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Abuelem Tarek T *Department of Neurosurgery, Baylor College of Medicine, Houston, Texas; ‡Department of Neurology, Baylor College of Medicine, Houston, - - 2013
Invasive monitoring using subdural electrodes is often valuable for characterizing the anatomic source of seizures in intractable epilepsy. Covering the interhemispheric surface with subdural electrodes represents a particular challenge, with a potentially higher risk of complications than covering the dorsolateral cortex. To better understand the safety and utility of interhemispheric ...
Matys Tomasz T *Section of Neuroradiology; and ‡Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, United Kingdom; §Department of Radiology, University of Cambridge, Cambridge, United - - 2013
The aqueduct of Sylvius (AqSylv) is a structure of increasing importance in neuroendoscopic procedures. However, there is currently no clear and adequate description of the normal anatomy of the AqSylv. To study in detail hitherto unavailable normal magnetic resonance imaging morphometry and anatomic variants of the AqSylv. We retrospectively studied ...
Kutlay Murat M Department of Neurosurgery, Gulhane Military Medical Academy, Etlik-Ankara, - - 2013
During tumor removal in the endoscopic endonasal approach to pituitary adenomas with a significant suprasellar extension, the early descent of diaphragma sellae obscuring the visualization of the surgical field is a surgical challenge. To describe a simple diaphragma retraction technique to eliminate this problem. A transparent flexible material (a strip ...
Kang Kai B KB *Department of Ophthalmology, Weill Cornell Medical College, New York, New York; †Division of Ophthalmology, Children's Hospital Los Angeles, Los Angeles, California; and Departments of ‡Ophthalmology and §Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, - - 2013
To describe the utility of using wide-angle digital imaging in the training for retinopathy of prematurity with laser and in identifying common locations of skip areas that were present after initial panretinal photocoagulation with indirect ophthalmoscopy by ophthalmologists-in-training. Retrospective review of digital retinal images of 22 eyes of 12 infants ...
Edmunds Julie M JM Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA, 19122, USA, - - 2013
The training literature suggests that ongoing support following initial therapist training enhances training outcomes, yet little is known about what occurs during ongoing support and what accounts for its effectiveness. The present study examined consultation sessions provided to 99 clinicians following training in cognitive-behavioral therapy for youth anxiety. Recorded consultation ...
Orsmond Gael I GI Department of Occupational Therapy, Boston University, Boston, MA, 02215, USA, - - 2013
Investigating social participation of young adults with an autism spectrum disorder (ASD) is important given the increasing number of youth aging into young adulthood. Social participation is an indicator of life quality and overall functioning. Using data from the National Longitudinal Transition Study 2, we examined rates of participation in ...
Ruano R R Baylor College of Medicine and Texas Children's Hospital, Department of Obstetics and Gynecology, Division of Maternal-Fetal Medicine, Houston, TX, USA; Faculdade de Medicina da Universidade de Sao Paulo, Department of Obstetrics and Gynecology, Sao Paulo, SP, - - 2013
To document perinatal outcomes following use of the 'Solomon technique' in the selective photocoagulation of placental anastomoses for severe twin-twin transfusion syndrome (TTTS). Between January 2010 and July 2012, data were collected from 102 consecutive monochorionic twin pregnancies complicated by severe TTTS that underwent fetoscopic laser ablation at four different ...
Manunta Maria D I MD Wolfson Centre for Gene Therapy of Childhood Disease, UCL-Institute of Child Health, University College London, 30 Guilford St., London, United - - 2013
Receptor-targeted nanocomplexes are nonviral vectors developed for gene delivery to the airway epithelium for the treatment of pulmonary disease associated with cystic fibrosis. The present study aimed to optimize the delivery of the nanocomplex by nebulization, and to monitor the in vivo deposition of radiolabeled vector in the airways of ...
Honkoop Persijn J PJ Department of Medical Decision Making, Leiden University Medical Center, The Netherlands • Department of Public Health and Primary Care, Leiden University Medical Center, the - - 2013
Online self-management programmes for asthma have recently become available. International guidelines suggest that the Asthma Control Questionnaire (ACQ) can be used in these programmes. In order to assess the current level of control and guide therapy, the same cut-off values are being used as in conventional asthma management. However, results ...
