory responses has not been demonstrated. Here, we show that survivin transgenic mice exhibit an increased antigen-driven Th2 ...
Hadeiba Husein - - 2013
Central tolerance is critical in establishing a peripheral T-cell repertoire purged of functional autoreactive T cells. One of the major requirements for effective central tolerance is the presentation of self and other innocuous antigens (Ags), including food, gut flora, or airway allergens, to developing T cells in the thymus. This seemingly ...
Pérez-Gil Jordi - - 2013
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including humans), which synthesize their isoprenoid precursors using the completely unrelated ...
Costanzo Maddalena - - 2013
The misfolding and aggregation of specific proteins is a common hallmark of many neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and Parkinson's diseases, as well as rarer disorders such as Huntington's and prion diseases. Among these, only prion diseases are 'infectious'. By seeding misfolding of the PrPC (normal ...
Jassal Mandeep S MS Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. - - 2013
Applied environmental strategies for asthma control are often expensive, but may save longer-term healthcare costs. Whether these savings outweigh additional costs of implementing these strategies is uncertain. We conducted a systematic review to estimate the expenditures and savings of environmental interventions for asthma in the state of Maryland. Direct costs ...
Seneviratne Uthpala U Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
Nitrosothiols (RSNOs) have been proposed as important intermediates in nitric oxide (NO(•)) metabolism, storage, and transport as well as mediators in numerous NO-signaling pathways. RSNO levels are finely regulated, and dysregulation is associated with the etiology of several pathologies. Current methods for RSNO quantification depend on indirect assays that limit ...
Ramos Rebecca - - 2013
In lieu of gifts, RNs donate their services, time, and money.
Wang Hongwei - - 2013
The therapeutic effects of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on cutaneous squamous cell carcinoma (SCC) are not fully understood, and the usefulness of topical PDT in the treatment of SCC is still debatable. The most interesting aspect in SCC PDT is perhaps its potential in inducing antitumor immune responses. ...
Firmes Luciana Barbosa - - 2013
The purpose of this study was to compare the effects of conjugated equine estrogens (CEE) and estradiol benzoate on the blood pressure and body weight of spontaneously hypertensive rats (SHRs) and the associated changes in several components of the natriuretic peptide system. The blood pressure of randomly distributed female SHRs ...
Holman Dawn M - - 2013
In an effort to explore opportunities for cancer prevention during preadolescence and adolescence, the Cancer Prevention Across the Lifespan workgroup within the Division of Cancer Prevention and Control at the Centers for Disease Control and Prevention (CDC) convened an informal panel of experts for a 2-day workshop August 9-10, 2011. ...
Suzuki Daisuke - - 2013
The transcription factor p63 plays an essential role in maintaining the proliferative potential of epidermal stem cells. We have shown recently that under homoeostatic conditions, phosphorylation of p63 increases during the early transition of stem cells to transit-amplifying cells in human epidermis. However, how p63 phosphorylation relates to the regenerative ...
Shao Zhenzhen - - 2013
The aim of this study is to assess the diagnostic performance of contrast-enhanced magnetic resonance (MR) imaging in patients with non-mass-like breast lesions in a meta-analysis. Literature study was performed on PubMed data base on the diagnostic performance of MR imaging in patients with non-mass-like breast lesions. Details of the ...
Tsutsumi Moe - - 2013
Recovery of cultured keratinocytes after scratch damage is considered to be a wound-healing model. In this study, we observed changes in intracellular calcium concentration ([Ca(2+) ]i ) in cultured human keratinocytes after scratch damage. Immediately after scratch damage, a wave of increased [Ca(2+) ]i radiated outward from the damaged area ...
Gehlert Sarah - - 2013
Turning disciplinary knowledge about preadolescents' and adolescents' exposure to risk factors for cancer as adults into solutions for preventing such an outcome requires that investigators from a variety of backgrounds and disciplines come together to share knowledge. Optimally, these collaborations would occur across two dimensions: (1) transdisciplinary, from the molecular ...
Lockmann Anike - - 2013
Many immunological experiments would be greatly facilitated if peripheral blood mononuclear cells (PBMC) preserved important functional properties over longer periods of time. Regarding adhesive interactions with endothelial cells, a crucial step of inflammatory processes, this had not been investigated yet. We demonstrate that PBMC subsets subjected to controlled cryopreservation retain ...
Pimenta Filipa - - 2013
The present study aims to validate a climacteric-specific measure of global quality of life, namely, the Utian Quality of Life Scale (UQoLS), in a community sample of women with different menopause status. A community sample of 1,003 Portuguese women in premenopause, perimenopause, and postmenopause filled out UQoLS, the Menopause Symptoms' ...
Holman Dawn M - - 2013
Exposure to ultraviolet radiation and a history of sunburn in childhood contribute to risk of skin cancer in adolescence and in adulthood, but many adolescents continue to seek a tan, either from the sun or from tanning beds (i.e., intentional tanning). To understand tanning behavior among adolescents, we conducted a ...
Rosenberg Karen - - 2013
Affiliation strengthens advocacy, political clout.
Behrend Susan Weiss - - 2013
An observational study was conducted in response to public concern regarding the release of both known and suspected environmental carcinogens following the terrorist attacks of September 11, 2001, at the World Trade Center (WTC) in New York, NY, and the potential increase of cancer incidence among exposed individuals. The study ...
Jacobson Joy - - 2013
Despite regional and national efforts to improve access, many eligible patients aren't getting the care they need.
Lehto Rebecca H - - 2013
Purpose/Objectives: To examine perceived cognitive effectiveness and worry in individuals with suspected lung cancer before and after surgical resection and to determine any differences between individuals with and without a postoperative diagnosis of lung cancer.Design: A repeated measures longitudinal design.Setting: A comprehensive cancer center and a Veterans Administration medical center ...
Adams Jeffrey M - - 2013
This study uses the qualitatively developed Adams Influence Model© (AIM) and concepts from the psychometrically validated Revised Professional Practice Environment scale to guide the development of the Leadership Influence Over Professional Practice Environments Scale. Nurse executives and others can use this scale individually or in conjunction with instruments targeting staff ...
Eisenberg Seth - - 2013
Purpose/Objectives: To evaluate the effectiveness of ondansetron for the prevention of nausea and vomiting from dimethylsulfoxide (DMSO) during autologous stem cell transplantation (ASCT) infusion.Design: Nonrandomized cohort using historical control.Setting: Comprehensive cancer center outpatient infusion department.Sample: 50 patients receiving ASCT in the outpatient setting.Methods: Patients were assessed for nausea and vomiting ...
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