Hansen Sean O SO Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, - - 2013
To evaluate retinal structural and functional abnormalities in a patient with acute macular neuroretinopathy. An adaptive optics scanning light ophthalmoscope was used to image the photoreceptor mosaic and assess rod and cone structure. Spectral-domain optical coherence tomography was used to examine retinal lamination. Microperimetry was used to assess function across ...
Flamar Anne-Laure AL aBaylor Institute for Immunology Research, Dallas, Texas, USA bANRS HIV Vaccine Network/Vaccine Research Institute, Paris cEcole doctorale Sciences de la Vie et de la Santé, Université Paris-Est, Créteil, France dINSERM U899 eNorth Texas Infectious Diseases, Dallas, Texas, USA fUniversité Paris-Est, Faculté de Médecine, INSERM U955 gAssistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, service d'immunologie clinique, Créteil, - - 2013
Targeting HIV antigens directly to dendritic cells using monoclonal antibodies against cell-surface receptors has been shown to evoke potent cellular immunity in animal models. The objective of this study was to configure an anti-human CD40 antibody fused to a string of five highly conserved CD4 and CD8 T-cell epitope-rich regions ...
Keller Sara C SC *Center for Healthcare Improvement and Patient Safety and †Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and ‡City of Philadelphia Department of Public Health, AIDS Activities Coordinating Office, Philadelphia, - - 2013
To compare the accuracy of linkage to care metrics for patients diagnosed with HIV using retention in care and virological suppression as the gold standards of effective linkage. A retrospective cohort study of patients aged 18 years and older with newly diagnosed HIV infection in the City of Philadelphia, 2007-2008. ...
Chiao Elizabeth Y EY *Department of Medicine, Baylor College of Medicine, Houston, TX; †Houston Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX; and ‡Baylor College of Medicine, Department of Medicine, Houston, - - 2013
Recent studies have shown that the incidence of squamous cell cancer of the anus (SCCA) has increased in the combined antiretroviral therapy (cART) era. The effect of undetectable HIV viral loads as a result of successful cART has not been evaluated. We performed a retrospective cohort study among male US ...
Kigozi Godfrey G *Rakai Health Sciences Program, Entebbe, Uganda; †Department of Urology, Mulago Hospital, Kampala, Uganda; ‡School of Public Health, Makerere University, Kampala, Uganda; §Department of Urology, Weill Cornell Medical College, Cornell University, New York, NY; ‖Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; and ¶College of Health Sciences, Makerere University, Kampala, - - 2013
Medical male circumcision (MMC) is recommended for HIV prevention in men. We assessed the acceptability and safety of the Shang Ring device compared with those of the dorsal slit method. HIV-negative, uncircumcised men aged 18 years or older who requested free MMC services in rural Rakai, Uganda, were informed about ...
Goldenberg Shira M SM *Division of Global Public Health, Department of Medicine University of California, San Diego, CA; †Departamento de Estudios de Poblacion, El Colegio de la Frontera Norte, Tijuana, Mexico; ‡Faculty of Medicine, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez, Mexico; and §Pro-COMUSIDA, Tijuana, - - 2013
To investigate individual, interpersonal, and social-structural factors associated with involuntary sex exchange among female sex workers (FSWs) along the Mexico-U.S. border. In 2010 to 2011, 214 FSWs from Tijuana (n = 106) and Ciudad Juarez (n = 108) aged ≥ 18 years who reported lifetime use of heroin, cocaine, crack, ...
Karim Saadia A SA Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, - - 2013
Src family kinase activity is elevated in a number of human cancers including breast cancer. This increased activity has been associated with aggressive disease and poor prognosis. Src inhibitors are currently in clinical development with a number of trials currently assessing their activity in breast cancer. However, the results to ...
Toyone Tomoaki T Department of Orthopaedic Surgery, Teikyo University Chiba Medical Center, Ichihara-city, Chiba, Japan. - - 2013
Prospective consecutive series. To evaluate the post-traumatic disc degeneration and range of motion 10 years after short-segment fixation without fusion for thoracolumbar burst fractures with neurological deficit. Early clinical results of short-segment fixation without fusion for thoracolumbar burst fractures were satisfactory. However, the long-term results have not been reported, and ...
Wagner Darcy E DE Department of Medicine, University of Vermont College of Medicine, Burlington, VT, - - 2013
For patients with end-stage lung diseases, lung transplantation is the only available therapeutic option. However, the number of suitable donor lungs is insufficient and lung transplants are complicated by significant graft failure and complications of immunosuppressive regimens. An alternative to classic organ replacement is desperately needed. Engineering of bioartificial organs ...
Maskew Mhairi M Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South - - 2013
The possible impact of coinfection with the Kaposi sarcoma-associated herpes virus (KSHV) on the response to antiretroviral therapy (ART) is unknown. Prospective studies are rare, particularly in Africa. We enrolled a prospective cohort of HIV-infected adults initiating ART in Johannesburg, South Africa. The subjects were defined as seropositive to KSHV ...
Pulgar Victor M VM Biomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC 27101, USA. - - 2013
Ouabain (Oua)-induced hypertension in rodents provides a model to study cardiovascular changes associated with human hypertension. We examined vascular function in rats after a long-term treatment with Oua. Systolic blood pressure was measured by tail-cuff plethysmography in male Sprague-Dawley rats treated with Oua (≈ 25 µg/d) or placebo for 8 ...
Deering Kathleen N KN BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, British Columbia, - - 2013
Among sex workers (SWs) in Vancouver, Canada, this study identified social, drug use, sex work, environmental-structural, and client-related factors associated with being offered and accepting more money after clients' demand for sex without a condom. Cross-sectional study using baseline (February 2010 to October 2011) data from a longitudinal cohort of ...
Stoilova-McPhie Svetla - - 2013
Factor VIII (FVIII) is the blood coagulation protein which when defective or deficient causes for hemophilia A, a severe hereditary bleeding disorder. Activated FVIII (FVIIIa) is the cofactor to the serine protease factor IXa (FIXa) within the membrane-bound Tenase complex, responsible for amplifying its proteolytic activity more than 100,000 times, ...
Hakem Ilhem F - - 2013
The compositional heterogeneity associated with polymer conjugation reactions of biomolecules is analyzed for the particular case of nonspecific PEGylation reactions. It is shown that the distribution of the number of PEG moieties grafted to biomolecules such as proteins is a binomial-type function of two parameters-the reaction efficiency as well as ...
Nguyen Hieu N - - 2013
The gene 5 protein (g5p) encoded by the Ff strains of Escherichia coli bacteriophages is a dimeric single-stranded DNA-binding protein (SSB) that consists of two identical OB-fold (oligonucleotide/oligosaccharide-binding) motifs. Ultrafast time-resolved fluorescence measurements were carried out to investigate the effect of g5p binding on the conformation of 2-aminopurine (2AP) labels ...
Kulkarni Ashok K - - 2013
The NMR and molecular dynamics methods are used to study the conformations of a hexapeptide, GRGDTP, which has been shown to be accessible to various types of cell-adhesion based cellular behaviors such as cell-to-matrix interactions, cell differentiation, immunogenicity development, gene expression, angiogenesis, metastasis, sex determination and gamete fusion. (1) H-NMR ...
Suzuki Nanao - - 2013
Calmodulin (CaM) is a Ca(2+) -binding protein that regulates a number of fundamental cellular activities. Nicotiana tabacum CaM (NtCaM) comprises 13 genes classified into three types, among which gene expression and target enzyme activation differ. We performed Fourier-transform infrared spectroscopy to compare the secondary and coordination structures of Mg(2+) and ...
Okuyama Kenji - - 2013
The single-crystal structure of the collagen-like peptide (Pro-Pro-Gly)4 -Hyp-Asp-Gly-(Pro-Pro-Gly)4 , was analyzed at 1.02 Å resolution. The overall average helical twist (θ = 49.6°) suggests that this peptide adopts a 7/2 triple-helical structure and that its conformation is very similar to that of (Gly-Pro-Hyp)9 , which has the typical repeating ...
Breivik Cathrine Nansdal CN Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway. - - 2013
There are few reports about the course of vestibular schwannoma (VS) patients following gamma knife radiosurgery (GKRS) compared with the course following conservative management (CM). In this study, we present prospectively collected data of 237 patients with unilateral VS extending outside the internal acoustic canal who received either GKRS (113) ...
Hauptman Jason S JS Department of Neurosurgery, Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles, California, - - 2013
It is unclear if socioeconomic factors like type of insurance influence time to referral and developmental outcomes for pediatric patients undergoing epilepsy surgery. This study determined whether private compared with state government insurance was associated with shorter intervals of seizure onset to surgery and better developmental quotients for pediatric patients ...
Ho Jennifer E JE Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, - - 2013
Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with existing cardiovascular disease. ST2 and its ligand, interleukin-33 (IL-33), are expressed in endothelial cells, and may play an important role in the development of early atherosclerosis and vascular biology. We sought to investigate the association of sST2 and progression ...
Geiger Hartmut H Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany. - - 2013
Hematopoietic stem cells (HSCs) continuously provide mature blood cells during the lifespan of a mammal. The functional decline in hematopoiesis in the elderly, which involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, is partly linked to HSC aging. Molecular mechanisms of HSC aging ...
Evans David T DT New England National Primate Research Center, Harvard Medical School, Southborough, Massachusetts, - - 2013
Over the past decades, AIDS research has made tremendous progress in all key areas, including pathogenesis, prevention, and treatment. In particular, the introduction of potent antiretroviral therapy (ART) has dramatically reduced the morbidity and mortality of HIV-infected individuals. However, several challenges remain, including the absence of a vaccine that can ...
Hallstrand Teal S TS Department of Medicine, University ofWashington, Seattle, WA, USA. - - 2013
Indirect airway hyperresponsiveness (AHR) is a fundamental feature of asthma that is manifest as exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 group X (sPLA2-X) plays a key role in regulating eicosanoid formation and the development of inflammation and AHR in murine models. We sought to examine sPLA2-X in the airway epithelium ...
Hsu Peter P Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, - - 2013
Hematopoietic stem cells (HSCs) residing in the hypoxic niches can both self-renew and give rise to progeny. Multiple regulatory mechanisms for these cellular processes have been identified. Emerging evidence has revealed that metabolism and bioenergetics play important roles in determining stem cell fate in concert with other regulatory networks. In ...
Schmitz Joern E JE Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. - - 2013
Soon after the discovery of HIV-infected humans, rhesus macaques in a colony at the New England Primate Research Center showed similar signs of a progressive immune suppression. The discovery of the simian immunodeficiency virus (SIV)-associated disease opened the door to study an AIDS-like illness in nonhuman primates (NHP). Even after ...
Wang Liqiang L Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, - - 2013
Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. In this study, we examined the effect of the site 1 sodium channel blocker tetrodotoxin (TTX) on the duration of corneal anesthesia, ...
Gangaputra Sapna S Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, WI 53717, - - 2013
To compare evaluation by clinical examination with image grading at a reading center for the classification of diabetic retinopathy and diabetic macular edema. Action to Control Cardiovascular Risk in Diabetes (ACCORD) and Family Investigations of Nephropathy in Diabetes (FIND) had similar methods of clinical and fundus photograph evaluation. For analysis ...
Barton Matthias M Molecular Internal Medicine, University of Zurich, Zurich, Switzerland. - - 2013
In view of recent findings on the anatomic heterogeneity of rapid vasodilation via estrogen receptor (ER)-dependent mechanisms, it is obvious that with regard to human physiology and disease much of it is still unknown, and research in this area is urgently needed. This is also important because chronic drug therapy ...
Marshall Paul W M PW School of Science and Health, University of Western Sydney, Penrith South, NSW 2751, Australia. - - 2013
Randomized controlled trial. This is the companion study to a previous publication that presented 8-week pain, disability, and trunk muscle motor control results. The objective of this study was to compare the effect of 8 weeks of specific trunk exercises and stationary cycling on outcomes measures of catastrophizing and fear-avoidance ...
Nichols Wilmer W WW Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32601, - - 2013
Wave reflections augment central aortic SBP and increase systolic pressure time integral (SPTI) thereby increasing left ventricular (LV) afterload and myocardial oxygen (MVO2) demand. When increased, such changes may contribute to myocardial ischemia and angina pectoris, especially when aortic diastolic time is decreased and myocardial perfusion pressure jeopardized. Accordingly, we ...
Chung Jae Lim JL Myung-Gok Eye Research Institute, Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South - - 2013
To compare the intraocular penetration of 4 fluoroquinolone eye drops after topical instillation into rabbit eyes. The tested drugs were levofloxacin 1.5% (LVFX), gatifloxacin 0.3%, moxifloxacin 0.5% (MFLX), and besifloxacin 0.6% (BFLX). Forty-eight New Zealand white rabbits were randomly assigned into 2 groups. For group 1 (40 rabbits, 80 eyes), ...
Fuchs Jonathan D JD San Francisco Department of Public Health, San Francisco, CA 94102, USA. - - 2013
In November 2010, the iPrEx study reported that preexposure prophylaxis (PrEP) with daily tenofovir disoproxil fumarate/emtricitabine reduced HIV infections by 44% among men who have sex with men and subsequent trials corroborated efficacy among heterosexual men and women. During regularly scheduled follow-up visits from January to March 2011, participants in ...
Huang Yvonne J - - 2013
Study of the human lung microbiome in the context of pulmonary health and disease is an area of emerging research interest that is being driven by several contributing factors. These factors include increased recognition of the diversity of human-associated microbiota, their roles in health and in diseases associated with chronic ...
Anderson William F WF DHHS/NIH/National Cancer Institute/Division of Cancer Epidemiology and Genetics/Biostatistics Branch, Bethesda, MD, USA. - - 2013
Long-term breast cancer trends in incidence in the United States (US) show rising estrogen receptor (ER)-positive rates and falling ER-negative rates. We hypothesized that these divergent trends reflect etiologic heterogeneity and that comparable trends should be observed in other countries with similar risk factor profiles. Therefore, we analyzed invasive female ...
DeSantiago Jaime J Section of Cardiology, Department of Medicine, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois 60612-7323, - - 2013
Mesenchymal stem cell (MSC) transplantation after ischemia/reperfusion (I/R) injury reduces infarct size and improves cardiac function. We used mouse ventricular myocytes (VMs) in an in vitro model of I/R to determine the mechanism by which MSCs prevent reperfusion injury by paracrine signaling. Exposure of mouse VMs to an ischemic challenge ...
Zhang Jingjing J Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, People's Republic of - - 2013
Different forms of biomaterials, including microspheres, sponges, hydrogels, and nanofibers, have been broadly used in cartilage regeneration; however, effects of internal structures of the biomaterials on cells and chondrogenesis remain largely unexplored. We hypothesized that different internal structures of sponges and hydrogels led to phenotypic disparity of the cells and ...
Kim Daniel C DC Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, - - 2013
Whispering gallery mode resonators are small, radially symmetric dielectrics that trap light through continuous total internal reflection. The resonant condition at which light is efficiently confined within the structure is linked with refractive index, which has led to the development of sensitive label-free sensing schemes based on whispering gallery mode ...
Smrž Daniel D Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. - - 2013
Following antigen/IgE-mediated aggregation of high affinity IgE-receptors (FcεRI), mast cells (MCs) degranulate and release inflammatory mediators leading to the induction of allergic reactions including anaphylaxis. Migration of MCs to resident tissues and sites of inflammation is regulated by tissue chemotactic factors such as stem cell factor (SCF (KIT ligand)). Despite ...
Li Mingming M Faculty of Dentistry, National University of Singapore, 11 Lower Kent Ridge Road, - - 2013
Human embryonic stem cells (hESCs) are uniquely endowed with a capacity for both self-renewal and multilineage differentiation. The aim of this investigation was to determine if short periods of cyclic mechanical strain enhanced dexamethasone, ascorbic acid, and β-glycerophosphate (triple-supplement)-induced osteogenesis and bone nodule formation by hESCs. Colonies were cultured for ...
Schwartz Daniel P - - 2013
Nummular headache (NH) is a rare headache disorder characterized by focal and well-circumscribed pain fixed within a rounded or oval/elliptical-shaped area of the head, typically 2 to 6 cm in diameter (Grosberg et al. Curr Pain Headache Rep 11:310-2, 2007). The disorder most commonly affects the parietal region and is almost ...
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